MAP3K8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mitogen-activated protein kinase kinase kinase 8|This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 1326)
External Link http://www.ncbi.nlm.nih.gov/gene/1326
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Genes

67 interacting proteins for MAP3K8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTL6A actin-like 6A
ACY3 aminoacylase 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK1 cyclin-dependent kinase 1
CHEK1 checkpoint kinase 1
CHUK conserved helix-loop-helix ubiquitous kinase
CLTC clathrin, heavy chain (Hc)
CREB1 cAMP responsive element binding protein 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPPK1 epiplakin 1
EZR ezrin
GLG1 golgi glycoprotein 1
GTF2I general transcription factor IIi
HIST1H2BB histone cluster 1, H2bb
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
KSR2 kinase suppressor of ras 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MSN moesin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PAPOLA poly(A) polymerase alpha
PFKL phosphofructokinase, liver
PLK1 polo-like kinase 1
RDX radixin
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL30 ribosomal protein L30
RPL6 ribosomal protein L6
RPS13 ribosomal protein S13
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUVBL1 RuvB-like AAA ATPase 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STIP1 stress-induced phosphoprotein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TNIP2 TNFAIP3 interacting protein 2
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TUBA3C tubulin, alpha 3c
TUBB tubulin, beta class I
TUBB4A tubulin, beta 4A class IVa