| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase kinase 5|Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4217) |
| External Link | https://ncbi.nlm.nih.gov/gene/4217 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the MAP3K5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CFD | complement factor D (adipsin) | 0.0138887 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0115296 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.0115066 |
| ACKR3 | atypical chemokine receptor 3 | 0.0110392 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | 0.0109952 |
| CYB5R1 | cytochrome b5 reductase 1 | 0.0108334 |
| ADIRF | adipogenesis regulatory factor | 0.010298 |
| IFI44L | interferon-induced protein 44-like | 0.0101619 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0100408 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00999902 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.00992519 |
| BAG2 | BCL2-associated athanogene 2 | 0.00985026 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00961021 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.00960666 |
| FBLN1 | fibulin 1 | 0.00949939 |
| DCN | decorin | 0.00931415 |
| NEBL | nebulette | 0.00920855 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00920024 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00913209 |
| GLUL | glutamate-ammonia ligase | 0.00884516 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 0.00881287 |
| ATF3 | activating transcription factor 3 | 0.00860207 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00858154 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00848897 |
| IFI44 | interferon-induced protein 44 | 0.00838715 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00821299 |
| AREG | amphiregulin | 0.00811997 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00809101 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00807747 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00803268 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00795255 |
| CHRDL1 | chordin-like 1 | 0.00792621 |
| PLN | phospholamban | 0.00791612 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00790518 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.00788063 |
| HMGB3 | high mobility group box 3 | 0.00776534 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00768306 |
| SH3BGR | SH3 domain binding glutamate-rich protein | 0.00768068 |
| TOX3 | TOX high mobility group box family member 3 | 0.00767771 |
| CLU | clusterin | 0.00767421 |
| PER2 | period circadian clock 2 | 0.00767278 |
| MX1 | MX dynamin-like GTPase 1 | 0.00766323 |
| PCP4 | Purkinje cell protein 4 | 0.0076569 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00764295 |
| TMEM47 | transmembrane protein 47 | 0.00762263 |
| METTL7A | methyltransferase like 7A | 0.00758745 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00753684 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00752346 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | 0.00752164 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00743453 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.00741494 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00740655 |
| TMEM176B | transmembrane protein 176B | 0.00734098 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00733412 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00732436 |
| TSNAX | translin-associated factor X | 0.00732192 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00720236 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00718985 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.0071626 |
| SFRP4 | secreted frizzled-related protein 4 | 0.00705969 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00703778 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00701121 |
| RRAGD | Ras-related GTP binding D | 0.00698864 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00686636 |
| C9ORF91 | chromosome 9 open reading frame 91 | 0.006812 |
| DIPK1A | divergent protein kinase domain 1A | 0.00680888 |
| ANK2 | ankyrin 2, neuronal | 0.00678831 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.0067852 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.00677609 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00675874 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.00674602 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 0.00671101 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0066908 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00665173 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.00662964 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00662636 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.00659418 |
| CLEC3B | C-type lectin domain family 3, member B | 0.00658397 |
| QKI | QKI, KH domain containing, RNA binding | 0.00657057 |
| EREG | epiregulin | 0.00653995 |
| NRN1 | neuritin 1 | 0.00653855 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00653153 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00652497 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00650195 |
| H2AFV | H2A histone family, member V | 0.00649515 |
| CA4 | carbonic anhydrase IV | 0.00645426 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00638451 |
| FAM107A | family with sequence similarity 107, member A | 0.00637087 |
| ESR1 | estrogen receptor 1 | 0.00631775 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00631771 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.0062923 |
| GPX2 | glutathione peroxidase 2 | 0.00627692 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00626558 |
| LYPLA1 | lysophospholipase I | 0.00621618 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00620317 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00618888 |
| MAOB | monoamine oxidase B | 0.00615694 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00615011 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00614799 |
| RTN2 | reticulon 2 | 0.00614125 |
| RBM34 | RNA binding motif protein 34 | 0.0061343 |
| OLFM1 | olfactomedin 1 | 0.00612578 |
| MPC1 | mitochondrial pyruvate carrier 1 | 0.00609264 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.00608293 |
| MYLIP | myosin regulatory light chain interacting protein | 0.00603412 |
| PALLD | palladin, cytoskeletal associated protein | 0.00601715 |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.0060116 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00599165 |
| CDC42 | cell division cycle 42 | 0.00598398 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00596535 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00595799 |
| IQCG | IQ motif containing G | 0.00595784 |
| ANOS1 | anosmin 1 | 0.00594336 |
| PIR | pirin (iron-binding nuclear protein) | 0.00593611 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.0059159 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00589334 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.00588427 |
| PALMD | palmdelphin | 0.0058599 |
| ASPN | asporin | 0.00585764 |
| PLTP | phospholipid transfer protein | 0.00585062 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00584464 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0058333 |
| MX2 | MX dynamin-like GTPase 2 | 0.00583176 |
| CYCS | cytochrome c, somatic | 0.00582565 |
| CD52 | CD52 molecule | 0.00581887 |
| CLCA4 | chloride channel accessory 4 | 0.00580517 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | 0.00579453 |
| TMEM14B | transmembrane protein 14B | 0.0057726 |
| CCNB1 | cyclin B1 | 0.00574741 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00574657 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.00574552 |
| CST1 | cystatin SN | 0.00574496 |
| CHCHD7 | coiled-coil-helix-coiled-coil-helix domain containing 7 | 0.00574329 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00574059 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.00572677 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00572219 |
| SIX1 | SIX homeobox 1 | 0.00572153 |
| CCN3 | cellular communication network factor 3 | 0.00571899 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.00571798 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00571768 |
| MT1X | metallothionein 1X | 0.00571286 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00568386 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00567897 |
| SST | somatostatin | 0.0056727 |
| MGP | matrix Gla protein | 0.00565197 |
| NME5 | NME/NM23 family member 5 | 0.00565104 |
| TPD52 | tumor protein D52 | 0.00564165 |
| GPATCH8 | G patch domain containing 8 | 0.00563659 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00559239 |
| OLFML3 | olfactomedin-like 3 | 0.00557085 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.005569 |
| TMEM70 | transmembrane protein 70 | 0.00556093 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00555074 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00555017 |
| C2 | complement component 2 | 0.00554599 |
| CTSK | cathepsin K | 0.00551634 |
| DACH1 | dachshund family transcription factor 1 | 0.00550995 |
| CFH | complement factor H | 0.00549288 |
| PRPF4 | pre-mRNA processing factor 4 | 0.00548277 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.00548176 |
| TMEM176A | transmembrane protein 176A | 0.00545349 |
| ANKRD46 | ankyrin repeat domain 46 | 0.00542541 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00540969 |
| ANGPT1 | angiopoietin 1 | 0.00540502 |
| CST4 | cystatin S | 0.00538041 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | 0.0053504 |
| MT2A | metallothionein 2A | 0.00533293 |
| PMP22 | peripheral myelin protein 22 | 0.00531461 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.00529081 |
| PRDX2 | peroxiredoxin 2 | 0.00525772 |
| HRASLS2 | HRAS-like suppressor 2 | 0.00523941 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00522347 |
| DST | dystonin | 0.00522083 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00521721 |
| FGL2 | fibrinogen-like 2 | 0.00520852 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 0.00520819 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00519737 |
| EFHC2 | EF-hand domain (C-terminal) containing 2 | 0.00519716 |
| ENY2 | enhancer of yellow 2 homolog (Drosophila) | 0.00519313 |
| MLF1 | myeloid leukemia factor 1 | 0.00517849 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.00517714 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00517131 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00516394 |
| STOM | stomatin | 0.00515726 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | 0.00514569 |
| RDH14 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | 0.00512693 |
| AK1 | adenylate kinase 1 | 0.00510998 |
| PLP1 | proteolipid protein 1 | 0.00510752 |
| SELENOW | selenoprotein W | 0.00509945 |
| HCCS | holocytochrome c synthase | 0.0050949 |
| GPR137B | G protein-coupled receptor 137B | 0.0050867 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 0.00508211 |
| KLF2 | Kruppel-like factor 2 | 0.00507942 |
| TYMP | thymidine phosphorylase | 0.00507614 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00507363 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 0.00506611 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.00505604 |
| KRT19 | keratin 19, type I | 0.00503977 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00503791 |
| MID1IP1 | MID1 interacting protein 1 | 0.00502412 |
| NDRG2 | NDRG family member 2 | 0.00500369 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 | 0.00500045 |
| INSR | insulin receptor | 0.00499675 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.00499175 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00498899 |
| CD9 | CD9 molecule | 0.00498851 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0049854 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.00498356 |
| PDHX | pyruvate dehydrogenase complex, component X | 0.00498015 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00497889 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00496963 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.00494908 |
| SAP30 | Sin3A-associated protein, 30kDa | 0.00493349 |
| KIF1A | kinesin family member 1A | 0.00492905 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | 0.00492387 |
| ACYP2 | acylphosphatase 2, muscle type | 0.0049216 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00491818 |
| GPSM2 | G-protein signaling modulator 2 | 0.00491617 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.00490171 |
| CFB | complement factor B | 0.00489073 |
| TADA2A | transcriptional adaptor 2A | 0.00487943 |
| DUOX1 | dual oxidase 1 | 0.0048778 |
| CLGN | calmegin | 0.00487756 |
| PPIF | peptidylprolyl isomerase F | 0.00487381 |
| APOD | apolipoprotein D | 0.00486946 |
| OLFML2B | olfactomedin-like 2B | 0.0048595 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00485872 |
| MEF2C | myocyte enhancer factor 2C | 0.00485452 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00484345 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.00483666 |
| BTG2 | BTG family, member 2 | 0.00482801 |
| CLEC7A | C-type lectin domain family 7, member A | 0.00482218 |
| PAK1IP1 | PAK1 interacting protein 1 | 0.00482093 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00480968 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00479546 |
| CD302 | CD302 molecule | 0.00477653 |
| ZBED1 | zinc finger, BED-type containing 1 | 0.00477358 |
| CD86 | CD86 molecule | 0.00477163 |
| IRF9 | interferon regulatory factor 9 | 0.00476906 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.0047598 |
| MT3 | metallothionein 3 | 0.00475968 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00475878 |
| AKIRIN1 | akirin 1 | 0.0047571 |
| MAIP1 | matrix AAA peptidase interacting protein 1 | 0.00474946 |
| IL7R | interleukin 7 receptor | 0.00474604 |
| THY1 | Thy-1 cell surface antigen | 0.00473975 |
| IRF7 | interferon regulatory factor 7 | 0.00472604 |
| IL33 | interleukin 33 | 0.00470569 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.00469472 |
| FKBP5 | FK506 binding protein 5 | 0.00469186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| XIC | X chromosome inactivation center | -0.0132257 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0125581 |
| PXDN | peroxidasin | -0.0117984 |
| CENPE | centromere protein E, 312kDa | -0.0116565 |
| PRKCA | protein kinase C, alpha | -0.0109454 |
| CANT1 | calcium activated nucleotidase 1 | -0.0108856 |
| VNN1 | vanin 1 | -0.0106698 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00996378 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00959124 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0093435 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | -0.00909578 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00909274 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00903123 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00891751 |
| MMP9 | matrix metallopeptidase 9 | -0.00870431 |
| WT1 | Wilms tumor 1 | -0.00847761 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00845484 |
| ZNF83 | zinc finger protein 83 | -0.00820388 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00788253 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00785376 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00773743 |
| SIRT3 | sirtuin 3 | -0.00759954 |
| DAPK1 | death-associated protein kinase 1 | -0.00759754 |
| HMG20B | high mobility group 20B | -0.00758497 |
| PCNA | proliferating cell nuclear antigen | -0.00756732 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -0.00753633 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00747941 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00742541 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00731975 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00728443 |
| ZW10 | zw10 kinetochore protein | -0.00725582 |
| GATA6 | GATA binding protein 6 | -0.00718962 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00718701 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.00714765 |
| MYOF | myoferlin | -0.00710854 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00704762 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00704396 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B | -0.00688996 |
| CUX1 | cut-like homeobox 1 | -0.00677963 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00672264 |
| ACTN1 | actinin, alpha 1 | -0.00668776 |
| TNF | tumor necrosis factor | -0.00662467 |
| CBS | cystathionine-beta-synthase | -0.00661886 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -0.00658285 |
| TUSC3 | tumor suppressor candidate 3 | -0.0065453 |
| LCN2 | lipocalin 2 | -0.00654021 |
| GLS | glutaminase | -0.00649137 |
| CYTL1 | cytokine-like 1 | -0.00647391 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.00644507 |
| KIF20A | kinesin family member 20A | -0.00644381 |
| AUTS2 | autism susceptibility candidate 2 | -0.00639207 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.00637454 |
| KLK5 | kallikrein-related peptidase 5 | -0.00637306 |
| ATP9A | ATPase, class II, type 9A | -0.00636649 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00632073 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | -0.0063043 |
| GYPC | glycophorin C (Gerbich blood group) | -0.00629264 |
| DTX4 | deltex 4, E3 ubiquitin ligase | -0.00624641 |
| REXO2 | RNA exonuclease 2 | -0.00621915 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00621688 |
| RGS13 | regulator of G-protein signaling 13 | -0.00621578 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0061969 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.00617096 |
| GSAP | gamma-secretase activating protein | -0.00616012 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.00615681 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00613253 |
| S100A12 | S100 calcium binding protein A12 | -0.006123 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0060932 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00606059 |
| OXTR | oxytocin receptor | -0.00605125 |
| PMM2 | phosphomannomutase 2 | -0.00604956 |
| NPTX2 | neuronal pentraxin II | -0.00600256 |
| ITGA6 | integrin, alpha 6 | -0.00597349 |
| TSPAN6 | tetraspanin 6 | -0.0059479 |
| GNAS | GNAS complex locus | -0.00593741 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00591109 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0059041 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00589556 |
| MBD4 | methyl-CpG binding domain protein 4 | -0.00588613 |
| LAMB1 | laminin, beta 1 | -0.00586914 |
| FSTL1 | follistatin-like 1 | -0.00586296 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.00586123 |
| NID2 | nidogen 2 (osteonidogen) | -0.00579335 |
| GRHPR | glyoxylate reductase/hydroxypyruvate reductase | -0.0057797 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00577589 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00577025 |
| PRSS21 | protease, serine, 21 (testisin) | -0.00572102 |
| MAGED1 | melanoma antigen family D1 | -0.00571904 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00568961 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00565812 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0056465 |
| MSLN | mesothelin | -0.00562146 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -0.00561377 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.00560857 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -0.00560096 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00557432 |
| ADM | adrenomedullin | -0.00556465 |
| NNMT | nicotinamide N-methyltransferase | -0.00556431 |
| CLTA | clathrin, light chain A | -0.00554999 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00554563 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.00547626 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0054659 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0054496 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00544172 |
| TRIB2 | tribbles pseudokinase 2 | -0.0054382 |
| SRGN | serglycin | -0.00541895 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00540731 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.0054047 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00540054 |
| ACO1 | aconitase 1, soluble | -0.00539169 |
| PLXNB2 | plexin B2 | -0.00538949 |
| CTSG | cathepsin G | -0.00538278 |
| MMRN1 | multimerin 1 | -0.00537901 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00536958 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | -0.00535043 |
| TMSB15A | thymosin beta 15a | -0.00534642 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00533566 |
| ELOB | elongin B | -0.00531753 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00531133 |
| TOX | thymocyte selection-associated high mobility group box | -0.00529692 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00525378 |
| FOCAD | focadhesin | -0.0052121 |
| MYO6 | myosin VI | -0.00521014 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.00520991 |
| MAP7 | microtubule-associated protein 7 | -0.00520974 |
| RSRP1 | arginine/serine-rich protein 1 | -0.00520203 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | -0.00519732 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00515908 |
| FAM198B | family with sequence similarity 198, member B | -0.00515775 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.00514548 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00513854 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00512579 |
| LTA4H | leukotriene A4 hydrolase | -0.00512114 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.00512054 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.00509541 |
| RRBP1 | ribosome binding protein 1 | -0.00508657 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00508294 |
| FZD6 | frizzled class receptor 6 | -0.0050637 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.00503471 |
| GSDMB | gasdermin B | -0.0050223 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0050161 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | -0.00500532 |
| KRT14 | keratin 14, type I | -0.00500471 |
| RAB21 | RAB21, member RAS oncogene family | -0.00500372 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00499987 |
| KRT17 | keratin 17, type I | -0.00499973 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.00499493 |
| TMEM243 | transmembrane protein 243, mitochondrial | -0.00499165 |
| PROM1 | prominin 1 | -0.0049592 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00495493 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00494721 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.00493706 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.00493612 |
| DUSP2 | dual specificity phosphatase 2 | -0.00492776 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | -0.00491236 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00490936 |
| FANCL | Fanconi anemia, complementation group L | -0.00488763 |
| TSC2 | tuberous sclerosis 2 | -0.00488463 |
| LIPG | lipase, endothelial | -0.00487134 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.00486699 |
| SEPTIN9 | septin 9 | -0.00484503 |
| PDZD2 | PDZ domain containing 2 | -0.00484061 |
| CALD1 | caldesmon 1 | -0.00483295 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | -0.00482 |
| PLAT | plasminogen activator, tissue | -0.00481314 |
| USP32P2 | ubiquitin specific peptidase 32 pseudogene 2 | -0.00481095 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.00479917 |
| NAV3 | neuron navigator 3 | -0.00479814 |
| SPATA20 | spermatogenesis associated 20 | -0.00479603 |
| TNIK | TRAF2 and NCK interacting kinase | -0.00477936 |
| IFT57 | intraflagellar transport 57 | -0.00477531 |
| NOTCH2NL | notch 2 N-terminal like | -0.0047741 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00475152 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00474655 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00474621 |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) | -0.00473782 |
| GOLM1 | golgi membrane protein 1 | -0.00473357 |
| ADA | adenosine deaminase | -0.00472845 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0047223 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -0.00471945 |
| CD151 | CD151 molecule (Raph blood group) | -0.00471729 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | -0.00471483 |
| SUSD5 | sushi domain containing 5 | -0.00470306 |
| DCPS | decapping enzyme, scavenger | -0.00469675 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.00469603 |
| POMZP3 | POM121 and ZP3 fusion | -0.00469379 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.00469034 |
| EHD2 | EH-domain containing 2 | -0.00468744 |
| NES | nestin | -0.00465754 |
| TGFB1 | transforming growth factor, beta 1 | -0.00465621 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -0.00465054 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00464818 |
| TUT4 | terminal uridylyl transferase 4 | -0.00464152 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00463942 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.00463486 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.004634 |
| HES1 | hes family bHLH transcription factor 1 | -0.00463269 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00461149 |
| KLK10 | kallikrein-related peptidase 10 | -0.00459319 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | -0.00458525 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00458488 |
| PDGFC | platelet derived growth factor C | -0.00458262 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00457808 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00457396 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00457369 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00456739 |
| ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif, 3 | -0.00456616 |
| MTMR11 | myotubularin related protein 11 | -0.00454632 |
| KIAA0100 | KIAA0100 | -0.00454535 |
| DSG3 | desmoglein 3 | -0.00454505 |
| ANXA3 | annexin A3 | -0.00454152 |
| IL1A | interleukin 1, alpha | -0.00453993 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00453924 |
| PLXNC1 | plexin C1 | -0.00452634 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.00452588 |
| KARS1 | lysyl-tRNA synthetase 1 | -0.00451849 |
| CRP | C-reactive protein, pentraxin-related | -0.00451479 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.00451327 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | -0.00449763 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.0044887 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00447774 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.004469 |
| TCAF1 | TRPM8 channel-associated factor 1 | -0.0044666 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00446354 |
| EIF3F | eukaryotic translation initiation factor 3, subunit F | -0.00445303 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00445206 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00442463 |
| PDLIM2 | PDZ and LIM domain 2 (mystique) | -0.00441569 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.00441055 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | -0.00440376 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00439946 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00437828 |
| HLTF | helicase-like transcription factor | -0.00437259 |
| TMEM135 | transmembrane protein 135 | -0.0043705 |
| PEG10 | paternally expressed 10 | -0.00436075 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.004355 |
| KRT7 | keratin 7, type II | -0.0043511 |
| RIC8A | RIC8 guanine nucleotide exchange factor A | -0.00434145 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00433964 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.00433861 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00433602 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0043345 |
| NSUN5P1 | NOP2/Sun domain family, member 5 pseudogene 1 | -0.00433211 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.00432796 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -0.00432274 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00432186 |
| YTHDC2 | YTH domain containing 2 | -0.00431814 |
| SULT2A1 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | -0.00431542 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.00431143 |
| PRG3 | proteoglycan 3 | -0.00431116 |
