MAP3K8 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase kinase kinase 8|This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 1326)
External Link http://www.ncbi.nlm.nih.gov/gene/1326
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Genes

17 substrates of the kinase MAP3K8 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
CDK1 cyclin-dependent kinase 1
CHEK1 checkpoint kinase 1
CREB1 cAMP responsive element binding protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EZR ezrin
HIST1H2BB histone cluster 1, H2bb
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MSN moesin
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
RDX radixin
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1