MAP3K7 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase kinase kinase 7|The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6885)
External Link http://www.ncbi.nlm.nih.gov/gene/6885
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Genes

9 substrates of the kinase MAP3K7 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
KSR1 kinase suppressor of ras 1
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTPN3 protein tyrosine phosphatase, non-receptor type 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1