MAPK14 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase 14|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1432)
External Link http://www.ncbi.nlm.nih.gov/gene/1432
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Genes

112 substrates of the kinase MAPK14 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AHNAK AHNAK nucleoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ATF2 activating transcription factor 2
ATG5 autophagy related 5
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BTG2 BTG family, member 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DLX5 distal-less homeobox 5
DROSHA drosha, ribonuclease type III
EEA1 early endosome antigen 1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
EPS15 epidermal growth factor receptor pathway substrate 15
ESR1 estrogen receptor 1
ETV6 ets variant 6
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR1 fibroblast growth factor receptor 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FPR1 formyl peptide receptor 1
GJA1 gap junction protein, alpha 1, 43kDa
GSK3B glycogen synthase kinase 3 beta
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HIST1H3A histone cluster 1, H3a
HNF4A hepatocyte nuclear factor 4, alpha
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IWS1 IWS1 homolog (S. cerevisiae)
JDP2 Jun dimerization protein 2
KARS lysyl-tRNA synthetase
KAT5 K(lysine) acetyltransferase 5
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KHSRP KH-type splicing regulatory protein
KRT8 keratin 8, type II
LIMK1 LIM domain kinase 1
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAOA monoamine oxidase A
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MITF microphthalmia-associated transcription factor
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYF6 myogenic factor 6 (herculin)
MZF1 myeloid zinc finger 1
NCF1 neutrophil cytosolic factor 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOXA1 NADPH oxidase activator 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDX1 pancreatic and duodenal homeobox 1
PGRMC1 progesterone receptor membrane component 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDX6 peroxiredoxin 6
PRKCE protein kinase C, epsilon
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PXN paxillin
RARG retinoic acid receptor, gamma
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCAN1 regulator of calcineurin 1
RPS27 ribosomal protein S27
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX2 runt-related transcription factor 2
S100A9 S100 calcium binding protein A9
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD9 SMAD family member 9
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SP7 Sp7 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCF3 transcription factor 3
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
USF1 upstream transcription factor 1
XBP1 X-box binding protein 1
ZNHIT1 zinc finger, HIT-type containing 1