MAPK3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase 3|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5595)
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Genes

281 genes differentially expressed following the MAPK3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD274 CD274 molecule 2.79339
KRT86 keratin 86, type II 2.79339
KRT80 keratin 80, type II 2.79339
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.79339
OR6C75 olfactory receptor, family 6, subfamily C, member 75 2.79339
PAX8 paired box 8 2.79339
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.79339
ROM1 retinal outer segment membrane protein 1 2.79339
OOSP1 oocyte secreted protein 1, pseudogene 2.79339
TNNI1 troponin I type 1 (skeletal, slow) 2.79339
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.79339
DGCR6 DiGeorge syndrome critical region gene 6 2.79339
LIX1 Lix1 homolog (chicken) 2.79339
S100A14 S100 calcium binding protein A14 2.79339
ACTL10 actin-like 10 2.79339
DMRT2 doublesex and mab-3 related transcription factor 2 2.79339
DAW1 dynein assembly factor with WDR repeat domains 1 2.79339
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.79339
NSG2 neuronal vesicle trafficking associated 2 2.79339
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.79339
PRDM1 PR domain containing 1, with ZNF domain 2.79339
TMEM255A transmembrane protein 255A 2.79339
C12ORF71 chromosome 12 open reading frame 71 2.74249
ENAH enabled homolog (Drosophila) 2.74249
SLC35G6 solute carrier family 35, member G6 2.74249
TRH thyrotropin-releasing hormone 2.74249
LDHC lactate dehydrogenase C 2.74249
PRODH2 proline dehydrogenase (oxidase) 2 2.74249
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.74249
FOXA1 forkhead box A1 2.74249
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.74249
OIT3 oncoprotein induced transcript 3 2.74249
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.74249
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.74249
DNASE1L2 deoxyribonuclease I-like 2 2.74249
RRAD Ras-related associated with diabetes 2.74249
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.74249
C8ORF74 chromosome 8 open reading frame 74 2.74249
COL15A1 collagen, type XV, alpha 1 2.74249
PRR29 proline rich 29 2.74249
ARSF arylsulfatase F 2.74249
GPR22 G protein-coupled receptor 22 2.74249
NEU4 sialidase 4 2.74249
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.74249
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.74249
HBB hemoglobin, beta 2.74249
GFAP glial fibrillary acidic protein 2.74249
KRT78 keratin 78, type II 2.74249
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.74249
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.74249
CXORF65 chromosome X open reading frame 65 2.74249
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.74249
HLX H2.0-like homeobox 2.74249
TMPRSS11D transmembrane protease, serine 11D 2.74249
TMPRSS6 transmembrane protease, serine 6 2.74249
MYZAP myocardial zonula adherens protein 2.74249
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.74249
MLN motilin 2.74249
FRG2C FSHD region gene 2 family, member C 2.74249
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.74249
ALX3 ALX homeobox 3 2.74249
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.74249
TRAPPC3L trafficking protein particle complex 3-like 2.74249
ALDOB aldolase B, fructose-bisphosphate 2.74249
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.74249
TMEM238L transmembrane protein 238 like 2.74249
LOC124903372 uncharacterized LOC124903372 2.74249
NOTCH2NLB notch 2 N-terminal like B 2.74249
EPCIP exosomal polycystin 1 interacting protein 2.74249
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.74249
TMPRSS4 transmembrane protease, serine 4 2.74249
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.74249
TSPAN1 tetraspanin 1 2.74249
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.74249
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.74249
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.74249
PCDHA3 protocadherin alpha 3 2.74249
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.74249
MEOX1 mesenchyme homeobox 1 2.74249
HAPLN2 hyaluronan and proteoglycan link protein 2 2.74249
IL6 interleukin 6 2.74249
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.74249
MYH14 myosin, heavy chain 14, non-muscle 2.74249
CELA2A chymotrypsin-like elastase family, member 2A 2.74249
BLNK B-cell linker 2.74249
NPIPB8 nuclear pore complex interacting protein family, member B8 2.74249
SOAT2 sterol O-acyltransferase 2 2.74249
LTB lymphotoxin beta (TNF superfamily, member 3) 2.74249
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.74249
GZMM granzyme M (lymphocyte met-ase 1) 2.74249
GOLGA8H golgin A8 family, member H 2.74249
PSKH2 protein serine kinase H2 2.74249
CDH10 cadherin 10, type 2 (T2-cadherin) 2.74249
TREH trehalase (brush-border membrane glycoprotein) 2.74249
PKDREJ polycystin (PKD) family receptor for egg jelly 2.74249
TPSB2 tryptase beta 2 (gene/pseudogene) 2.74249
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.74249
KLHL41 kelch-like family member 41 2.74249
TAS2R50 taste receptor, type 2, member 50 2.74249
NUTM1 NUT midline carcinoma, family member 1 2.74249
BTNL8 butyrophilin-like 8 2.74249
FHL1 four and a half LIM domains 1 2.74249
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.74249
UBQLNL ubiquilin-like 2.74249
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.74249
TMEM132D transmembrane protein 132D 2.74249
GAL3ST2 galactose-3-O-sulfotransferase 2 2.74249
SHISA8 shisa family member 8 2.74249
LMOD3 leiomodin 3 (fetal) 2.74249
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.74249
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.74249
NPY2R neuropeptide Y receptor Y2 2.74249
WNT1 wingless-type MMTV integration site family, member 1 2.74249
GBX2 gastrulation brain homeobox 2 2.74249
OTP orthopedia homeobox 2.74249
GOLGA8T golgin A8 family, member T 2.74249
TMEM31 transmembrane protein 31 2.74249
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.74249
SPHKAP SPHK1 interactor, AKAP domain containing 2.74249
PDCD1LG2 programmed cell death 1 ligand 2 2.74249
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.74249
VSTM1 V-set and transmembrane domain containing 1 2.74249
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.74249
CATIP ciliogenesis associated TTC17 interacting protein 2.74249
GP5 glycoprotein V (platelet) 2.74249
COMP cartilage oligomeric matrix protein 2.74249
EBF2 early B-cell factor 2 2.74249
A3GALT2 alpha 1,3-galactosyltransferase 2 2.74249
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.74249
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.74249
FAM9B family with sequence similarity 9, member B 2.74249
KIAA1755 KIAA1755 2.74249
SLC7A4 solute carrier family 7, member 4 2.74249
FADS6 fatty acid desaturase 6 2.74249
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.74249
TMEM86A transmembrane protein 86A 2.74249
ITPKA inositol-trisphosphate 3-kinase A 2.74249
GPR78 G protein-coupled receptor 78 2.74249
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.74249
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.74249
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.74249
ARGFX arginine-fifty homeobox 2.74249
FAM9C family with sequence similarity 9, member C 2.74249
ST18 suppression of tumorigenicity 18, zinc finger 2.74249
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.74249
LVRN laeverin 2.74249
SMYD1 SET and MYND domain containing 1 2.74249
KCNU1 potassium channel, subfamily U, member 1 2.74249
TCF21 transcription factor 21 2.74249
FEZF2 FEZ family zinc finger 2 2.74249
PHEX phosphate regulating endopeptidase homolog, X-linked 2.69698
ENKUR enkurin, TRPC channel interacting protein 2.69447
C6ORF58 chromosome 6 open reading frame 58 2.69447
RBM15 RNA binding motif protein 15 2.68375
ABHD11 abhydrolase domain containing 11 2.60081
ENTREP3 endosomal transmembrane epsin interactor 3 2.58177
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.57611
MKRN1 makorin ring finger protein 1 2.55685
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.49258
WDR76 WD repeat domain 76 2.45462
ENTREP2 endosomal transmembrane epsin interactor 2 2.40818
C16ORF96 chromosome 16 open reading frame 96 2.40104
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.38084
ZNF213 zinc finger protein 213 2.3496
S1PR5 sphingosine-1-phosphate receptor 5 2.32221
CT55 cancer/testis antigen 55 2.32221
BTK Bruton agammaglobulinemia tyrosine kinase 2.30337
MCM10 minichromosome maintenance complex component 10 2.29575
ZNF609 zinc finger protein 609 2.29171
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.26156
CLIC2 chloride intracellular channel 2 2.24777
PDLIM2 PDZ and LIM domain 2 (mystique) 2.23653
EPHA8 EPH receptor A8 2.19684
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.19598
CCDC40 coiled-coil domain containing 40 2.19308
DNAH17 dynein, axonemal, heavy chain 17 2.19308
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 2.1738
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.15549
PDE4A phosphodiesterase 4A, cAMP-specific 2.14427
DPH1 diphthamide biosynthesis 1 2.13747
TECR trans-2,3-enoyl-CoA reductase 2.1333
DGKE diacylglycerol kinase, epsilon 64kDa 2.12707
NSUN6 NOP2/Sun domain family, member 6 2.10868
ANKRD42 ankyrin repeat domain 42 2.10679
ASB1 ankyrin repeat and SOCS box containing 1 2.10649
CLDN10 claudin 10 2.09108
SPRYD3 SPRY domain containing 3 2.05757
ZBTB32 zinc finger and BTB domain containing 32 2.05363
SPTB spectrin, beta, erythrocytic 2.053
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 2.04581
ZNF350 zinc finger protein 350 2.04547
RXRA retinoid X receptor, alpha 2.04132
PCSK7 proprotein convertase subtilisin/kexin type 7 2.04033
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.03826
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.03777
MMD2 monocyte to macrophage differentiation-associated 2 2.03673
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.02563
MAML2 mastermind-like 2 (Drosophila) 2.01992
ANKRD12 ankyrin repeat domain 12 2.01992

decreased expression

Symbol Name Standardized Value
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.76058
FNDC11 fibronectin type III domain containing 11 -2.76058
RPH3A rabphilin 3A -2.76058
TMEM79 transmembrane protein 79 -2.76058
KYNU kynureninase -2.76058
CCDC39 coiled-coil domain containing 39 -2.74249
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.74249
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -2.74249
RGS17 regulator of G-protein signaling 17 -2.74249
SIRT7 sirtuin 7 -2.74249
CMIP c-Maf inducing protein -2.74249
SHOC1 shortage in chiasmata 1 -2.74249
TRIM56 tripartite motif containing 56 -2.74249
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.74249
SUCLG1 succinate-CoA ligase, alpha subunit -2.69698
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 -2.69638
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.69638
FKBP1C FK506 binding protein 1C -2.69638
THSD8 thrombospondin type 1 domain containing 8 -2.69638
FGF10 fibroblast growth factor 10 -2.69638
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.69638
PAX7 paired box 7 -2.69638
ZNF835 zinc finger protein 835 -2.69638
C17ORF107 chromosome 17 open reading frame 107 -2.69638
CD27 CD27 molecule -2.69638
PRELP proline/arginine-rich end leucine-rich repeat protein -2.69638
RPS21-DT RPS21 divergent transcript -2.69638
ZAN zonadhesin (gene/pseudogene) -2.69638
CAMK2B calcium/calmodulin-dependent protein kinase II beta -2.69638
CXCR6 chemokine (C-X-C motif) receptor 6 -2.69638
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -2.69638
PRDM6 PR domain containing 6 -2.69638
FGF18 fibroblast growth factor 18 -2.69638
NUDCD1 NudC domain containing 1 -2.69472
ANKRD7 ankyrin repeat domain 7 -2.66802
MX1 MX dynamin-like GTPase 1 -2.65484
GSG1L GSG1-like -2.65273
FITM2 fat storage-inducing transmembrane protein 2 -2.64073
ZNF483 zinc finger protein 483 -2.58974
CRIP1 cysteine-rich protein 1 (intestinal) -2.58345
PNMA8C PNMA family member 8C -2.58345
LYPD1 LY6/PLAUR domain containing 1 -2.58177
UBE2A ubiquitin-conjugating enzyme E2A -2.58177
CDKL5 cyclin-dependent kinase-like 5 -2.49601
SOX7 SRY (sex determining region Y)-box 7 -2.49601
BBS2 Bardet-Biedl syndrome 2 -2.48619
IGSF10 immunoglobulin superfamily, member 10 -2.47885
FAM43A family with sequence similarity 43, member A -2.47885
ZNF74 zinc finger protein 74 -2.43055
ZNF274 zinc finger protein 274 -2.35647
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -2.3496
C6ORF62 chromosome 6 open reading frame 62 -2.32221
IFI30 interferon, gamma-inducible protein 30 -2.31149
TCHP trichoplein, keratin filament binding -2.31077
CPD carboxypeptidase D -2.30544
TP53 tumor protein p53 -2.30337
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -2.2901
ZNF506 zinc finger protein 506 -2.28635
CEP350 centrosomal protein 350kDa -2.2788
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -2.26085
NCOA5 nuclear receptor coactivator 5 -2.25332
TRAF5 TNF receptor-associated factor 5 -2.22612
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.22311
BTG1 B-cell translocation gene 1, anti-proliferative -2.20779
MMP16 matrix metallopeptidase 16 (membrane-inserted) -2.20323
UNC5A unc-5 homolog A (C. elegans) -2.15341
RPAP2 RNA polymerase II associated protein 2 -2.1302
LHCGR luteinizing hormone/choriogonadotropin receptor -2.11191
MEST mesoderm specific transcript -2.11021
DZIP3 DAZ interacting zinc finger protein 3 -2.10963
RSRP1 arginine/serine-rich protein 1 -2.10679
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.10679
TEKT3 tektin 3 -2.10679
MATK megakaryocyte-associated tyrosine kinase -2.10067
DNM1 dynamin 1 -2.0869
CCDC32 coiled-coil domain containing 32 -2.0784
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -2.06605
C1QL1 complement component 1, q subcomponent-like 1 -2.04547
ANKRD30BL ankyrin repeat domain 30B-like -2.04435
MCC mutated in colorectal cancers -2.03777
PARD3 par-3 family cell polarity regulator -2.03777
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.00522