MCC Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description mutated in colorectal cancers|This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4163)
External Link http://www.ncbi.nlm.nih.gov/gene/4163
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Genes

239 interacting proteins for hub protein MCC from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACAT1 acetyl-CoA acetyltransferase 1
ACAT2 acetyl-CoA acetyltransferase 2
ACOT13 acyl-CoA thioesterase 13
AHCY adenosylhomocysteinase
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AK2 adenylate kinase 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA2 annexin A2
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APEH acylaminoacyl-peptide hydrolase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APRT adenine phosphoribosyltransferase
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BCAS2 breast carcinoma amplified sequence 2
CACYBP calcyclin binding protein
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CBR1 carbonyl reductase 1
CCNA1 cyclin A1
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CLIC1 chloride intracellular channel 1
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
CLTC clathrin, heavy chain (Hc)
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
CNBP CCHC-type zinc finger, nucleic acid binding protein
COMT catechol-O-methyltransferase
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COPS6 COP9 signalosome subunit 6
CRYZ crystallin, zeta (quinone reductase)
CS citrate synthase
CSDE1 cold shock domain containing E1, RNA-binding
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CUL1 cullin 1
CUL2 cullin 2
CUTA cutA divalent cation tolerance homolog (E. coli)
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
CYCS cytochrome c, somatic
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DNM2 dynamin 2
DRG1 developmentally regulated GTP binding protein 1
DUSP3 dual specificity phosphatase 3
ECH1 enoyl CoA hydratase 1, peroxisomal
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECI1 enoyl-CoA delta isomerase 1
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3J eukaryotic translation initiation factor 3, subunit J
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4H eukaryotic translation initiation factor 4H
EIF6 eukaryotic translation initiation factor 6
EPRS glutamyl-prolyl-tRNA synthetase
ERBB2IP erbb2 interacting protein
ERP29 endoplasmic reticulum protein 29
ESD esterase D
ETFA electron-transfer-flavoprotein, alpha polypeptide
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FKBP3 FK506 binding protein 3, 25kDa
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GLOD4 glyoxalase domain containing 4
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA4 golgin A4
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRB2 growth factor receptor-bound protein 2
GSPT1 G1 to S phase transition 1
HADH hydroxyacyl-CoA dehydrogenase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA4L heat shock 70kDa protein 4-like
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ICT1 immature colon carcinoma transcript 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KATNAL2 katanin p60 subunit A-like 2
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC59 leucine rich repeat containing 59
LTA4H leukotriene A4 hydrolase
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MARS methionyl-tRNA synthetase
MASP2 mannan-binding lectin serine peptidase 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLEC malectin
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOB4 MOB family member 4, phocein
MRPL14 mitochondrial ribosomal protein L14
MRPS16 mitochondrial ribosomal protein S16
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH10 myosin, heavy chain 10, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NASP nuclear autoantigenic sperm protein (histone-binding)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPEPPS aminopeptidase puromycin sensitive
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUP155 nucleoporin 155kDa
OAT ornithine aminotransferase
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCBP3 poly(rC) binding protein 3
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PDCD5 programmed cell death 5
PDCD6IP programmed cell death 6 interacting protein
PDHB pyruvate dehydrogenase (lipoamide) beta
PFAS phosphoribosylformylglycinamidine synthase
PFDN2 prefoldin subunit 2
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PGRMC1 progesterone receptor membrane component 1
PHB2 prohibitin 2
PNP purine nucleoside phosphorylase
PNPT1 polyribonucleotide nucleotidyltransferase 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSPC1 paraspeckle component 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
PUS7 pseudouridylate synthase 7 (putative)
PYCR2 pyrroline-5-carboxylate reductase family, member 2
PYGL phosphorylase, glycogen, liver
RAB1B RAB1B, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RANBP1 RAN binding protein 1
RAP1B RAP1B, member of RAS oncogene family
RASAL2 RAS protein activator like 2
REXO2 RNA exonuclease 2
RHOC ras homolog family member C
RNMTL1 RNA methyltransferase like 1
RPL21 ribosomal protein L21
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPS14 ribosomal protein S14
RPS3A ribosomal protein S3A
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRM1 ribonucleotide reductase M1
S100A9 S100 calcium binding protein A9
SAR1A secretion associated, Ras related GTPase 1A
SCRIB scribbled planar cell polarity protein
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEC13 SEC13 homolog (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SEPT2 septin 2
SF3B6 splicing factor 3b, subunit 6, 14kDa
SFXN1 sideroflexin 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNX27 sorting nexin family member 27
SNX3 sorting nexin 3
SOD2 superoxide dismutase 2, mitochondrial
SSRP1 structure specific recognition protein 1
STK24 serine/threonine kinase 24
STOML2 stomatin (EPB72)-like 2
STRIP1 striatin interacting protein 1
STRN striatin, calmodulin binding protein
STRN3 striatin, calmodulin binding protein 3
STRN4 striatin, calmodulin binding protein 4
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYMPK symplekin
TAGLN2 transgelin 2
TALDO1 transaldolase 1
TARS threonyl-tRNA synthetase
TBCA tubulin folding cofactor A
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TKT transketolase
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMED2 transmembrane emp24 domain trafficking protein 2
TMX1 thioredoxin-related transmembrane protein 1
TP53RK TP53 regulating kinase
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPP2 tripeptidyl peptidase II
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TSFM Ts translation elongation factor, mitochondrial
TSN translin
TUFM Tu translation elongation factor, mitochondrial
UBA2 ubiquitin-like modifier activating enzyme 2
UBE2M ubiquitin-conjugating enzyme E2M
UBXN1 UBX domain protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
VARS valyl-tRNA synthetase
VARS2 valyl-tRNA synthetase 2, mitochondrial
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WDR5 WD repeat domain 5
ZBTB24 zinc finger and BTB domain containing 24