MAPK10 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description mitogen-activated protein kinase 10|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5602)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_MAPK10
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Genes

82 co-expressed genes for MAPK10 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTRT1 actin-related protein T1
AHCYL1 adenosylhomocysteinase-like 1
ALDOC aldolase C, fructose-bisphosphate
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP21 Rho GTPase activating protein 21
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BBS2 Bardet-Biedl syndrome 2
BTBD3 BTB (POZ) domain containing 3
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBX7 chromobox homolog 7
CLDND1 claudin domain containing 1
CLIP3 CAP-GLY domain containing linker protein 3
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTNND2 catenin (cadherin-associated protein), delta 2
DCLK1 doublecortin-like kinase 1
DDHD2 DDHD domain containing 2
DLG1 discs, large homolog 1 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNM3 dynamin 3
DTNA dystrobrevin, alpha
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM107A family with sequence similarity 107, member A
FAM171B family with sequence similarity 171, member B
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
FAM219A family with sequence similarity 219, member A
FBXW11 F-box and WD repeat domain containing 11
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF1 fibroblast growth factor 1 (acidic)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIPK2 homeodomain interacting protein kinase 2
IDS iduronate 2-sulfatase
IL17D interleukin 17D
IQSEC1 IQ motif and Sec7 domain 1
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP4 low density lipoprotein receptor-related protein 4
MAPK10 mitogen-activated protein kinase 10
MBP myelin basic protein
MKL2 MKL/myocardin-like 2
NCS1 neuronal calcium sensor 1
NDFIP2 Nedd4 family interacting protein 2
NDRG2 NDRG family member 2
NFASC neurofascin
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NRSN1 neurensin 1
NSF N-ethylmaleimide-sensitive factor
PCDH7 protocadherin 7
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLP1 proteolipid protein 1
PREPL prolyl endopeptidase-like
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RAB6B RAB6B, member RAS oncogene family
RNF141 ring finger protein 141
SCAMP5 secretory carrier membrane protein 5
SCD5 stearoyl-CoA desaturase 5
SCN2B sodium channel, voltage gated, type II beta subunit
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK3 SIK family kinase 3
SLAIN1 SLAIN motif family, member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNAP91 synaptosomal-associated protein, 91kDa
SYT11 synaptotagmin XI
TACC1 transforming, acidic coiled-coil containing protein 1
TEF thyrotrophic embryonic factor
TMOD2 tropomodulin 2 (neuronal)
TOLLIP toll interacting protein
TTYH2 tweety family member 2
VSNL1 visinin-like 1