MAP3K6 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase kinase kinase 6|This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 9064)
External Link https://ncbi.nlm.nih.gov/gene/9064
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Genes

496 genes differentially expressed following the MAP3K6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NELL2 NEL-like 2 (chicken) 0.011591
CP ceruloplasmin (ferroxidase) 0.0106068
SUB1 SUB1 homolog (S. cerevisiae) 0.0103411
SFRP1 secreted frizzled-related protein 1 0.0102252
ACTA1 actin, alpha 1, skeletal muscle 0.0101999
XIC X chromosome inactivation center 0.00999281
MYBPC1 myosin binding protein C, slow type 0.00984263
COL15A1 collagen, type XV, alpha 1 0.00965156
ELP1 elongator acetyltransferase complex subunit 1 0.00945997
TNC tenascin C 0.00945677
SMC1A structural maintenance of chromosomes 1A 0.00941658
S100P S100 calcium binding protein P 0.0093846
PEG3 paternally expressed 3 0.0089997
IPO5 importin 5 0.00882292
PI3 peptidase inhibitor 3, skin-derived 0.00867987
CXCL9 chemokine (C-X-C motif) ligand 9 0.00853158
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.0084654
OLFM1 olfactomedin 1 0.00839698
MEF2C myocyte enhancer factor 2C 0.00825668
TTN titin 0.00818671
DMD dystrophin 0.00811243
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00810948
MYOT myotilin 0.00808642
ACTC1 actin, alpha, cardiac muscle 1 0.00805434
GLG1 golgi glycoprotein 1 0.00805129
LHFP lipoma HMGIC fusion partner 0.00803197
DIO2 deiodinase, iodothyronine, type II 0.00802349
DLK1 delta-like 1 homolog (Drosophila) 0.00800902
PBX1 pre-B-cell leukemia homeobox 1 0.00774191
KIAA0100 KIAA0100 0.00772642
CAV1 caveolin 1, caveolae protein, 22kDa 0.00770145
IGF1 insulin-like growth factor 1 (somatomedin C) 0.00762172
IGFBP1 insulin-like growth factor binding protein 1 0.00757757
GBP2 guanylate binding protein 2, interferon-inducible 0.00755822
FABP7 fatty acid binding protein 7, brain 0.00752131
DES desmin 0.00750244
KANK2 KN motif and ankyrin repeat domains 2 0.00750137
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.00749905
KLHL41 kelch-like family member 41 0.00748448
NLGN4X neuroligin 4, X-linked 0.00746607
CKM creatine kinase, muscle 0.00744843
NPTXR neuronal pentraxin receptor 0.00737819
ESR1 estrogen receptor 1 0.00736876
MICU2 mitochondrial calcium uptake 2 0.00735462
CCNA2 cyclin A2 0.00728174
SORD sorbitol dehydrogenase 0.00725467
LRP4 low density lipoprotein receptor-related protein 4 0.00724512
HMGB1 high mobility group box 1 0.00724387
GAS1 growth arrest-specific 1 0.00723538
C1R complement component 1, r subcomponent 0.00723528
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.00722382
S100A7 S100 calcium binding protein A7 0.00720071
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00719515
C3 complement component 3 0.00718575
RXRA retinoid X receptor, alpha 0.00714099
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00713057
CAV2 caveolin 2 0.00708463
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.0070296
ZMIZ1 zinc finger, MIZ-type containing 1 0.00696525
TNNC1 troponin C type 1 (slow) 0.00696292
STEAP3 STEAP family member 3, metalloreductase 0.00695872
NID1 nidogen 1 0.00695242
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.00689828
C2CD5 C2 calcium-dependent domain containing 5 0.00688656
RFC3 replication factor C (activator 1) 3, 38kDa 0.00687835
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.00686329
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.00686255
SLPI secretory leukocyte peptidase inhibitor 0.00685813
SPARCL1 SPARC-like 1 (hevin) 0.00685385
PTCH1 patched 1 0.0068105
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.00679873
PIR pirin (iron-binding nuclear protein) 0.00676343
BAG2 BCL2-associated athanogene 2 0.00675913
LPP LIM domain containing preferred translocation partner in lipoma 0.00675744
BHLHE41 basic helix-loop-helix family, member e41 0.00675032
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 0.00669333
COL5A1 collagen, type V, alpha 1 0.00666954
HOMER1 homer scaffolding protein 1 0.00663657
BCHE butyrylcholinesterase 0.00663181
ICMT isoprenylcysteine carboxyl methyltransferase 0.00661766
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00660742
PLN phospholamban 0.00657636
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.00656826
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.00656154
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.00654961
CCL8 chemokine (C-C motif) ligand 8 0.00654272
ITM2A integral membrane protein 2A 0.00650968
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.0065015
CCL4 chemokine (C-C motif) ligand 4 0.00648072
KYNU kynureninase 0.00647896
MTA1 metastasis associated 1 0.00645683
NRN1 neuritin 1 0.00638523
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.00630744
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.00629395
FERMT2 fermitin family member 2 0.00628515
IGFBP5 insulin-like growth factor binding protein 5 0.00627816
FHOD3 formin homology 2 domain containing 3 0.00625336
CHRDL1 chordin-like 1 0.00622871
SORBS1 sorbin and SH3 domain containing 1 0.0062028
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.00616641
TNNC2 troponin C type 2 (fast) 0.00614099
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.00610467
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00609752
IGFBP4 insulin-like growth factor binding protein 4 0.00609252
MPZL2 myelin protein zero-like 2 0.00609103
CBS cystathionine-beta-synthase 0.0060802
MAP1B microtubule-associated protein 1B 0.00606456
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.00604692
DENND2B DENN domain containing 2B 0.00602313
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.0060198
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.00601037
MAGEA12 melanoma antigen family A12 0.00600472
PUF60 poly-U binding splicing factor 60KDa 0.00599728
SMC2 structural maintenance of chromosomes 2 0.005981
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.00596215
MAGEA3 melanoma antigen family A3 0.00595434
ACTG2 actin, gamma 2, smooth muscle, enteric 0.00592915
FADS1 fatty acid desaturase 1 0.00592471
SLN sarcolipin 0.00592347
CA3 carbonic anhydrase III 0.00592089
RPIA ribose 5-phosphate isomerase A 0.00591837
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.00589259
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.00588895
SCRIB scribbled planar cell polarity protein 0.00588775
PCGF2 polycomb group ring finger 2 0.00588723
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00586983
CDK14 cyclin-dependent kinase 14 0.00586758
ADAMDEC1 ADAM-like, decysin 1 0.00586412
STC1 stanniocalcin 1 0.0058637
KIF11 kinesin family member 11 0.00584976
FGG fibrinogen gamma chain 0.00579803
MXRA5 matrix-remodelling associated 5 0.0057966
NDC80 NDC80 kinetochore complex component 0.00579571
GPX3 glutathione peroxidase 3 0.00578743
SPC25 SPC25, NDC80 kinetochore complex component 0.00578463
OPA1 optic atrophy 1 (autosomal dominant) 0.00576766
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0057508
PURA purine-rich element binding protein A 0.00573345
NAMPT nicotinamide phosphoribosyltransferase 0.00568
TSPAN12 tetraspanin 12 0.00564026
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00563573
GBP1 guanylate binding protein 1, interferon-inducible 0.00562098
WWTR1 WW domain containing transcription regulator 1 0.00560442
MYBPC2 myosin binding protein C, fast type 0.00559706
SMPX small muscle protein, X-linked 0.00559516
PER3 period circadian clock 3 0.00558532
SVIL supervillin 0.00558398
SPIN1 spindlin 1 0.00557393
SAMD4A sterile alpha motif domain containing 4A 0.00555322
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0055396
TIMP4 TIMP metallopeptidase inhibitor 4 0.00553396
NAV2 neuron navigator 2 0.00552237
CADPS2 Ca++-dependent secretion activator 2 0.00550695
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.00548404
IL33 interleukin 33 0.00548226
RHCG Rh family, C glycoprotein 0.00547937
SATB2 SATB homeobox 2 0.00547807
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00546683
FBXO5 F-box protein 5 0.00545616
IQGAP2 IQ motif containing GTPase activating protein 2 0.00545537
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 0.00545224
KIF14 kinesin family member 14 0.0054412
CXCL5 chemokine (C-X-C motif) ligand 5 0.00542927
FLNA filamin A, alpha 0.00542827
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00541346
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.00539969
NFIB nuclear factor I/B 0.00539647
TNS3 tensin 3 0.00539084
PODXL podocalyxin-like 0.00539034
DLG5 discs, large homolog 5 (Drosophila) 0.00538903
DPYD dihydropyrimidine dehydrogenase 0.0053862
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.00538269
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00537951
CRISP3 cysteine-rich secretory protein 3 0.00537495
ZMYM2 zinc finger, MYM-type 2 0.00533201
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00533191
PDLIM5 PDZ and LIM domain 5 0.00532227
CXCL6 chemokine (C-X-C motif) ligand 6 0.0053113
ACACA acetyl-CoA carboxylase alpha 0.00530592
PDS5B PDS5 cohesin associated factor B 0.00529151
LDB2 LIM domain binding 2 0.00528991
BCLAF1 BCL2-associated transcription factor 1 0.00528221
SEH1L SEH1-like (S. cerevisiae) 0.00528022
SEPP1 selenoprotein P, plasma, 1 0.00526987
KIF18B kinesin family member 18B 0.00525774
DZIP1 DAZ interacting zinc finger protein 1 0.00525422
CEP55 centrosomal protein 55kDa 0.00524428
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.00523987
STON1 stonin 1 0.00522842
DDR2 discoidin domain receptor tyrosine kinase 2 0.00522679
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00522396
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00521463
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.00520763
PEG10 paternally expressed 10 0.00520477
TENM1 teneurin transmembrane protein 1 0.00519323
TNNI2 troponin I type 2 (skeletal, fast) 0.00518662
INTS8 integrator complex subunit 8 0.00518001
SUN1 Sad1 and UNC84 domain containing 1 0.00517414
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.00515707
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.00515526
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.00514811
GYG2 glycogenin 2 0.00514796
DCHS1 dachsous cadherin-related 1 0.00514538
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.00514483
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.00513875
CKAP2 cytoskeleton associated protein 2 0.00513739
SASH1 SAM and SH3 domain containing 1 0.0051367
ITSN1 intersectin 1 (SH3 domain protein) 0.00513449
OBI1 ORC ubiquitin ligase 1 0.00512678
TPM3 tropomyosin 3 0.00512307
SEC63 SEC63 homolog (S. cerevisiae) 0.00512057
MMP7 matrix metallopeptidase 7 0.00512046
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.00511627
RDX radixin 0.0051041
NOVA1 neuro-oncological ventral antigen 1 0.00509383
TMEM38B transmembrane protein 38B 0.0050934
TNPO1 transportin 1 0.00509196
RYR1 ryanodine receptor 1 (skeletal) 0.00508537
CFD complement factor D (adipsin) 0.00508045
INHBB inhibin, beta B 0.00507896
SEPHS1 selenophosphate synthetase 1 0.00507649
FAM120A family with sequence similarity 120A 0.00507466
PADI2 peptidyl arginine deiminase, type II 0.00506653
PDE8B phosphodiesterase 8B 0.00506535
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00505244
ECPAS Ecm29 proteasome adaptor and scaffold 0.00505187
COL1A2 collagen, type I, alpha 2 0.00504828
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.00502114
NCAM1 neural cell adhesion molecule 1 0.00502031
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.00501602
TSPAN7 tetraspanin 7 0.00501259
H2AFV H2A histone family, member V 0.00501172
TTC3 tetratricopeptide repeat domain 3 0.00500838
LMO2 LIM domain only 2 (rhombotin-like 1) 0.00499834
C1S complement component 1, s subcomponent 0.00497545
OGN osteoglycin 0.00496721
PPL periplakin 0.00495157
ACD adrenocortical dysplasia homolog (mouse) 0.00494446
RTN2 reticulon 2 0.00493742
PDGFD platelet derived growth factor D 0.00493193
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.00492438
FCGBP Fc fragment of IgG binding protein 0.00492355
C7 complement component 7 0.00490991
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.00490785
SLIT2 slit homolog 2 (Drosophila) 0.00490736
HAMP hepcidin antimicrobial peptide 0.00490336
CCL20 chemokine (C-C motif) ligand 20 0.00487492
ECT2 epithelial cell transforming 2 0.00486402
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.00484735

decreased expression

Symbol Name Standardized Value
IFI6 interferon, alpha-inducible protein 6 -0.0188243
MAP7 microtubule-associated protein 7 -0.0145038
HSPA1A heat shock 70kDa protein 1A -0.0138233
IFI27 interferon, alpha-inducible protein 27 -0.0132046
CEMIP cell migration inducing protein, hyaluronan binding -0.0117351
CRIP1 cysteine-rich protein 1 (intestinal) -0.0113486
ZNF652 zinc finger protein 652 -0.0108859
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.0105686
NPIPB3 nuclear pore complex interacting protein family, member B3 -0.0105237
EIF5A eukaryotic translation initiation factor 5A -0.0103986
S100A10 S100 calcium binding protein A10 -0.0103169
GNAS GNAS complex locus -0.0101184
ADIRF adipogenesis regulatory factor -0.0100546
GUSBP3 glucuronidase, beta pseudogene 3 -0.0100411
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.00971769
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00967826
CA2 carbonic anhydrase II -0.00915123
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.00888475
HIST1H2BD histone cluster 1, H2bd -0.00887058
SH3BP4 SH3-domain binding protein 4 -0.00858786
GPNMB glycoprotein (transmembrane) nmb -0.0085166
CSTA cystatin A (stefin A) -0.00847307
MXRA7 matrix-remodelling associated 7 -0.00821465
AUTS2 autism susceptibility candidate 2 -0.00813137
FXYD3 FXYD domain containing ion transport regulator 3 -0.00810119
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.00808713
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.00805266
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -0.00803365
EPCAM epithelial cell adhesion molecule -0.00801688
PXDC1 PX domain containing 1 -0.00793984
CPB1 carboxypeptidase B1 (tissue) -0.0079004
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00782817
DDIT3 DNA-damage-inducible transcript 3 -0.00780892
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00776468
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.00761118
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00753258
CPA3 carboxypeptidase A3 (mast cell) -0.00748201
EGFL6 EGF-like-domain, multiple 6 -0.00746967
CHIC2 cysteine-rich hydrophobic domain 2 -0.00746266
DACH1 dachshund family transcription factor 1 -0.00743414
ANXA3 annexin A3 -0.00735092
COL9A3 collagen, type IX, alpha 3 -0.00728089
FOLR1 folate receptor 1 (adult) -0.0072237
ESRP1 epithelial splicing regulatory protein 1 -0.00721413
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.00713597
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.00708285
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.00704839
THBS2 thrombospondin 2 -0.00701675
DIPK1A divergent protein kinase domain 1A -0.00694856
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00693995
TGFBI transforming growth factor, beta-induced, 68kDa -0.00691727
ALCAM activated leukocyte cell adhesion molecule -0.00691281
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0069041
C6ORF48 chromosome 6 open reading frame 48 -0.00688796
ACP5 acid phosphatase 5, tartrate resistant -0.00688109
REG1A regenerating islet-derived 1 alpha -0.00686799
C21ORF91 chromosome 21 open reading frame 91 -0.00685361
RAB32 RAB32, member RAS oncogene family -0.00683582
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.00679569
OXA1L oxidase (cytochrome c) assembly 1-like -0.00679346
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.00675837
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.00673703
PLAAT3 phospholipase A and acyltransferase 3 -0.00672185
SAT1 spermidine/spermine N1-acetyltransferase 1 -0.00672091
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.00667945
DAD1 defender against cell death 1 -0.00660412
ADM adrenomedullin -0.00659969
NUTF2 nuclear transport factor 2 -0.00658199
GPX1 glutathione peroxidase 1 -0.00655829
CYB5R2 cytochrome b5 reductase 2 -0.00654558
HIST1H2BK histone cluster 1, H2bk -0.00651452
LAMP3 lysosomal-associated membrane protein 3 -0.00648881
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.00645839
STK10 serine/threonine kinase 10 -0.00643672
RPS27L ribosomal protein S27-like -0.00642907
INHBA inhibin, beta A -0.00641976
PFDN5 prefoldin subunit 5 -0.00639271
ATP5F1E ATP synthase F1 subunit epsilon -0.00638775
HIST1H2AE histone cluster 1, H2ae -0.00637188
DNALI1 dynein, axonemal, light intermediate chain 1 -0.00636413
SLC25A46 solute carrier family 25, member 46 -0.00635204
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.00634661
KRT18 keratin 18, type I -0.00632832
ASS1 argininosuccinate synthase 1 -0.00630468
MYO1B myosin IB -0.00629462
AREG amphiregulin -0.00629267
MYRF myelin regulatory factor -0.00628734
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.00627776
TUBB2A tubulin, beta 2A class IIa -0.00626706
ATOX1 antioxidant 1 copper chaperone -0.00625697
MLPH melanophilin -0.00625468
SARS1 seryl-tRNA synthetase 1 -0.00624478
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -0.00623144
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.00621011
ACOT9 acyl-CoA thioesterase 9 -0.00617168
EIF3G eukaryotic translation initiation factor 3, subunit G -0.00615761
KDM5D lysine (K)-specific demethylase 5D -0.00614778
TCL1A T-cell leukemia/lymphoma 1A -0.00614409
LYPD1 LY6/PLAUR domain containing 1 -0.00614108
ZNF160 zinc finger protein 160 -0.00613344
EGR1 early growth response 1 -0.00612689
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -0.00612647
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.00612359
TSPAN13 tetraspanin 13 -0.00607898
SLC38A2 solute carrier family 38, member 2 -0.00607026
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.00606642
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -0.00604519
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -0.00603295
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.00603185
S100A6 S100 calcium binding protein A6 -0.00602511
DSP desmoplakin -0.00602065
MSMB microseminoprotein, beta- -0.00601677
MVP major vault protein -0.00600803
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00600324
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -0.00599904
ATG101 autophagy related 101 -0.00598741
ODC1 ornithine decarboxylase 1 -0.00598628
ELOVL1 ELOVL fatty acid elongase 1 -0.00595194
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.00594553
PRAME preferentially expressed antigen in melanoma -0.00593392
REEP5 receptor accessory protein 5 -0.00587733
TPD52L1 tumor protein D52-like 1 -0.00587597
TARP TCR gamma alternate reading frame protein -0.00584601
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.00584055
GSTO1 glutathione S-transferase omega 1 -0.00581809
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.00579891
TOX4 TOX high mobility group box family member 4 -0.00577242
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0057566
IRF9 interferon regulatory factor 9 -0.00575108
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00574076
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.00570588
NEU1 sialidase 1 (lysosomal sialidase) -0.00567332
UXT ubiquitously-expressed, prefoldin-like chaperone -0.00567184
FLRT3 fibronectin leucine rich transmembrane protein 3 -0.00566084
CDC42 cell division cycle 42 -0.00565503
HINT1 histidine triad nucleotide binding protein 1 -0.00565171
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -0.00564837
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00564528
LRRC37A3 leucine rich repeat containing 37, member A3 -0.00563057
ELOB elongin B -0.00562632
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -0.00561969
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.00561639
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.00560792
LMCD1 LIM and cysteine-rich domains 1 -0.00559492
CASP8 caspase 8, apoptosis-related cysteine peptidase -0.00559361
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00559354
AMZ2 archaelysin family metallopeptidase 2 -0.00556151
HIST1H2BH histone cluster 1, H2bh -0.00556014
GRB7 growth factor receptor-bound protein 7 -0.00555819
GMPR guanosine monophosphate reductase -0.00554909
ZNF165 zinc finger protein 165 -0.00554013
DCT dopachrome tautomerase -0.00550429
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.00549168
CHMP4A charged multivesicular body protein 4A -0.00546911
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00546567
HIST1H2AC histone cluster 1, H2ac -0.00545954
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.00541356
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -0.00540467
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.00540138
TPSAB1 tryptase alpha/beta 1 -0.00539748
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -0.00538293
SLC31A2 solute carrier family 31 (copper transporter), member 2 -0.00536863
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -0.00536293
GSTP1 glutathione S-transferase pi 1 -0.00536206
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.00536048
SLC44A4 solute carrier family 44, member 4 -0.00535832
DMTF1 cyclin D binding myb-like transcription factor 1 -0.00535546
GTF2H5 general transcription factor IIH, polypeptide 5 -0.00533279
TMEM131L transmembrane 131 like -0.00533279
IFI30 interferon, gamma-inducible protein 30 -0.00527516
HMOX2 heme oxygenase 2 -0.00527203
TSPAN1 tetraspanin 1 -0.00527102
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -0.00525031
CADM1 cell adhesion molecule 1 -0.00524546
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.00523947
IFI35 interferon-induced protein 35 -0.00523502
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.00523112
EZR ezrin -0.0052213
CEPT1 choline/ethanolamine phosphotransferase 1 -0.00521958
MRPL40 mitochondrial ribosomal protein L40 -0.0052075
FAM171A1 family with sequence similarity 171, member A1 -0.00520543
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.00520474
LUM lumican -0.0051988
TCF7 transcription factor 7 (T-cell specific, HMG-box) -0.00519773
HSPB1 heat shock 27kDa protein 1 -0.00519205
ATF3 activating transcription factor 3 -0.00518778
HOXD1 homeobox D1 -0.00518739
UROS uroporphyrinogen III synthase -0.00516726
PHC3 polyhomeotic homolog 3 (Drosophila) -0.00514703
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.00514556
RRAGC Ras-related GTP binding C -0.00513825
IRF7 interferon regulatory factor 7 -0.00512584
LGALS3 lectin, galactoside-binding, soluble, 3 -0.00512451
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00510588
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00510513
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -0.00510083
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.00508901
ZNHIT1 zinc finger, HIT-type containing 1 -0.00508508
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -0.00506916
CCNG2 cyclin G2 -0.00505023
ABHD4 abhydrolase domain containing 4 -0.00504566
ZNF721 zinc finger protein 721 -0.00504526
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00504165
NAGK N-acetylglucosamine kinase -0.00503867
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00503711
TMSB15A thymosin beta 15a -0.0050342
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00502499
CAVIN3 caveolae associated protein 3 -0.00502469
TUFT1 tuftelin 1 -0.00502044
OSTF1 osteoclast stimulating factor 1 -0.00501387
EVI2A ecotropic viral integration site 2A -0.00501354
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0049961
SST somatostatin -0.0049934
MELK maternal embryonic leucine zipper kinase -0.0049845
ISG20 interferon stimulated exonuclease gene 20kDa -0.00498314
RNH1 ribonuclease/angiogenin inhibitor 1 -0.00498179
QPCT glutaminyl-peptide cyclotransferase -0.00497584
GSTZ1 glutathione S-transferase zeta 1 -0.00496704
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00496582
WDR61 WD repeat domain 61 -0.00496268
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -0.00496195
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -0.00496184
DYNLT1 dynein, light chain, Tctex-type 1 -0.0049604
RPL26L1 ribosomal protein L26-like 1 -0.00495708
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.00494839
RPS14P3 ribosomal protein S14 pseudogene 3 -0.00493494
NDE1 nudE neurodevelopment protein 1 -0.00493029
NPC2 Niemann-Pick disease, type C2 -0.00492177
GABARAPL1 GABA(A) receptor-associated protein like 1 -0.00491814
DDIT4 DNA-damage-inducible transcript 4 -0.00491712
KLK5 kallikrein-related peptidase 5 -0.00490357
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -0.00488762
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00487809
AVPI1 arginine vasopressin-induced 1 -0.00487375
PRSS3 protease, serine, 3 -0.00486691
ZNF395 zinc finger protein 395 -0.00486476
RNFT1 ring finger protein, transmembrane 1 -0.00485988
MAGEB2 melanoma antigen family B2 -0.00485377
HSPA2 heat shock 70kDa protein 2 -0.00485105
SFTPD surfactant protein D -0.00484323
AGTR1 angiotensin II receptor, type 1 -0.00483786
DCN decorin -0.00483068
ANXA2P2 annexin A2 pseudogene 2 -0.0048285
SFTPC surfactant protein C -0.00482705
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 -0.00482299
ADI1 acireductone dioxygenase 1 -0.00482195
CHP1 calcineurin-like EF-hand protein 1 -0.00481043