MAPK cascade Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. (Gene Ontology, GO_0000165)
External Link http://amigo.geneontology.org/amigo/term/GO_0000165
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Genes

99 genes participating in the MAPK cascade biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
APOA1 apolipoprotein A-I
AVP arginine vasopressin
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCM2 cerebral cavernous malformation 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDK1 cyclin-dependent kinase 1
CTSH cathepsin H
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL18 interleukin 18
IL1B interleukin 1, beta
IL31RA interleukin 31 receptor A
ITGAV integrin, alpha V
KARS1 lysyl-tRNA synthetase 1
KDR kinase insert domain receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS9 lectin, galactoside-binding, soluble, 9
LRRK2 leucine-rich repeat kinase 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MEN1 multiple endocrine neoplasia I
MINK1 misshapen-like kinase 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MT3 metallothionein 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NF1 neurofibromin 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRTN neurturin
PABPN1 poly(A) binding protein, nuclear 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLVAP plasmalemma vesicle associated protein
POU4F2 POU class 4 homeobox 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCE1 Ras converting CAAX endopeptidase 1
RIT2 Ras-like without CAAX 2
SBK2 SH3 domain binding kinase family, member 2
SETX senataxin
SHANK3 SH3 and multiple ankyrin repeat domains 3
SOX9 SRY (sex determining region Y)-box 9
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNIK TRAF2 and NCK interacting kinase
USP17L2 ubiquitin specific peptidase 17-like family member 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC9 zinc finger, DHHC-type containing 9
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2