MAPT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description microtubule-associated protein tau|This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4137)
External Link http://www.ncbi.nlm.nih.gov/gene/4137
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Genes

136 interacting proteins for MAPT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTB actin, beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
BAG1 BCL2-associated athanogene
BIN1 bridging integrator 1
BRSK1 BR serine/threonine kinase 1
BRSK2 BR serine/threonine kinase 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAPN2 calpain 2, (m/II) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DCTN1 dynactin 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EP300 E1A binding protein p300
FKBP4 FK506 binding protein 4, 59kDa
FMR1 fragile X mental retardation 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDAC6 histone deacetylase 6
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
INA internexin neuronal intermediate filament protein, alpha
IQGAP1 IQ motif containing GTPase activating protein 1
LIMS1 LIM and senescent cell antigen-like domains 1
LRRK2 leucine-rich repeat kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH1 myosin, heavy chain 1, skeletal muscle, adult
NCL nucleolin
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
NRF1 nuclear respiratory factor 1
NUB1 negative regulator of ubiquitin-like proteins 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PASK PAS domain containing serine/threonine kinase
PEG10 paternally expressed 10
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PKN1 protein kinase N1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP5C protein phosphatase 5, catalytic subunit
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRNP prion protein
PSEN1 presenilin 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PTK2B protein tyrosine kinase 2 beta
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL28 ribosomal protein L28
RPL6 ribosomal protein L6
RPLP0 ribosomal protein, large, P0
RPS27A ribosomal protein S27a
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100B S100 calcium binding protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTB spectrin, beta, erythrocytic
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAU1 staufen double-stranded RNA binding protein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
SYK spleen tyrosine kinase
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTBK1 tau tubulin kinase 1
TTLL6 tubulin tyrosine ligase-like family member 6
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
UBB ubiquitin B
UBC ubiquitin C
UBE2D2 ubiquitin-conjugating enzyme E2D 2
USP9Y ubiquitin specific peptidase 9, Y-linked
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta