MAPK10 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description mitogen-activated protein kinase 10|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5602)
External Link http://www.ncbi.nlm.nih.gov/gene/5602
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Genes

179 interacting proteins for hub protein MAPK10 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ADD1 adducin 1 (alpha)
AFF4 AF4/FMR2 family, member 4
AMPH amphiphysin
ANAPC2 anaphase promoting complex subunit 2
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
ARHGAP12 Rho GTPase activating protein 12
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASXL2 additional sex combs like transcriptional regulator 2
ATF2 activating transcription factor 2
ATN1 atrophin 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCOR BCL6 corepressor
CCDC6 coiled-coil domain containing 6
CCNL1 cyclin L1
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CDK5 cyclin-dependent kinase 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP290 centrosomal protein 290kDa
COBL cordon-bleu WH2 repeat protein
COIL coilin
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYAA crystallin, alpha A
DIABLO diablo, IAP-binding mitochondrial protein
DMAP1 DNA methyltransferase 1 associated protein 1
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP16 dual specificity phosphatase 16
DUSP2 dual specificity phosphatase 2
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4B eukaryotic translation initiation factor 4B
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPS15 epidermal growth factor receptor pathway substrate 15
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
EXOC8 exocyst complex component 8
FGFR1OP FGFR1 oncogene partner
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCH1 GTP cyclohydrolase 1
GFAP glial fibrillary acidic protein
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM5 glutamate receptor, metabotropic 5
GRSF1 G-rich RNA sequence binding factor 1
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GYS1 glycogen synthase 1 (muscle)
HDAC1 histone deacetylase 1
HDAC9 histone deacetylase 9
HMGA1 high mobility group AT-hook 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSF1 heat shock transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGSF9B immunoglobulin superfamily, member 9B
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITSN1 intersectin 1 (SH3 domain protein)
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIF1B kinesin family member 1B
KIF26A kinesin family member 26A
KMT2D lysine (K)-specific methyltransferase 2D
LIFR leukemia inhibitory factor receptor alpha
LMNB1 lamin B1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP4 microtubule-associated protein 4
MAPK10 mitogen-activated protein kinase 10
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MDC1 mediator of DNA-damage checkpoint 1
MECOM MDS1 and EVI1 complex locus
MEF2A myocyte enhancer factor 2A
MOBP myelin-associated oligodendrocyte basic protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
MYT1 myelin transcription factor 1
NAP1L1 nucleosome assembly protein 1-like 1
NCK2 NCK adaptor protein 2
NDEL1 nudE neurodevelopment protein 1-like 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFIA nuclear factor I/A
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUP214 nucleoporin 214kDa
ORC1 origin recognition complex, subunit 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDS5B PDS5 cohesin associated factor B
PHACTR1 phosphatase and actin regulator 1
PLEC plectin
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP4R2 protein phosphatase 4, regulatory subunit 2
PRKCQ protein kinase C, theta
PRRC2A proline-rich coiled-coil 2A
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRR protein tyrosine phosphatase, receptor type, R
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD18 RAD18 E3 ubiquitin protein ligase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RBM39 RNA binding motif protein 39
RBM6 RNA binding motif protein 6
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
RPAP1 RNA polymerase II associated protein 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTN4 reticulon 4
RXRA retinoid X receptor, alpha
SARM1 sterile alpha and TIR motif containing 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNPH syntaphilin
SNTA1 syntrophin, alpha 1
SPAG9 sperm associated antigen 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCIN1 SRC kinase signaling inhibitor 1
SRRM2 serine/arginine repetitive matrix 2
SRRT serrate, RNA effector molecule
STMN1 stathmin 1
STMN2 stathmin 2
SYAP1 synapse associated protein 1
SYN1 synapsin I
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAL2 T-cell acute lymphocytic leukemia 2
TCF20 transcription factor 20 (AR1)
TP53 tumor protein p53
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
USP47 ubiquitin specific peptidase 47
WTAP Wilms tumor 1 associated protein
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF239 zinc finger protein 239