| Dataset | KEA Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | megakaryocyte-associated tyrosine kinase|The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4145) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/4145 |
| Similar Terms | |
| Downloads & Tools |
5 substrates of the kinase MATK from the curated KEA Substrates of Kinases dataset.
