MCF7_Alendronate sodium trihydrate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 1µM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_Alendronate sodium trihydrate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPB1 heat shock 27kDa protein 1 0.235885
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.158627
FDPS farnesyl diphosphate synthase 0.122216
KRT18 keratin 18, type I 0.11769
KRT19 keratin 19, type I 0.10037
SQLE squalene epoxidase 0.0949291
LDLR low density lipoprotein receptor 0.088461
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.08159
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0786709
USP32 ubiquitin specific peptidase 32 0.0786609
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0779786
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0756486
DTNA dystrobrevin, alpha 0.072788
NAV1 neuron navigator 1 0.0697958
IGF1R insulin-like growth factor 1 receptor 0.0670327
BCAS3 breast carcinoma amplified sequence 3 0.0661463
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0657411
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.0653604
GREB1 growth regulation by estrogen in breast cancer 1 0.0643017
DSPP dentin sialophosphoprotein 0.0630472
FOXO3 forkhead box O3 0.0624218
AREG amphiregulin 0.0614877
CFAP97D1 CFAP97 domain containing 1 0.0599616
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0592174
MVD mevalonate (diphospho) decarboxylase 0.0588256
RNF115 ring finger protein 115 0.0588056
PATJ PATJ crumbs cell polarity complex component 0.0573112
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0571419
RPL12 ribosomal protein L12 0.0567805
BCAS1 breast carcinoma amplified sequence 1 0.0567617
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0540652
MLPH melanophilin 0.053391
SPTSSB serine palmitoyltransferase, small subunit B 0.0533029
RPS21 ribosomal protein S21 0.0526672
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0508874
RPS3 ribosomal protein S3 0.0495528
RPS5 ribosomal protein S5 0.0493806
RPLP0 ribosomal protein, large, P0 0.0487563
SREBF2 sterol regulatory element binding transcription factor 2 0.0483295
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0472834
GATA3 GATA binding protein 3 0.0472434
ACSS2 acyl-CoA synthetase short-chain family member 2 0.045625
UBL4A ubiquitin-like 4A 0.0451257
INSIG1 insulin induced gene 1 0.0445886
LMBR1 limb development membrane protein 1 0.0421839
NBEAL1 neurobeachin-like 1 0.0412282
IDI1 isopentenyl-diphosphate delta isomerase 1 0.041067
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.040446
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0396515
GSK3B glycogen synthase kinase 3 beta 0.0396211
GTF2I general transcription factor IIi 0.0393365
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0380137
BRWD1 bromodomain and WD repeat domain containing 1 0.037984
KMT2C lysine (K)-specific methyltransferase 2C 0.037968
FOXP1 forkhead box P1 0.0376977
RPL28 ribosomal protein L28 0.0373047
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0369413
ABHD2 abhydrolase domain containing 2 0.0368096
TUBA1A tubulin, alpha 1a 0.0366069
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0361888
PBX1 pre-B-cell leukemia homeobox 1 0.0356844
EVL Enah/Vasp-like 0.0355487
DHCR7 7-dehydrocholesterol reductase 0.0354962
MYH14 myosin, heavy chain 14, non-muscle 0.0353955
RPLP1 ribosomal protein, large, P1 0.0351178
LGALS3 lectin, galactoside-binding, soluble, 3 0.0349888
RBM6 RNA binding motif protein 6 0.0347184
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.034579
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0345011
RPL8 ribosomal protein L8 0.034417
KDM2A lysine (K)-specific demethylase 2A 0.034404
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0340796
ATOSA atos homolog A 0.0338885
SYTL2 synaptotagmin-like 2 0.0326073
FGF13 fibroblast growth factor 13 0.0324558
PDE8A phosphodiesterase 8A 0.0323404
N4BP2L2 NEDD4 binding protein 2-like 2 0.0318478
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0313803
ATP9A ATPase, class II, type 9A 0.030901
RAD51B RAD51 paralog B 0.0308674
FLNA filamin A, alpha 0.0307991
TRIM37 tripartite motif containing 37 0.0306362
EZR ezrin 0.0305578
SQSTM1 sequestosome 1 0.0304112
CDPF1 cysteine-rich, DPF motif domain containing 1 0.030404
KDM5B lysine (K)-specific demethylase 5B 0.0303819
SVIL supervillin 0.0300609
CDK19 cyclin-dependent kinase 19 0.0299101
LPIN1 lipin 1 0.0298891
RPS11 ribosomal protein S11 0.0298712
DSCAM Down syndrome cell adhesion molecule 0.0297039
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.029493
CTSD cathepsin D 0.028983
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0289123
RAD9A RAD9 homolog A (S. pombe) 0.0288102
KLF6 Kruppel-like factor 6 0.0285833
UBE2B ubiquitin-conjugating enzyme E2B 0.0283781
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.028133
CALCR calcitonin receptor 0.0280306
FTH1 ferritin, heavy polypeptide 1 0.0279168
AHNAK AHNAK nucleoprotein 0.02767
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0274541
PCED1B PC-esterase domain containing 1B 0.0274391
RPL30 ribosomal protein L30 0.0274019
DAAM1 dishevelled associated activator of morphogenesis 1 0.0272983
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0272771
ZNF217 zinc finger protein 217 0.027113
THSD4 thrombospondin, type I, domain containing 4 0.0269404
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.026919
OGA O-GlcNAcase 0.0265653
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.0264231
RPL7A ribosomal protein L7a 0.0264192
IER5L immediate early response 5-like 0.0261759
GDF15 growth differentiation factor 15 0.0260651
CFDP1 craniofacial development protein 1 0.0259589
PTMS parathymosin 0.0258538
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0255628
REST RE1-silencing transcription factor 0.0255604
NPEPPS aminopeptidase puromycin sensitive 0.0255246
WSB1 WD repeat and SOCS box containing 1 0.0255189
RPL37A ribosomal protein L37a 0.0254136
MYO9A myosin IXA 0.0253959
ENSA endosulfine alpha 0.0253319
GTF2IRD1 GTF2I repeat domain containing 1 0.0252762
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.0251541
CUX1 cut-like homeobox 1 0.025022
ADGRG6 adhesion G protein-coupled receptor G6 0.0247753
ATXN7 ataxin 7 0.0246926
GOLGB1 golgin B1 0.024662
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0246187
TNRC6B trinucleotide repeat containing 6B 0.0245157
KDM4C lysine (K)-specific demethylase 4C 0.024355
TMOD3 tropomodulin 3 (ubiquitous) 0.0243046
MAVS mitochondrial antiviral signaling protein 0.0241348
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0240985
TOP2B topoisomerase (DNA) II beta 180kDa 0.0239985
MLXIP MLX interacting protein 0.023789
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0236012
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0234813
PCDHB16 protocadherin beta 16 0.0234459
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0233335
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0232689
ITGB4 integrin, beta 4 0.02311
SOS2 son of sevenless homolog 2 (Drosophila) 0.0230704
CTBP2 C-terminal binding protein 2 0.0230694
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0230278
CLDN3 claudin 3 0.0227347
KRT80 keratin 80, type II 0.0227276
CCSER2 coiled-coil serine-rich protein 2 0.0227049
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0226329
RGS6 regulator of G-protein signaling 6 0.0226315
CNKSR3 CNKSR family member 3 0.0225925
MUSK muscle, skeletal, receptor tyrosine kinase 0.0225541
GPR137C G protein-coupled receptor 137C 0.0225437
ESYT2 extended synaptotagmin-like protein 2 0.022509
S100A14 S100 calcium binding protein A14 0.0224962
BICRAL BICRA like chromatin remodeling complex associated protein 0.0223813
TMED8 transmembrane emp24 protein transport domain containing 8 0.0222395
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.0221739
S100A10 S100 calcium binding protein A10 0.0221464
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0221007
ELOVL6 ELOVL fatty acid elongase 6 0.0220271
RSRP1 arginine/serine-rich protein 1 0.0217729
THOC7 THO complex 7 0.0214979
CELF1 CUGBP, Elav-like family member 1 0.0214337
RPS18 ribosomal protein S18 0.0213348
UBE2H ubiquitin-conjugating enzyme E2H 0.0212923
CTNND2 catenin (cadherin-associated protein), delta 2 0.0211908
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.021113
CHURC1 churchill domain containing 1 0.0211061
GOLGA2 golgin A2 0.02106
JMJD1C jumonji domain containing 1C 0.0206199
CLDN4 claudin 4 0.0205895
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.0205627
KMT2A lysine (K)-specific methyltransferase 2A 0.0205245
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0205064
DNASE1 deoxyribonuclease I 0.0204941
EEF2 eukaryotic translation elongation factor 2 0.0204876
COX5B cytochrome c oxidase subunit Vb 0.0204288
ZNF106 zinc finger protein 106 0.0203568
MRPL13 mitochondrial ribosomal protein L13 0.0203373
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0203027
TTLL10 tubulin tyrosine ligase-like family member 10 0.0202987
TRIM56 tripartite motif containing 56 0.0202929
AK1 adenylate kinase 1 0.0202564
SMIM14 small integral membrane protein 14 0.0201331
XRN1 5'-3' exoribonuclease 1 0.0201102
ADGRV1 adhesion G protein-coupled receptor V1 0.0199684
TMSB10 thymosin beta 10 0.0197368
HDGF hepatoma-derived growth factor 0.0196753
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0195783
DNAAF9 dynein axonemal assembly factor 9 0.0195288
AAK1 AP2 associated kinase 1 0.0195025
RPS20 ribosomal protein S20 0.0194559
FTL ferritin, light polypeptide 0.0194309
ACTN1 actinin, alpha 1 0.0193787
GAB2 GRB2-associated binding protein 2 0.019363
GNAS GNAS complex locus 0.0192673
RPL35A ribosomal protein L35a 0.0192584
BABAM2 BRISC and BRCA1 A complex member 2 0.0191659
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0191471
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.0190654
MUC1 mucin 1, cell surface associated 0.0190488
CLU clusterin 0.0190275
MYL12B myosin, light chain 12B, regulatory 0.0189681
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0189329
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.0189279
ATXN1 ataxin 1 0.0189278
JUND jun D proto-oncogene 0.0188676
PHACTR2 phosphatase and actin regulator 2 0.0188411
INSR insulin receptor 0.0187256
C6ORF141 chromosome 6 open reading frame 141 0.0186839
ACLY ATP citrate lyase 0.0186471
FOXA1 forkhead box A1 0.0184591
PRUNE2 prune homolog 2 (Drosophila) 0.0184331
RUFY1 RUN and FYVE domain containing 1 0.0184053
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0183962
HOOK2 hook microtubule-tethering protein 2 0.0183868
SETDB1 SET domain, bifurcated 1 0.0182772
PXDN peroxidasin 0.0181264
PSD3 pleckstrin and Sec7 domain containing 3 0.0180934
DRAM1 DNA-damage regulated autophagy modulator 1 0.0180708
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.0179978
ARSG arylsulfatase G 0.0179848
ARFGEF3 ARFGEF family member 3 0.0179683
ICA1 islet cell autoantigen 1, 69kDa 0.0179454
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0179206
RSF1 remodeling and spacing factor 1 0.0178449
TSPAN15 tetraspanin 15 0.0178363
BPTF bromodomain PHD finger transcription factor 0.0178281
DSTYK dual serine/threonine and tyrosine protein kinase 0.0178245
SIL1 SIL1 nucleotide exchange factor 0.017776
AMBRA1 autophagy/beclin-1 regulator 1 0.0176988
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0176861
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.0176847
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0.017639
IER3 immediate early response 3 0.0176148
SNED1 sushi, nidogen and EGF-like domains 1 0.0176126
PRKCH protein kinase C, eta 0.0176024
MACF1 microtubule-actin crosslinking factor 1 0.01758
TINCR tissue differentiation-inducing non-protein coding RNA 0.0175037
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0174861
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0174562
RPS15 ribosomal protein S15 0.0174361
CERS6 ceramide synthase 6 0.0174317
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0173661
YPEL3 yippee-like 3 (Drosophila) 0.017299
HIP1 huntingtin interacting protein 1 0.0172636
JUN jun proto-oncogene 0.0172416
FOXN3 forkhead box N3 0.017219
TMEM65 transmembrane protein 65 0.0172034
STXBP1 syntaxin binding protein 1 0.0171805
ISG20 interferon stimulated exonuclease gene 20kDa 0.0171567
VMP1 vacuole membrane protein 1 0.0171111
HEATR6 HEAT repeat containing 6 0.0170962
CEP95 centrosomal protein 95kDa 0.0170023
PAWR PRKC, apoptosis, WT1, regulator 0.0169867
CHD6 chromodomain helicase DNA binding protein 6 0.0168774
NRIP1 nuclear receptor interacting protein 1 0.0167874
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0167254
SERINC5 serine incorporator 5 0.0167111
ABLIM1 actin binding LIM protein 1 0.0166516
KCTD20 potassium channel tetramerization domain containing 20 0.0166375
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0165412
DIDO1 death inducer-obliterator 1 0.0165341
TBC1D17 TBC1 domain family, member 17 0.0165302
TUBD1 tubulin, delta 1 0.0164817
RPL11 ribosomal protein L11 0.0164714
KIF16B kinesin family member 16B 0.0164301
QSER1 glutamine and serine rich 1 0.0164139
CBX5 chromobox homolog 5 0.0163797
ANXA2 annexin A2 0.0162806
TM7SF2 transmembrane 7 superfamily member 2 0.0161657
ZNF721 zinc finger protein 721 0.0161552
SOS1 son of sevenless homolog 1 (Drosophila) 0.0161336
GSE1 Gse1 coiled-coil protein 0.0160829
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0160472
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.015909
SYT1 synaptotagmin I 0.0158421
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.0158245
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0158064
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 0.0157568
SH3D19 SH3 domain containing 19 0.0157146
ULK1 unc-51 like autophagy activating kinase 1 0.0156473
EXOC6 exocyst complex component 6 0.0156469
WIPF1 WAS/WASL interacting protein family, member 1 0.0156402
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.015599
TXNIP thioredoxin interacting protein 0.0155097
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.015506
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.015464
FHIT fragile histidine triad 0.0154628
PRXL2A peroxiredoxin like 2A 0.0154403
S100A11 S100 calcium binding protein A11 0.0154391
NIPAL2 NIPA-like domain containing 2 0.0153864
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0153331
FLNB filamin B, beta 0.015329
KPNB1 karyopherin (importin) beta 1 0.0153007
DPYD dihydropyrimidine dehydrogenase 0.0152862
SLFN5 schlafen family member 5 0.0152815
RNPS1 RNA binding protein S1, serine-rich domain 0.0152578
SPPL3 signal peptide peptidase like 3 0.0152522
R3HDM2 R3H domain containing 2 0.0152336
KLHL24 kelch-like family member 24 0.0151135
BRAT1 BRCA1-associated ATM activator 1 0.0151084
TLK2 tousled-like kinase 2 0.0151069
RPS25 ribosomal protein S25 0.0151066
RNF43 ring finger protein 43 0.0150828
TESK2 testis-specific kinase 2 0.0150275
CUEDC1 CUE domain containing 1 0.0150063
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.015002
SAMD4A sterile alpha motif domain containing 4A 0.0149821
RPS27L ribosomal protein S27-like 0.0149799
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0149309
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.0149146
RHOA ras homolog family member A 0.0149145
CEP89 centrosomal protein 89kDa 0.0148568
UVRAG UV radiation resistance associated 0.0148239
CAPNS1 calpain, small subunit 1 0.0148024
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0148006
RHOB ras homolog family member B 0.0147829
ATF7IP activating transcription factor 7 interacting protein 0.0147736
ADAR adenosine deaminase, RNA-specific 0.0147245
MSMO1 methylsterol monooxygenase 1 0.0147148
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.0147116
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0147
TBC1D12 TBC1 domain family, member 12 0.0146614
RNF167 ring finger protein 167 0.0146422
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0146079
LOC112694756 uncharaterized LOC112694756 0.0145647
DCLK1 doublecortin-like kinase 1 0.0145634
EHBP1 EH domain binding protein 1 0.0145564
ZBTB10 zinc finger and BTB domain containing 10 0.0145143
TJP1 tight junction protein 1 0.0145071
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0144806
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.0144744
TMSB4X thymosin beta 4, X-linked 0.0144005
NUMB numb homolog (Drosophila) 0.0143814
TMEM135 transmembrane protein 135 0.0143708
SKIL SKI-like proto-oncogene 0.0143545
UBAP1 ubiquitin associated protein 1 0.0143479
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0143396
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0143345
EXT1 exostosin glycosyltransferase 1 0.0143125
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0142834
RTF2 replication termination factor 2 0.0142768
LARP1 La ribonucleoprotein domain family, member 1 0.0142355
PGPEP1 pyroglutamyl-peptidase I 0.0142335
SPATA7 spermatogenesis associated 7 0.0142244
CCDC92 coiled-coil domain containing 92 0.0141687
RUFY2 RUN and FYVE domain containing 2 0.0141517
NBR1 neighbor of BRCA1 gene 1 0.0141359
GRAMD1A GRAM domain containing 1A 0.014115
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0141085
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0140909
PACS2 phosphofurin acidic cluster sorting protein 2 0.0140259
FRMD5 FERM domain containing 5 0.0140123
RPL10A ribosomal protein L10a 0.0140104
PRSS23 protease, serine, 23 0.0139783
MYO15B myosin XVB 0.0139586
FASN fatty acid synthase 0.0139446
NEK8 NIMA-related kinase 8 0.0139086
MYO1B myosin IB 0.0138772
SUSD1 sushi domain containing 1 0.01385
YIPF4 Yip1 domain family, member 4 0.0138496
RPS28 ribosomal protein S28 0.0138377
ABHD11 abhydrolase domain containing 11 0.0138324
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0138035
ERG28 ergosterol biosynthesis 28 homolog 0.0137977
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0137772
LTBP4 latent transforming growth factor beta binding protein 4 0.0137755
RNFT1 ring finger protein, transmembrane 1 0.0137691
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 0.0136376
RECQL5 RecQ protein-like 5 0.0136325
LMAN2 lectin, mannose-binding 2 0.0136262
AGO4 argonaute RISC catalytic component 4 0.0136213
OSBPL2 oxysterol binding protein-like 2 0.0136178
TBL1X transducin (beta)-like 1X-linked 0.0135403
FBXL2 F-box and leucine-rich repeat protein 2 0.0135204
ATP5F1E ATP synthase F1 subunit epsilon 0.0135048
SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.0134732
EMCN endomucin 0.013466
NEBL nebulette 0.0134565
ZNF91 zinc finger protein 91 0.0134388
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.0133981
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0133721
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0133447
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.0133444
FAM117B family with sequence similarity 117, member B 0.0133353
RPS19 ribosomal protein S19 0.0133148
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0133055
NBPF15 neuroblastoma breakpoint family, member 15 0.013261
PRKG1 protein kinase, cGMP-dependent, type I 0.0132289
SDCCAG8 serologically defined colon cancer antigen 8 0.0132191
PHF20 PHD finger protein 20 0.0132071
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.0131962
NRBP1 nuclear receptor binding protein 1 0.0131954
SSH1 slingshot protein phosphatase 1 0.0131941
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.0131936
AUTS2 autism susceptibility candidate 2 0.0131689
APP amyloid beta (A4) precursor protein 0.0131498
CYBA cytochrome b-245, alpha polypeptide 0.0131433
ZXDC ZXD family zinc finger C 0.0131342
GIPC1 GIPC PDZ domain containing family, member 1 0.0131275
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0131227
ATP11A ATPase, class VI, type 11A 0.013114
SNX13 sorting nexin 13 0.013102
C6ORF62 chromosome 6 open reading frame 62 0.0130978
MAP2K5 mitogen-activated protein kinase kinase 5 0.0130924
MFGE8 milk fat globule-EGF factor 8 protein 0.0130677
STYXL1 serine/threonine/tyrosine interacting-like 1 0.0130674
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.013066
SIN3A SIN3 transcription regulator family member A 0.0130586
TXNRD1 thioredoxin reductase 1 0.0130542
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0130251
INTS6 integrator complex subunit 6 0.0130219
STK10 serine/threonine kinase 10 0.0130107
PPCDC phosphopantothenoylcysteine decarboxylase 0.013006
COX19 COX19 cytochrome c oxidase assembly factor 0.0129983
UNC13B unc-13 homolog B (C. elegans) 0.0129808
YPEL1 yippee-like 1 (Drosophila) 0.0129415
EPB41 erythrocyte membrane protein band 4.1 0.0129411
ACBD3 acyl-CoA binding domain containing 3 0.0129409
RGS12 regulator of G-protein signaling 12 0.0129131
TDG thymine-DNA glycosylase 0.0128784
CAMTA1 calmodulin binding transcription activator 1 0.0128153
WASF2 WAS protein family, member 2 0.0127944
DUSP16 dual specificity phosphatase 16 0.0127847
ASXL1 additional sex combs like transcriptional regulator 1 0.0127582
ZCCHC8 zinc finger, CCHC domain containing 8 0.0127166
BICDL1 BICD family like cargo adaptor 1 0.0126608
SLC35E2B solute carrier family 35, member E2B 0.0126363
LONP1 lon peptidase 1, mitochondrial 0.0126053
CLDN7 claudin 7 0.0125846
OSBPL9 oxysterol binding protein-like 9 0.012566
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0125651
NPC1 Niemann-Pick disease, type C1 0.0125576
SLC35E1 solute carrier family 35, member E1 0.0124439
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0124412
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0124267
ACADVL acyl-CoA dehydrogenase, very long chain 0.0124242
RACK1 receptor for activated C kinase 1 0.0123877
CATSPERB catsper channel auxiliary subunit beta 0.0123646
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0123624
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0123502
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 0.0123355
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0123028
NHP2 NHP2 ribonucleoprotein 0.0123011
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0122995
COXFA4 cytochrome c oxidase associated subunit FA4 0.0122863
RPL38 ribosomal protein L38 0.0122746
ATN1 atrophin 1 0.0122696
RORA RAR-related orphan receptor A 0.0122599
PAPOLA poly(A) polymerase alpha 0.0122408
TACSTD2 tumor-associated calcium signal transducer 2 0.012238
AFF1 AF4/FMR2 family, member 1 0.012235
CEP104 centrosomal protein 104kDa 0.0121964
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0121955
RNASE7 ribonuclease, RNase A family, 7 0.0121947
NMT1 N-myristoyltransferase 1 0.0121921
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0121733
PGR progesterone receptor 0.0121562
SEPHS1 selenophosphate synthetase 1 0.0121512
CHMP5 charged multivesicular body protein 5 0.0121047
RPL14 ribosomal protein L14 0.0120601
AK3 adenylate kinase 3 0.0120544
PYGB phosphorylase, glycogen; brain 0.0120382
NUP43 nucleoporin 43kDa 0.0120208
MAP3K21 mitogen-activated protein kinase kinase kinase 21 0.0120041
LAMA4 laminin, alpha 4 0.0120002
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.011997
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.011975
NCOA4 nuclear receptor coactivator 4 0.0119673
PLIN3 perilipin 3 0.0119294
PLEKHM3 pleckstrin homology domain containing, family M, member 3 0.0118726
GPR107 G protein-coupled receptor 107 0.011816
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.0118127
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.0117953
OSBPL11 oxysterol binding protein-like 11 0.0117942
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.011787
BRD2 bromodomain containing 2 0.0117699
MGLL monoglyceride lipase 0.0117649
MICALL2 MICAL-like 2 0.0117639
CD47 CD47 molecule 0.0117184
LURAP1L leucine rich adaptor protein 1-like 0.0117078
CMYA5 cardiomyopathy associated 5 0.0117029
DSTN destrin (actin depolymerizing factor) 0.0116853
ADCY1 adenylate cyclase 1 (brain) 0.0116625
PTMA prothymosin, alpha 0.0116609
TDRD3 tudor domain containing 3 0.0116574
DAPK3 death-associated protein kinase 3 0.0116559
TOB1 transducer of ERBB2, 1 0.0116555
MACC1 metastasis associated in colon cancer 1 0.0116363
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0116269
CRACD capping protein inhibiting regulator of actin dynamics 0.0116133
USP34 ubiquitin specific peptidase 34 0.0116053
PLPP1 phospholipid phosphatase 1 0.011605
DOCK5 dedicator of cytokinesis 5 0.0115984
RPS12 ribosomal protein S12 0.0115945
RPL18 ribosomal protein L18 0.0115856
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.0115837

decreased expression

Symbol Name Standardized Value
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.185256
SULF2 sulfatase 2 -0.115025
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.104644
GFRA1 GDNF family receptor alpha 1 -0.101429
WWOX WW domain containing oxidoreductase -0.0977788
ESR1 estrogen receptor 1 -0.0929055
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0926546
GPC6 glypican 6 -0.0876854
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.0860746
PARD6B par-6 family cell polarity regulator beta -0.0808369
PARD3 par-3 family cell polarity regulator -0.0728054
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.072228
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0718926
SMYD3 SET and MYND domain containing 3 -0.0696975
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0691916
AGR2 anterior gradient 2 -0.0676581
MTDH metadherin -0.0657425
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0642647
BMP7 bone morphogenetic protein 7 -0.0635246
EMP2 epithelial membrane protein 2 -0.0629031
CALR calreticulin -0.0572792
PKM pyruvate kinase, muscle -0.0559617
LRP1B low density lipoprotein receptor-related protein 1B -0.0554366
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0550536
CCND1 cyclin D1 -0.0527907
IFI6 interferon, alpha-inducible protein 6 -0.051876
BIRC6 baculoviral IAP repeat containing 6 -0.0512495
MKI67 marker of proliferation Ki-67 -0.04613
ENO1 enolase 1, (alpha) -0.0456448
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0443459
CYRIB CYFIP related Rac1 interactor B -0.0438147
HDLBP high density lipoprotein binding protein -0.0434599
PBX3 pre-B-cell leukemia homeobox 3 -0.042862
ATAD2 ATPase family, AAA domain containing 2 -0.042263
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0421404
TENM3 teneurin transmembrane protein 3 -0.0417275
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0415079
PKP4 plakophilin 4 -0.0412158
FAF1 Fas (TNFRSF6) associated factor 1 -0.0410831
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0409288
SDK1 sidekick cell adhesion molecule 1 -0.0400944
UGDH UDP-glucose 6-dehydrogenase -0.0393555
ZNRF3 zinc and ring finger 3 -0.0392051
POTEF POTE ankyrin domain family, member F -0.0391157
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0390192
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0374467
NRCAM neuronal cell adhesion molecule -0.0372091
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.036942
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0365263
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0362263
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0359889
MSI2 musashi RNA-binding protein 2 -0.035743
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0349528
MED13 mediator complex subunit 13 -0.0349402
MACROD2 MACRO domain containing 2 -0.034327
GLG1 golgi glycoprotein 1 -0.0342632
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.0342018
DIAPH1 diaphanous-related formin 1 -0.0338379
PRKCA protein kinase C, alpha -0.0335226
TMEM150C transmembrane protein 150C -0.0325056
RANBP17 RAN binding protein 17 -0.0323585
JARID2 jumonji, AT rich interactive domain 2 -0.032008
MALRD1 MAM and LDL receptor class A domain containing 1 -0.031785
PRR11 proline rich 11 -0.0316131
RNF216 ring finger protein 216 -0.0315704
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0312812
TRPS1 trichorhinophalangeal syndrome I -0.0308512
KTN1 kinectin 1 (kinesin receptor) -0.0300929
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0299985
R3HDM1 R3H domain containing 1 -0.0296499
SMC4 structural maintenance of chromosomes 4 -0.0289612
TPX2 TPX2, microtubule-associated -0.0289348
SEPTIN9 septin 9 -0.028296
SLC38A1 solute carrier family 38, member 1 -0.0282944
FGF12 fibroblast growth factor 12 -0.0282942
RSL1D1 ribosomal L1 domain containing 1 -0.0282743
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0278609
PCDH7 protocadherin 7 -0.0278221
H3-3B H3.3 histone B -0.0278147
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0277345
ZMYND8 zinc finger, MYND-type containing 8 -0.0276163
PSPC1 paraspeckle component 1 -0.0272605
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0272285
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.0269325
NUP153 nucleoporin 153kDa -0.0267656
CANX calnexin -0.0264202
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0264014
RERG RAS-like, estrogen-regulated, growth inhibitor -0.0263632
RPS24 ribosomal protein S24 -0.0261636
SCFD2 sec1 family domain containing 2 -0.0260741
CKAP5 cytoskeleton associated protein 5 -0.0260219
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0260185
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0257619
PRKCE protein kinase C, epsilon -0.0257058
THADA thyroid adenoma associated -0.0256354
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0255615
CSDE1 cold shock domain containing E1, RNA-binding -0.0254506
TPD52L1 tumor protein D52-like 1 -0.0250284
PUS7 pseudouridylate synthase 7 (putative) -0.024961
PRKCSH protein kinase C substrate 80K-H -0.0248716
PRRC2C proline-rich coiled-coil 2C -0.0245901
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0245254
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0245157
LY6E lymphocyte antigen 6 complex, locus E -0.0242091
APOD apolipoprotein D -0.0241947
CCDC47 coiled-coil domain containing 47 -0.0240835
CREBBP CREB binding protein -0.0239306
PLXDC2 plexin domain containing 2 -0.0237497
NCOA2 nuclear receptor coactivator 2 -0.023738
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0235194
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0234798
NPDC1 neural proliferation, differentiation and control, 1 -0.0234388
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0234049
RPS8 ribosomal protein S8 -0.0232156
WAC WW domain containing adaptor with coiled-coil -0.0231611
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0227603
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.022678
MAP7 microtubule-associated protein 7 -0.0226371
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0226239
SPIDR scaffolding protein involved in DNA repair -0.0225856
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0225549
RPLP2 ribosomal protein, large, P2 -0.0224176
NECAB1 N-terminal EF-hand calcium binding protein 1 -0.0222806
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0222571
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0221882
TFF1 trefoil factor 1 -0.0221577
ACTN4 actinin, alpha 4 -0.0221072
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.022063
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0220454
TUG1 taurine up-regulated 1 (non-protein coding) -0.0220277
ZNF609 zinc finger protein 609 -0.0219581
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0219389
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.021758
RPL19 ribosomal protein L19 -0.0216804
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0216654
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0215116
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0214951
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.0214636
SFPQ splicing factor proline/glutamine-rich -0.0214316
CADM1 cell adhesion molecule 1 -0.0214187
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.021405
HM13 histocompatibility (minor) 13 -0.0212651
SERBP1 SERPINE1 mRNA binding protein 1 -0.0212262
TCERG1 transcription elongation regulator 1 -0.0212167
SPPL2A signal peptide peptidase like 2A -0.0212074
SENP6 SUMO1/sentrin specific peptidase 6 -0.0211648
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0211159
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0210211
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208902
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0207526
INVS inversin -0.0207498
TET2 tet methylcytosine dioxygenase 2 -0.0205861
XPO4 exportin 4 -0.0205551
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0205297
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0205208
THOC2 THO complex 2 -0.0204926
AURKA aurora kinase A -0.0204169
NCOA6 nuclear receptor coactivator 6 -0.0202144
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0202002
CADPS2 Ca++-dependent secretion activator 2 -0.0201057
PTGES2 prostaglandin E synthase 2 -0.0199547
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0197888
MRTFA myocardin related transcription factor A -0.019739
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0197125
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0196622
HELLS helicase, lymphoid-specific -0.0196495
RPN1 ribophorin I -0.0195753
BSG basigin (Ok blood group) -0.0195531
CDK6 cyclin-dependent kinase 6 -0.0195357
RNF24 ring finger protein 24 -0.0194557
GDI2 GDP dissociation inhibitor 2 -0.0194339
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.019414
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0193656
ZNF652 zinc finger protein 652 -0.0193576
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.0193491
CALU calumenin -0.0192916
TMX1 thioredoxin-related transmembrane protein 1 -0.0191711
SEC11A SEC11 homolog A (S. cerevisiae) -0.0190964
KIF4A kinesin family member 4A -0.0190804
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.0190592
DLG1 discs, large homolog 1 (Drosophila) -0.0190276
SFXN2 sideroflexin 2 -0.019018
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0189559
ZSWIM6 zinc finger, SWIM-type containing 6 -0.018935
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0189053
GSPT1 G1 to S phase transition 1 -0.0189049
MED13L mediator complex subunit 13-like -0.0188284
PRC1 protein regulator of cytokinesis 1 -0.0187921
ANKRD17 ankyrin repeat domain 17 -0.0187895
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0187814
VAV2 vav 2 guanine nucleotide exchange factor -0.0186082
RAB7A RAB7A, member RAS oncogene family -0.0185361
FREM2 FRAS1 related extracellular matrix protein 2 -0.018507
MGP matrix Gla protein -0.0184824
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0184724
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0183871
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0183259
PITPNA phosphatidylinositol transfer protein, alpha -0.0183068
COP1 COP1 E3 ubiquitin ligase -0.0182266
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0181542
HMCN1 hemicentin 1 -0.0180875
CDK17 cyclin-dependent kinase 17 -0.0180846
H1-10 H1.10 linker histone -0.0179953
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0179939
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0179891
TNPO1 transportin 1 -0.0179006
ALMS1 Alstrom syndrome protein 1 -0.0178526
EPCAM epithelial cell adhesion molecule -0.0178053
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0177831
RPS29 ribosomal protein S29 -0.0177794
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0176866
GRHL2 grainyhead-like 2 (Drosophila) -0.0176864
SYAP1 synapse associated protein 1 -0.0175885
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0175434
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0175185
TAOK3 TAO kinase 3 -0.0175052
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0174983
THBS1 thrombospondin 1 -0.0174917
SUMO2 small ubiquitin-like modifier 2 -0.017439
NRG3 neuregulin 3 -0.0174257
UBL3 ubiquitin-like 3 -0.0174102
PRKCI protein kinase C, iota -0.0173988
LONRF2 LON peptidase N-terminal domain and ring finger 2 -0.017395
ELOB elongin B -0.0173856
LTAP1 lipid transport auxiliary protein 1 -0.0173348
JPT2 Jupiter microtubule associated homolog 2 -0.0173064
STK24 serine/threonine kinase 24 -0.0172738
CKAP4 cytoskeleton-associated protein 4 -0.0172532
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0172384
NHSL1 NHS-like 1 -0.0171757
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0171667
MCM6 minichromosome maintenance complex component 6 -0.0171227
TRERF1 transcriptional regulating factor 1 -0.0170911
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0170054
NRF1 nuclear respiratory factor 1 -0.0169807
EEA1 early endosome antigen 1 -0.0169651
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0169376
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0168937
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0168724
CLTC clathrin, heavy chain (Hc) -0.0168512
TBC1D5 TBC1 domain family, member 5 -0.0168055
SKA2 spindle and kinetochore associated complex subunit 2 -0.0167847
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.016725
CCT7 chaperonin containing TCP1, subunit 7 (eta) -0.0167246
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.0166844
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0166417
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.01662
PTBP2 polypyrimidine tract binding protein 2 -0.0166022
ETF1 eukaryotic translation termination factor 1 -0.0165467
VTA1 vesicle (multivesicular body) trafficking 1 -0.016532
NAP1L1 nucleosome assembly protein 1-like 1 -0.0165139
RAB2A RAB2A, member RAS oncogene family -0.0164955
KNL1 kinetochore scaffold 1 -0.0164817
FOXK1 forkhead box K1 -0.0164524
RNASE3 ribonuclease, RNase A family, 3 -0.0164404
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0163477
MAST4 microtubule associated serine/threonine kinase family member 4 -0.016347
LMX1B LIM homeobox transcription factor 1, beta -0.0163079
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0163062
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0162247
SKP1 S-phase kinase-associated protein 1 -0.016214
EPHA4 EPH receptor A4 -0.0161966
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0161634
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0161627
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0161482
LDHA lactate dehydrogenase A -0.0161465
NUP107 nucleoporin 107kDa -0.0161373
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.0161273
MPHOSPH9 M-phase phosphoprotein 9 -0.0161006
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -0.0160684
TMEM164 transmembrane protein 164 -0.0159279
ZFHX3 zinc finger homeobox 3 -0.0159163
CD81 CD81 molecule -0.015916
BRCA2 breast cancer 2, early onset -0.0159069
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.015769
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0157389
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0157374
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0157357
FCHSD2 FCH and double SH3 domains 2 -0.0157276
TRIP12 thyroid hormone receptor interactor 12 -0.0156855
ANO6 anoctamin 6 -0.0156742
ZNF367 zinc finger protein 367 -0.0156371
ZFAND3 zinc finger, AN1-type domain 3 -0.0156263
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0156038
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0155652
CIP2A cellular inhibitor of PP2A -0.0155497
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.015528
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0155233
ARHGAP11B Rho GTPase activating protein 11B -0.0155158
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0154893
ELOVL1 ELOVL fatty acid elongase 1 -0.0154713
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0154538
NMD3 NMD3 ribosome export adaptor -0.0153917
HEATR1 HEAT repeat containing 1 -0.0153631
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.015351
CHD4 chromodomain helicase DNA binding protein 4 -0.0153306
FKBP4 FK506 binding protein 4, 59kDa -0.0153155
ANLN anillin, actin binding protein -0.0152675
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.0152168
TMPO thymopoietin -0.0151963
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0151791
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0151716
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0151658
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0151194
CEP128 centrosomal protein 128kDa -0.015109
PA2G4 proliferation-associated 2G4, 38kDa -0.0149926
UGCG UDP-glucose ceramide glucosyltransferase -0.0149821
TASOR2 transcription activation suppressor family member 2 -0.0149261
PTPRF protein tyrosine phosphatase, receptor type, F -0.0149235
CLINT1 clathrin interactor 1 -0.0148323
PTRH2 peptidyl-tRNA hydrolase 2 -0.0148294
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0146769
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0146766
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.014622
PPP5C protein phosphatase 5, catalytic subunit -0.0145944
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0145642
DTNB dystrobrevin, beta -0.0145443
DNM1L dynamin 1-like -0.0145382
PRPF8 pre-mRNA processing factor 8 -0.0144739
TRAPPC10 trafficking protein particle complex 10 -0.0144474
PNN pinin, desmosome associated protein -0.0144458
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0144343
RHOBTB3 Rho-related BTB domain containing 3 -0.0144122
FKBP5 FK506 binding protein 5 -0.0143206
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0143205
RANGAP1 Ran GTPase activating protein 1 -0.0143148
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.014277
KDM6A lysine (K)-specific demethylase 6A -0.0142758
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0142552
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0142255
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0142152
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0141946
NUP205 nucleoporin 205kDa -0.0141605
PTEN phosphatase and tensin homolog -0.0141496
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -0.0141209
GMDS GDP-mannose 4,6-dehydratase -0.0141126
IPO7 importin 7 -0.01411
EIF3I eukaryotic translation initiation factor 3, subunit I -0.0141055
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.014085
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -0.0140812
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0140793
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0140536
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0140246
DLC1 DLC1 Rho GTPase activating protein -0.0140179
RPL39 ribosomal protein L39 -0.0140062
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0139941
SCAMP2 secretory carrier membrane protein 2 -0.0139794
RBMX RNA binding motif protein, X-linked -0.0139665
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.0139527
ITGAV integrin, alpha V -0.0139494
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0138966
PDZRN3 PDZ domain containing ring finger 3 -0.0138795
USP15 ubiquitin specific peptidase 15 -0.0138192
TMEM132A transmembrane protein 132A -0.0137234
SPOPL speckle-type POZ protein-like -0.0136749
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0136509
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0136343
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.013632
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.0136227
IPO9 importin 9 -0.0136132
DBF4 DBF4 zinc finger -0.0136122
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0135971
DAD1 defender against cell death 1 -0.0135795
COL4A5 collagen, type IV, alpha 5 -0.0135438
NOP58 NOP58 ribonucleoprotein -0.0135385
MCM4 minichromosome maintenance complex component 4 -0.0135092
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.0134733
MAPK1 mitogen-activated protein kinase 1 -0.0134491
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.013443
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0134213
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -0.0134144
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0133644
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0133637
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0133523
H4C3 H4 clustered histone 3 -0.0133431
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0133048
UTP4 UTP4 small subunit processome component -0.0132917
SH3GLB2 SH3-domain GRB2-like endophilin B2 -0.013251
SFXN5 sideroflexin 5 -0.0132073
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0132001
WDFY3 WD repeat and FYVE domain containing 3 -0.0131846
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0131286
RC3H2 ring finger and CCCH-type domains 2 -0.0131268
MBD5 methyl-CpG binding domain protein 5 -0.0131216
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.013075
LRRC58 leucine rich repeat containing 58 -0.0130451
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0130276
MIA3 melanoma inhibitory activity family, member 3 -0.0130243
KYNU kynureninase -0.0130052
RPS10 ribosomal protein S10 -0.0129601
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0129524
TMEM245 transmembrane protein 245 -0.0129405
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -0.0129021
LIN7A lin-7 homolog A (C. elegans) -0.0128999
TNPO2 transportin 2 -0.0128959
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -0.0128847
GATAD2A GATA zinc finger domain containing 2A -0.0128626
NCOR1 nuclear receptor corepressor 1 -0.0128608
OSBPL10 oxysterol binding protein-like 10 -0.0128505
KHSRP KH-type splicing regulatory protein -0.0128498
RNF4 ring finger protein 4 -0.0128454
STRBP spermatid perinuclear RNA binding protein -0.0128118
TTC19 tetratricopeptide repeat domain 19 -0.0128052
CUL3 cullin 3 -0.0127971
IWS1 IWS1 homolog (S. cerevisiae) -0.0127936
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0127772
SETD5 SET domain containing 5 -0.012749
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0127393
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0127252
BID BH3 interacting domain death agonist -0.0127229
FANCL Fanconi anemia, complementation group L -0.012722
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0127066
XPO1 exportin 1 -0.0127006
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0126837
SFXN1 sideroflexin 1 -0.01265
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -0.0126275
URGCP upregulator of cell proliferation -0.0126022
SRSF10 serine/arginine-rich splicing factor 10 -0.0125726
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0125667
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.0125599
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0125436
CCDC14 coiled-coil domain containing 14 -0.0125381
PERP PERP, TP53 apoptosis effector -0.0125286
ZHX3 zinc fingers and homeoboxes 3 -0.0125247
NUP155 nucleoporin 155kDa -0.0125005
WASL Wiskott-Aldrich syndrome-like -0.0124863
MGST1 microsomal glutathione S-transferase 1 -0.0124651
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0124562
AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.0124131
GSTCD glutathione S-transferase, C-terminal domain containing -0.0124118
FERMT2 fermitin family member 2 -0.0123928
GRN granulin -0.0123869
NDC80 NDC80 kinetochore complex component -0.0123854
TNPO3 transportin 3 -0.0123578
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0123335
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0122704
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0122409
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0122394
EMB embigin -0.0122327
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -0.012224
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -0.0122056
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -0.0121438
SPATS2 spermatogenesis associated, serine-rich 2 -0.0121161
URI1 URI1, prefoldin-like chaperone -0.0121144
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.012071
RBM14-RBM4 RBM14-RBM4 readthrough -0.0120622
CDV3 CDV3 homolog (mouse) -0.0120576
CLPTM1L CLPTM1-like -0.0120284
KIF2C kinesin family member 2C -0.0120215
ZNF592 zinc finger protein 592 -0.0120045
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0119869
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0119612
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0119598
BRI3BP BRI3 binding protein -0.0119468
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0119394
NPNT nephronectin -0.0119039
FBXW11 F-box and WD repeat domain containing 11 -0.0118868
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0118836
AKIRIN1 akirin 1 -0.0118831
LIN52 lin-52 DREAM MuvB core complex component -0.0118799
SORCS2 sortilin-related VPS10 domain containing receptor 2 -0.0118325
CHSY1 chondroitin sulfate synthase 1 -0.0118239
CDCA4 cell division cycle associated 4 -0.0118074
SRSF7 serine/arginine-rich splicing factor 7 -0.0118052
PARD3B par-3 family cell polarity regulator beta -0.0117796
PTPRG protein tyrosine phosphatase, receptor type, G -0.0117639
PHTF1 putative homeodomain transcription factor 1 -0.0117604
NUP188 nucleoporin 188kDa -0.011746
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -0.0117353
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 -0.0117136
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -0.0116518
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0116421
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0116408
METTL8 methyltransferase like 8 -0.0116402
MCM7 minichromosome maintenance complex component 7 -0.0116401
CLSTN2 calsyntenin 2 -0.0116369
STRN3 striatin, calmodulin binding protein 3 -0.0116348
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0116314
FANCI Fanconi anemia, complementation group I -0.0115575
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0115553
EIF3G eukaryotic translation initiation factor 3, subunit G -0.011498
FAM234A family with sequence similarity 234 member A -0.0114739
ZBTB35 zinc finger and BTB domain containing 35 -0.0114727
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0114702
USF3 upstream transcription factor family member 3 -0.0114571
ASF1B anti-silencing function 1B histone chaperone -0.0114541
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -0.0114522
SGO2 shugoshin 2 -0.011451
SLC35B1 solute carrier family 35, member B1 -0.0114046
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0113722
TOP1 topoisomerase (DNA) I -0.011363
DNMBP dynamin binding protein -0.0113627
PNPLA8 patatin-like phospholipase domain containing 8 -0.0113591
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0113497
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -0.0113251
CEP15 centrosomal protein 15 -0.0113028
DIAPH3 diaphanous-related formin 3 -0.0112929
RCL1 RNA terminal phosphate cyclase-like 1 -0.0112856
TUFM Tu translation elongation factor, mitochondrial -0.0112328
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0112132