MAPK8 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description mitogen-activated protein kinase 8|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 5599)
External Link http://www.ncbi.nlm.nih.gov/gene/5599
Similar Terms
Downloads & Tools

Genes

346 interacting proteins for hub protein MAPK8 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADCY6 adenylate cyclase 6
ADD2 adducin 2 (beta)
ADRB2 adrenoceptor beta 2, surface
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
AHNAK AHNAK nucleoprotein
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKAP1 A kinase (PRKA) anchor protein 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANAPC1 anaphase promoting complex subunit 1
ANK2 ankyrin 2, neuronal
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID1A AT rich interactive domain 1A (SWI-like)
ATF2 activating transcription factor 2
ATN1 atrophin 1
ATXN7 ataxin 7
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAD BCL2-associated agonist of cell death
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCLAF1 BCL2-associated transcription factor 1
BID BH3 interacting domain death agonist
BLM Bloom syndrome, RecQ helicase-like
BMF Bcl2 modifying factor
BPTF bromodomain PHD finger transcription factor
BSN bassoon presynaptic cytomatrix protein
BUB3 BUB3 mitotic checkpoint protein
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALD1 caldesmon 1
CASKIN1 CASK interacting protein 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAST calpastatin
CCNT2 cyclin T2
CDC23 cell division cycle 23
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK16 cyclin-dependent kinase 16
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHEK2 checkpoint kinase 2
CHRM2 cholinergic receptor, muscarinic 2
CIC capicua transcriptional repressor
CLASP1 cytoplasmic linker associated protein 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
COPS2 COP9 signalosome subunit 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTBP1 C-terminal binding protein 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CUL3 cullin 3
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAXX death-domain associated protein
DCLK1 doublecortin-like kinase 1
DCX doublecortin
DEAF1 DEAF1 transcription factor
DES desmin
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DNM1 dynamin 1
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP16 dual specificity phosphatase 16
DUSP2 dual specificity phosphatase 2
DUSP22 dual specificity phosphatase 22
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EHBP1 EH domain binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELF2 E74-like factor 2 (ets domain transcription factor)
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPS8L2 EPS8-like 2
ERBB2IP erbb2 interacting protein
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
ETV1 ets variant 1
EWSR1 EWS RNA-binding protein 1
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO38 F-box protein 38
FGFR1OP FGFR1 oncogene partner
FLII flightless I homolog (Drosophila)
FOXO4 forkhead box O4
FUBP1 far upstream element (FUSE) binding protein 1
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GEMIN5 gem (nuclear organelle) associated protein 5
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA2 golgin A2
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HDAC1 histone deacetylase 1
HDAC6 histone deacetylase 6
HDAC9 histone deacetylase 9
HDGF hepatoma-derived growth factor
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPK heterogeneous nuclear ribonucleoprotein K
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSF4 heat shock transcription factor 4
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL27RA interleukin 27 receptor, alpha
IRAK1 interleukin-1 receptor-associated kinase 1
IRF2BPL interferon regulatory factor 2 binding protein-like
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ISL2 ISL LIM homeobox 2
ITCH itchy E3 ubiquitin protein ligase
ITSN1 intersectin 1 (SH3 domain protein)
JDP2 Jun dimerization protein 2
JKAMP JNK1/MAPK8-associated membrane protein
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5C lysine (K)-specific demethylase 5C
KLF16 Kruppel-like factor 16
KRT8 keratin 8, type II
LAT linker for activation of T cells
LEF1 lymphoid enhancer-binding factor 1
LIMD1 LIM domains containing 1
LMNA lamin A/C
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MAP1S microtubule-associated protein 1S
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4 microtubule-associated protein 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MATK megakaryocyte-associated tyrosine kinase
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MEF2A myocyte enhancer factor 2A
MEF2D myocyte enhancer factor 2D
MICALL1 MICAL-like 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSN moesin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYT1 myelin transcription factor 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NCOA3 nuclear receptor coactivator 3
NDEL1 nudE neurodevelopment protein 1-like 1
NEFM neurofilament, medium polypeptide
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2 nuclear factor, erythroid 2
NFIA nuclear factor I/A
NFIB nuclear factor I/B
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NMT1 N-myristoyltransferase 1
NOP2 NOP2 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP214 nucleoporin 214kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PAX2 paired box 2
PCDH1 protocadherin 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEC plectin
PLK2 polo-like kinase 2
POGZ pogo transposable element with ZNF domain
PPARG peroxisome proliferator-activated receptor gamma
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRDM2 PR domain containing 2, with ZNF domain
PRICKLE3 prickle homolog 3 (Drosophila)
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRRC2A proline-rich coiled-coil 2A
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRR protein tyrosine phosphatase, receptor type, R
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD18 RAD18 E3 ubiquitin protein ligase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARA retinoic acid receptor, alpha
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM15 RNA binding motif protein 15
RBMX RNA binding motif protein, X-linked
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REST RE1-silencing transcription factor
RET ret proto-oncogene
RHOA ras homolog family member A
RNMT RNA (guanine-7-) methyltransferase
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RREB1 ras responsive element binding protein 1
RTN4 reticulon 4
RXRA retinoid X receptor, alpha
S100A11 S100 calcium binding protein A11
SCML2 sex comb on midleg-like 2 (Drosophila)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SH2D3A SH2 domain containing 3A
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC41A3 solute carrier family 41, member 3
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SNN stannin
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOX11 SRY (sex determining region Y)-box 11
SP1 Sp1 transcription factor
SPAG9 sperm associated antigen 9
SPAST spastin
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SRRT serrate, RNA effector molecule
SSBP4 single stranded DNA binding protein 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
STMN1 stathmin 1
STMN2 stathmin 2
SUGP2 SURP and G patch domain containing 2
SYMPK symplekin
SYN1 synapsin I
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TFCP2 transcription factor CP2
TLK2 tousled-like kinase 2
TMEM245 transmembrane protein 245
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TPD52L2 tumor protein D52-like 2
TPPP tubulin polymerization promoting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TWIST1 twist family bHLH transcription factor 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UIMC1 ubiquitin interaction motif containing 1
VRK2 vaccinia related kinase 2
WDR62 WD repeat domain 62
WWOX WW domain containing oxidoreductase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZEB1 zinc finger E-box binding homeobox 1
ZMYM2 zinc finger, MYM-type 2
ZNF516 zinc finger protein 516