MBD1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description methyl-CpG binding domain protein 1|The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 4152)
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Genes

274 genes differentially expressed following the MBD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRDM7 PR domain containing 7 3.61381
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.61381
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.61381
SIX6 SIX homeobox 6 3.61381
ERFE erythroferrone 3.61381
IRX1 iroquois homeobox 1 3.61381
FOXJ1 forkhead box J1 3.61381
C1ORF141 chromosome 1 open reading frame 141 3.61381
DMRT1 doublesex and mab-3 related transcription factor 1 3.59586
SLC36A3 solute carrier family 36, member 3 3.59586
PCDHGA4 protocadherin gamma subfamily A, 4 3.59586
NPNT nephronectin 3.59586
LDHAL6B lactate dehydrogenase A-like 6B 3.59586
DUSP10 dual specificity phosphatase 10 3.59586
WFDC8 WAP four-disulfide core domain 8 3.59586
SP5 Sp5 transcription factor 3.59586
SNAI2 snail family zinc finger 2 3.59586
SHISA7 shisa family member 7 3.59586
SCN2B sodium channel, voltage gated, type II beta subunit 3.59586
SLC22A14 solute carrier family 22, member 14 3.59586
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.59586
DMRTC1B DMRT-like family C1B 3.59395
PAX5 paired box 5 3.59395
GJA10 gap junction protein, alpha 10, 62kDa 3.59395
GARIN6 golgi associated RAB2 interactor family member 6 3.59395
ZBTB42 zinc finger and BTB domain containing 42 3.59395
NCF1 neutrophil cytosolic factor 1 3.59395
SSTR1 somatostatin receptor 1 3.59395
C1ORF146 chromosome 1 open reading frame 146 3.59395
BTLA B and T lymphocyte associated 3.59395
SLC35G5 solute carrier family 35, member G5 3.59395
CD160 CD160 molecule 3.59395
HCRTR1 hypocretin (orexin) receptor 1 3.59395
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.59395
GNLY granulysin 3.59395
KNG1 kininogen 1 3.59395
ODAPH odontogenesis associated phosphoprotein 3.59395
TMEM270 transmembrane protein 270 3.59395
TCHHL1 trichohyalin-like 1 3.59395
LBX2 ladybird homeobox 2 3.59395
IRF2-DT IRF2 divergent transcript 3.59395
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.59395
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.59395
SHE Src homology 2 domain containing E 3.59395
OR1D2 olfactory receptor, family 1, subfamily D, member 2 3.59395
FABP12 fatty acid binding protein 12 3.59395
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.59395
SPDEF SAM pointed domain containing ETS transcription factor 3.59395
MCTS2 MCTS family member 2 3.59395
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.59395
ACP4 acid phosphatase 4 3.59395
ADGB androglobin 3.59395
STPG3 sperm-tail PG-rich repeat containing 3 3.59395
ASPA aspartoacylase 3.59395
RSPO3 R-spondin 3 3.59395
SIGLECL1 SIGLEC family like 1 3.59395
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.59395
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.59395
TLR1 toll-like receptor 1 3.59395
TLR7 toll-like receptor 7 3.59395
TLR4 toll-like receptor 4 3.59395
KLB klotho beta 3.59395
MYH15 myosin, heavy chain 15 3.59395
SLC45A2 solute carrier family 45, member 2 3.59395
RNF113B ring finger protein 113B 3.59395
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.59395
MYOG myogenin (myogenic factor 4) 3.59395
GTSF1 gametocyte specific factor 1 3.59395
ADIG adipogenin 3.59395
ZAR1L zygote arrest 1-like 3.59395
HNF1A HNF1 homeobox A 3.59395
FOXC1 forkhead box C1 3.59395
GATA4 GATA binding protein 4 3.59395
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.59395
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.59395
MSX1 msh homeobox 1 3.59395
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.59395
RNF17 ring finger protein 17 3.59395
LAPTM5 lysosomal protein transmembrane 5 3.59395
FAM187B family with sequence similarity 187, member B 3.59395
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.59395
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.59395
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.59395
LORICRIN loricrin cornified envelope precursor protein 3.59395
ACOT4 acyl-CoA thioesterase 4 3.59395
PCDHA7 protocadherin alpha 7 3.59395
RHOXF2 Rhox homeobox family, member 2 3.59395
MAGEB2 melanoma antigen family B2 3.59395
AMBP alpha-1-microglobulin/bikunin precursor 3.59395
VSIR V-set immunoregulatory receptor 3.59395
CLDN14 claudin 14 3.59395
VSIG2 V-set and immunoglobulin domain containing 2 3.59395
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.59395
GOLGA8J golgin A8 family, member J 3.59395
BAHCC1 BAH domain and coiled-coil containing 1 3.59395
PCDHGA7 protocadherin gamma subfamily A, 7 3.59395
FAM209A family with sequence similarity 209, member A 3.59395
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.59395
MAMLD1 mastermind-like domain containing 1 3.59395
CDH10 cadherin 10, type 2 (T2-cadherin) 3.59395
TDRD10 tudor domain containing 10 3.59395
ZNF628 zinc finger protein 628 3.59395
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.59395
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 3.59395
UBQLNL ubiquilin-like 3.59395
LCT lactase 3.59395
EPYC epiphycan 3.59395
KRT15 keratin 15, type I 3.59395
KIF4B kinesin family member 4B 3.59395
DEFB114 defensin, beta 114 3.59395
VWA7 von Willebrand factor A domain containing 7 3.59395
TMEM132D transmembrane protein 132D 3.59395
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.59395
SFTA2 surfactant associated 2 3.59395
LAMB3 laminin, beta 3 3.59395
CASQ2 calsequestrin 2 (cardiac muscle) 3.59395
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.59395
PLA2G2C phospholipase A2, group IIC 3.59395
LRRC26 leucine rich repeat containing 26 3.59395
GPR149 G protein-coupled receptor 149 3.59395
RBBP8NL RBBP8 N-terminal like 3.59395
PSG3 pregnancy specific beta-1-glycoprotein 3 3.59395
LHX2 LIM homeobox 2 3.59395
PRH2 proline-rich protein HaeIII subfamily 2 3.59395
PRSS33 protease, serine, 33 3.59395
SIGLEC11 sialic acid binding Ig-like lectin 11 3.59395
ANKRD53 ankyrin repeat domain 53 3.59395
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.59395
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.59395
MAEL maelstrom spermatogenic transposon silencer 3.59395
IL23R interleukin 23 receptor 3.59395
LVRN laeverin 3.59395
NKPD1 NTPase, KAP family P-loop domain containing 1 3.59395
HIC1 hypermethylated in cancer 1 3.59395
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.59395
LPA lipoprotein, Lp(a) 3.59395
RHOJ ras homolog family member J 3.59395
SOST sclerostin 3.59395
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.59395
VPREB3 pre-B lymphocyte 3 3.59395
TDO2 tryptophan 2,3-dioxygenase 3.59395
LEP leptin 3.59395
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.59395
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.59395
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.59395
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.59395
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.59395
SPX spexin hormone 3.59395
GRAPL GRB2-related adaptor protein-like 3.59395
DMRTC1 DMRT-like family C1 3.59395
FRMPD1 FERM and PDZ domain containing 1 3.59395
GRAP2 GRB2-related adaptor protein 2 3.59395
CCDC18 coiled-coil domain containing 18 3.56933
SYCP3 synaptonemal complex protein 3 3.56933
TEX11 testis expressed 11 3.56933
DCST2 DC-STAMP domain containing 2 3.56933
TAMALIN trafficking regulator and scaffold protein tamalin 3.56933
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.53267
AOC2 amine oxidase, copper containing 2 (retina-specific) 3.09585
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 3.0731
TGM2 transglutaminase 2 3.03313
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.93465
MYH13 myosin, heavy chain 13, skeletal muscle 2.88182
STX6 syntaxin 6 2.88182
ANO3 anoctamin 3 2.87726
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 2.82682
COL27A1 collagen, type XXVII, alpha 1 2.81625
BASP1 brain abundant, membrane attached signal protein 1 2.64601
ERV3-1 endogenous retrovirus group 3, member 1 2.60345
SLC16A6 solute carrier family 16, member 6 2.58301
FAM131C family with sequence similarity 131, member C 2.58301
IZUMO1 izumo sperm-egg fusion 1 2.58301
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.58301
PLEKHO2 pleckstrin homology domain containing, family O member 2 2.54111
LRRC73 leucine rich repeat containing 73 2.50576
GIMAP4 GTPase, IMAP family member 4 2.50576
ZBED4 zinc finger, BED-type containing 4 2.4861
PROSER1 proline and serine rich 1 2.45852
TBCB tubulin folding cofactor B 2.45589
ECM1 extracellular matrix protein 1 2.33098
GPR20 G protein-coupled receptor 20 2.33098
SPATS1 spermatogenesis associated, serine-rich 1 2.26924
GLRX glutaredoxin (thioltransferase) 2.22014
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 2.21034
ZNF687 zinc finger protein 687 2.20499
ORC6 origin recognition complex, subunit 6 2.16864
GCLM glutamate-cysteine ligase, modifier subunit 2.16259
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.16174
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.15226
KHDC1 KH homology domain containing 1 2.14762
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 2.14762
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.14079
RPE ribulose-5-phosphate-3-epimerase 2.13999
PSIP1 PC4 and SFRS1 interacting protein 1 2.13458
LIPT2-AS1 LIPT2 antisense RNA 1 2.09248
METTL25B methyltransferase like 25B 2.09084
TENM3 teneurin transmembrane protein 3 2.08178
TCP10L t-complex 10-like 2.0796
ZBTB7A zinc finger and BTB domain containing 7A 2.05176
EDA ectodysplasin A 2.03709
SSTR2 somatostatin receptor 2 2.02859
MAP3K15 mitogen-activated protein kinase kinase kinase 15 2.01919
RUBCN rubicon autophagy regulator 2.01516
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.01516
DLL3 delta-like 3 (Drosophila) 2.00045

decreased expression

Symbol Name Standardized Value
CFAP57 cilia and flagella associated protein 57 -3.61381
MRPL53 mitochondrial ribosomal protein L53 -3.59395
BTN1A1 butyrophilin, subfamily 1, member A1 -3.59395
TSKS testis-specific serine kinase substrate -3.56933
GREM1 gremlin 1, DAN family BMP antagonist -3.56933
DNAH8 dynein, axonemal, heavy chain 8 -3.56933
LGI2 leucine-rich repeat LGI family, member 2 -3.56933
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -3.56933
C19ORF67 chromosome 19 open reading frame 67 -3.56933
RAG1 recombination activating gene 1 -3.56933
AGTR1 angiotensin II receptor, type 1 -3.56933
LOX lysyl oxidase -3.56933
POMC proopiomelanocortin -3.56933
C3ORF80 chromosome 3 open reading frame 80 -3.56933
IL5 interleukin 5 -3.56933
WNT16 wingless-type MMTV integration site family, member 16 -3.56933
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -3.56933
TBPL2 TATA box binding protein like 2 -3.56933
KCNK2 potassium channel, two pore domain subfamily K, member 2 -3.56933
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -3.56933
PRR35 proline rich 35 -3.56933
CRHR1 corticotropin releasing hormone receptor 1 -3.56933
TMEM204 transmembrane protein 204 -3.56933
MR1 major histocompatibility complex, class I-related -3.56933
NUPR1 nuclear protein, transcriptional regulator, 1 -3.56933
RSAD2 radical S-adenosyl methionine domain containing 2 -3.56933
LOXHD1 lipoxygenase homology domains 1 -3.56933
CCDC177 coiled-coil domain containing 177 -3.56933
KLHL17 kelch-like family member 17 -3.47802
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -3.45836
VWA5B1 von Willebrand factor A domain containing 5B1 -3.45836
OLFM3 olfactomedin 3 -3.28428
CCNJL cyclin J-like -3.03002
RUFY1 RUN and FYVE domain containing 1 -2.96207
DISP2 dispatched homolog 2 (Drosophila) -2.87035
IFI27 interferon, alpha-inducible protein 27 -2.87035
CRLF3 cytokine receptor-like factor 3 -2.74684
USF1 upstream transcription factor 1 -2.72166
NCOR2 nuclear receptor corepressor 2 -2.71234
HOOK1 hook microtubule-tethering protein 1 -2.58301
SH2D4A SH2 domain containing 4A -2.40858
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.40271
C20ORF203 chromosome 20 open reading frame 203 -2.36525
ANAPC10 anaphase promoting complex subunit 10 -2.33228
CTXN1 cortexin 1 -2.32881
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.31732
IFIH1 interferon induced with helicase C domain 1 -2.30148
DPPA3 developmental pluripotency associated 3 -2.30148
CLDN18 claudin 18 -2.26387
IRF4 interferon regulatory factor 4 -2.22014
TMEM64 transmembrane protein 64 -2.20714
ARMC8 armadillo repeat containing 8 -2.19778
ACKR4 atypical chemokine receptor 4 -2.19713
FBXO4 F-box protein 4 -2.19713
WSCD2 WSC domain containing 2 -2.19713
LOC112694756 uncharaterized LOC112694756 -2.19713
SSC5D scavenger receptor cysteine rich family, 5 domains -2.19713
SRSF2 serine/arginine-rich splicing factor 2 -2.18277
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.16914
AHSP alpha hemoglobin stabilizing protein -2.16914
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 -2.09248
COX7B cytochrome c oxidase subunit VIIb -2.08482
LNP1 leukemia NUP98 fusion partner 1 -2.07456
MKRN2OS MKRN2 opposite strand -2.05517
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.04904
PGAP1 post-GPI attachment to proteins 1 -2.03923
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.01516
POLR1H RNA polymerase I subunit H -2.0015
CALN1 calneuron 1 -2.00045