MCC13 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from -666 (Catalogue of Somatic Mutations In Cancer)
External Link https://depmap.org/portal/cell_line/ACH-001550
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Genes

330 gene knockdowns changing fitness of MCC13 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
EMD emerin 8.78763
TRAF1 TNF receptor-associated factor 1 8.69967
LBR lamin B receptor 8.52177
HABP4 hyaluronan binding protein 4 8.15917
PCDHAC2 protocadherin alpha subfamily C, 2 6.86836
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 6.77031
SUN2 Sad1 and UNC84 domain containing 2 6.75562
VGLL4 vestigial-like family member 4 6.64225
PRDM5 PR domain containing 5 6.61048
DOK2 docking protein 2, 56kDa 6.15895
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 6.15423
SCX scleraxis basic helix-loop-helix transcription factor 5.7406
RNF222 ring finger protein 222 5.71027
NEMP1 nuclear envelope integral membrane protein 1 5.63525
SYT3 synaptotagmin III 5.40076
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 5.39066
BOK BCL2-related ovarian killer 5.38235
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 5.2155
CIB1 calcium and integrin binding 1 (calmyrin) 5.14081
SUCO SUN domain containing ossification factor 4.97287
ACTL7B actin-like 7B 4.96624
DAB2IP DAB2 interacting protein 4.832
TRPC3 transient receptor potential cation channel, subfamily C, member 3 4.82988
PCDHGA3 protocadherin gamma subfamily A, 3 4.81421
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 4.77778
ZDHHC2 zinc finger, DHHC-type containing 2 4.77452
MGA MGA, MAX dimerization protein 4.75709
HRAS Harvey rat sarcoma viral oncogene homolog 4.72516
TRPC5 transient receptor potential cation channel, subfamily C, member 5 4.68637
ASCL4 achaete-scute family bHLH transcription factor 4 4.68497
B3GAT2 beta-1,3-glucuronyltransferase 2 4.67562
TACR1 tachykinin receptor 1 4.59257
C9ORF172 chromosome 9 open reading frame 172 4.59109
GLI4 GLI family zinc finger 4 4.56839
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 4.56523
RTL8B retrotransposon Gag like 8B 4.55927
ZNF8 zinc finger protein 8 4.45493
GPR27 G protein-coupled receptor 27 4.42152
AMDHD1 amidohydrolase domain containing 1 4.37588
C1ORF233 chromosome 1 open reading frame 233 4.37349
ASIC4 acid sensing (proton gated) ion channel family member 4 4.34438
GPR87 G protein-coupled receptor 87 4.28024
TMEM109 transmembrane protein 109 4.20567
LTN1 listerin E3 ubiquitin protein ligase 1 4.18658
GFY golgi-associated, olfactory signaling regulator 4.15096
APP amyloid beta (A4) precursor protein 4.13477
PLXDC2 plexin domain containing 2 4.09517
RPL3L ribosomal protein L3-like 4.04296
GPR156 G protein-coupled receptor 156 4.02321
FAM181A family with sequence similarity 181, member A 3.97387
NTF3 neurotrophin 3 3.95134
ACOT8 acyl-CoA thioesterase 8 3.93962
EPN3 epsin 3 3.93556
KRT81 keratin 81, type II 3.93384
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.91449
ACSS1 acyl-CoA synthetase short-chain family member 1 3.90568
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.85811
MTDH metadherin 3.85605
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 3.84906
PTH2 parathyroid hormone 2 3.78887
DSP desmoplakin 3.74676
SOCS2 suppressor of cytokine signaling 2 3.74359
BARX1 BARX homeobox 1 3.70926
DPPA5 developmental pluripotency associated 5 3.70854
TRH thyrotropin-releasing hormone 3.65377
BTD biotinidase 3.6532
RTL8C retrotransposon Gag like 8C 3.60603
MMP17 matrix metallopeptidase 17 (membrane-inserted) 3.59547
ARSI arylsulfatase family, member I 3.59026
OCA2 oculocutaneous albinism II 3.55132
HIST1H3H histone cluster 1, H3h 3.54282
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 3.54054
NCOR2 nuclear receptor corepressor 2 3.49121
CYS1 cystin 1 3.48284
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.47756
PCDH19 protocadherin 19 3.46347
MROH7 maestro heat-like repeat family member 7 3.45483
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 3.43393
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 3.41996
LMNB1 lamin B1 3.39628
RETREG3 reticulophagy regulator family member 3 3.3719
GPATCH8 G patch domain containing 8 3.35759
BTN1A1 butyrophilin, subfamily 1, member A1 3.3553
TMEM89 transmembrane protein 89 3.35271
C6ORF222 chromosome 6 open reading frame 222 3.3523
DTNBP1 dystrobrevin binding protein 1 3.33233
HIST1H4L histone cluster 1, H4l 3.33012
TXLNA taxilin alpha 3.32558
UNC13D unc-13 homolog D (C. elegans) 3.29312
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 3.28409
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 3.2531
AGTR2 angiotensin II receptor, type 2 3.25079
ZCCHC13 zinc finger, CCHC domain containing 13 3.24874
TTC19 tetratricopeptide repeat domain 19 3.24289
OR1J2 olfactory receptor, family 1, subfamily J, member 2 3.2281
C16ORF95 chromosome 16 open reading frame 95 3.22145
MYO5B myosin VB 3.21929
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 3.21634
LIN7C lin-7 homolog C (C. elegans) 3.19881
FGFBP3 fibroblast growth factor binding protein 3 3.16008
L3MBTL1 l(3)mbt-like 1 (Drosophila) 3.14509
PINK1 PTEN induced putative kinase 1 3.14023
RELL1 RELT-like 1 3.12689
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 3.12281
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.12011
MYF5 myogenic factor 5 3.10877
COPS9 COP9 signalosome subunit 9 3.08583
TMEM54 transmembrane protein 54 3.0389
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 3.02348
PER3 period circadian clock 3 3.01687
TOR1AIP1 torsin A interacting protein 1 3.0013
DNM1 dynamin 1 2.99949
ICAM5 intercellular adhesion molecule 5, telencephalin 2.9909
GPR132 G protein-coupled receptor 132 2.97798
HACD1 3-hydroxyacyl-CoA dehydratase 1 2.95194
PPP1R3F protein phosphatase 1, regulatory subunit 3F 2.94674
RERGL RERG/RAS-like 2.93918
SSTR4 somatostatin receptor 4 2.93869
UBAP1L ubiquitin associated protein 1-like 2.92428
ZSWIM3 zinc finger, SWIM-type containing 3 2.89722
TPRG1L tumor protein p63 regulated 1-like 2.89361
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.88995
NRG2 neuregulin 2 2.8688
FKBP8 FK506 binding protein 8, 38kDa 2.86586
SPTBN4 spectrin, beta, non-erythrocytic 4 2.86049
CRHR1 corticotropin releasing hormone receptor 1 2.84683
MIGA1 mitoguardin 1 2.83832
CDKL5 cyclin-dependent kinase-like 5 2.83359
SUN3 Sad1 and UNC84 domain containing 3 2.82862
SFTPC surfactant protein C 2.82536
PIH1D1 PIH1 domain containing 1 2.80709
TWIST1 twist family bHLH transcription factor 1 2.80157
ACSS2 acyl-CoA synthetase short-chain family member 2 2.77521
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.76461
TLR1 toll-like receptor 1 2.76452
CNTNAP3 contactin associated protein-like 3 2.76377
HIST1H3C histone cluster 1, H3c 2.75452
IGFBP3 insulin-like growth factor binding protein 3 2.7496
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 2.7434
ZACN zinc activated ligand-gated ion channel 2.73993
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.73981
TSPAN33 tetraspanin 33 2.70899
SMYD1 SET and MYND domain containing 1 2.70837
FGF11 fibroblast growth factor 11 2.70249
PLXNC1 plexin C1 2.69983
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.69775
RGAG1 retrotransposon gag domain containing 1 2.69757
MROH1 maestro heat-like repeat family member 1 2.69506
ANKRD46 ankyrin repeat domain 46 2.6905
A3GALT2 alpha 1,3-galactosyltransferase 2 2.68708
TAPT1 transmembrane anterior posterior transformation 1 2.68672
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.6861
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.68202
RNASEH1 ribonuclease H1 2.67939
PUDP pseudouridine 5'-phosphatase 2.66648
OSBPL10 oxysterol binding protein-like 10 2.66615
GPR155 G protein-coupled receptor 155 2.64614
POU3F1 POU class 3 homeobox 1 2.64095
TNIP3 TNFAIP3 interacting protein 3 2.63834
NKX3-2 NK3 homeobox 2 2.63772
HOXD13 homeobox D13 2.62625
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 2.62203
FOXA1 forkhead box A1 2.61204
ARFIP2 ADP-ribosylation factor interacting protein 2 2.61057
FBXW8 F-box and WD repeat domain containing 8 2.60349
NRL neural retina leucine zipper 2.5999
EPB42 erythrocyte membrane protein band 4.2 2.59035
LMNTD2 lamin tail domain containing 2 2.5831
SAC3D1 SAC3 domain containing 1 2.58283
IDE insulin-degrading enzyme 2.57746
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.57658
PNOC prepronociceptin 2.57383
RITA1 RBPJ interacting and tubulin associated 1 2.56959
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 2.56942
ZFP90 ZFP90 zinc finger protein 2.569
HOOK3 hook microtubule-tethering protein 3 2.56882
TIMP1 TIMP metallopeptidase inhibitor 1 2.56755
C10ORF105 chromosome 10 open reading frame 105 2.56269
BAD BCL2-associated agonist of cell death 2.55202
CDX4 caudal type homeobox 4 2.53657
ZNF680 zinc finger protein 680 2.53496
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.53485
TMEM174 transmembrane protein 174 2.53394
TMEM140 transmembrane protein 140 2.53141
PRR19 proline rich 19 2.51195
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.50704
TOR4A torsin family 4, member A 2.49926
CYB561 cytochrome b561 2.49617
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.49603
FBXO22 F-box protein 22 2.49491
GPATCH2 G patch domain containing 2 2.48931
TUBA1A tubulin, alpha 1a 2.48703
PROCA1 protein interacting with cyclin A1 2.48112
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.48088
RGMA repulsive guidance molecule family member a 2.46691
TMEM179B transmembrane protein 179B 2.46661
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.45793
PCSK4 proprotein convertase subtilisin/kexin type 4 2.45181
ARTN artemin 2.44636
SMLR1 small leucine-rich protein 1 2.44494
KLK4 kallikrein-related peptidase 4 2.44133
P3H1 prolyl 3-hydroxylase 1 2.43949
ADAP1 ArfGAP with dual PH domains 1 2.43116
WWP1 WW domain containing E3 ubiquitin protein ligase 1 2.42823
PAQR6 progestin and adipoQ receptor family member VI 2.42476
ZNF696 zinc finger protein 696 2.41744
RNF123 ring finger protein 123 2.40992
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 2.40884
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.40853
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.40092
RFLNA refilin A 2.39936
PARD3B par-3 family cell polarity regulator beta 2.39455
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.39242
KIF1A kinesin family member 1A 2.39203
KRT20 keratin 20, type I 2.38888
BTNL8 butyrophilin-like 8 2.38759
STAB1 stabilin 1 2.38603
CADM1 cell adhesion molecule 1 2.38269
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.36621
BSN bassoon presynaptic cytomatrix protein 2.35455
MID2 midline 2 2.35166
TENM3 teneurin transmembrane protein 3 2.34515
QDPR quinoid dihydropteridine reductase 2.34476
KRTAP1-1 keratin associated protein 1-1 2.34081
POU1F1 POU class 1 homeobox 1 2.33729
THAP10 THAP domain containing 10 2.33458
CAVIN2 caveolae associated protein 2 2.33406
SOWAHD sosondowah ankyrin repeat domain family member D 2.32893
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 2.32363
FGF14 fibroblast growth factor 14 2.30973
CSTB cystatin B (stefin B) 2.29675
MMEL1 membrane metallo-endopeptidase-like 1 2.28984
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.27295
RASD2 RASD family, member 2 2.27206
MB myoglobin 2.26983
MAGED1 melanoma antigen family D1 2.26912
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.26714
GGTLC1 gamma-glutamyltransferase light chain 1 2.26216
TM4SF5 transmembrane 4 L six family member 5 2.26134
SLC25A53 solute carrier family 25, member 53 2.26129
RIC3 RIC3 acetylcholine receptor chaperone 2.261
RETREG1 reticulophagy regulator 1 2.25284
PRKCZ protein kinase C, zeta 2.24319
FBXO31 F-box protein 31 2.23521
NAGLU N-acetylglucosaminidase, alpha 2.23471
CABP7 calcium binding protein 7 2.23295
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.22911
ZMPSTE24 zinc metallopeptidase STE24 2.22221
TMEM51 transmembrane protein 51 2.21846
ACRV1 acrosomal vesicle protein 1 2.2184
SAMD4A sterile alpha motif domain containing 4A 2.21669
INSL3 insulin-like 3 (Leydig cell) 2.21659
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.21573
LRRN2 leucine rich repeat neuronal 2 2.21567
AQP3 aquaporin 3 (Gill blood group) 2.21096
ZNF428 zinc finger protein 428 2.20971
ZNF853 zinc finger protein 853 2.20839
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2.20806
IPO5 importin 5 2.20619
OVCA2 ovarian tumor suppressor candidate 2 2.20533
RNF135 ring finger protein 135 2.20315
ARL4D ADP-ribosylation factor-like 4D 2.2024
PODXL2 podocalyxin-like 2 2.19962
NAV1 neuron navigator 1 2.18738
CDC25A cell division cycle 25A 2.18534
UCMA upper zone of growth plate and cartilage matrix associated 2.17922
CST9L cystatin 9-like 2.17561
GUCY1B3 guanylate cyclase 1, soluble, beta 3 2.17103
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.16828
RAP2A RAP2A, member of RAS oncogene family 2.16807
PELI3 pellino E3 ubiquitin protein ligase family member 3 2.16567
TMEM185B transmembrane protein 185B 2.15823
LRRC8E leucine rich repeat containing 8 family, member E 2.156
GSK3A glycogen synthase kinase 3 alpha 2.1557
PYY peptide YY 2.14978
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.14871
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.14254
PGAP3 post-GPI attachment to proteins 3 2.13739
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.13705
EPC2 enhancer of polycomb homolog 2 (Drosophila) 2.13407
RCOR2 REST corepressor 2 2.1271
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 2.1259
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 2.11654
PTPRG protein tyrosine phosphatase, receptor type, G 2.1153
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.11495
TMIE transmembrane inner ear 2.11276
MGST2 microsomal glutathione S-transferase 2 2.11131
RBP3 retinol binding protein 3, interstitial 2.11045
C9ORF173 chromosome 9 open reading frame 173 2.10854
BHLHA9 basic helix-loop-helix family, member a9 2.10762
RNFT2 ring finger protein, transmembrane 2 2.10729
ZNF668 zinc finger protein 668 2.10429
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.10425
MXRA8 matrix-remodelling associated 8 2.10339
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.10305
GP5 glycoprotein V (platelet) 2.10201
DRAM1 DNA-damage regulated autophagy modulator 1 2.09811
CORO7 coronin 7 2.08925
ZNF75A zinc finger protein 75a 2.08193
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2.07771
HPD 4-hydroxyphenylpyruvate dioxygenase 2.07742
GSPT2 G1 to S phase transition 2 2.07647
KRTAP15-1 keratin associated protein 15-1 2.07411
CASS4 Cas scaffolding protein family member 4 2.07317
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.07232
HRH3 histamine receptor H3 2.06709
PSKH1 protein serine kinase H1 2.06389
PALM paralemmin 2.06232
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.06129
APLN apelin 2.06073
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.05899
MYCBPAP MYCBP associated protein 2.05351
CHGA chromogranin A 2.05285
PCNX3 pecanex 3 2.05161
CCDC42B coiled-coil domain containing 42B 2.04681
ZNF622 zinc finger protein 622 2.04519
C1ORF95 chromosome 1 open reading frame 95 2.04061
PXDC1 PX domain containing 1 2.04057
CDCA7L cell division cycle associated 7-like 2.03595
ACMSD aminocarboxymuconate semialdehyde decarboxylase 2.03537
WDTC1 WD and tetratricopeptide repeats 1 2.03395
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.03282
ANKRD30B ankyrin repeat domain 30B 2.03174
DIAPH3 diaphanous-related formin 3 2.03113
SALL2 spalt-like transcription factor 2 2.02649
OR2T2 olfactory receptor, family 2, subfamily T, member 2 2.02638
FAM81A family with sequence similarity 81, member A 2.02607
TSSK6 testis-specific serine kinase 6 2.02139
CNOT12 CCR4-NOT transcription complex subunit 12 2.0105
PRELP proline/arginine-rich end leucine-rich repeat protein 2.00794