MAPKAPK5 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase-activated protein kinase 5|The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] (NCBI Entrez Gene Database, 8550)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase MAPKAPK5 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
RPH3A rabphilin 3A
RPL34 ribosomal protein L34
KMT2C lysine (K)-specific methyltransferase 2C
OSBPL5 oxysterol binding protein-like 5
MATR3 matrin 3
FRMD8 FERM domain containing 8
EP400 E1A binding protein p400
EHBP1 EH domain binding protein 1
CEP295 centrosomal protein 295kDa
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
PITPNM3 PITPNM family member 3
GANAB glucosidase, alpha; neutral AB
GPR183 G protein-coupled receptor 183
WWTR1 WW domain containing transcription regulator 1
MYO1G myosin IG
CORO7 coronin 7
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
CDK12 cyclin-dependent kinase 12
CDK16 cyclin-dependent kinase 16
ANKRD11 ankyrin repeat domain 11
SHE Src homology 2 domain containing E
FAM208A family with sequence similarity 208, member A
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
PRICKLE2 prickle homolog 2 (Drosophila)
USP24 ubiquitin specific peptidase 24
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
LSP1 lymphocyte-specific protein 1
MRVI1 murine retrovirus integration site 1 homolog
GLI2 GLI family zinc finger 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
DAP3 death associated protein 3
PTPDC1 protein tyrosine phosphatase domain containing 1
NAV1 neuron navigator 1
KIAA1109 KIAA1109
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
CRTC3 CREB regulated transcription coactivator 3
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PTGFRN prostaglandin F2 receptor inhibitor
ZBTB11 zinc finger and BTB domain containing 11
BCL9L B-cell CLL/lymphoma 9-like
ERBB2IP erbb2 interacting protein
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
PRRC2B proline-rich coiled-coil 2B
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
DOCK2 dedicator of cytokinesis 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
LMOD1 leiomodin 1 (smooth muscle)
TMEM131 transmembrane protein 131
LIMCH1 LIM and calponin homology domains 1
DRD3 dopamine receptor D3
FASN fatty acid synthase
ANKRD33B ankyrin repeat domain 33B
SYNE2 spectrin repeat containing, nuclear envelope 2
APC adenomatous polyposis coli
DST dystonin
PHF3 PHD finger protein 3
SLC45A4 solute carrier family 45, member 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
KIDINS220 kinase D-interacting substrate, 220kDa
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
ZNF516 zinc finger protein 516
NUMBL numb homolog (Drosophila)-like
PLCL1 phospholipase C-like 1
ILDR1 immunoglobulin-like domain containing receptor 1
COPS6 COP9 signalosome subunit 6
INF2 inverted formin, FH2 and WH2 domain containing
SOWAHA sosondowah ankyrin repeat domain family member A
ARHGAP21 Rho GTPase activating protein 21
BOD1L1 biorientation of chromosomes in cell division 1-like 1
NUMB numb homolog (Drosophila)
XPO1 exportin 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
AMPD2 adenosine monophosphate deaminase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
MAST2 microtubule associated serine/threonine kinase 2
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
KANSL1 KAT8 regulatory NSL complex subunit 1
PYGB phosphorylase, glycogen; brain
CDC25B cell division cycle 25B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
CCSAP centriole, cilia and spindle-associated protein
CLK3 CDC-like kinase 3
HSPB1 heat shock 27kDa protein 1
NAV3 neuron navigator 3
NAV2 neuron navigator 2
PCF11 PCF11 cleavage and polyadenylation factor subunit
ZFP64 ZFP64 zinc finger protein
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
NCAPH non-SMC condensin I complex, subunit H
BCAS1 breast carcinoma amplified sequence 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26