MBD2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description methyl-CpG binding domain protein 2|DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 8932)
External Link http://www.ncbi.nlm.nih.gov/gene/8932
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Genes

188 interacting proteins for MBD2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACTL6A actin-like 6A
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADNP activity-dependent neuroprotector homeobox
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEND3 BEN domain containing 3
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BRMS1 breast cancer metastasis suppressor 1
BRMS1L breast cancer metastasis-suppressor 1-like
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C11ORF30 chromosome 11 open reading frame 30
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CD8A CD8a molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDYL chromodomain protein, Y-like
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CLOCK clock circadian regulator
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CXCL10 chemokine (C-X-C motif) ligand 10
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF3A eukaryotic translation initiation factor 3, subunit A
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ESD esterase D
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FAM60A family with sequence similarity 60, member A
GATAD1 GATA zinc finger domain containing 1
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GPN1 GPN-loop GTPase 1
GSE1 Gse1 coiled-coil protein
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDIP1 HDAC and MIER1 interacting protein 1
HINFP histone H4 transcription factor
HMG20A high mobility group 20A
HMG20B high mobility group 20B
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF2 IKAROS family zinc finger 2 (Helios)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INO80E INO80 complex subunit E
IPO5 importin 5
KDM1A lysine (K)-specific demethylase 1A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNA6 karyopherin alpha 6 (importin alpha 7)
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
MBD3 methyl-CpG binding domain protein 3
MBD3L1 methyl-CpG binding domain protein 3-like 1
MBD3L2 methyl-CpG binding domain protein 3-like 2
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIER1 mesoderm induction early response 1, transcriptional regulator
MIER2 mesoderm induction early response 1, family member 2
MIER3 mesoderm induction early response 1, family member 3
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
NARS asparaginyl-tRNA synthetase
NAV3 neuron navigator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFDN2 prefoldin subunit 2
PFDN5 prefoldin subunit 5
PFDN6 prefoldin subunit 6
PHF12 PHD finger protein 12
PHF21A PHD finger protein 21A
PKNOX1 PBX/knotted 1 homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDM16 PR domain containing 16
PRMT1 protein arginine methyltransferase 1
PRMT5 protein arginine methyltransferase 5
PRR11 proline rich 11
PTK2B protein tyrosine kinase 2 beta
PWWP2A PWWP domain containing 2A
RAD50 RAD50 homolog (S. cerevisiae)
RAN RAN, member RAS oncogene family
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RCOR1 REST corepressor 1
RCOR2 REST corepressor 2
RCOR3 REST corepressor 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RREB1 ras responsive element binding protein 1
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SAP30 Sin3A-associated protein, 30kDa
SAP30L SAP30-like
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOGA3 SOGA family member 3
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRRM2 serine/arginine repetitive matrix 2
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THYN1 thymocyte nuclear protein 1
TNRC18 trinucleotide repeat containing 18
TOPBP1 topoisomerase (DNA) II binding protein 1
TRERF1 transcriptional regulating factor 1
TRIM27 tripartite motif containing 27
TRMT61A tRNA methyltransferase 61A
TTF2 transcription termination factor, RNA polymerase II
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBC ubiquitin C
UBP1 upstream binding protein 1 (LBP-1a)
UBTF upstream binding transcription factor, RNA polymerase I
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USF2 upstream transcription factor 2, c-fos interacting
VBP1 von Hippel-Lindau binding protein 1
VRK1 vaccinia related kinase 1
WDR5 WD repeat domain 5
WDR77 WD repeat domain 77
WIZ widely interspaced zinc finger motifs
YEATS2 YEATS domain containing 2
ZBTB2 zinc finger and BTB domain containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZMYM2 zinc finger, MYM-type 2
ZMYM3 zinc finger, MYM-type 3
ZMYND8 zinc finger, MYND-type containing 8
ZNF217 zinc finger protein 217
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZNF512B zinc finger protein 512B
ZNF516 zinc finger protein 516
ZNF521 zinc finger protein 521
ZNF592 zinc finger protein 592
ZNF609 zinc finger protein 609
ZNF687 zinc finger protein 687
ZNF827 zinc finger protein 827
ZZZ3 zinc finger, ZZ-type containing 3