| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase kinase kinase 8|This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 1326) |
| External Link | https://ncbi.nlm.nih.gov/gene/1326 |
| Similar Terms | |
| Downloads & Tools |
497 genes differentially expressed following the MAP3K8 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KIF20A | kinesin family member 20A | 0.0163025 |
| CHKB | choline kinase beta | 0.0143821 |
| SIRT3 | sirtuin 3 | 0.013146 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.013085 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0128574 |
| ZW10 | zw10 kinetochore protein | 0.0117181 |
| PRKCA | protein kinase C, alpha | 0.0116391 |
| NELL2 | NEL-like 2 (chicken) | 0.0115516 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.0107829 |
| MATN2 | matrilin 2 | 0.0107799 |
| MPPED2 | metallophosphoesterase domain containing 2 | 0.010765 |
| CENPE | centromere protein E, 312kDa | 0.0107616 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0103527 |
| CD320 | CD320 molecule | 0.0102688 |
| LMNB2 | lamin B2 | 0.0101365 |
| HOXB2 | homeobox B2 | 0.0101195 |
| ITM2A | integral membrane protein 2A | 0.00999526 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00979614 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00960557 |
| PTCH1 | patched 1 | 0.00948266 |
| CDC20 | cell division cycle 20 | 0.00934925 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.00929042 |
| PCNA | proliferating cell nuclear antigen | 0.00926208 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.00909487 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00901847 |
| FASN | fatty acid synthase | 0.00901131 |
| GAL | galanin/GMAP prepropeptide | 0.0089772 |
| MSX1 | msh homeobox 1 | 0.00890343 |
| TNC | tenascin C | 0.00884538 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00878182 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00877387 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00874203 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.00873068 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00861107 |
| FOXM1 | forkhead box M1 | 0.00859967 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00856117 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 0.00841299 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00833689 |
| BOP1 | block of proliferation 1 | 0.00831955 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00826058 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00822308 |
| EFNA5 | ephrin-A5 | 0.00820088 |
| HMGB1 | high mobility group box 1 | 0.00817091 |
| CYTL1 | cytokine-like 1 | 0.00816527 |
| LMNB1 | lamin B1 | 0.00808591 |
| PLK1 | polo-like kinase 1 | 0.0080719 |
| PXDN | peroxidasin | 0.00798372 |
| RTN1 | reticulon 1 | 0.00797953 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.0079623 |
| TSPAN7 | tetraspanin 7 | 0.00794232 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00794 |
| S100B | S100 calcium binding protein B | 0.00786458 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.00784244 |
| MTMR11 | myotubularin related protein 11 | 0.00783828 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00783202 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00779255 |
| NNMT | nicotinamide N-methyltransferase | 0.00773182 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.00770446 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00769684 |
| ANXA6 | annexin A6 | 0.00769657 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.00760456 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00755901 |
| NLGN4X | neuroligin 4, X-linked | 0.00754145 |
| NES | nestin | 0.00754138 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00750537 |
| SLC2A4RG | SLC2A4 regulator | 0.00748788 |
| MEX3D | mex-3 RNA binding family member D | 0.00747587 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00746027 |
| SMTN | smoothelin | 0.00744735 |
| CD200 | CD200 molecule | 0.00738273 |
| RTN2 | reticulon 2 | 0.00736152 |
| GAS1 | growth arrest-specific 1 | 0.00734271 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | 0.0073302 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.0073099 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | 0.0072884 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.00727101 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | 0.00725025 |
| TMSB15A | thymosin beta 15a | 0.00723966 |
| PRC1 | protein regulator of cytokinesis 1 | 0.00723115 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00719915 |
| FGF9 | fibroblast growth factor 9 | 0.00715693 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.00712765 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00711252 |
| HMGB2 | high mobility group box 2 | 0.00701782 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.00700843 |
| HOXB5 | homeobox B5 | 0.00699413 |
| H2AX | H2A.X variant histone | 0.00699161 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00698068 |
| SCRIB | scribbled planar cell polarity protein | 0.00696895 |
| CBX5 | chromobox homolog 5 | 0.00694089 |
| NPTX2 | neuronal pentraxin II | 0.00691904 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | 0.00691849 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.00690081 |
| PNMA1 | paraneoplastic Ma antigen 1 | 0.00688288 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00682735 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00682127 |
| TGM2 | transglutaminase 2 | 0.00680409 |
| CD151 | CD151 molecule (Raph blood group) | 0.00677873 |
| TBL1X | transducin (beta)-like 1X-linked | 0.00676141 |
| CPE | carboxypeptidase E | 0.00672521 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00670595 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.00665404 |
| KIAA0226L | KIAA0226-like | 0.00665369 |
| PIMREG | PICALM interacting mitotic regulator | 0.0066476 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 0.00660901 |
| TCTN2 | tectonic family member 2 | 0.00659689 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.0065845 |
| CBS | cystathionine-beta-synthase | 0.00657545 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00657151 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0065706 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0065646 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00655507 |
| WT1 | Wilms tumor 1 | 0.00655307 |
| NIPSNAP2 | nipsnap homolog 2 | 0.00653645 |
| WDR61 | WD repeat domain 61 | 0.00651702 |
| SACS | sacsin molecular chaperone | 0.00650311 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.00648902 |
| TMEM109 | transmembrane protein 109 | 0.00643715 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | 0.00643205 |
| CCNB1 | cyclin B1 | 0.00642317 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00641514 |
| OIP5 | Opa interacting protein 5 | 0.00641069 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | 0.00640382 |
| ACTN1 | actinin, alpha 1 | 0.00640351 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0064031 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00640291 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00637689 |
| RPA1 | replication protein A1, 70kDa | 0.00637464 |
| OLFM1 | olfactomedin 1 | 0.00637295 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00636846 |
| SDC3 | syndecan 3 | 0.0063671 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.00633584 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.00632269 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.00631156 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00630209 |
| TRIP13 | thyroid hormone receptor interactor 13 | 0.00628496 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0062758 |
| GPM6A | glycoprotein M6A | 0.0062346 |
| TSPAN6 | tetraspanin 6 | 0.00623138 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.00621661 |
| CLC | Charcot-Leyden crystal galectin | 0.00620399 |
| CP | ceruloplasmin (ferroxidase) | 0.00618131 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.00617889 |
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.00617791 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00617261 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00617162 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 0.00615655 |
| CYC1 | cytochrome c-1 | 0.00614566 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00614363 |
| ESR1 | estrogen receptor 1 | 0.00613148 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00612552 |
| TRRAP | transformation/transcription domain-associated protein | 0.00610903 |
| ELP1 | elongator acetyltransferase complex subunit 1 | 0.0061082 |
| HOXA11 | homeobox A11 | 0.00609439 |
| FANCL | Fanconi anemia, complementation group L | 0.00608552 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00604389 |
| PRKCB | protein kinase C, beta | 0.005998 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00598663 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00598291 |
| CRMP1 | collapsin response mediator protein 1 | 0.00598129 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0059741 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.00597388 |
| ARL6IP4 | ADP-ribosylation factor-like 6 interacting protein 4 | 0.00596977 |
| MCM5 | minichromosome maintenance complex component 5 | 0.00595174 |
| JADE2 | jade family PHD finger 2 | 0.00594414 |
| STON1 | stonin 1 | 0.00592218 |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | 0.0059196 |
| SRGN | serglycin | 0.00591882 |
| OLFM4 | olfactomedin 4 | 0.00591271 |
| CEP55 | centrosomal protein 55kDa | 0.00590699 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00589596 |
| NMB | neuromedin B | 0.00588097 |
| CLIP3 | CAP-GLY domain containing linker protein 3 | 0.00585616 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.00585116 |
| TIMELESS | timeless circadian clock | 0.00584447 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.00584303 |
| GOLM1 | golgi membrane protein 1 | 0.00583794 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.00583759 |
| MLEC | malectin | 0.00583687 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.00583507 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.00581589 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00581438 |
| RAB6B | RAB6B, member RAS oncogene family | 0.00580261 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00579624 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00579495 |
| TCF4 | transcription factor 4 | 0.00578974 |
| IGSF1 | immunoglobulin superfamily, member 1 | 0.0057837 |
| EPHB3 | EPH receptor B3 | 0.00577695 |
| EFNB3 | ephrin-B3 | 0.00576187 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00575869 |
| OPHN1 | oligophrenin 1 | 0.00572707 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00571689 |
| FERMT2 | fermitin family member 2 | 0.00571002 |
| GTF3A | general transcription factor IIIA | 0.00571 |
| TRIM9 | tripartite motif containing 9 | 0.00570962 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 0.00569584 |
| SATB2 | SATB homeobox 2 | 0.00568411 |
| DIXDC1 | DIX domain containing 1 | 0.00568279 |
| ZNF835 | zinc finger protein 835 | 0.00567928 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00567738 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00566957 |
| EMP3 | epithelial membrane protein 3 | 0.00566912 |
| SALL2 | spalt-like transcription factor 2 | 0.00566378 |
| GYG2 | glycogenin 2 | 0.00565918 |
| CD93 | CD93 molecule | 0.0056506 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.005648 |
| GSAP | gamma-secretase activating protein | 0.00564742 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00563984 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00563158 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 0.00562625 |
| DHFR | dihydrofolate reductase | 0.00561611 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | 0.00560865 |
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.00560864 |
| ASPH | aspartate beta-hydroxylase | 0.00559955 |
| EHD2 | EH-domain containing 2 | 0.00557795 |
| MAGEF1 | melanoma antigen family F1 | 0.00557298 |
| ASRGL1 | asparaginase like 1 | 0.0055641 |
| STX1A | syntaxin 1A (brain) | 0.00556292 |
| PMF1 | polyamine-modulated factor 1 | 0.0055616 |
| MCM3 | minichromosome maintenance complex component 3 | 0.00555719 |
| ZNF532 | zinc finger protein 532 | 0.00555547 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00555161 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | 0.00554598 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.00553978 |
| TMEM106C | transmembrane protein 106C | 0.00553967 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00553903 |
| HOXB6 | homeobox B6 | 0.00553624 |
| POTEKP | POTE ankyrin domain family, member K, pseudogene | 0.00552682 |
| PLS1 | plastin 1 | 0.00552235 |
| SRM | spermidine synthase | 0.00552079 |
| FBN2 | fibrillin 2 | 0.00551018 |
| TK1 | thymidine kinase 1, soluble | 0.00550441 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00549793 |
| PWP1 | PWP1 homolog (S. cerevisiae) | 0.00549621 |
| THYN1 | thymocyte nuclear protein 1 | 0.005486 |
| PCLAF | PCNA clamp associated factor | 0.00547823 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.00547259 |
| IPO5 | importin 5 | 0.00547015 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.00546778 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00546552 |
| PCNT | pericentrin | 0.00546481 |
| NLGN1 | neuroligin 1 | 0.0054645 |
| KIF18B | kinesin family member 18B | 0.00546208 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00546124 |
| DPP6 | dipeptidyl-peptidase 6 | 0.00545158 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.00545051 |
| ATN1 | atrophin 1 | 0.00544548 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.00544531 |
| TARDBP | TAR DNA binding protein | 0.00543352 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00543211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | -0.0175409 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0168256 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.0164085 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.0158239 |
| RRAGD | Ras-related GTP binding D | -0.0157533 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0148213 |
| RNF167 | ring finger protein 167 | -0.0130798 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0130728 |
| ATF3 | activating transcription factor 3 | -0.0128475 |
| MX1 | MX dynamin-like GTPase 1 | -0.0127758 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.0125639 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.0124447 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.0124293 |
| MAL | mal, T-cell differentiation protein | -0.0122113 |
| S100A14 | S100 calcium binding protein A14 | -0.0121765 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0119944 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0118086 |
| S100A7 | S100 calcium binding protein A7 | -0.011704 |
| IFI44L | interferon-induced protein 44-like | -0.0116628 |
| S100A8 | S100 calcium binding protein A8 | -0.0116029 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.0115499 |
| PERP | PERP, TP53 apoptosis effector | -0.0115038 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0113749 |
| CD52 | CD52 molecule | -0.0113589 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0113196 |
| IFI44 | interferon-induced protein 44 | -0.0112057 |
| IL1RN | interleukin 1 receptor antagonist | -0.0110578 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0108915 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0106792 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0106392 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0105956 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0105275 |
| KRT5 | keratin 5, type II | -0.0103339 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.010291 |
| KLHL24 | kelch-like family member 24 | -0.0102845 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.010261 |
| TSPAN8 | tetraspanin 8 | -0.0102608 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0101626 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0100997 |
| GPR137B | G protein-coupled receptor 137B | -0.0100897 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0100636 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.0099483 |
| CSTA | cystatin A (stefin A) | -0.00989587 |
| LCN2 | lipocalin 2 | -0.00988778 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00986358 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00977472 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00975905 |
| MMP1 | matrix metallopeptidase 1 | -0.00969774 |
| ECM1 | extracellular matrix protein 1 | -0.00967015 |
| EPCAM | epithelial cell adhesion molecule | -0.00958611 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00950703 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.00948 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00945827 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0094128 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00936276 |
| MICB | MHC class I polypeptide-related sequence B | -0.0092768 |
| S100A9 | S100 calcium binding protein A9 | -0.00927442 |
| LY96 | lymphocyte antigen 96 | -0.00916672 |
| VNN1 | vanin 1 | -0.00914736 |
| EGR1 | early growth response 1 | -0.00907231 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | -0.00904614 |
| TUBB2A | tubulin, beta 2A class IIa | -0.0090456 |
| MVP | major vault protein | -0.00904381 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00903186 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.0088678 |
| CYB5R1 | cytochrome b5 reductase 1 | -0.00879171 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00878185 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0087102 |
| HMOX1 | heme oxygenase 1 | -0.0086556 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.00865549 |
| UBASH3A | ubiquitin associated and SH3 domain containing A | -0.00850908 |
| KRT15 | keratin 15, type I | -0.00850257 |
| TRIM22 | tripartite motif containing 22 | -0.00849858 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00847744 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.00847708 |
| TLR4 | toll-like receptor 4 | -0.0084022 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.00839573 |
| TJP2 | tight junction protein 2 | -0.00838572 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00830546 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00827049 |
| QPRT | quinolinate phosphoribosyltransferase | -0.00825766 |
| TSPYL5 | TSPY-like 5 | -0.00823827 |
| MAGEA3 | melanoma antigen family A3 | -0.00822495 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00821516 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.00818374 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00818238 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.00813909 |
| THBS2 | thrombospondin 2 | -0.00812384 |
| FOXC1 | forkhead box C1 | -0.00808131 |
| ANGPT1 | angiopoietin 1 | -0.00806763 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0080582 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00798642 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | -0.0079783 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00797784 |
| INHBA | inhibin, beta A | -0.00796842 |
| PSAP | prosaposin | -0.00795671 |
| C21ORF91 | chromosome 21 open reading frame 91 | -0.00791501 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00790163 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00789257 |
| IL1R1 | interleukin 1 receptor, type I | -0.00786085 |
| SDC1 | syndecan 1 | -0.007855 |
| MGAM | maltase-glucoamylase | -0.00783954 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0078203 |
| CTSS | cathepsin S | -0.00779995 |
| DUOX1 | dual oxidase 1 | -0.00778347 |
| MOSPD1 | motile sperm domain containing 1 | -0.00777405 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.0077558 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00773508 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00771887 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00769826 |
| KRT14 | keratin 14, type I | -0.00767693 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.0076703 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00765849 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.0076399 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | -0.00762324 |
| UPP1 | uridine phosphorylase 1 | -0.00759381 |
| DSP | desmoplakin | -0.00757592 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00755691 |
| TGFA | transforming growth factor, alpha | -0.00754695 |
| ZNF165 | zinc finger protein 165 | -0.00753198 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00752273 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | -0.00750635 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0074577 |
| AREG | amphiregulin | -0.0074299 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00740612 |
| IL1R2 | interleukin 1 receptor, type II | -0.00739356 |
| MYO1B | myosin IB | -0.00738724 |
| NEBL | nebulette | -0.00733958 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00732669 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00730884 |
| PXDC1 | PX domain containing 1 | -0.00729333 |
| AHR | aryl hydrocarbon receptor | -0.00728985 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00726829 |
| GOLT1B | golgi transport 1B | -0.00724841 |
| KLF2 | Kruppel-like factor 2 | -0.00724274 |
| FOSL2 | FOS-like antigen 2 | -0.00723458 |
| GRN | granulin | -0.00722262 |
| CTBS | chitobiase, di-N-acetyl- | -0.00721484 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00720975 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00718367 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00717167 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.00713419 |
| S100P | S100 calcium binding protein P | -0.00712766 |
| SELE | selectin E | -0.00710743 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00706141 |
| CES1 | carboxylesterase 1 | -0.00702712 |
| BBX | bobby sox homolog (Drosophila) | -0.00701014 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00700599 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.00700333 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.00700203 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00697022 |
| RRAD | Ras-related associated with diabetes | -0.00695628 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.00695515 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.00694092 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.00692739 |
| BEX4 | brain expressed, X-linked 4 | -0.00692668 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.00690856 |
| IFT20 | intraflagellar transport 20 | -0.00687978 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.00687692 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0068713 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00686065 |
| LPIN1 | lipin 1 | -0.00685684 |
| DIO1 | deiodinase, iodothyronine, type I | -0.00684436 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00682061 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.00679728 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | -0.00678419 |
| SNAI2 | snail family zinc finger 2 | -0.00677415 |
| RTCA | RNA 3'-terminal phosphate cyclase | -0.00677282 |
| DCN | decorin | -0.00674591 |
| STC1 | stanniocalcin 1 | -0.00674547 |
| MINK1 | misshapen-like kinase 1 | -0.00674241 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.00674071 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00673833 |
| RHOBTB1 | Rho-related BTB domain containing 1 | -0.00671503 |
| ZNF394 | zinc finger protein 394 | -0.006703 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.00670257 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00669575 |
| HSPA8 | heat shock 70kDa protein 8 | -0.00666338 |
| MMP3 | matrix metallopeptidase 3 | -0.00665815 |
| KIF1C | kinesin family member 1C | -0.00665785 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.00665766 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00663365 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00661588 |
| GEMIN6 | gem (nuclear organelle) associated protein 6 | -0.00661121 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.00659034 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.0065891 |
| HIST1H2AE | histone cluster 1, H2ae | -0.00657805 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00657404 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00657117 |
| DUSP10 | dual specificity phosphatase 10 | -0.00657092 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00655466 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00655141 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.00654496 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00652965 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | -0.00652769 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | -0.00651403 |
| IDS | iduronate 2-sulfatase | -0.00650413 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00650084 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00648602 |
| ABHD5 | abhydrolase domain containing 5 | -0.00644823 |
| CCP110 | centriolar coiled coil protein 110kDa | -0.00644627 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00644129 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00643502 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | -0.00643391 |
| PLBD1 | phospholipase B domain containing 1 | -0.00643018 |
| CRNN | cornulin | -0.00642691 |
| RBM47 | RNA binding motif protein 47 | -0.00642232 |
| MX2 | MX dynamin-like GTPase 2 | -0.00642083 |
| KL | klotho | -0.00640588 |
| USP18 | ubiquitin specific peptidase 18 | -0.00640253 |
| COG7 | component of oligomeric golgi complex 7 | -0.00640079 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -0.00639981 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.00639561 |
| H1-2 | H1.2 linker histone, cluster member | -0.00638061 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00637075 |
| KRT6A | keratin 6A, type II | -0.00636454 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00635619 |
| SQSTM1 | sequestosome 1 | -0.00635576 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.00634607 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00632186 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00632082 |
| KLF9 | Kruppel-like factor 9 | -0.00629129 |
| KRT13 | keratin 13, type I | -0.00627259 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00627222 |
| PLPP3 | phospholipid phosphatase 3 | -0.00626369 |
| CLEC2B | C-type lectin domain family 2, member B | -0.00626103 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00625654 |
| KLF6 | Kruppel-like factor 6 | -0.00623662 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.00623097 |
| SP100 | SP100 nuclear antigen | -0.00622863 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.00619292 |
| PPL | periplakin | -0.00618732 |
| TRIM38 | tripartite motif containing 38 | -0.00614454 |
| MIR22HG | MIR22 host gene | -0.00613274 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00610613 |
| STOM | stomatin | -0.0061055 |
| IL1B | interleukin 1, beta | -0.00607724 |
| CAB39 | calcium binding protein 39 | -0.00607569 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -0.00607562 |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | -0.00607394 |
| AMDHD2 | amidohydrolase domain containing 2 | -0.0060704 |
| CGGBP1 | CGG triplet repeat binding protein 1 | -0.00606458 |
| GP1BB | glycoprotein Ib (platelet), beta polypeptide | -0.00605934 |
| BCL2A1 | BCL2-related protein A1 | -0.00605835 |
| UBFD1 | ubiquitin family domain containing 1 | -0.00604988 |
| ADIRF | adipogenesis regulatory factor | -0.00604173 |
| CRCT1 | cysteine-rich C-terminal 1 | -0.00603968 |
