MAP4K4 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description mitogen-activated protein kinase kinase kinase kinase 4|The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9448)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_MAP4K4
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Genes

171 co-expressed genes for MAP4K4 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABHD6 abhydrolase domain containing 6
ABI2 abl-interactor 2
ACTRT1 actin-related protein T1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHCYL1 adenosylhomocysteinase-like 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD17 ankyrin repeat domain 17
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APC2 adenomatosis polyposis coli 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP21 Rho GTPase activating protein 21
ARL8B ADP-ribosylation factor-like 8B
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATMIN ATM interactor
ATRN attractin
BBS2 Bardet-Biedl syndrome 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1ORF198 chromosome 1 open reading frame 198
C2CD3 C2 calcium-dependent domain containing 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASC4 cancer susceptibility candidate 4
CCDC88A coiled-coil domain containing 88A
CCDC92 coiled-coil domain containing 92
CEP350 centrosomal protein 350kDa
CHST10 carbohydrate sulfotransferase 10
CLASP2 cytoplasmic linker associated protein 2
CLCN3 chloride channel, voltage-sensitive 3
CLDND1 claudin domain containing 1
CLEC16A C-type lectin domain family 16, member A
CLIP3 CAP-GLY domain containing linker protein 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDHD2 DDHD domain containing 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLG1 discs, large homolog 1 (Drosophila)
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DTNA dystrobrevin, alpha
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DZIP3 DAZ interacting zinc finger protein 3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPT1 ethanolaminephosphotransferase 1
ERBB2IP erbb2 interacting protein
FADS1 fatty acid desaturase 1
FAM168B family with sequence similarity 168, member B
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
FAM219A family with sequence similarity 219, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FBXO21 F-box protein 21
FBXW11 F-box and WD repeat domain containing 11
FMNL2 formin-like 2
FRYL FRY-like
GAB2 GRB2-associated binding protein 2
GBA2 glucosidase, beta (bile acid) 2
GLTP glycolipid transfer protein
GOLGA7 golgin A7
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPM6B glycoprotein M6B
GPR107 G protein-coupled receptor 107
GPRC5B G protein-coupled receptor, class C, group 5, member B
GZF1 GDNF-inducible zinc finger protein 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HMBOX1 homeobox containing 1
IL17D interleukin 17D
IL6ST interleukin 6 signal transducer
IPO5 importin 5
IPO7 importin 7
KDM3B lysine (K)-specific demethylase 3B
KIAA0430 KIAA0430
KIAA1109 KIAA1109
KIDINS220 kinase D-interacting substrate, 220kDa
KIF1B kinesin family member 1B
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LRP4 low density lipoprotein receptor-related protein 4
LRRC8A leucine rich repeat containing 8 family, member A
MACF1 microtubule-actin crosslinking factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MFSD8 major facilitator superfamily domain containing 8
MTMR2 myotubularin related protein 2
MTMR4 myotubularin related protein 4
MTUS1 microtubule associated tumor suppressor 1
MYO10 myosin X
MYO9A myosin IXA
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NGRN neugrin, neurite outgrowth associated
NPTN neuroplastin
OAZ2 ornithine decarboxylase antizyme 2
OCIAD1 OCIA domain containing 1
PACS2 phosphofurin acidic cluster sorting protein 2
PDE4DIP phosphodiesterase 4D interacting protein
PDZD2 PDZ domain containing 2
PEAK1 pseudopodium-enriched atypical kinase 1
PHAX phosphorylated adaptor for RNA export
PHF10 PHD finger protein 10
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POGZ pogo transposable element with ZNF domain
POMT2 protein-O-mannosyltransferase 2
PPIG peptidylprolyl isomerase G (cyclophilin G)
PREPL prolyl endopeptidase-like
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PSAT1 phosphoserine aminotransferase 1
PTK2 protein tyrosine kinase 2
PTPRD protein tyrosine phosphatase, receptor type, D
RAB22A RAB22A, member RAS oncogene family
RABL2B RAB, member of RAS oncogene family-like 2B
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAN RAN, member RAS oncogene family
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RDX radixin
RMDN3 regulator of microtubule dynamics 3
RNF13 ring finger protein 13
RNF141 ring finger protein 141
RTN4 reticulon 4
SAP30L SAP30-like
SCAMP5 secretory carrier membrane protein 5
SCD5 stearoyl-CoA desaturase 5
SESN3 sestrin 3
SH2B1 SH2B adaptor protein 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIK3 SIK family kinase 3
SIRT2 sirtuin 2
SLAIN1 SLAIN motif family, member 1
SLC18B1 solute carrier family 18, subfamily B, member 1
SNX27 sorting nexin family member 27
SPAG9 sperm associated antigen 9
SPIRE1 spire-type actin nucleation factor 1
STX12 syntaxin 12
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D10B TBC1 domain family, member 10B
TBCK TBC1 domain containing kinase
TJAP1 tight junction associated protein 1 (peripheral)
TMEM30A transmembrane protein 30A
TMOD2 tropomodulin 2 (neuronal)
TNIK TRAF2 and NCK interacting kinase
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNS2 tensin 2
TRIM37 tripartite motif containing 37
TSNAX translin-associated factor X
TSPYL4 TSPY-like 4
TTL tubulin tyrosine ligase
TTYH2 tweety family member 2
UBE2H ubiquitin-conjugating enzyme E2H
UBE2K ubiquitin-conjugating enzyme E2K
UBL3 ubiquitin-like 3
ULK2 unc-51 like autophagy activating kinase 2
USP46 ubiquitin specific peptidase 46
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WBP2 WW domain binding protein 2
WSB1 WD repeat and SOCS box containing 1
WSB2 WD repeat and SOCS box containing 2
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZEB2 zinc finger E-box binding homeobox 2
ZFAND3 zinc finger, AN1-type domain 3
ZFP14 ZFP14 zinc finger protein
ZNF275 zinc finger protein 275
ZNF404 zinc finger protein 404
ZNF565 zinc finger protein 565
ZNF710 zinc finger protein 710
ZNF84 zinc finger protein 84