MAPK3 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase 3|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5595)
External Link http://www.ncbi.nlm.nih.gov/gene/5595
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Genes

183 substrates of the kinase MAPK3 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABI1 abl-interactor 1
ADAM17 ADAM metallopeptidase domain 17
AEBP1 AE binding protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ARHGAP31 Rho GTPase activating protein 31
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB1 arrestin, beta 1
ASB2 ankyrin repeat and SOCS box containing 2
ATF2 activating transcription factor 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRA biliverdin reductase A
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG2 BTG family, member 2
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALD1 caldesmon 1
CANX calnexin
CAPN2 calpain 2, (m/II) large subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CDCA5 cell division cycle associated 5
CDK2 cyclin-dependent kinase 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CIC capicua transcriptional repressor
CIITA class II, major histocompatibility complex, transactivator
CREBBP CREB binding protein
CREM cAMP responsive element modulator
CTTN cortactin
DNM1L dynamin 1-like
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
E2F4 E2F transcription factor 4, p107/p130-binding
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK1 ELK1, member of ETS oncogene family
EPS8 epidermal growth factor receptor pathway substrate 8
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV6 ets variant 6
EWSR1 EWS RNA-binding protein 1
EXOC7 exocyst complex component 7
FAM195B family with sequence similarity 195, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GORASP2 golgi reassembly stacking protein 2, 55kDa
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
H3F3B H3 histone, family 3B (H3.3B)
HDAC6 histone deacetylase 6
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSF1 heat shock transcription factor 1
HSPB8 heat shock 22kDa protein 8
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
ITGB4 integrin, beta 4
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KARS lysyl-tRNA synthetase
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KLC1 kinesin light chain 1
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LIFR leukemia inhibitory factor receptor alpha
LRP6 low density lipoprotein receptor-related protein 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEA11 melanoma antigen family A11
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MCTS1 malignant T cell amplified sequence 1
MED1 mediator complex subunit 1
MED14 mediator complex subunit 14
MITF microphthalmia-associated transcription factor
MKL1 megakaryoblastic leukemia (translocation) 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTMR2 myotubularin related protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYLK myosin light chain kinase
MYOCD myocardin
MZF1 myeloid zinc finger 1
NCF1 neutrophil cytosolic factor 1
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NDEL1 nudE neurodevelopment protein 1-like 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS2 nitric oxide synthase 2, inducible
NOXA1 NADPH oxidase activator 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUP153 nucleoporin 153kDa
NUP214 nucleoporin 214kDa
NUP50 nucleoporin 50kDa
PALLD palladin, cytoskeletal associated protein
PAPOLA poly(A) polymerase alpha
PDE4D phosphodiesterase 4D, cAMP-specific
PGR progesterone receptor
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PML promyelocytic leukemia
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKCA protein kinase C, alpha
PTK2 protein tyrosine kinase 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRR protein tyrosine phosphatase, receptor type, R
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP3 RAN binding protein 3
RARG retinoic acid receptor, gamma
RCAN1 regulator of calcineurin 1
RPS3 ribosomal protein S3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
SH2B1 SH2B adaptor protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD2 SMAD family member 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STIM1 stromal interaction molecule 1
STMN1 stathmin 1
SULT4A1 sulfotransferase family 4A, member 1
SYN3 synapsin III
TAL1 T-cell acute lymphocytic leukemia 1
TAL2 T-cell acute lymphocytic leukemia 2
TH tyrosine hydroxylase
THRB thyroid hormone receptor, beta
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
TTK TTK protein kinase
TWIST1 twist family bHLH transcription factor 1
WASF2 WAS protein family, member 2
WWC1 WW and C2 domain containing 1
XBP1 X-box binding protein 1
ZC3HC1 zinc finger, C3HC-type containing 1