MAP3K5 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase kinase kinase 5|Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4217)
External Link http://www.ncbi.nlm.nih.gov/gene/4217
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Genes

11 substrates of the kinase MAP3K5 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DAXX death-domain associated protein
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
PDPK1 3-phosphoinositide dependent protein kinase 1
STRAP serine/threonine kinase receptor associated protein
ZNF622 zinc finger protein 622