MAPK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase 1|This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5594)
External Link http://www.ncbi.nlm.nih.gov/gene/5594
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Genes

293 substrates of the kinase MAPK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABI1 abl-interactor 1
ADAM17 ADAM metallopeptidase domain 17
AEBP1 AE binding protein 1
AHCTF1 AT hook containing transcription factor 1
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
AMPH amphiphysin
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
AR androgen receptor
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB1 arrestin, beta 1
ASB2 ankyrin repeat and SOCS box containing 2
ATF2 activating transcription factor 2
ATG2B autophagy related 2B
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG2 BTG family, member 2
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALD1 caldesmon 1
CAPN2 calpain 2, (m/II) large subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CCNB1 cyclin B1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDCA5 cell division cycle associated 5
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP55 centrosomal protein 55kDa
CIC capicua transcriptional repressor
CIITA class II, major histocompatibility complex, transactivator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT12 CCR4-NOT transcription complex subunit 12
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTTN cortactin
DAPK1 death-associated protein kinase 1
DAZAP1 DAZ associated protein 1
DCP1A decapping mRNA 1A
DENND4C DENN/MADD domain containing 4C
DLG2 discs, large homolog 2 (Drosophila)
DLG5 discs, large homolog 5 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30
DNM1L dynamin 1-like
DOCK1 dedicator of cytokinesis 1
DUSP1 dual specificity phosphatase 1
DUSP16 dual specificity phosphatase 16
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK1 ELK1, member of ETS oncogene family
EP300 E1A binding protein p300
ERF Ets2 repressor factor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV3 ets variant 3
EWSR1 EWS RNA-binding protein 1
EXOC7 exocyst complex component 7
FAM195B family with sequence similarity 195, member B
FAM207A family with sequence similarity 207, member A
FAM65A family with sequence similarity 65, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GIGYF2 GRB10 interacting GYF protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GLI2 GLI family zinc finger 2
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRB10 growth factor receptor-bound protein 10
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
GTSE1 G-2 and S-phase expressed 1
H3F3B H3 histone, family 3B (H3.3B)
HDAC6 histone deacetylase 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H3A histone cluster 1, H3a
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
IER3 immediate early response 3
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLC1 kinesin light chain 1
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
L1CAM L1 cell adhesion molecule
LARP1 La ribonucleoprotein domain family, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIFR leukemia inhibitory factor receptor alpha
LMNA lamin A/C
LRP6 low density lipoprotein receptor-related protein 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAP1A microtubule-associated protein 1A
MAP1B microtubule-associated protein 1B
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK7 mitogen-activated protein kinase 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPT microtubule-associated protein tau
MAST1 microtubule associated serine/threonine kinase 1
MAST2 microtubule associated serine/threonine kinase 2
MAST4 microtubule associated serine/threonine kinase family member 4
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MCTS1 malignant T cell amplified sequence 1
MED1 mediator complex subunit 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MITF microphthalmia-associated transcription factor
MKL1 megakaryoblastic leukemia (translocation) 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTMR2 myotubularin related protein 2
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
MYO9B myosin IXB
MYOCD myocardin
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA6 nuclear receptor coactivator 6
NCOR2 nuclear receptor corepressor 2
NDEL1 nudE neurodevelopment protein 1-like 1
NEFL neurofilament, light polypeptide
NEUROD1 neuronal differentiation 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NID1 nidogen 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NOXA1 NADPH oxidase activator 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP214 nucleoporin 214kDa
NUP50 nucleoporin 50kDa
PALLD palladin, cytoskeletal associated protein
PAPOLA poly(A) polymerase alpha
PARP1 poly (ADP-ribose) polymerase 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDX1 pancreatic and duodenal homeobox 1
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PGR progesterone receptor
PHF2 PHD finger protein 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKM pyruvate kinase, muscle
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PML promyelocytic leukemia
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRDX6 peroxiredoxin 6
PRKCA protein kinase C, alpha
PRRC2A proline-rich coiled-coil 2A
PTK2 protein tyrosine kinase 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRR protein tyrosine phosphatase, receptor type, R
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAI1 retinoic acid induced 1
RAI14 retinoic acid induced 14
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM17 RNA binding motif protein 17
RBPMS RNA binding protein with multiple splicing
RCAN1 regulator of calcineurin 1
RELL1 RELT-like 1
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
RGS19 regulator of G-protein signaling 19
RIPK3 receptor-interacting serine-threonine kinase 3
RORA RAR-related orphan receptor A
RPS3 ribosomal protein S3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RTN4 reticulon 4
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
SAFB scaffold attachment factor B
SAFB2 scaffold attachment factor B2
SH2B1 SH2B adaptor protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNED1 sushi, nidogen and EGF-like domains 1
SNX2 sorting nexin 2
SORBS3 sorbin and SH3 domain containing 3
SOS1 son of sevenless homolog 1 (Drosophila)
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SSBP3 single stranded DNA binding protein 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STIM1 stromal interaction molecule 1
STK10 serine/threonine kinase 10
STMN1 stathmin 1
STMN3 stathmin-like 3
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TBC1D23 TBC1 domain family, member 23
TCF3 transcription factor 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGS1 trimethylguanosine synthase 1
TH tyrosine hydroxylase
THRB thyroid hormone receptor, beta
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TPPP tubulin polymerization promoting protein
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TSC2 tuberous sclerosis 2
TTK TTK protein kinase
TWIST1 twist family bHLH transcription factor 1
UBAP2 ubiquitin associated protein 2
UBAP2L ubiquitin associated protein 2-like
UGDH UDP-glucose 6-dehydrogenase
WASF2 WAS protein family, member 2
WIZ widely interspaced zinc finger motifs
WWC1 WW and C2 domain containing 1
XBP1 X-box binding protein 1
XRN2 5'-3' exoribonuclease 2
ZC3HC1 zinc finger, C3HC-type containing 1
ZFP36 ZFP36 ring finger protein