| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | mitogen-activated protein kinase-activated protein kinase 5|The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] (NCBI Entrez Gene Database, 8550) |
| External Link | https://ncbi.nlm.nih.gov/gene/8550 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the MAPKAPK5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| XIC | X chromosome inactivation center | 0.00738746 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.006821 |
| LTF | lactotransferrin | 0.00668762 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00663642 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00638454 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00613822 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00610714 |
| HBD | hemoglobin, delta | 0.00559192 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00543899 |
| CNN3 | calponin 3, acidic | 0.00540187 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00537583 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00532028 |
| RGS4 | regulator of G-protein signaling 4 | 0.00531474 |
| MAL | mal, T-cell differentiation protein | 0.0052956 |
| PDGFC | platelet derived growth factor C | 0.00529504 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00527588 |
| CD200 | CD200 molecule | 0.00514163 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00508763 |
| EMX2 | empty spiracles homeobox 2 | 0.00491306 |
| H1-0 | H1.0 linker histone | 0.00490377 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00482305 |
| ELANE | elastase, neutrophil expressed | 0.00469532 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00455138 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00451128 |
| EREG | epiregulin | 0.00448131 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00444252 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00443435 |
| CST7 | cystatin F (leukocystatin) | 0.00442705 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00442184 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00437937 |
| MSX1 | msh homeobox 1 | 0.00434205 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00432865 |
| TPM4 | tropomyosin 4 | 0.0043139 |
| PRKCB | protein kinase C, beta | 0.00428845 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00423612 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.00423187 |
| HOXB7 | homeobox B7 | 0.00417904 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00417334 |
| CTSG | cathepsin G | 0.00417319 |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | 0.00412713 |
| KRT7 | keratin 7, type II | 0.00411884 |
| HOXB2 | homeobox B2 | 0.00410042 |
| WT1 | Wilms tumor 1 | 0.00408062 |
| NVL | nuclear VCP-like | 0.00407427 |
| RNF167 | ring finger protein 167 | 0.00403317 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00402165 |
| TBL1X | transducin (beta)-like 1X-linked | 0.00401863 |
| PFKP | phosphofructokinase, platelet | 0.00399977 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00399187 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00391016 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00388088 |
| CHI3L2 | chitinase 3-like 2 | 0.00377929 |
| NPY | neuropeptide Y | 0.00370631 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.00370363 |
| NPR3 | natriuretic peptide receptor 3 | 0.0036784 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.00365367 |
| KYNU | kynureninase | 0.00365198 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00364136 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00363435 |
| CDC20 | cell division cycle 20 | 0.00361738 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.00353737 |
| GPX1 | glutathione peroxidase 1 | 0.00352791 |
| CSTA | cystatin A (stefin A) | 0.00349429 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00347642 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0034616 |
| CHMP4A | charged multivesicular body protein 4A | 0.00343443 |
| HSPA12A | heat shock 70kDa protein 12A | 0.003408 |
| NMB | neuromedin B | 0.00340456 |
| COCH | cochlin | 0.00340289 |
| HPSE | heparanase | 0.00340238 |
| MT2A | metallothionein 2A | 0.00340222 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00340151 |
| CLIC4 | chloride intracellular channel 4 | 0.00339551 |
| SERHL2 | serine hydrolase-like 2 | 0.00339544 |
| RGS10 | regulator of G-protein signaling 10 | 0.00339447 |
| STAG3 | stromal antigen 3 | 0.00337687 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00337109 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00337055 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.00336004 |
| SIRT3 | sirtuin 3 | 0.00335832 |
| BCL2A1 | BCL2-related protein A1 | 0.00335383 |
| PF4 | platelet factor 4 | 0.00335235 |
| MRPL33 | mitochondrial ribosomal protein L33 | 0.00335095 |
| CORO1C | coronin, actin binding protein, 1C | 0.00334608 |
| PLEK | pleckstrin | 0.00334507 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.00334119 |
| IL2RB | interleukin 2 receptor, beta | 0.00333154 |
| LST1 | leukocyte specific transcript 1 | 0.00332121 |
| BCHE | butyrylcholinesterase | 0.00332058 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00331164 |
| S100B | S100 calcium binding protein B | 0.00331093 |
| USP3 | ubiquitin specific peptidase 3 | 0.00329723 |
| PRAME | preferentially expressed antigen in melanoma | 0.00328341 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.0032816 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00327792 |
| KRT10 | keratin 10, type I | 0.00327243 |
| PCP4 | Purkinje cell protein 4 | 0.00326752 |
| ANXA1 | annexin A1 | 0.00325554 |
| MMD | monocyte to macrophage differentiation-associated | 0.00323997 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00322964 |
| DAD1 | defender against cell death 1 | 0.00321467 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00320788 |
| SHTN1 | shootin 1 | 0.00319924 |
| PEG3 | paternally expressed 3 | 0.00318498 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.00317542 |
| COMMD3 | COMM domain containing 3 | 0.00316729 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.00316111 |
| PLIN1 | perilipin 1 | 0.00315002 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00314666 |
| XCL1 | chemokine (C motif) ligand 1 | 0.00314032 |
| GNLY | granulysin | 0.00313796 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00312512 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00311719 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0031136 |
| STAT4 | signal transducer and activator of transcription 4 | 0.00311276 |
| TNIK | TRAF2 and NCK interacting kinase | 0.00311194 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0031063 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00309853 |
| CCN3 | cellular communication network factor 3 | 0.00309224 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00308883 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00308839 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00308447 |
| ERGIC2 | ERGIC and golgi 2 | 0.00306374 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.00305992 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00304716 |
| PTH2R | parathyroid hormone 2 receptor | 0.00304271 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 0.00303625 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.00303449 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00302831 |
| PENK | proenkephalin | 0.00302601 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00301144 |
| RNF130 | ring finger protein 130 | 0.00300992 |
| CTPS1 | CTP synthase 1 | 0.00299411 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.00298474 |
| GPR88 | G protein-coupled receptor 88 | 0.00298371 |
| KRT14 | keratin 14, type I | 0.00297855 |
| SELL | selectin L | 0.00296644 |
| CUL4B | cullin 4B | 0.00296418 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.00296141 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00296082 |
| ABHD10 | abhydrolase domain containing 10 | 0.00295528 |
| SNX10 | sorting nexin 10 | 0.00292893 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00292758 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.00291942 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00291428 |
| YME1L1 | YME1-like 1 ATPase | 0.00291166 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 0.00290828 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00290725 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.00288697 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.0028818 |
| RPS17 | ribosomal protein S17 | 0.00287885 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00286597 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.00286459 |
| TMEM126B | transmembrane protein 126B | 0.00286189 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00285392 |
| RPL26 | ribosomal protein L26 | 0.00285127 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 0.00284366 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.00284273 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00284197 |
| CASC3 | cancer susceptibility candidate 3 | 0.00283899 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00283728 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.00283345 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.0028294 |
| CALML5 | calmodulin-like 5 | 0.00282502 |
| SEC11A | SEC11 homolog A (S. cerevisiae) | 0.00281819 |
| PRSS8 | protease, serine, 8 | 0.00280442 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00280278 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00280011 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.00279868 |
| SPEN | spen family transcriptional repressor | 0.0027932 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00279156 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00278966 |
| MPO | myeloperoxidase | 0.00278689 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.00278297 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00278256 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.00278074 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.00277736 |
| LYST | lysosomal trafficking regulator | 0.00277381 |
| APOC1 | apolipoprotein C-I | 0.00277368 |
| P2RY14 | purinergic receptor P2Y, G-protein coupled, 14 | 0.00277255 |
| CD83 | CD83 molecule | 0.00276763 |
| VCAN | versican | 0.00276294 |
| ANO3 | anoctamin 3 | 0.00276123 |
| MICA | MHC class I polypeptide-related sequence A | 0.00275881 |
| DENND4B | DENN/MADD domain containing 4B | 0.00275456 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.00274997 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00274965 |
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 | 0.00274898 |
| NKX2-2 | NK2 homeobox 2 | 0.00274883 |
| DNM3 | dynamin 3 | 0.00274827 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00274038 |
| CPOX | coproporphyrinogen oxidase | 0.00273091 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00271873 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.00271783 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00271595 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.00271346 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00270821 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00270755 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.0026994 |
| RNF144A | ring finger protein 144A | 0.0026984 |
| TMEM223 | transmembrane protein 223 | 0.00269675 |
| ZNF266 | zinc finger protein 266 | 0.00269054 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | 0.00268936 |
| GNAS | GNAS complex locus | 0.00268759 |
| TCEAL1 | transcription elongation factor A (SII)-like 1 | 0.00268692 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.00268518 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00268285 |
| CHKB | choline kinase beta | 0.00268002 |
| RPIA | ribose 5-phosphate isomerase A | 0.00267881 |
| DCT | dopachrome tautomerase | 0.00266787 |
| UBB | ubiquitin B | 0.0026638 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.00266011 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00265501 |
| MPHOSPH6 | M-phase phosphoprotein 6 | 0.00264161 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.0026411 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00263705 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.00263692 |
| WASF1 | WAS protein family, member 1 | 0.00263486 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | 0.00263322 |
| RPL5 | ribosomal protein L5 | 0.00263029 |
| MFF | mitochondrial fission factor | 0.00262659 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.00262098 |
| PRF1 | perforin 1 (pore forming protein) | 0.00262043 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00260943 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.00260826 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00260668 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00260648 |
| MRPL49 | mitochondrial ribosomal protein L49 | 0.00260289 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00260168 |
| SMC6 | structural maintenance of chromosomes 6 | 0.00259823 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.0025974 |
| FLNA | filamin A, alpha | 0.00259733 |
| DENND5A | DENN/MADD domain containing 5A | 0.00259536 |
| CCK | cholecystokinin | 0.00259194 |
| AIM2 | absent in melanoma 2 | 0.00258737 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.00258635 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.00257496 |
| STK32B | serine/threonine kinase 32B | 0.00256926 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00256916 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | 0.0025682 |
| DAZAP2 | DAZ associated protein 2 | 0.00256735 |
| MMP8 | matrix metallopeptidase 8 | 0.00256723 |
| CTNNBL1 | catenin, beta like 1 | 0.00256653 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00256052 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00255602 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00254698 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00254603 |
| PRKCA | protein kinase C, alpha | 0.00254528 |
| SOAT1 | sterol O-acyltransferase 1 | 0.0025438 |
| MEIS1 | Meis homeobox 1 | 0.00253902 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0109671 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00991216 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00964315 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00935607 |
| RGS5 | regulator of G-protein signaling 5 | -0.00920501 |
| GPX2 | glutathione peroxidase 2 | -0.00809461 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00792568 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00768922 |
| FCGBP | Fc fragment of IgG binding protein | -0.00712307 |
| CFH | complement factor H | -0.00697063 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0068714 |
| ANOS1 | anosmin 1 | -0.00660836 |
| SDC2 | syndecan 2 | -0.00642704 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00608321 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00605455 |
| TMEM176B | transmembrane protein 176B | -0.00603707 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.00593133 |
| MAP7 | microtubule-associated protein 7 | -0.00586094 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00578318 |
| TSPAN8 | tetraspanin 8 | -0.00567416 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00564835 |
| ACKR3 | atypical chemokine receptor 3 | -0.00536653 |
| CCN2 | cellular communication network factor 2 | -0.00531417 |
| MMP3 | matrix metallopeptidase 3 | -0.00529413 |
| PODXL | podocalyxin-like | -0.00521357 |
| ELN | elastin | -0.00520788 |
| XPO7 | exportin 7 | -0.00519712 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.00519116 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00513672 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0051207 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00510674 |
| CSRP2 | cysteine and glycine-rich protein 2 | -0.00505762 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00505606 |
| MGLL | monoglyceride lipase | -0.00498973 |
| PLPP3 | phospholipid phosphatase 3 | -0.00497857 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00496862 |
| SIK1 | salt-inducible kinase 1 | -0.00493554 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00491569 |
| WDR7 | WD repeat domain 7 | -0.00490587 |
| TRIM29 | tripartite motif containing 29 | -0.004887 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00485343 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00484206 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00479753 |
| CLU | clusterin | -0.00478965 |
| VWF | von Willebrand factor | -0.0047813 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00475033 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0047461 |
| SOD3 | superoxide dismutase 3, extracellular | -0.00473745 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00471783 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00471296 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00469962 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00462082 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.0046147 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00457815 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00454368 |
| MGP | matrix Gla protein | -0.0045422 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00445807 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00444006 |
| FBLN1 | fibulin 1 | -0.0043962 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0043921 |
| CH25H | cholesterol 25-hydroxylase | -0.00437132 |
| FOXF1 | forkhead box F1 | -0.00436661 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00435863 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00430072 |
| COL16A1 | collagen, type XVI, alpha 1 | -0.00429918 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00424 |
| DAXX | death-domain associated protein | -0.00423194 |
| DSG3 | desmoglein 3 | -0.00422538 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00422431 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00422181 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0042134 |
| PPL | periplakin | -0.00419973 |
| OLFM4 | olfactomedin 4 | -0.00415307 |
| TOB1 | transducer of ERBB2, 1 | -0.00414707 |
| EPHB2 | EPH receptor B2 | -0.00414053 |
| A2M | alpha-2-macroglobulin | -0.00412989 |
| PERP | PERP, TP53 apoptosis effector | -0.00411545 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00410907 |
| PBK | PDZ binding kinase | -0.00410644 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00406954 |
| TMEM176A | transmembrane protein 176A | -0.0040419 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00404182 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -0.00402127 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00400399 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00399464 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00399151 |
| EXPH5 | exophilin 5 | -0.00394753 |
| GOLIM4 | golgi integral membrane protein 4 | -0.00394536 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00394405 |
| TCF4 | transcription factor 4 | -0.0039264 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00391266 |
| FBLN5 | fibulin 5 | -0.00387438 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.003872 |
| DACH1 | dachshund family transcription factor 1 | -0.00387099 |
| BMP2 | bone morphogenetic protein 2 | -0.00387068 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0038596 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | -0.00385195 |
| METTL7A | methyltransferase like 7A | -0.00385021 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.00384998 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.003825 |
| STC1 | stanniocalcin 1 | -0.00378639 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00377902 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00376879 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00375866 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00374356 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00373811 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00372705 |
| PLXNA1 | plexin A1 | -0.00371629 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00370007 |
| AGR2 | anterior gradient 2 | -0.00368751 |
| AK1 | adenylate kinase 1 | -0.00367091 |
| CCNA2 | cyclin A2 | -0.00366982 |
| NES | nestin | -0.00366533 |
| L1TD1 | LINE-1 type transposase domain containing 1 | -0.00366395 |
| AUTS2 | autism susceptibility candidate 2 | -0.00366215 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00365852 |
| IL7R | interleukin 7 receptor | -0.00365699 |
| C1R | complement component 1, r subcomponent | -0.00363836 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00362546 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00361276 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | -0.00357993 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00357574 |
| S100A11 | S100 calcium binding protein A11 | -0.00357195 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00356495 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00356191 |
| CLIC5 | chloride intracellular channel 5 | -0.00355495 |
| PCDH17 | protocadherin 17 | -0.00355138 |
| NLGN4X | neuroligin 4, X-linked | -0.00354844 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00354567 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00354127 |
| HOMER1 | homer scaffolding protein 1 | -0.0035356 |
| KIAA0930 | KIAA0930 | -0.00351337 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00350234 |
| GAL | galanin/GMAP prepropeptide | -0.00349219 |
| KRT20 | keratin 20, type I | -0.0034856 |
| LMNA | lamin A/C | -0.00347629 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.00346807 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00344956 |
| FZD10 | frizzled class receptor 10 | -0.00343963 |
| GRN | granulin | -0.00343862 |
| SELENBP1 | selenium binding protein 1 | -0.00343836 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00343797 |
| MUC13 | mucin 13, cell surface associated | -0.00342987 |
| IL20RA | interleukin 20 receptor, alpha | -0.00342401 |
| TNNC1 | troponin C type 1 (slow) | -0.00342067 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00341775 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00341716 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00339977 |
| E2F2 | E2F transcription factor 2 | -0.00338755 |
| FBLN2 | fibulin 2 | -0.00338627 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00337381 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00335746 |
| ATF3 | activating transcription factor 3 | -0.00335729 |
| RASA4 | RAS p21 protein activator 4 | -0.00335404 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -0.00334365 |
| NEBL | nebulette | -0.00333183 |
| ABHD2 | abhydrolase domain containing 2 | -0.00332206 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0033151 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00331387 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00330184 |
| ADIRF | adipogenesis regulatory factor | -0.00329578 |
| CD163 | CD163 molecule | -0.00329449 |
| ANXA4 | annexin A4 | -0.00329338 |
| PALLD | palladin, cytoskeletal associated protein | -0.00328537 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00328138 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.00328095 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.00328013 |
| FILIP1L | filamin A interacting protein 1-like | -0.00326054 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00324933 |
| REG1B | regenerating islet-derived 1 beta | -0.00323625 |
| FAIM | Fas apoptotic inhibitory molecule | -0.00323623 |
| OXTR | oxytocin receptor | -0.00322543 |
| TMEM47 | transmembrane protein 47 | -0.00322427 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00320881 |
| FAM107A | family with sequence similarity 107, member A | -0.00319611 |
| FABP1 | fatty acid binding protein 1, liver | -0.00318123 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 | -0.00317409 |
| TP63 | tumor protein p63 | -0.0031733 |
| CYTIP | cytohesin 1 interacting protein | -0.00316844 |
| RELN | reelin | -0.00316275 |
| LPIN1 | lipin 1 | -0.00313106 |
| MMP12 | matrix metallopeptidase 12 | -0.00313027 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.003126 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.00312554 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00312365 |
| PIGN | phosphatidylinositol glycan anchor biosynthesis, class N | -0.00312127 |
| EMP2 | epithelial membrane protein 2 | -0.00311405 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00311291 |
| TAGLN | transgelin | -0.00309586 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00309449 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00307884 |
| PLK1 | polo-like kinase 1 | -0.00307146 |
| DUSP7 | dual specificity phosphatase 7 | -0.0030655 |
| LAMA2 | laminin, alpha 2 | -0.00306322 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | -0.0030617 |
| STAP2 | signal transducing adaptor family member 2 | -0.00306064 |
| BRD2 | bromodomain containing 2 | -0.0030599 |
| FKBP5 | FK506 binding protein 5 | -0.00305646 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.0030475 |
| LAMA5 | laminin, alpha 5 | -0.00304213 |
| AOC1 | amine oxidase, copper containing 1 | -0.00303829 |
| SYNM | synemin, intermediate filament protein | -0.00303426 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00303365 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | -0.00303183 |
| TTN | titin | -0.00302987 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | -0.00302028 |
| ASS1 | argininosuccinate synthase 1 | -0.00301533 |
| NPEPL1 | aminopeptidase-like 1 | -0.0030102 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00300636 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | -0.00300552 |
| MIR22HG | MIR22 host gene | -0.00300016 |
| CLIC3 | chloride intracellular channel 3 | -0.00299742 |
| COL3A1 | collagen, type III, alpha 1 | -0.00298911 |
| MVP | major vault protein | -0.00298587 |
| KLF13 | Kruppel-like factor 13 | -0.00298082 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | -0.00296415 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00296101 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00295456 |
| MUC4 | mucin 4, cell surface associated | -0.0029535 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00295341 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00294843 |
| DPEP1 | dipeptidase 1 (renal) | -0.00294729 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | -0.00293636 |
| MAT2A | methionine adenosyltransferase II, alpha | -0.00293629 |
| CALML3 | calmodulin-like 3 | -0.00293432 |
| EPHA2 | EPH receptor A2 | -0.00293138 |
| RRAD | Ras-related associated with diabetes | -0.00293134 |
| OLFML1 | olfactomedin-like 1 | -0.00292122 |
| C4BPA | complement component 4 binding protein, alpha | -0.00290632 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.00289326 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00289259 |
| STAB1 | stabilin 1 | -0.00288392 |
| CTSK | cathepsin K | -0.00288155 |
| MAOA | monoamine oxidase A | -0.00288054 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.00286958 |
| HSPA4L | heat shock 70kDa protein 4-like | -0.00286881 |
| FOXF2 | forkhead box F2 | -0.00286821 |
| EZR | ezrin | -0.0028671 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.00286601 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.00286399 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.00286355 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.00285338 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00284865 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00284658 |
| LAMB3 | laminin, beta 3 | -0.00284213 |
| MMP10 | matrix metallopeptidase 10 | -0.00283839 |
| PPAP2A | phosphatidic acid phosphatase type 2A | -0.00283146 |
| ASPN | asporin | -0.00283022 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00282995 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.00282963 |
