MAPK7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitogen-activated protein kinase 7|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5598)
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Genes

289 genes differentially expressed following the MAPK7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLR8 toll-like receptor 8 2.4306
SRL sarcalumenin 2.4306
CFHR3 complement factor H-related 3 2.4306
LAPTM5 lysosomal protein transmembrane 5 2.4306
FOLR1 folate receptor 1 (adult) 2.4306
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.4306
RBM10 RNA binding motif protein 10 2.4306
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.4306
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B 2.4306
ASB15 ankyrin repeat and SOCS box containing 15 2.4306
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.4306
FAM153A family with sequence similarity 153, member A 2.4306
KLF14 Kruppel-like factor 14 2.4306
SIM2 single-minded family bHLH transcription factor 2 2.4306
GOLGA7B golgin A7 family, member B 2.4306
ULBP1 UL16 binding protein 1 2.4306
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.4306
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.4306
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.4306
PTGDR2 prostaglandin D2 receptor 2 2.4306
REXO2 RNA exonuclease 2 2.4306
ZNF436 zinc finger protein 436 2.4306
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.4306
CTRC chymotrypsin C (caldecrin) 2.4306
XAF1 XIAP associated factor 1 2.4306
SKOR1 SKI family transcriptional corepressor 1 2.4306
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.4306
PAX6 paired box 6 2.4306
VEZF1 vascular endothelial zinc finger 1 2.4306
PECAM1 platelet/endothelial cell adhesion molecule 1 2.4306
ARSF arylsulfatase F 2.4306
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.4306
COX17 COX17 cytochrome c oxidase copper chaperone 2.4306
CELA1 chymotrypsin-like elastase family, member 1 2.4306
LACTBL1 lactamase, beta-like 1 2.4306
TMEM191B transmembrane protein 191B 2.4306
ADTRP androgen-dependent TFPI-regulating protein 2.4306
IGFL3 IGF-like family member 3 2.4306
SPINK6 serine peptidase inhibitor, Kazal type 6 2.4306
TMEM176B transmembrane protein 176B 2.4306
ERV3-1 endogenous retrovirus group 3, member 1 2.4306
MAGEA2 melanoma antigen family A2 2.4306
FGL1 fibrinogen-like 1 2.4306
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.4306
PGBDF plakoglobin binding and degradation factor 2.4306
PPP1R18 protein phosphatase 1, regulatory subunit 18 2.4306
BLK BLK proto-oncogene, Src family tyrosine kinase 2.4306
IL2RB interleukin 2 receptor, beta 2.4306
LOC124906892 uncharacterized LOC124906892 2.4306
RTL5 retrotransposon Gag like 5 2.4306
TLCD3B TLC domain containing 3B 2.4306
MINAR2 membrane integral NOTCH2 associated receptor 2 2.4306
CCDC198 coiled-coil domain containing 198 2.4306
DEPP1 DEPP autophagy regulator 1 2.4306
TMEM275 transmembrane protein 275 2.4306
ERVW-1 endogenous retrovirus group W, member 1 2.4306
CES4A carboxylesterase 4A 2.4306
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.4306
TAS2R60 taste receptor, type 2, member 60 2.4306
SLC49A3 solute carrier family 49 member 3 2.4306
ODAPH odontogenesis associated phosphoprotein 2.4306
SPMIP1 sperm microtubule inner protein 1 2.4306
OR56B2 olfactory receptor family 56 subfamily B member 2 2.4306
FAM237A family with sequence similarity 237 member A 2.4306
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.4306
NHERF4 NHERF family PDZ scaffold protein 4 2.4306
H2BK1 H2B.K variant histone 1 2.4306
SMIM45 small integral membrane protein 45 2.4306
H3C14 H3 clustered histone 14 2.4306
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.4306
CIBAR2 CBY1 interacting BAR domain containing 2 2.4306
RHCG Rh family, C glycoprotein 2.4306
SMLR1 small leucine-rich protein 1 2.4306
GPR84 G protein-coupled receptor 84 2.4306
UTS2 urotensin 2 2.4306
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.4306
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.4306
S100B S100 calcium binding protein B 2.4306
CCR4 chemokine (C-C motif) receptor 4 2.4306
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.4306
PRR18 proline rich 18 2.4306
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.4306
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.4306
SOAT2 sterol O-acyltransferase 2 2.4306
LRRN4CL LRRN4 C-terminal like 2.4306
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.4306
NEURL3 neuralized E3 ubiquitin protein ligase 3 2.4306
PAPOLB poly(A) polymerase beta (testis specific) 2.4306
BDKRB1 bradykinin receptor B1 2.4306
MYEOV myeloma overexpressed 2.4306
FOXC1 forkhead box C1 2.4306
RASD1 RAS, dexamethasone-induced 1 2.4306
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.4306
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.4306
MROH5 maestro heat-like repeat family member 5 2.4306
TPTE transmembrane phosphatase with tensin homology 2.4306
CD177 CD177 molecule 2.4306
DCLK1 doublecortin-like kinase 1 2.4306
LCN1 lipocalin 1 2.4306
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.4306
SERINC4 serine incorporator 4 2.4306
NIPAL4 NIPA-like domain containing 4 2.4306
AKNAD1 AKNA domain containing 1 2.4306
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.4306
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.4306
IL36R interleukin 36 receptor 2.4306
CCDC185 coiled-coil domain containing 185 2.4306
HHATL hedgehog acyltransferase-like 2.4306
AQP8 aquaporin 8 2.4306
CIDEA cell death-inducing DFFA-like effector a 2.4306
SMYD1 SET and MYND domain containing 1 2.4306
BLID BH3-like motif containing, cell death inducer 2.4306
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.4306
APOH apolipoprotein H (beta-2-glycoprotein I) 2.4306
VAX2 ventral anterior homeobox 2 2.4306
CCDC158 coiled-coil domain containing 158 2.4306
MRLN myoregulin 2.4306
KLHL6 kelch-like family member 6 2.4306
AQP9 aquaporin 9 2.4306
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.4306
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.4306
SLC38A3 solute carrier family 38, member 3 2.4306
PSG5 pregnancy specific beta-1-glycoprotein 5 2.4306
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.4306
MYADML2 myeloid-associated differentiation marker-like 2 2.4306
FAIM2 Fas apoptotic inhibitory molecule 2 2.4306
GBX1 gastrulation brain homeobox 1 2.4306
NPY2R neuropeptide Y receptor Y2 2.4306
GOLGA8M golgin A8 family, member M 2.4306
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.4306
PHACTR3 phosphatase and actin regulator 3 2.4306
CTSF cathepsin F 2.4306
GPR68 G protein-coupled receptor 68 2.4306
IL19 interleukin 19 2.4306
DHH desert hedgehog 2.4306
CER1 cerberus 1, DAN family BMP antagonist 2.4306
C8ORF89 chromosome 8 open reading frame 89 2.4306
PCDHA10 protocadherin alpha 10 2.4306
LRRC15 leucine rich repeat containing 15 2.4306
CHIT1 chitinase 1 (chitotriosidase) 2.4306
CALR3 calreticulin 3 2.4306
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.4306
TSPYL6 TSPY-like 6 2.4306
BCL2A1 BCL2-related protein A1 2.4306
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.4306
TGM4 transglutaminase 4 2.4306
HEPN1 hepatocellular carcinoma, down-regulated 1 2.4306
TAS2R46 taste receptor, type 2, member 46 2.4306
SLC38A11 solute carrier family 38, member 11 2.4306
AHSG alpha-2-HS-glycoprotein 2.4306
DNAH8 dynein, axonemal, heavy chain 8 2.4306
PGR progesterone receptor 2.4306
TMEM88 transmembrane protein 88 2.4306
UBASH3A ubiquitin associated and SH3 domain containing A 2.4306
PMCH pro-melanin-concentrating hormone 2.4306
BTBD18 BTB (POZ) domain containing 18 2.4306
SOST sclerostin 2.4306
C5ORF46 chromosome 5 open reading frame 46 2.4306
CLEC2A C-type lectin domain family 2, member A 2.4306
GRM6 glutamate receptor, metabotropic 6 2.4306
PITX2 paired-like homeodomain 2 2.4306
GGN gametogenetin 2.4306
ADRA1B adrenoceptor alpha 1B 2.4306
CARNS1 carnosine synthase 1 2.4306
POTEC POTE ankyrin domain family, member C 2.4306
AMER3 APC membrane recruitment protein 3 2.4306
GCM1 glial cells missing homolog 1 (Drosophila) 2.4306
PPY pancreatic polypeptide 2.4306
VSX1 visual system homeobox 1 2.4306
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.4306
PRDM12 PR domain containing 12 2.4306
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.4306
NUTM2F NUT family member 2F 2.4306
KLLN killin, p53-regulated DNA replication inhibitor 2.4306
LST1 leukocyte specific transcript 1 2.4306
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 2.41317
C13ORF42 chromosome 13 open reading frame 42 2.37974
CELA2B chymotrypsin-like elastase family, member 2B 2.37974
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.37552
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.35456
ATOH7 atonal homolog 7 (Drosophila) 2.35456
C2ORF72 chromosome 2 open reading frame 72 2.35456
AQP7 aquaporin 7 2.35456
CUX2 cut-like homeobox 2 2.35332
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.33694
MED6 mediator complex subunit 6 2.32762
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.30632
KIF11 kinesin family member 11 2.29554
PCM1 pericentriolar material 1 2.26318
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.25022
CNGB1 cyclic nucleotide gated channel beta 1 2.2187
TMPRSS13 transmembrane protease, serine 13 2.2187
FAM221A family with sequence similarity 221, member A 2.21336
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 2.21178
PTK2 protein tyrosine kinase 2 2.21074
MRPL4 mitochondrial ribosomal protein L4 2.18325
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.1788
HSPA8 heat shock 70kDa protein 8 2.15994
ZNF23 zinc finger protein 23 2.15284
PLBD1 phospholipase B domain containing 1 2.1365
DENND2B DENN domain containing 2B 2.12657
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.09426
CHIC1 cysteine-rich hydrophobic domain 1 2.08862
FERMT1 fermitin family member 1 2.08862
BAIAP2L1 BAI1-associated protein 2-like 1 2.08862
GOLIM4 golgi integral membrane protein 4 2.07965
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 2.07498
PLXNA2 plexin A2 2.04336
TRIP4 thyroid hormone receptor interactor 4 2.01775
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.01527
SMIM12 small integral membrane protein 12 2.00999
SPEG SPEG complex locus 2.00537

decreased expression

Symbol Name Standardized Value
PAX7 paired box 7 -2.4306
PTK6 protein tyrosine kinase 6 -2.4306
GPR3 G protein-coupled receptor 3 -2.4306
MYL5 myosin, light chain 5, regulatory -2.4306
ASCL3 achaete-scute family bHLH transcription factor 3 -2.4306
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.4306
MMP12 matrix metallopeptidase 12 -2.4306
KCTD4 potassium channel tetramerization domain containing 4 -2.4306
SYT13 synaptotagmin XIII -2.4306
LY86 lymphocyte antigen 86 -2.4306
TBC1D22A TBC1 domain family, member 22A -2.4306
SOWAHB sosondowah ankyrin repeat domain family member B -2.4306
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 -2.4306
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -2.4306
HSBP1L1 heat shock factor binding protein 1-like 1 -2.4306
ASCC2 activating signal cointegrator 1 complex subunit 2 -2.4306
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -2.4306
QRICH1 glutamine-rich 1 -2.4306
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -2.4306
ZCCHC3 zinc finger, CCHC domain containing 3 -2.4306
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.4306
TFEB transcription factor EB -2.4306
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.4306
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) -2.4306
RELN reelin -2.4306
ANKRD55 ankyrin repeat domain 55 -2.4306
GMCL1 germ cell-less, spermatogenesis associated 1 -2.4306
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.4306
MYOCOS myocilin opposite strand -2.4306
PCDHAC2 protocadherin alpha subfamily C, 2 -2.4306
CBLIF cobalamin binding intrinsic factor -2.4306
CYS1 cystin 1 -2.4306
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.4306
FAM209B family with sequence similarity 209, member B -2.4306
SAMD15 sterile alpha motif domain containing 15 -2.4306
MYH15 myosin, heavy chain 15 -2.4306
EXOC3L1 exocyst complex component 3-like 1 -2.4306
EDN3 endothelin 3 -2.4306
TTYH3 tweety family member 3 -2.4306
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.4306
RSAD2 radical S-adenosyl methionine domain containing 2 -2.4306
ATP9B ATPase, class II, type 9B -2.41663
RASGEF1B RasGEF domain family, member 1B -2.34887
GRIK5 glutamate receptor, ionotropic, kainate 5 -2.34507
TMEM229A transmembrane protein 229A -2.30493
CALHM2 calcium homeostasis modulator 2 -2.30493
PTPRU protein tyrosine phosphatase, receptor type, U -2.28572
TENM3 teneurin transmembrane protein 3 -2.26113
DRC2 dynein regulatory complex subunit 2 -2.21178
ADSS2 adenylosuccinate synthase 2 -2.20768
TPD52 tumor protein D52 -2.18692
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.1591
KIFAP3 kinesin-associated protein 3 -2.13672
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.1276
ASB14 ankyrin repeat and SOCS box containing 14 -2.116
PMPCB peptidase (mitochondrial processing) beta -2.11272
UBQLN4 ubiquilin 4 -2.10898
TTPA tocopherol (alpha) transfer protein -2.10084
H3C4 H3 clustered histone 4 -2.08884
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -2.08884
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.08222
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.08164
ZNF699 zinc finger protein 699 -2.0809
SRP68 signal recognition particle 68kDa -2.07335
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.07335
GMPR2 guanosine monophosphate reductase 2 -2.07243
HIP1 huntingtin interacting protein 1 -2.05947
NME9 NME/NM23 family member 9 -2.05102
BEND4 BEN domain containing 4 -2.03263
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.02846
EDN1 endothelin 1 -2.02846
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.01775
NDN necdin, melanoma antigen (MAGE) family member -2.01775
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -2.01775
TCEAL9 transcription elongation factor A like 9 -2.01227
SPDL1 spindle apparatus coiled-coil protein 1 -2.00877
CCDC33 coiled-coil domain containing 33 -2.00877