MAPK cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. (Gene Ontology, GO_0000165)
External Link http://amigo.geneontology.org/amigo/term/GO:0000165
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Genes

120 genes participating in the MAPK cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
APOA1 apolipoprotein A-I
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
C6ORF89 chromosome 6 open reading frame 89
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCL3 chemokine (C-C motif) ligand 3
CCM2 cerebral cavernous malformation 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDK1 cyclin-dependent kinase 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTSH cathepsin H
DAXX death-domain associated protein
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
FGF10 fibroblast growth factor 10
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
GPS1 G protein pathway suppressor 1
GPS2 G protein pathway suppressor 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL31RA interleukin 31 receptor A
ITGAV integrin, alpha V
KARS1 lysyl-tRNA synthetase 1
LGALS9 lectin, galactoside-binding, soluble, 9
LRRK2 leucine-rich repeat kinase 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K15 mitogen-activated protein kinase kinase kinase 15
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MEN1 multiple endocrine neoplasia I
MINK1 misshapen-like kinase 1
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NF1 neurofibromin 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRTN neurturin
PABPN1 poly(A) binding protein, nuclear 1
PBK PDZ binding kinase
PKN1 protein kinase N1
PLVAP plasmalemma vesicle associated protein
POU4F2 POU class 4 homeobox 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCE1 Ras converting CAAX endopeptidase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIT2 Ras-like without CAAX 2
RNASE3 ribonuclease, RNase A family, 3
SBK2 SH3 domain binding kinase family, member 2
SCG2 secretogranin II
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
SHANK3 SH3 and multiple ankyrin repeat domains 3
SOX9 SRY (sex determining region Y)-box 9
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNIK TRAF2 and NCK interacting kinase
TRIB1 tribbles pseudokinase 1
USP17L2 ubiquitin specific peptidase 17-like family member 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC9 zinc finger, DHHC-type containing 9
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2