MAPK8 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description mitogen-activated protein kinase 8|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 5599)
External Link http://www.ncbi.nlm.nih.gov/gene/5599
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Genes

81 substrates of the kinase MAPK8 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATF2 activating transcription factor 2
ATN1 atrophin 1
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMF Bcl2 modifying factor
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCP1A decapping mRNA 1A
DCX doublecortin
DIABLO diablo, IAP-binding mitochondrial protein
DUSP8 dual specificity phosphatase 8
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EWSR1 EWS RNA-binding protein 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HNRNPK heterogeneous nuclear ribonucleoprotein K
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITCH itchy E3 ubiquitin protein ligase
JDP2 Jun dimerization protein 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KRT8 keratin 8, type II
LAT linker for activation of T cells
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2 nuclear factor, erythroid 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRL neural retina leucine zipper
PPARG peroxisome proliferator-activated receptor gamma
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PXN paxillin
RARA retinoic acid receptor, alpha
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SP1 Sp1 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
STMN1 stathmin 1
STMN2 stathmin 2
SYT4 synaptotagmin IV
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta