| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase 1|This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5594) |
| External Link | https://ncbi.nlm.nih.gov/gene/5594 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the MAPK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DES | desmin | 0.00888281 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00856741 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00835394 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00828502 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0081833 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00799881 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00792773 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00789497 |
| C7 | complement component 7 | 0.00788596 |
| PDZK1 | PDZ domain containing 1 | 0.00780261 |
| RTN2 | reticulon 2 | 0.00777401 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00768908 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.0076885 |
| TBC1D16 | TBC1 domain family, member 16 | 0.00744207 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00732036 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00719726 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.0071731 |
| GRB14 | growth factor receptor-bound protein 14 | 0.0071557 |
| MATN2 | matrilin 2 | 0.00713532 |
| CTSG | cathepsin G | 0.00704599 |
| OLFM4 | olfactomedin 4 | 0.00702208 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.00693035 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00683896 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00681441 |
| OLFML3 | olfactomedin-like 3 | 0.00672838 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00672237 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00669969 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00668318 |
| REEP1 | receptor accessory protein 1 | 0.00665976 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00658944 |
| HOXC6 | homeobox C6 | 0.00658479 |
| CTBP2 | C-terminal binding protein 2 | 0.00658284 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 0.00652751 |
| NEFH | neurofilament, heavy polypeptide | 0.00651389 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00630087 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00625878 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.0062007 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00618776 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0061867 |
| ARG1 | arginase 1 | 0.00617947 |
| NAV2 | neuron navigator 2 | 0.00609911 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00609247 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 0.00609116 |
| STON1 | stonin 1 | 0.00602301 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.00598201 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00598059 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.00596634 |
| OLFM1 | olfactomedin 1 | 0.00596476 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.00591528 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.00589278 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.00587749 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00582951 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00578422 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.00572836 |
| MFAP2 | microfibrillar-associated protein 2 | 0.00570501 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00569777 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00567535 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.00562851 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | 0.00561568 |
| ANXA6 | annexin A6 | 0.00559885 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00558109 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00556815 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00555478 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00551248 |
| DPT | dermatopontin | 0.00550154 |
| KRT2 | keratin 2, type II | 0.00549442 |
| ASS1 | argininosuccinate synthase 1 | 0.00548224 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.00545386 |
| SMTN | smoothelin | 0.00543783 |
| ESR1 | estrogen receptor 1 | 0.00541486 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 0.00537937 |
| TMEM176B | transmembrane protein 176B | 0.00537358 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00537101 |
| CBS | cystathionine-beta-synthase | 0.00535411 |
| PER3 | period circadian clock 3 | 0.00533667 |
| ZIC1 | Zic family member 1 | 0.0053191 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.00530664 |
| NXN | nucleoredoxin | 0.00529284 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 0.00529211 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.00528948 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | 0.00528743 |
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit | 0.00528223 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.00527123 |
| APOD | apolipoprotein D | 0.00524278 |
| FLNC | filamin C, gamma | 0.00523921 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00523507 |
| BIN1 | bridging integrator 1 | 0.00522559 |
| STK10 | serine/threonine kinase 10 | 0.00522384 |
| LOR | loricrin | 0.00520113 |
| PGLS | 6-phosphogluconolactonase | 0.00518063 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.00518026 |
| PFKM | phosphofructokinase, muscle | 0.00517342 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00515966 |
| AMOTL2 | angiomotin like 2 | 0.00514502 |
| PLA1A | phospholipase A1 member A | 0.00510571 |
| GSTT1 | glutathione S-transferase theta 1 | 0.00509519 |
| FLNA | filamin A, alpha | 0.0050819 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0050799 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00507239 |
| TSPAN8 | tetraspanin 8 | 0.00505782 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00504379 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00503959 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.00503774 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 | 0.00503501 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 0.00503338 |
| LCN2 | lipocalin 2 | 0.00502933 |
| PLN | phospholamban | 0.00501462 |
| DSG1 | desmoglein 1 | 0.00498325 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00498295 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00495047 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00493075 |
| SLC2A4RG | SLC2A4 regulator | 0.00490284 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00489712 |
| CALML5 | calmodulin-like 5 | 0.0048901 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00488842 |
| TYRP1 | tyrosinase-related protein 1 | 0.00488147 |
| HRASLS | HRAS-like suppressor | 0.00487043 |
| CAMP | cathelicidin antimicrobial peptide | 0.00486858 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00483966 |
| ANK2 | ankyrin 2, neuronal | 0.00483189 |
| SALL2 | spalt-like transcription factor 2 | 0.00482542 |
| CLDN3 | claudin 3 | 0.00481302 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00481265 |
| CRYAB | crystallin, alpha B | 0.00480713 |
| SFTPA2 | surfactant protein A2 | 0.0048031 |
| FNBP1 | formin binding protein 1 | 0.00480136 |
| TGFB3 | transforming growth factor, beta 3 | 0.00479785 |
| OPHN1 | oligophrenin 1 | 0.00478901 |
| NINL | ninein-like | 0.00478211 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.00477207 |
| IL17RB | interleukin 17 receptor B | 0.00475583 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.00475177 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00474712 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.00471804 |
| NMU | neuromedin U | 0.00471529 |
| MCM5 | minichromosome maintenance complex component 5 | 0.004707 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00469491 |
| PYCARD | PYD and CARD domain containing | 0.00469162 |
| TUBA1A | tubulin, alpha 1a | 0.00468729 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00468233 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.0046798 |
| CTSH | cathepsin H | 0.00467421 |
| ASMTL | acetylserotonin O-methyltransferase-like | 0.00466222 |
| COL3A1 | collagen, type III, alpha 1 | 0.00464791 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.00464068 |
| HIP1R | huntingtin interacting protein 1 related | 0.00462816 |
| GPR137B | G protein-coupled receptor 137B | 0.00460945 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00460595 |
| NOTCH2NL | notch 2 N-terminal like | 0.00459528 |
| UBXN1 | UBX domain protein 1 | 0.00454733 |
| NSG1 | neuron specific gene family member 1 | 0.00453789 |
| MXRA8 | matrix-remodelling associated 8 | 0.00453388 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | 0.00453319 |
| CFD | complement factor D (adipsin) | 0.00452749 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | 0.0045146 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.00448543 |
| C6 | complement component 6 | 0.00446962 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.004469 |
| PITX2 | paired-like homeodomain 2 | 0.00446047 |
| BCHE | butyrylcholinesterase | 0.00445717 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00444688 |
| KIAA0232 | KIAA0232 | 0.0044347 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00442042 |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 0.00440204 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00439196 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.00436338 |
| ACP3 | acid phosphatase 3 | 0.00436266 |
| CCNF | cyclin F | 0.00436139 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00435079 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.00433922 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.00433358 |
| AGRN | agrin | 0.00432207 |
| PCGF2 | polycomb group ring finger 2 | 0.00431911 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.00431375 |
| RAPSN | receptor-associated protein of the synapse | 0.00430925 |
| COLEC12 | collectin sub-family member 12 | 0.00430538 |
| RAP2A | RAP2A, member of RAS oncogene family | 0.00430477 |
| NVL | nuclear VCP-like | 0.00429996 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00428551 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.00428262 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.00427763 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | 0.00427423 |
| SDC3 | syndecan 3 | 0.00427396 |
| DCLK1 | doublecortin-like kinase 1 | 0.00426823 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00426704 |
| DSC1 | desmocollin 1 | 0.00426188 |
| VNN1 | vanin 1 | 0.00425728 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00425268 |
| CNN1 | calponin 1, basic, smooth muscle | 0.00424202 |
| TSPAN15 | tetraspanin 15 | 0.00423733 |
| EXOSC10 | exosome component 10 | 0.00423401 |
| RAI2 | retinoic acid induced 2 | 0.00422274 |
| CLCN4 | chloride channel, voltage-sensitive 4 | 0.00422021 |
| TCTN1 | tectonic family member 1 | 0.00421256 |
| MRPL23 | mitochondrial ribosomal protein L23 | 0.00420565 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00418071 |
| HAL | histidine ammonia-lyase | 0.00416803 |
| NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha | 0.00415496 |
| SLC35E2B | solute carrier family 35, member E2B | 0.00415288 |
| AMPH | amphiphysin | 0.00414315 |
| INTS1 | integrator complex subunit 1 | 0.00413997 |
| NCOR2 | nuclear receptor corepressor 2 | 0.00412756 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00412501 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | 0.0041184 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00410811 |
| WDR13 | WD repeat domain 13 | 0.00409772 |
| RXRA | retinoid X receptor, alpha | 0.00409681 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.00409627 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00409419 |
| GPX4 | glutathione peroxidase 4 | 0.00409383 |
| KRT1 | keratin 1, type II | 0.00408853 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.00408802 |
| FRZB | frizzled-related protein | 0.00408654 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00408421 |
| FAM50A | family with sequence similarity 50, member A | 0.00408389 |
| PLXNB2 | plexin B2 | 0.00407475 |
| THAP11 | THAP domain containing 11 | 0.00406992 |
| CDCA4 | cell division cycle associated 4 | 0.00405785 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00405766 |
| MGP | matrix Gla protein | 0.00405526 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00405221 |
| CCDC28B | coiled-coil domain containing 28B | 0.00405103 |
| PCP4 | Purkinje cell protein 4 | 0.00404662 |
| FHOD3 | formin homology 2 domain containing 3 | 0.00403763 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.00403558 |
| DVL1 | dishevelled segment polarity protein 1 | 0.00402742 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00401922 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.00401346 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.0039992 |
| PALMD | palmdelphin | 0.00399702 |
| NISCH | nischarin | 0.00399161 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00398901 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 0.00398473 |
| CLOCK | clock circadian regulator | 0.0039818 |
| JAK1 | Janus kinase 1 | 0.00397816 |
| SASH1 | SAM and SH3 domain containing 1 | 0.00396495 |
| MGLL | monoglyceride lipase | 0.00396183 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.00395716 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.00395139 |
| RUFY2 | RUN and FYVE domain containing 2 | 0.00395025 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00394327 |
| ZW10 | zw10 kinetochore protein | 0.0039314 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00392931 |
| IQCE | IQ motif containing E | 0.00392371 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.00392253 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00391799 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00391624 |
| PDLIM5 | PDZ and LIM domain 5 | 0.00391294 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.00390363 |
| STAG2 | stromal antigen 2 | 0.00389794 |
| Symbol | Name | Standardized Value |
|---|---|---|
| S100A8 | S100 calcium binding protein A8 | -0.0133327 |
| KRT7 | keratin 7, type II | -0.0103917 |
| KRT14 | keratin 14, type I | -0.0103629 |
| CA12 | carbonic anhydrase XII | -0.0102937 |
| ADM | adrenomedullin | -0.0101114 |
| ITGA6 | integrin, alpha 6 | -0.00997873 |
| CA2 | carbonic anhydrase II | -0.00995301 |
| S100A2 | S100 calcium binding protein A2 | -0.00985862 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00956832 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00922021 |
| CD9 | CD9 molecule | -0.00910483 |
| KRT17 | keratin 17, type I | -0.00869279 |
| GCH1 | GTP cyclohydrolase 1 | -0.00839219 |
| GLUL | glutamate-ammonia ligase | -0.00826353 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00803373 |
| SDC2 | syndecan 2 | -0.00801849 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0079874 |
| EMP1 | epithelial membrane protein 1 | -0.00791008 |
| KRT19 | keratin 19, type I | -0.0078504 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00781977 |
| CLDND1 | claudin domain containing 1 | -0.00766885 |
| IL1B | interleukin 1, beta | -0.00765772 |
| KRT13 | keratin 13, type I | -0.00764631 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00762015 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00752982 |
| ZNF395 | zinc finger protein 395 | -0.00751513 |
| MAGEA3 | melanoma antigen family A3 | -0.00747022 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.00731966 |
| RGCC | regulator of cell cycle | -0.0072926 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00725855 |
| CNN3 | calponin 3, acidic | -0.00719212 |
| CD34 | CD34 molecule | -0.00717872 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00716891 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00714289 |
| HDGFL3 | HDGF like 3 | -0.00713335 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00710412 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00709773 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0069971 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00695546 |
| KRT15 | keratin 15, type I | -0.0069328 |
| KRT18 | keratin 18, type I | -0.00689382 |
| HK2 | hexokinase 2 | -0.00689203 |
| GLUD2 | glutamate dehydrogenase 2 | -0.00686949 |
| S100A9 | S100 calcium binding protein A9 | -0.00686875 |
| GPX2 | glutathione peroxidase 2 | -0.00685823 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00683446 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00681463 |
| RGS4 | regulator of G-protein signaling 4 | -0.00675963 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00669826 |
| BTG3 | BTG family, member 3 | -0.00669299 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00668866 |
| CD200 | CD200 molecule | -0.0065597 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00654668 |
| ADIRF | adipogenesis regulatory factor | -0.00651775 |
| CD69 | CD69 molecule | -0.00650822 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00646418 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00643969 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.00637538 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00634041 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00632232 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00631722 |
| CSRP2 | cysteine and glycine-rich protein 2 | -0.00630696 |
| MAP7 | microtubule-associated protein 7 | -0.00630151 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00628814 |
| CLCA4 | chloride channel accessory 4 | -0.0062815 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00627355 |
| INHBA | inhibin, beta A | -0.00626764 |
| PRKCH | protein kinase C, eta | -0.00623815 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00616221 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00614094 |
| ABLIM1 | actin binding LIM protein 1 | -0.00606498 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00605085 |
| NMD3 | NMD3 ribosome export adaptor | -0.00605044 |
| SPRR3 | small proline-rich protein 3 | -0.00602461 |
| TMEM230 | transmembrane protein 230 | -0.00593744 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.005936 |
| TPM4 | tropomyosin 4 | -0.00589718 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00588365 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00586339 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.00586162 |
| KRT5 | keratin 5, type II | -0.00581335 |
| MMP12 | matrix metallopeptidase 12 | -0.00580558 |
| AREG | amphiregulin | -0.00580053 |
| KRT8 | keratin 8, type II | -0.00580041 |
| RBM34 | RNA binding motif protein 34 | -0.00575813 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.00574813 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.00573165 |
| PLPBP | pyridoxal phosphate binding protein | -0.00571874 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.00569121 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.00567376 |
| SELENOT | selenoprotein T | -0.00567155 |
| TMEM243 | transmembrane protein 243, mitochondrial | -0.00566666 |
| IMPA1 | inositol(myo)-1(or 4)-monophosphatase 1 | -0.0056622 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00565261 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.00561321 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -0.00560653 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00559598 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.00558877 |
| STOM | stomatin | -0.00558432 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.0055597 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00554946 |
| DAZAP2 | DAZ associated protein 2 | -0.00554734 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00552357 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00551667 |
| TRAM1 | translocation associated membrane protein 1 | -0.0054866 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00548453 |
| XPO7 | exportin 7 | -0.00548254 |
| SULF1 | sulfatase 1 | -0.00548213 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00544599 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00544132 |
| VEGFC | vascular endothelial growth factor C | -0.00543912 |
| PCNA | proliferating cell nuclear antigen | -0.00543909 |
| PLAU | plasminogen activator, urokinase | -0.00542007 |
| CYB5R4 | cytochrome b5 reductase 4 | -0.00540603 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00537268 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.00535883 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0053558 |
| MCL1 | myeloid cell leukemia 1 | -0.00535398 |
| KRT23 | keratin 23, type I | -0.00534633 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00532787 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.00532411 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00527807 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00526518 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.00523434 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00522607 |
| FYB1 | FYN binding protein 1 | -0.00522471 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00517852 |
| KRT6A | keratin 6A, type II | -0.00517783 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.00517047 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00516148 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00515154 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00514239 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00512852 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0051267 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00512641 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.00512509 |
| IL6 | interleukin 6 | -0.00511265 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.00509684 |
| CCND1 | cyclin D1 | -0.00507138 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00506671 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00506343 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.00505467 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00503522 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00503247 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00502607 |
| DUSP6 | dual specificity phosphatase 6 | -0.00500192 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00500002 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00496513 |
| IL1RN | interleukin 1 receptor antagonist | -0.00495885 |
| CANX | calnexin | -0.00494887 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00494735 |
| HPGDS | hematopoietic prostaglandin D synthase | -0.00494507 |
| LBH | limb bud and heart development | -0.00493569 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | -0.00493332 |
| RBBP4 | retinoblastoma binding protein 4 | -0.0049306 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00492103 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00491213 |
| COMMD3 | COMM domain containing 3 | -0.00490215 |
| IL6ST | interleukin 6 signal transducer | -0.00489197 |
| UCK2 | uridine-cytidine kinase 2 | -0.00489152 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.0048798 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00486101 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00485979 |
| ITM2A | integral membrane protein 2A | -0.00485339 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00483545 |
| PIP | prolactin-induced protein | -0.00483419 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00483181 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | -0.00482613 |
| TSPAN5 | tetraspanin 5 | -0.00482538 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.00482121 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00482093 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.00480877 |
| ELMO1 | engulfment and cell motility 1 | -0.0048016 |
| NCALD | neurocalcin delta | -0.00478063 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0047519 |
| FOXA2 | forkhead box A2 | -0.00474925 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0047478 |
| KRT6B | keratin 6B, type II | -0.00473903 |
| GRAMD2B | GRAM domain containing 2B | -0.00473532 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.00471106 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.00471079 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00470475 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | -0.00469623 |
| SNAI2 | snail family zinc finger 2 | -0.00469457 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00469074 |
| RNF14 | ring finger protein 14 | -0.00468113 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.00467008 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.00466198 |
| THBD | thrombomodulin | -0.00465959 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00465861 |
| SPRR1B | small proline-rich protein 1B | -0.0046554 |
| PRNP | prion protein | -0.00465408 |
| LRRC59 | leucine rich repeat containing 59 | -0.00464614 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.00463735 |
| TM2D1 | TM2 domain containing 1 | -0.00463729 |
| CTSL | cathepsin L | -0.00463455 |
| COMMD10 | COMM domain containing 10 | -0.00461375 |
| RHEBP1 | Ras-homolog enriched in brain pseudogene 1 | -0.00461007 |
| TRIB2 | tribbles pseudokinase 2 | -0.00460496 |
| LAMC2 | laminin, gamma 2 | -0.00459225 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.00458482 |
| ADORA2B | adenosine A2b receptor | -0.00456608 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 | -0.00454011 |
| ECHDC1 | ethylmalonyl-CoA decarboxylase 1 | -0.00453581 |
| LPXN | leupaxin | -0.00453078 |
| CLU | clusterin | -0.00453024 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00451343 |
| CHMP5 | charged multivesicular body protein 5 | -0.00450605 |
| COG5 | component of oligomeric golgi complex 5 | -0.0044957 |
| MRPL42 | mitochondrial ribosomal protein L42 | -0.00448916 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00448915 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00448827 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00447657 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00447276 |
| ZNF586 | zinc finger protein 586 | -0.0044674 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.00446723 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00446232 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.00445451 |
| FDX1 | ferredoxin 1 | -0.0044461 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | -0.00444524 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00443837 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | -0.00443148 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00442954 |
| PRF1 | perforin 1 (pore forming protein) | -0.00442532 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00441997 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -0.00441817 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.00441495 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | -0.00441413 |
| MAT2B | methionine adenosyltransferase II, beta | -0.00440395 |
| SLC35G2 | solute carrier family 35, member G2 | -0.00439923 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00439866 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0043984 |
| STK17A | serine/threonine kinase 17a | -0.0043974 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00439619 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.00438434 |
| CTSB | cathepsin B | -0.00438075 |
| TOX | thymocyte selection-associated high mobility group box | -0.00438074 |
| AGPS | alkylglycerone phosphate synthase | -0.00437885 |
| KLF9 | Kruppel-like factor 9 | -0.00437804 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00436563 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0043458 |
| RIT1 | Ras-like without CAAX 1 | -0.00434492 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | -0.00434417 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00434279 |
| MMP1 | matrix metallopeptidase 1 | -0.00433855 |
| CD164 | CD164 molecule, sialomucin | -0.00433173 |
| LOXL2 | lysyl oxidase-like 2 | -0.00431989 |
| NGDN | neuroguidin, EIF4E binding protein | -0.00431748 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0043125 |
