MATK Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description megakaryocyte-associated tyrosine kinase|The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4145)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_MATK
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Genes

25 co-expressed genes for MATK from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABHD17A abhydrolase domain containing 17A
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
BTN3A3 butyrophilin, subfamily 3, member A3
CD247 CD247 molecule
CTSW cathepsin W
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMM granzyme M (lymphocyte met-ase 1)
IL18RAP interleukin 18 receptor accessory protein
IL2RB interleukin 2 receptor, beta
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MATK megakaryocyte-associated tyrosine kinase
NKG7 natural killer cell granule protein 7
PRF1 perforin 1 (pore forming protein)
PRKCH protein kinase C, eta
PTGDR prostaglandin D2 receptor (DP)
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
S1PR5 sphingosine-1-phosphate receptor 5
SUN2 Sad1 and UNC84 domain containing 2
TRD T cell receptor delta locus
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa