MCCC2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description methylcrotonoyl-CoA carboxylase 2 (beta)|This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 64087)
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Genes

312 genes differentially expressed following the MCCC2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NXPH3 neurexophilin 3 3.18375
IL1R2 interleukin 1 receptor, type II 3.18375
GSTA1 glutathione S-transferase alpha 1 3.18375
PRDM16 PR domain containing 16 3.18375
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.18375
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.18375
MIA melanoma inhibitory activity 3.18375
CLDN34 claudin 34 3.18375
GRXCR1 glutaredoxin, cysteine rich 1 3.18375
BDKRB2 bradykinin receptor B2 3.18375
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.18375
SLC35G5 solute carrier family 35, member G5 3.18375
CXCR2 chemokine (C-X-C motif) receptor 2 3.18375
BTNL2 butyrophilin-like 2 3.18375
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.18375
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.18375
AADACL2 arylacetamide deacetylase-like 2 3.18375
POPDC2 popeye domain containing 2 3.18375
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.18375
ALX1 ALX homeobox 1 3.18375
ARSH arylsulfatase family, member H 3.18375
SMIM41 small integral membrane protein 41 3.18375
TPPP3 tubulin polymerization-promoting protein family member 3 3.18375
CPLX3 complexin 3 3.08087
PAX3 paired box 3 3.08087
TM4SF20 transmembrane 4 L six family member 20 3.08087
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.08087
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.08087
TRAF3IP3 TRAF3 interacting protein 3 3.08087
ASGR2 asialoglycoprotein receptor 2 3.08087
OR6Y1 olfactory receptor, family 6, subfamily Y, member 1 3.08087
KCNU1 potassium channel, subfamily U, member 1 3.08087
NMUR2 neuromedin U receptor 2 3.08087
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.08087
SLC25A41 solute carrier family 25, member 41 3.08087
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.08087
TSHZ1 teashirt zinc finger homeobox 1 3.08087
FABP12 fatty acid binding protein 12 3.08087
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.08087
C9ORF152 chromosome 9 open reading frame 152 3.08087
COL15A1 collagen, type XV, alpha 1 3.08087
TAS2R10 taste receptor, type 2, member 10 3.08087
C3ORF22 chromosome 3 open reading frame 22 3.08087
CA7 carbonic anhydrase VII 3.08087
ITGA8 integrin, alpha 8 3.08087
BMP5 bone morphogenetic protein 5 3.08087
PECAM1 platelet/endothelial cell adhesion molecule 1 3.08087
GIMAP4 GTPase, IMAP family member 4 3.08087
C19ORF67 chromosome 19 open reading frame 67 3.08087
RSPO3 R-spondin 3 3.08087
MYO16 myosin XVI 3.08087
ASB10 ankyrin repeat and SOCS box containing 10 3.08087
FAM156B family with sequence similarity 156, member B 3.08087
HBA1 hemoglobin, alpha 1 3.08087
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.08087
GATA5 GATA binding protein 5 3.08087
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.08087
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.08087
FOXC1 forkhead box C1 3.08087
LOC124906892 uncharacterized LOC124906892 3.08087
RDH8 retinol dehydrogenase 8 (all-trans) 3.08087
ASB4 ankyrin repeat and SOCS box containing 4 3.08087
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.08087
KRT80 keratin 80, type II 3.08087
RD3 retinal degeneration 3 3.08087
CLDN16 claudin 16 3.08087
OTOS otospiralin 3.08087
FAM237B family with sequence similarity 237 member B 3.08087
DYNLT4 dynein light chain Tctex-type 4 3.08087
MEIOSIN meiosis initiator 3.08087
DNAAF6 dynein axonemal assembly factor 6 3.08087
TBC1D3I TBC1 domain family member 3I 3.08087
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.08087
DLK2 delta-like 2 homolog (Drosophila) 3.08087
DNASE1L2 deoxyribonuclease I-like 2 3.08087
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.08087
ZNF208 zinc finger protein 208 3.08087
ZSCAN5B zinc finger and SCAN domain containing 5B 3.08087
ANXA13 annexin A13 3.08087
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.08087
SELPLG selectin P ligand 3.08087
RNF17 ring finger protein 17 3.08087
SBK3 SH3 domain binding kinase family, member 3 3.08087
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.08087
TLR8 toll-like receptor 8 3.08087
SLC45A2 solute carrier family 45, member 2 3.08087
PRRT4 proline-rich transmembrane protein 4 3.08087
GSC goosecoid homeobox 3.08087
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.08087
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.08087
ACE2 angiotensin I converting enzyme 2 3.08087
SPEGNB SPEG neighbor 3.08087
EGR2 early growth response 2 3.08087
PSG3 pregnancy specific beta-1-glycoprotein 3 3.08087
CDH26 cadherin 26 3.08087
ZNF703 zinc finger protein 703 3.08087
NIM1K NIM1 serine/threonine protein kinase 3.08087
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.08087
MEIS1 Meis homeobox 1 3.08087
A3GALT2 alpha 1,3-galactosyltransferase 2 3.08087
KRT3 keratin 3, type II 3.08087
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.08087
PCDHGB4 protocadherin gamma subfamily B, 4 3.08087
MORC1 MORC family CW-type zinc finger 1 3.08087
TBPL2 TATA box binding protein like 2 3.08087
CPN2 carboxypeptidase N, polypeptide 2 3.08087
C5AR2 complement component 5a receptor 2 3.08087
LHX5 LIM homeobox 5 3.08087
F13B coagulation factor XIII, B polypeptide 3.08087
TAS2R50 taste receptor, type 2, member 50 3.08087
C8ORF89 chromosome 8 open reading frame 89 3.08087
CLEC9A C-type lectin domain family 9, member A 3.08087
COL17A1 collagen, type XVII, alpha 1 3.08087
DHH desert hedgehog 3.08087
ALOXE3 arachidonate lipoxygenase 3 3.08087
CYS1 cystin 1 3.08087
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 3.08087
DLX2 distal-less homeobox 2 3.08087
ERCC1 excision repair cross-complementation group 1 3.08087
CPA4 carboxypeptidase A4 3.08087
CD5L CD5 molecule-like 3.08087
OTOP2 otopetrin 2 3.08087
ZIM2 zinc finger, imprinted 2 3.08087
PRTN3 proteinase 3 3.08087
MAEL maelstrom spermatogenic transposon silencer 3.08087
SLITRK1 SLIT and NTRK-like family, member 1 3.08087
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.08087
CLCNKA chloride channel, voltage-sensitive Ka 3.08087
CCNO cyclin O 3.08087
PADI1 peptidyl arginine deiminase, type I 3.08087
HEPACAM hepatic and glial cell adhesion molecule 3.08087
ERAP2 endoplasmic reticulum aminopeptidase 2 3.08087
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.08087
TAS2R46 taste receptor, type 2, member 46 3.08087
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 3.08087
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.08087
DSPP dentin sialophosphoprotein 3.08087
TMEM52B transmembrane protein 52B 3.08087
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.08087
FGF9 fibroblast growth factor 9 3.08087
SLC10A5 solute carrier family 10, member 5 3.08087
ROM1 retinal outer segment membrane protein 1 3.08087
BOLA2 bolA family member 2 3.08087
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.08087
LAMB3 laminin, beta 3 3.08087
SLC38A11 solute carrier family 38, member 11 3.08087
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.08087
CLCA4 chloride channel accessory 4 3.08087
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.08087
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.08087
C1ORF87 chromosome 1 open reading frame 87 2.98403
LOXL4 lysyl oxidase-like 4 2.98403
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.9636
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.9271
ZIC5 Zic family member 5 2.92426
FAM162B family with sequence similarity 162, member B 2.87513
TPK1 thiamin pyrophosphokinase 1 2.84481
ANO10 anoctamin 10 2.83961
ARL4C ADP-ribosylation factor-like 4C 2.8372
CRYM crystallin, mu 2.71729
SELENOK selenoprotein K 2.69492
GOLGA4 golgin A4 2.51568
TP53TG5 TP53 target 5 2.4902
MASP2 mannan-binding lectin serine peptidase 2 2.4902
ENDOG endonuclease G 2.44158
PGAP2 post-GPI attachment to proteins 2 2.42766
METTL26 methyltransferase like 26 2.40669
KDM4D lysine (K)-specific demethylase 4D 2.39114
ANO9 anoctamin 9 2.38342
WAC WW domain containing adaptor with coiled-coil 2.36236
RABL2A RAB, member of RAS oncogene family-like 2A 2.34647
TENT5B terminal nucleotidyltransferase 5B 2.34236
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.34027
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.30756
CBX4 chromobox homolog 4 2.30047
TASP1 taspase, threonine aspartase, 1 2.24462
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.23879
ZDHHC4 zinc finger, DHHC-type containing 4 2.2378
ZNF747 zinc finger protein 747 2.23104
SP2 Sp2 transcription factor 2.21123
MANF mesencephalic astrocyte-derived neurotrophic factor 2.20926
H1-6 H1.6 linker histone, cluster member 2.20926
TMEM184A transmembrane protein 184A 2.20926
EPB41 erythrocyte membrane protein band 4.1 2.18997
FAM107B family with sequence similarity 107, member B 2.1837
ERCC3 excision repair cross-complementation group 3 2.1837
RTBDN retbindin 2.17805
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.17805
HYKK hydroxylysine kinase 2.17802
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.1484
NECAP2 NECAP endocytosis associated 2 2.13661
KAT14 lysine acetyltransferase 14 2.12733
LIN7B lin-7 homolog B (C. elegans) 2.12733
DCAF5 DDB1 and CUL4 associated factor 5 2.12733
AGO1 argonaute RISC catalytic component 1 2.10622
RNF212 ring finger protein 212 2.10552
KDM7A lysine (K)-specific demethylase 7A 2.10155
VAMP3 vesicle-associated membrane protein 3 2.09055
DNAH12 dynein, axonemal, heavy chain 12 2.09055
FER1L6 fer-1-like family member 6 2.09055
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.09055
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.0552
USP9X ubiquitin specific peptidase 9, X-linked 2.04394
ZNF773 zinc finger protein 773 2.03731
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.03059
MBNL3 muscleblind-like splicing regulator 3 2.00989
MYG1 MYG1 exonuclease 2.00989

decreased expression

Symbol Name Standardized Value
MLIP muscular LMNA-interacting protein -3.18375
SPATA16 spermatogenesis associated 16 -3.18375
LHX6 LIM homeobox 6 -3.18375
TMEM213 transmembrane protein 213 -3.18375
CSAG3 CSAG family, member 3 -3.18375
NUTM2F NUT family member 2F -3.08087
FGF20 fibroblast growth factor 20 -3.08087
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B -3.08087
AGTR1 angiotensin II receptor, type 1 -3.08087
FAM153A family with sequence similarity 153, member A -3.08087
DES desmin -3.08087
CCDC17 coiled-coil domain containing 17 -3.08087
PTGER3 prostaglandin E receptor 3 (subtype EP3) -3.08087
PRICKLE4 prickle homolog 4 (Drosophila) -3.08087
FOXA2 forkhead box A2 -3.08087
ADAMTSL2 ADAMTS-like 2 -3.08087
MEIG1 meiosis/spermiogenesis associated 1 -3.08087
NPC1L1 NPC1-like 1 -3.08087
NELFA negative elongation factor complex member A -3.08087
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -3.08087
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -3.08087
IL5RA interleukin 5 receptor, alpha -3.08087
LAMP3 lysosomal-associated membrane protein 3 -3.08087
CALCA calcitonin-related polypeptide alpha -3.08087
UBXN1 UBX domain protein 1 -3.08087
SCN7A sodium channel, voltage gated, type VII alpha subunit -3.08087
RIPPLY3 ripply transcriptional repressor 3 -3.08087
MINDY4B MINDY family member 4B -3.08087
KLK5 kallikrein-related peptidase 5 -3.08087
CD68 CD68 molecule -3.08087
CATIP ciliogenesis associated TTC17 interacting protein -3.08087
GREP1 glycine rich extracellular protein 1 -3.08087
LHX2 LIM homeobox 2 -3.08087
CCNI2 cyclin I family, member 2 -3.08087
FBXO39 F-box protein 39 -3.08087
HNF1B HNF1 homeobox B -3.08087
CDHR4 cadherin-related family member 4 -3.08087
GPR12 G protein-coupled receptor 12 -3.08087
FRK fyn-related Src family tyrosine kinase -3.08087
RTL5 retrotransposon Gag like 5 -3.08087
GADD45B growth arrest and DNA-damage-inducible, beta -2.98537
IGSF8 immunoglobulin superfamily, member 8 -2.98403
PRPF4 pre-mRNA processing factor 4 -2.817
TMT1A thiol methyltransferase 1A -2.63308
RPL39 ribosomal protein L39 -2.61999
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -2.61731
NTHL1 nth endonuclease III-like 1 (E. coli) -2.60689
ASMT acetylserotonin O-methyltransferase -2.55097
LOC124904542 uncharacterized LOC124904542 -2.55097
SCAMP4 secretory carrier membrane protein 4 -2.54735
FLII flightless I homolog (Drosophila) -2.43583
COA6 cytochrome c oxidase assembly factor 6 -2.43583
MYZAP myocardial zonula adherens protein -2.42879
EAPP E2F-associated phosphoprotein -2.41834
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.41638
TMEM240 transmembrane protein 240 -2.39897
NEFM neurofilament, medium polypeptide -2.39145
SORBS2 sorbin and SH3 domain containing 2 -2.37667
A1BG alpha-1-B glycoprotein -2.36778
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 -2.33371
TMEM68 transmembrane protein 68 -2.31639
RUNDC3A RUN domain containing 3A -2.31071
PCP4L1 Purkinje cell protein 4 like 1 -2.31071
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.31071
CPE carboxypeptidase E -2.30193
RPS23 ribosomal protein S23 -2.29564
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.27586
NLRC5 NLR family, CARD domain containing 5 -2.2378
ZNF724 zinc finger protein 724 -2.2378
ARNT aryl hydrocarbon receptor nuclear translocator -2.23422
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.23422
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.23422
FBLN7 fibulin 7 -2.23422
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.23104
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.23104
PWP1 PWP1 homolog (S. cerevisiae) -2.2219
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.21857
LGI2 leucine-rich repeat LGI family, member 2 -2.21857
AKIRIN1 akirin 1 -2.21123
PRXL2C peroxiredoxin like 2C -2.20768
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.20768
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -2.1837
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.17048
C4ORF50 chromosome 4 open reading frame 50 -2.17048
TRIM45 tripartite motif containing 45 -2.17018
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.13734
ZFAT zinc finger and AT hook domain containing -2.12915
KCTD17 potassium channel tetramerization domain containing 17 -2.12889
HIP1 huntingtin interacting protein 1 -2.12733
CNTNAP2 contactin associated protein-like 2 -2.11725
NOP53 NOP53 ribosome biogenesis factor -2.10155
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.09055
DDRGK1 DDRGK domain containing 1 -2.09055
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.09055
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.08608
CHURC1 churchill domain containing 1 -2.07342
SCGB3A2 secretoglobin, family 3A, member 2 -2.06652
PAN2 PAN2 poly(A) specific ribonuclease subunit -2.04941
SPART spartin -2.04394
NCAM2 neural cell adhesion molecule 2 -2.04394
LINC02983 long intergenic non-protein coding RNA 2983 -2.03039
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -2.02189
GRPR gastrin-releasing peptide receptor -2.01988
WDR7 WD repeat domain 7 -2.01455
SLC33A2 solute carrier family 33 member 2 -2.00989