MCF7_Alendronate sodium trihydrate_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 10µM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_Alendronate sodium trihydrate_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.238949
HSPB1 heat shock 27kDa protein 1 0.160372
DSPP dentin sialophosphoprotein 0.157294
FDPS farnesyl diphosphate synthase 0.131527
SQLE squalene epoxidase 0.101862
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0936819
TFF1 trefoil factor 1 0.0922215
KRT19 keratin 19, type I 0.0903074
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0825489
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0775623
SPTSSB serine palmitoyltransferase, small subunit B 0.0756015
DSCAM Down syndrome cell adhesion molecule 0.0728913
BCAS1 breast carcinoma amplified sequence 1 0.0652982
ABHD2 abhydrolase domain containing 2 0.0643066
NEBL nebulette 0.0631046
BCAS3 breast carcinoma amplified sequence 3 0.0630199
RPS3 ribosomal protein S3 0.0616105
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0609125
LDLR low density lipoprotein receptor 0.0603459
MALRD1 MAM and LDL receptor class A domain containing 1 0.0602178
RPL18 ribosomal protein L18 0.0583879
XBP1 X-box binding protein 1 0.0543368
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0539075
BRWD1 bromodomain and WD repeat domain containing 1 0.0534961
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0533724
UBE2H ubiquitin-conjugating enzyme E2H 0.0521111
ENSA endosulfine alpha 0.0516183
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0516048
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0512536
OGA O-GlcNAcase 0.0511853
KMT2A lysine (K)-specific methyltransferase 2A 0.0509743
NAV1 neuron navigator 1 0.0508458
FOXO3 forkhead box O3 0.0502808
TXNIP thioredoxin interacting protein 0.0502364
RPS2 ribosomal protein S2 0.0502065
MVD mevalonate (diphospho) decarboxylase 0.0496858
DTNA dystrobrevin, alpha 0.0486255
KRT18 keratin 18, type I 0.0477653
INSIG1 insulin induced gene 1 0.0474981
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0472031
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0447854
GOLGB1 golgin B1 0.0442517
RDX radixin 0.0434406
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0426502
GATA3 GATA binding protein 3 0.0425454
ZNF217 zinc finger protein 217 0.0424745
DHCR7 7-dehydrocholesterol reductase 0.0421316
RPLP0 ribosomal protein, large, P0 0.0420301
AHNAK AHNAK nucleoprotein 0.0419479
IGF1R insulin-like growth factor 1 receptor 0.0412216
ATP9A ATPase, class II, type 9A 0.0408204
TRIM56 tripartite motif containing 56 0.040798
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0407019
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0391274
PATJ PATJ crumbs cell polarity complex component 0.0389358
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0386481
DST dystonin 0.0380565
KLF6 Kruppel-like factor 6 0.0377062
NECAB1 N-terminal EF-hand calcium binding protein 1 0.0374961
SGMS1 sphingomyelin synthase 1 0.0369001
ZFHX3 zinc finger homeobox 3 0.036845
MUSK muscle, skeletal, receptor tyrosine kinase 0.0368039
PBX1 pre-B-cell leukemia homeobox 1 0.0366953
FGF13 fibroblast growth factor 13 0.0365915
TBL1X transducin (beta)-like 1X-linked 0.0364079
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0363576
NBEAL1 neurobeachin-like 1 0.0363493
SLC38A2 solute carrier family 38, member 2 0.036196
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0352627
AREG amphiregulin 0.0344909
PCED1B PC-esterase domain containing 1B 0.0344825
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0343694
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0338835
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0338588
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0337942
BPTF bromodomain PHD finger transcription factor 0.0337238
CHD9 chromodomain helicase DNA binding protein 9 0.0334265
ADGRG6 adhesion G protein-coupled receptor G6 0.0333305
WIPF1 WAS/WASL interacting protein family, member 1 0.0331252
LPIN1 lipin 1 0.0326534
FOXP1 forkhead box P1 0.032403
MYH14 myosin, heavy chain 14, non-muscle 0.0323762
RPL15 ribosomal protein L15 0.0323759
NRIP1 nuclear receptor interacting protein 1 0.0323388
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0323068
SOX4 SRY (sex determining region Y)-box 4 0.0322971
GATAD2B GATA zinc finger domain containing 2B 0.0322179
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0321822
PACS1 phosphofurin acidic cluster sorting protein 1 0.0317412
PLXDC2 plexin domain containing 2 0.0315429
GREB1 growth regulation by estrogen in breast cancer 1 0.0313851
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.031348
LGALS3 lectin, galactoside-binding, soluble, 3 0.0311256
IQCN IQ motif containing N 0.031052
CFAP97D1 CFAP97 domain containing 1 0.0309748
CHD6 chromodomain helicase DNA binding protein 6 0.0305967
KLHL24 kelch-like family member 24 0.0305039
PAWR PRKC, apoptosis, WT1, regulator 0.0302987
WASF2 WAS protein family, member 2 0.0300956
ANKRD11 ankyrin repeat domain 11 0.0298787
RPS8 ribosomal protein S8 0.0297297
ZBTB20 zinc finger and BTB domain containing 20 0.0296901
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0296039
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0294285
RPS5 ribosomal protein S5 0.0290266
GSK3B glycogen synthase kinase 3 beta 0.0289297
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0287906
JUN jun proto-oncogene 0.0285564
TMOD3 tropomodulin 3 (ubiquitous) 0.0284221
USP32 ubiquitin specific peptidase 32 0.0278926
ATXN3 ataxin 3 0.027782
GPR137C G protein-coupled receptor 137C 0.0277168
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.0275456
ITPRID2 ITPR interacting domain containing 2 0.0273453
MORC4 MORC family CW-type zinc finger 4 0.0273241
IQGAP1 IQ motif containing GTPase activating protein 1 0.0272289
IGFBP4 insulin-like growth factor binding protein 4 0.0270419
RHOBTB3 Rho-related BTB domain containing 3 0.0269035
MAPK6 mitogen-activated protein kinase 6 0.0266507
KDM5B lysine (K)-specific demethylase 5B 0.026583
MYO16 myosin XVI 0.0261159
TGFB2 transforming growth factor, beta 2 0.0258915
ZHX2 zinc fingers and homeoboxes 2 0.025748
WDR59 WD repeat domain 59 0.0255515
FOXN3 forkhead box N3 0.0255482
PTPRF protein tyrosine phosphatase, receptor type, F 0.0255229
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0253894
RACK1 receptor for activated C kinase 1 0.025293
MRPL13 mitochondrial ribosomal protein L13 0.0252586
GIGYF2 GRB10 interacting GYF protein 2 0.0252447
EIF1 eukaryotic translation initiation factor 1 0.0251962
RPL28 ribosomal protein L28 0.0251541
MYO9A myosin IXA 0.0247669
RPS11 ribosomal protein S11 0.0247436
ELOVL6 ELOVL fatty acid elongase 6 0.0247212
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.024639
EZR ezrin 0.0245389
MACC1 metastasis associated in colon cancer 1 0.0244063
MLXIP MLX interacting protein 0.0241856
USP34 ubiquitin specific peptidase 34 0.0241497
LOC112694756 uncharaterized LOC112694756 0.0241443
PGPEP1 pyroglutamyl-peptidase I 0.0239748
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0239609
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0238592
SIL1 SIL1 nucleotide exchange factor 0.0238524
UBE2B ubiquitin-conjugating enzyme E2B 0.0238145
PHF3 PHD finger protein 3 0.0238063
CLDN3 claudin 3 0.0235608
RPL10A ribosomal protein L10a 0.0235406
RIN2 Ras and Rab interactor 2 0.0231528
PCLO piccolo presynaptic cytomatrix protein 0.0231362
PRKCH protein kinase C, eta 0.0231196
MAML3 mastermind-like 3 (Drosophila) 0.0230936
LPP LIM domain containing preferred translocation partner in lipoma 0.0229878
RPS23 ribosomal protein S23 0.0229446
GAB2 GRB2-associated binding protein 2 0.0228592
CPA6 carboxypeptidase A6 0.0228281
SAMD12 sterile alpha motif domain containing 12 0.0227024
ABHD18 abhydrolase domain containing 18 0.0226466
SERINC5 serine incorporator 5 0.0226416
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0226152
MIPOL1 mirror-image polydactyly 1 0.0225242
RPS29 ribosomal protein S29 0.0225008
CEP95 centrosomal protein 95kDa 0.0223233
PSD3 pleckstrin and Sec7 domain containing 3 0.0222407
KRT80 keratin 80, type II 0.0221812
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0220306
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0220059
SKIL SKI-like proto-oncogene 0.0219712
ZNF148 zinc finger protein 148 0.0219513
SH3D19 SH3 domain containing 19 0.0219406
RPL11 ribosomal protein L11 0.0219137
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0218989
RNFT1 ring finger protein, transmembrane 1 0.0218623
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.0218023
RPL14 ribosomal protein L14 0.0217422
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0216602
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0216575
CBR4 carbonyl reductase 4 0.0216518
KLHL36 kelch-like family member 36 0.0216396
LMBR1 limb development membrane protein 1 0.0215996
NIPBL Nipped-B homolog (Drosophila) 0.0215766
DSTYK dual serine/threonine and tyrosine protein kinase 0.0215246
RPL37A ribosomal protein L37a 0.0214402
SPPL2A signal peptide peptidase like 2A 0.0213875
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.0213558
MSMO1 methylsterol monooxygenase 1 0.0213487
STK38 serine/threonine kinase 38 0.0213365
UBC ubiquitin C 0.0213059
TUBA1A tubulin, alpha 1a 0.0212313
MRTFA myocardin related transcription factor A 0.0209299
N4BP2L2 NEDD4 binding protein 2-like 2 0.0207877
FBXW11 F-box and WD repeat domain containing 11 0.0207694
RPS21 ribosomal protein S21 0.0207288
IER5L immediate early response 5-like 0.020672
ATOSA atos homolog A 0.0206153
NPC2 Niemann-Pick disease, type C2 0.0204302
GDF15 growth differentiation factor 15 0.020361
KIAA1217 KIAA1217 0.0203036
COBL cordon-bleu WH2 repeat protein 0.0201907
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0201701
ALCAM activated leukocyte cell adhesion molecule 0.0201543
SYTL2 synaptotagmin-like 2 0.0200751
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0200646
MYO1D myosin ID 0.0200334
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0199968
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0199865
BBX bobby sox homolog (Drosophila) 0.0199047
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.0198245
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0198115
REST RE1-silencing transcription factor 0.0197414
RHOB ras homolog family member B 0.0197306
TESK2 testis-specific kinase 2 0.0197248
ICA1 islet cell autoantigen 1, 69kDa 0.0196792
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0196491
TPD52 tumor protein D52 0.0195333
SREBF2 sterol regulatory element binding transcription factor 2 0.0195126
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0195019
SHTN1 shootin 1 0.0194934
DDIT4 DNA-damage-inducible transcript 4 0.019425
TMEM120B transmembrane protein 120B 0.0193092
LARP1 La ribonucleoprotein domain family, member 1 0.0192705
CST3 cystatin C 0.0192431
TCAF1 TRPM8 channel-associated factor 1 0.0192378
MXD4 MAX dimerization protein 4 0.0192142
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0191973
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0190888
CXXC5 CXXC finger protein 5 0.0190636
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0188862
SEC31A SEC31 homolog A (S. cerevisiae) 0.0188685
GLCCI1 glucocorticoid induced 1 0.0188477
ZDHHC7 zinc finger, DHHC-type containing 7 0.0188299
ARHGAP12 Rho GTPase activating protein 12 0.0187916
TGOLN2 trans-golgi network protein 2 0.01875
MLPH melanophilin 0.018676
KIF5B kinesin family member 5B 0.0186085
MAP7 microtubule-associated protein 7 0.0185922
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.01859
NINL ninein-like 0.0184075
CDT1 chromatin licensing and DNA replication factor 1 0.0183745
CUEDC1 CUE domain containing 1 0.0183421
MRPS18B mitochondrial ribosomal protein S18B 0.0183081
SMIM14 small integral membrane protein 14 0.0182795
RPL13A ribosomal protein L13a 0.0182773
ULK1 unc-51 like autophagy activating kinase 1 0.0182759
NEK8 NIMA-related kinase 8 0.0182041
HIP1 huntingtin interacting protein 1 0.0182021
UTRN utrophin 0.0181882
VEZF1 vascular endothelial zinc finger 1 0.0181571
PNISR PNN-interacting serine/arginine-rich protein 0.0181392
BTG1 B-cell translocation gene 1, anti-proliferative 0.018131
ESYT2 extended synaptotagmin-like protein 2 0.0181306
DEPDC5 DEP domain containing 5 0.0180963
ZNF703 zinc finger protein 703 0.0180663
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.0180593
STC2 stanniocalcin 2 0.0179701
TUT7 terminal uridylyl transferase 7 0.0179666
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0179665
ANKRD28 ankyrin repeat domain 28 0.0178895
MPHOSPH8 M-phase phosphoprotein 8 0.0178366
SOS1 son of sevenless homolog 1 (Drosophila) 0.0177776
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0177673
RPS13 ribosomal protein S13 0.0177033
TOB1 transducer of ERBB2, 1 0.0176433
ANKRD13C ankyrin repeat domain 13C 0.0176354
MARF1 meiosis regulator and mRNA stability factor 1 0.0176123
DHCR24 24-dehydrocholesterol reductase 0.0176102
POGZ pogo transposable element with ZNF domain 0.0175408
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0175277
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0174387
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0174162
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.01737
ANXA2 annexin A2 0.0173681
HOOK2 hook microtubule-tethering protein 2 0.0173078
GABPB2 GA binding protein transcription factor, beta subunit 2 0.0172793
R3HDM2 R3H domain containing 2 0.0172563
ACLY ATP citrate lyase 0.0172527
SVIL supervillin 0.0172129
PER3 period circadian clock 3 0.0171331
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.017109
CD2AP CD2-associated protein 0.0171011
CALCR calcitonin receptor 0.0169729
FLNB filamin B, beta 0.0168936
SPG11 spastic paraplegia 11 (autosomal recessive) 0.016786
BCL2 B-cell CLL/lymphoma 2 0.0167737
RPL12 ribosomal protein L12 0.0167731
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0167463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0167311
HDAC8 histone deacetylase 8 0.0167167
SYT1 synaptotagmin I 0.0166726
TET3 tet methylcytosine dioxygenase 3 0.0166636
MUC16 mucin 16, cell surface associated 0.0166445
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0166125
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0165939
FBXO42 F-box protein 42 0.0165685
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0165333
SEPTIN6 septin 6 0.016478
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0162299
CEMIP2 cell migration inducing hyaluronidase 2 0.0162054
MB21D2 Mab-21 domain containing 2 0.0161633
PTMA prothymosin, alpha 0.0161224
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0161139
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 0.0160422
RPS9 ribosomal protein S9 0.015965
AAK1 AP2 associated kinase 1 0.0159261
TMED8 transmembrane emp24 protein transport domain containing 8 0.0159058
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0158692
LMNA lamin A/C 0.0158438
YPEL1 yippee-like 1 (Drosophila) 0.0158345
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0157648
THSD4 thrombospondin, type I, domain containing 4 0.0157437
RPS12 ribosomal protein S12 0.0157436
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0157091
PGR progesterone receptor 0.0156965
ATXN2 ataxin 2 0.0156929
CCN5 cellular communication network factor 5 0.0156774
CLIP1 CAP-GLY domain containing linker protein 1 0.0156638
NPC1 Niemann-Pick disease, type C1 0.0155917
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0154027
GATAD2A GATA zinc finger domain containing 2A 0.015381
WSB1 WD repeat and SOCS box containing 1 0.0153726
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0153543
BRD3 bromodomain containing 3 0.0153408
SERP1 stress-associated endoplasmic reticulum protein 1 0.0152219
GAN gigaxonin 0.0152149
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0152108
STAG2 stromal antigen 2 0.0151616
NUDCD3 NudC domain containing 3 0.0151184
SFTPA2 surfactant protein A2 0.0151163
YPEL3 yippee-like 3 (Drosophila) 0.0151127
KRIT1 KRIT1, ankyrin repeat containing 0.0150713
NFE2L1 nuclear factor, erythroid 2-like 1 0.0150708
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0150705
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.0150525
ADGRV1 adhesion G protein-coupled receptor V1 0.0150255
MAVS mitochondrial antiviral signaling protein 0.0149973
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0149795
IRF2BPL interferon regulatory factor 2 binding protein-like 0.0149741
TOM1L1 target of myb1 (chicken)-like 1 0.0149404
DNAH14 dynein, axonemal, heavy chain 14 0.0148644
SQSTM1 sequestosome 1 0.0148397
BICRAL BICRA like chromatin remodeling complex associated protein 0.0148063
EEIG2 EEIG family member 2 0.0147695
RPS10 ribosomal protein S10 0.0147633
THRAP3 thyroid hormone receptor associated protein 3 0.014752
SELENOI selenoprotein I 0.0146798
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0146627
IGBP1 immunoglobulin (CD79A) binding protein 1 0.0146514
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 0.0146448
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0146218
TM7SF2 transmembrane 7 superfamily member 2 0.0146148
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0145794
SPPL3 signal peptide peptidase like 3 0.0145554
FAM174B family with sequence similarity 174, member B 0.0144626
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0144474
PRXL2A peroxiredoxin like 2A 0.0144156
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0144148
WASHC4 WASH complex subunit 4 0.0143721
PRR14L proline rich 14-like 0.0143424
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0143149
RNF213 ring finger protein 213 0.014295
OPHN1 oligophrenin 1 0.0142125
PTK2 protein tyrosine kinase 2 0.0141444
RPL34 ribosomal protein L34 0.0141168
CMYA5 cardiomyopathy associated 5 0.0140988
S100A14 S100 calcium binding protein A14 0.0140792
GOLGA2 golgin A2 0.0140301
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0140234
TUBGCP2 tubulin, gamma complex associated protein 2 0.0139631
RHOD ras homolog family member D 0.0139233
PHF20 PHD finger protein 20 0.0138659
CFAP44 cilia and flagella associated protein 44 0.013852
PRSS8 protease, serine, 8 0.0138471
PNPLA8 patatin-like phospholipase domain containing 8 0.0138124
NRBP1 nuclear receptor binding protein 1 0.0137923
SAMD4A sterile alpha motif domain containing 4A 0.0137792
NPEPPS aminopeptidase puromycin sensitive 0.0136203
SUMF1 sulfatase modifying factor 1 0.0135683
NKTR natural killer cell triggering receptor 0.0135681
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0135664
TCF12 transcription factor 12 0.0135501
TACSTD2 tumor-associated calcium signal transducer 2 0.013544
SP100 SP100 nuclear antigen 0.0135413
TMCC1 transmembrane and coiled-coil domain family 1 0.0135403
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0135122
RPSA ribosomal protein SA 0.0134449
NXNL2 nucleoredoxin-like 2 0.013444
SLC35E1 solute carrier family 35, member E1 0.0134316
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0134293
RPS18 ribosomal protein S18 0.0134276
RPS16 ribosomal protein S16 0.013421
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.013418
L2HGDH L-2-hydroxyglutarate dehydrogenase 0.0134125
CAPN9 calpain 9 0.0133939
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0133872
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0133774
CSAD cysteine sulfinic acid decarboxylase 0.0133631
SNX29 sorting nexin 29 0.0133512
RICTOR RPTOR independent companion of MTOR, complex 2 0.0133457
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.013341
DCAF5 DDB1 and CUL4 associated factor 5 0.0133186
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.013256
PHF21A PHD finger protein 21A 0.0132478
MAP2K2 mitogen-activated protein kinase kinase 2 0.0131933
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.0131885
ZER1 zyg-11 related, cell cycle regulator 0.013183
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0131523
RABGAP1 RAB GTPase activating protein 1 0.0131256
SPNS1 spinster homolog 1 (Drosophila) 0.0130889
USP11 ubiquitin specific peptidase 11 0.0130887
MTPN myotrophin 0.0130803
SNX27 sorting nexin family member 27 0.0130511
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.0130112
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0129515
PKNOX1 PBX/knotted 1 homeobox 1 0.0129289
RPS4X ribosomal protein S4, X-linked 0.0129107
ZNF37A zinc finger protein 37A 0.012908
MYO15B myosin XVB 0.0128981
RAD9A RAD9 homolog A (S. pombe) 0.0128911
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.0128718
TGIF1 TGFB-induced factor homeobox 1 0.0128539
SDC4 syndecan 4 0.0128337
ZFC3H1 zinc finger, C3H1-type containing 0.0128273
REXO2 RNA exonuclease 2 0.0128051
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0127495
TSG101 tumor susceptibility 101 0.0127372
ATF5 activating transcription factor 5 0.01271
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0126782
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0126582
PANK3 pantothenate kinase 3 0.0126534
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0126365
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.0126227
BTBD7 BTB (POZ) domain containing 7 0.0126123
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.0126069
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0126068
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.012586
VGLL4 vestigial-like family member 4 0.0125698
RNF13 ring finger protein 13 0.0125493
HELZ helicase with zinc finger 0.0125241
IER3 immediate early response 3 0.012511
UBA6 ubiquitin-like modifier activating enzyme 6 0.0124966
COX5B cytochrome c oxidase subunit Vb 0.012493
RSF1 remodeling and spacing factor 1 0.0124902
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.01249
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0124799
KIF16B kinesin family member 16B 0.0124656
DNM1 dynamin 1 0.0124378
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0124361
ARHGAP21 Rho GTPase activating protein 21 0.0124025
FAXDC2 fatty acid hydroxylase domain containing 2 0.012395
TMC4 transmembrane channel-like 4 0.0123518
RPL35A ribosomal protein L35a 0.0123495
UBXN7 UBX domain protein 7 0.0123388
NAV2 neuron navigator 2 0.0123127
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0123117
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0122814
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0122702
RAD51B RAD51 paralog B 0.0122415
RNF43 ring finger protein 43 0.0122356
BCAR1 breast cancer anti-estrogen resistance 1 0.0122279
SPAG9 sperm associated antigen 9 0.012222
SPATS2 spermatogenesis associated, serine-rich 2 0.0122117
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.0121781
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.0121767
XRN2 5'-3' exoribonuclease 2 0.0121457
PRRC2C proline-rich coiled-coil 2C 0.0121245
RBBP7 retinoblastoma binding protein 7 0.0120946
PRUNE2 prune homolog 2 (Drosophila) 0.0120835
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0120731
POU2F1 POU class 2 homeobox 1 0.0120487
WDR26 WD repeat domain 26 0.0120274
S100A10 S100 calcium binding protein A10 0.0120272
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.0120254
HOMER2 homer scaffolding protein 2 0.0120108
TMEM260 transmembrane protein 260 0.0120056
CDC25B cell division cycle 25B 0.011998
CREBRF CREB3 regulatory factor 0.0119878
ARL3 ADP-ribosylation factor-like 3 0.0119543
HIPK3 homeodomain interacting protein kinase 3 0.0119489
HDGF hepatoma-derived growth factor 0.0119361
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.0119191
DAND5 DAN domain family member 5, BMP antagonist 0.0118958
TMSB10 thymosin beta 10 0.0118928
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0118672
PCYOX1 prenylcysteine oxidase 1 0.0118629
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.0118583
SENP5 SUMO1/sentrin specific peptidase 5 0.0118576
NCKAP1 NCK-associated protein 1 0.0118302
RBM47 RNA binding motif protein 47 0.0118102
LIMD1 LIM domains containing 1 0.0117827
UBE2O ubiquitin-conjugating enzyme E2O 0.0117697
KEAP1 kelch-like ECH-associated protein 1 0.0117577
SASH1 SAM and SH3 domain containing 1 0.0117499
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0116949
BLTP1 bridge-like lipid transfer protein family member 1 0.011646
ARRDC3 arrestin domain containing 3 0.0116457
OXR1 oxidation resistance 1 0.011638
TACC1 transforming, acidic coiled-coil containing protein 1 0.0116087
ZNF785 zinc finger protein 785 0.0115939
RAB22A RAB22A, member RAS oncogene family 0.0115618

decreased expression

Symbol Name Standardized Value
SULF2 sulfatase 2 -0.154271
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142023
GFRA1 GDNF family receptor alpha 1 -0.121807
BMP7 bone morphogenetic protein 7 -0.102423
ESR1 estrogen receptor 1 -0.0985977
KRT8 keratin 8, type II -0.0926427
TRIM37 tripartite motif containing 37 -0.0902198
LRP1B low density lipoprotein receptor-related protein 1B -0.0865611
WWOX WW domain containing oxidoreductase -0.0849003
GPC6 glypican 6 -0.0804016
PBX3 pre-B-cell leukemia homeobox 3 -0.0754532
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0701839
PKM pyruvate kinase, muscle -0.06613
AGR2 anterior gradient 2 -0.0608367
MSI2 musashi RNA-binding protein 2 -0.0561892
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0560813
POTEF POTE ankyrin domain family, member F -0.0549472
EMP2 epithelial membrane protein 2 -0.0547365
BSG basigin (Ok blood group) -0.0536414
PARD6B par-6 family cell polarity regulator beta -0.0520839
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0513485
PARD3 par-3 family cell polarity regulator -0.0492951
ENO1 enolase 1, (alpha) -0.0482288
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.0475118
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.046423
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0460488
PRR11 proline rich 11 -0.0442272
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0438727
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0433275
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0431778
DIAPH1 diaphanous-related formin 1 -0.0429373
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0427736
PTPRG protein tyrosine phosphatase, receptor type, G -0.0418245
ZMYND8 zinc finger, MYND-type containing 8 -0.0412567
CANX calnexin -0.041232
CALR calreticulin -0.0404477
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0401784
ZMYM2 zinc finger, MYM-type 2 -0.0398027
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0396956
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0394762
NRCAM neuronal cell adhesion molecule -0.0393649
GPHN gephyrin -0.0389575
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0384914
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0366156
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.035847
MKI67 marker of proliferation Ki-67 -0.0358106
ZNF609 zinc finger protein 609 -0.0356749
NCAM2 neural cell adhesion molecule 2 -0.0356433
ATAD2 ATPase family, AAA domain containing 2 -0.0351574
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0345986
PRKCE protein kinase C, epsilon -0.0337121
CA12 carbonic anhydrase XII -0.0336794
TRIM33 tripartite motif containing 33 -0.0335612
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.032657
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0323961
TMEM178B transmembrane protein 178B -0.0322818
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0321853
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0321724
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0318911
ACTN4 actinin, alpha 4 -0.0318724
NCOA3 nuclear receptor coactivator 3 -0.031262
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0311678
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0311657
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0305411
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0305141
GMDS GDP-mannose 4,6-dehydratase -0.0304193
FKBP4 FK506 binding protein 4, 59kDa -0.0303514
NCOA2 nuclear receptor coactivator 2 -0.0296526
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0290066
MED12L mediator complex subunit 12-like -0.0289156
GSE1 Gse1 coiled-coil protein -0.0288739
TNRC18 trinucleotide repeat containing 18 -0.0283556
FAF1 Fas (TNFRSF6) associated factor 1 -0.0282929
LY6E lymphocyte antigen 6 complex, locus E -0.0281451
VAV2 vav 2 guanine nucleotide exchange factor -0.0280838
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0279708
TUBD1 tubulin, delta 1 -0.0279482
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0279406
STK24 serine/threonine kinase 24 -0.027556
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0273633
MED13 mediator complex subunit 13 -0.0272457
GPATCH2 G patch domain containing 2 -0.0271735
DSTN destrin (actin depolymerizing factor) -0.0270925
ZFAND3 zinc finger, AN1-type domain 3 -0.0266576
NPDC1 neural proliferation, differentiation and control, 1 -0.0259439
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0255508
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.025483
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0254489
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0252898
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0250067
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0248804
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0248323
TPM4 tropomyosin 4 -0.0247821
TMEM150C transmembrane protein 150C -0.0246819
SCAMP2 secretory carrier membrane protein 2 -0.0245785
ETF1 eukaryotic translation termination factor 1 -0.0243418
MIDEAS mitotic deacetylase associated SANT domain protein -0.0240973
UGDH UDP-glucose 6-dehydrogenase -0.0240056
UBE3C ubiquitin protein ligase E3C -0.0239273
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0238948
ZHX3 zinc fingers and homeoboxes 3 -0.0236672
JARID2 jumonji, AT rich interactive domain 2 -0.0235431
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0234409
PUS7 pseudouridylate synthase 7 (putative) -0.0233914
PTRH2 peptidyl-tRNA hydrolase 2 -0.0233458
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.023343
SRPK1 SRSF protein kinase 1 -0.023194
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0230848
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0230619
TUBA1B tubulin, alpha 1b -0.0229824
OSBPL10 oxysterol binding protein-like 10 -0.0229272
LARP4B La ribonucleoprotein domain family, member 4B -0.022742
TRRAP transformation/transcription domain-associated protein -0.0227341
MBNL1 muscleblind-like splicing regulator 1 -0.0226899
TTF2 transcription termination factor, RNA polymerase II -0.022609
NF1 neurofibromin 1 -0.0225002
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.022446
SFXN2 sideroflexin 2 -0.0224261
RPL38 ribosomal protein L38 -0.022425
SAPCD2 suppressor APC domain containing 2 -0.0223293
APRT adenine phosphoribosyltransferase -0.0223162
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0223157
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0223015
NRG3 neuregulin 3 -0.022041
MTDH metadherin -0.0219364
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0219003
CAMKMT calmodulin-lysine N-methyltransferase -0.0217987
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0217635
TPX2 TPX2, microtubule-associated -0.0217592
ITM2B integral membrane protein 2B -0.0217164
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0215652
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0214742
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0214697
NCKAP5 NCK-associated protein 5 -0.0214416
TPI1 triosephosphate isomerase 1 -0.0212542
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0212163
PRC1 protein regulator of cytokinesis 1 -0.0211561
SET SET nuclear proto-oncogene -0.0211003
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0210946
RAB31 RAB31, member RAS oncogene family -0.0210701
DLG1 discs, large homolog 1 (Drosophila) -0.0210481
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0210004
AFG2A AFG2 AAA ATPase homolog A -0.0208723
CD81 CD81 molecule -0.0208583
MACROD2 MACRO domain containing 2 -0.0207678
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0206851
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0206718
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0205206
ZFR zinc finger RNA binding protein -0.0205006
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0204699
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0204686
NSD2 nuclear receptor binding SET domain protein 2 -0.0203965
TUBB4B tubulin, beta 4B class IVb -0.0203778
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.020376
DPH6 diphthamine biosynthesis 6 -0.0202989
RNASE3 ribonuclease, RNase A family, 3 -0.0202929
CKAP4 cytoskeleton-associated protein 4 -0.0202867
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0201038
ACTG1 actin gamma 1 -0.0200465
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0200317
SEPTIN9 septin 9 -0.0199881
RSL1D1 ribosomal L1 domain containing 1 -0.0199806
MACROD1 MACRO domain containing 1 -0.0196907
DENND1A DENN/MADD domain containing 1A -0.0196602
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0196318
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0196101
ANLN anillin, actin binding protein -0.0195756
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -0.0195294
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0195167
INTS2 integrator complex subunit 2 -0.0195103
SRPK2 SRSF protein kinase 2 -0.0194977
IFI6 interferon, alpha-inducible protein 6 -0.0193889
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0193451
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0192473
THBS1 thrombospondin 1 -0.0191968
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0191505
TASOR2 transcription activation suppressor family member 2 -0.019075
VAV3 vav 3 guanine nucleotide exchange factor -0.0190487
CCNF cyclin F -0.0190432
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -0.0189269
DOCK1 dedicator of cytokinesis 1 -0.0187924
PRKD2 protein kinase D2 -0.0187855
TOP1 topoisomerase (DNA) I -0.0187139
SOGA1 suppressor of glucose, autophagy associated 1 -0.0185745
PKN2 protein kinase N2 -0.0185612
NUP107 nucleoporin 107kDa -0.0185076
HMCN1 hemicentin 1 -0.0184538
LONRF2 LON peptidase N-terminal domain and ring finger 2 -0.0184467
PRICKLE2 prickle homolog 2 (Drosophila) -0.0184175
FANCA Fanconi anemia, complementation group A -0.0183896
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.0183407
CD59 CD59 molecule, complement regulatory protein -0.0183199
BIRC6 baculoviral IAP repeat containing 6 -0.0182918
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0182526
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.018233
ODF2 outer dense fiber of sperm tails 2 -0.0182152
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) -0.0181989
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0181827
GRHL2 grainyhead-like 2 (Drosophila) -0.0181685
DEPDC1B DEP domain containing 1B -0.0181485
KCMF1 potassium channel modulatory factor 1 -0.0181423
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0181064
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0180037
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0179997
CUL3 cullin 3 -0.0179725
EML4 echinoderm microtubule associated protein like 4 -0.0179617
TIAM1 T-cell lymphoma invasion and metastasis 1 -0.0179351
CDC42SE2 CDC42 small effector 2 -0.017807
RABGAP1L RAB GTPase activating protein 1-like -0.0177819
CHLSN cholesin -0.0176821
GRB2 growth factor receptor-bound protein 2 -0.0176372
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.017614
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.017579
TET2 tet methylcytosine dioxygenase 2 -0.0175579
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0175389
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0175184
XPO4 exportin 4 -0.0175129
SCAF8 SR-related CTD-associated factor 8 -0.0174319
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.017425
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0174246
GMPS guanine monphosphate synthase -0.0173282
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -0.0173226
TXN2 thioredoxin 2 -0.0172235
TRAPPC9 trafficking protein particle complex 9 -0.0172227
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0172205
ADIPOR2 adiponectin receptor 2 -0.0172163
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0171666
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.0171566
LMAN2 lectin, mannose-binding 2 -0.017105
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.0171035
HDLBP high density lipoprotein binding protein -0.0170365
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0170199
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0169971
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0169912
TEX14 testis expressed 14 -0.0169879
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0169785
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.0169758
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0168808
LMNB1 lamin B1 -0.0168669
CLU clusterin -0.0168669
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0168013
ARHGAP24 Rho GTPase activating protein 24 -0.0167643
FAM168A family with sequence similarity 168, member A -0.0167232
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.016667
CCT7 chaperonin containing TCP1, subunit 7 (eta) -0.0166489
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.016627
NUP160 nucleoporin 160kDa -0.0166209
RASAL2 RAS protein activator like 2 -0.016615
SKP1 S-phase kinase-associated protein 1 -0.0166069
SYNGR2 synaptogyrin 2 -0.0165121
NUDCD1 NudC domain containing 1 -0.0165003
HM13 histocompatibility (minor) 13 -0.0164563
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0164536
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0164409
DDHD1 DDHD domain containing 1 -0.0164065
EIF4B eukaryotic translation initiation factor 4B -0.0163419
YARS1 tyrosyl-tRNA synthetase 1 -0.0163048
MLEC malectin -0.0162999
ANKRD17 ankyrin repeat domain 17 -0.0162924
SETX senataxin -0.0162794
EXOC4 exocyst complex component 4 -0.0162629
SMC4 structural maintenance of chromosomes 4 -0.0162406
CYB561 cytochrome b561 -0.0162321
RPL30 ribosomal protein L30 -0.0162268
DCTN4 dynactin 4 (p62) -0.0161472
RHEB Ras homolog enriched in brain -0.0161291
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0161139
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0160221
ESRP1 epithelial splicing regulatory protein 1 -0.0159888
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0159577
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0159489
AKAP1 A kinase (PRKA) anchor protein 1 -0.0159474
R3HDM1 R3H domain containing 1 -0.0159327
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -0.0159267
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.0159215
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -0.0159132
KIF14 kinesin family member 14 -0.0158987
ITGAV integrin, alpha V -0.0158488
PITPNB phosphatidylinositol transfer protein, beta -0.0158106
SSR1 signal sequence receptor, alpha -0.0158069
PHACTR4 phosphatase and actin regulator 4 -0.0157626
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0157191
TULP4 tubby like protein 4 -0.0156583
DLC1 DLC1 Rho GTPase activating protein -0.0155624
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0155587
SETD5 SET domain containing 5 -0.0154695
LSG1 large 60S subunit nuclear export GTPase 1 -0.0154674
WAC WW domain containing adaptor with coiled-coil -0.0154178
TTC3 tetratricopeptide repeat domain 3 -0.0154066
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0153985
MPRIP myosin phosphatase Rho interacting protein -0.0153622
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0153147
H4C3 H4 clustered histone 3 -0.0152942
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0152892
TMEM87A transmembrane protein 87A -0.0152809
HELLS helicase, lymphoid-specific -0.0152776
E2F3 E2F transcription factor 3 -0.0152448
CCNK cyclin K -0.0152363
JPT1 Jupiter microtubule associated homolog 1 -0.0152047
KARS1 lysyl-tRNA synthetase 1 -0.0151257
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0151238
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0151173
TPM3 tropomyosin 3 -0.0151014
KIF18B kinesin family member 18B -0.0151006
ARHGAP11B Rho GTPase activating protein 11B -0.0150601
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.0150411
CADPS2 Ca++-dependent secretion activator 2 -0.0150072
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0149951
SYT12 synaptotagmin XII -0.0149658
CBX3 chromobox homolog 3 -0.0149515
TMX4 thioredoxin-related transmembrane protein 4 -0.0149172
TMEM117 transmembrane protein 117 -0.0148802
MIS18BP1 MIS18 binding protein 1 -0.0148751
CHSY1 chondroitin sulfate synthase 1 -0.0148285
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0148014
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0147817
SMYD3 SET and MYND domain containing 3 -0.014773
AMZ1 archaelysin family metallopeptidase 1 -0.0147519
CENPP centromere protein P -0.0147514
FNBP4 formin binding protein 4 -0.0147486
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0147363
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0147248
RAD21 RAD21 homolog (S. pombe) -0.0146932
PKP4 plakophilin 4 -0.0146906
TRIM25 tripartite motif containing 25 -0.0146552
WDFY3 WD repeat and FYVE domain containing 3 -0.0146384
EIF3I eukaryotic translation initiation factor 3, subunit I -0.0145737
CNKSR3 CNKSR family member 3 -0.0145437
WDR20 WD repeat domain 20 -0.0144666
AURKA aurora kinase A -0.0144562
BCAP31 B-cell receptor-associated protein 31 -0.0144494
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0144085
OLA1 Obg-like ATPase 1 -0.0143691
OSBPL1A oxysterol binding protein-like 1A -0.0143572
RCC1 regulator of chromosome condensation 1 -0.0143304
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0142742
IGSF3 immunoglobulin superfamily, member 3 -0.0142659
NUP98 nucleoporin 98kDa -0.0142652
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0142639
PARN poly(A)-specific ribonuclease -0.0142417
BRCA2 breast cancer 2, early onset -0.0142388
MYO5C myosin VC -0.0142086
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.014203
TOR1AIP2 torsin A interacting protein 2 -0.0142023
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -0.0141899
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0141727
CCNB1 cyclin B1 -0.0141587
IPO11 importin 11 -0.0141448
LAMA5 laminin, alpha 5 -0.0141424
RGS6 regulator of G-protein signaling 6 -0.0141338
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0141255
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -0.0140773
STAU1 staufen double-stranded RNA binding protein 1 -0.0140481
BICD1 bicaudal D homolog 1 (Drosophila) -0.0140346
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0140267
MCM4 minichromosome maintenance complex component 4 -0.0140217
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0140209
LRP6 low density lipoprotein receptor-related protein 6 -0.0140002
WWC1 WW and C2 domain containing 1 -0.0139549
TPD52L1 tumor protein D52-like 1 -0.0139232
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.0139205
SPIDR scaffolding protein involved in DNA repair -0.013913
TLN2 talin 2 -0.0139129
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0139086
TPT1 tumor protein, translationally-controlled 1 -0.0138788
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.0138787
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -0.0138751
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0138268
RC3H2 ring finger and CCCH-type domains 2 -0.0138104
SERBP1 SERPINE1 mRNA binding protein 1 -0.0138053
RYK receptor-like tyrosine kinase -0.0137793
ASTN2 astrotactin 2 -0.0137655
ADCY9 adenylate cyclase 9 -0.0136822
RPL7L1 ribosomal protein L7-like 1 -0.0136697
CLTA clathrin, light chain A -0.0136655
NOP58 NOP58 ribonucleoprotein -0.0136633
CASZ1 castor zinc finger 1 -0.0136113
ORC5 origin recognition complex, subunit 5 -0.0135636
LAMP2 lysosomal-associated membrane protein 2 -0.0135588
RFWD3 ring finger and WD repeat domain 3 -0.0135582
DYNC2I2 dynein 2 intermediate chain 2 -0.0135404
WEE1 WEE1 G2 checkpoint kinase -0.0135194
NAP1L4 nucleosome assembly protein 1-like 4 -0.0135135
USP37 ubiquitin specific peptidase 37 -0.0134859
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0134831
COPS3 COP9 signalosome subunit 3 -0.0134367
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0134307
RAI1 retinoic acid induced 1 -0.013416
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0134157
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0134147
CTBP2 C-terminal binding protein 2 -0.0134068
TBK1 TANK-binding kinase 1 -0.0134019
HEATR1 HEAT repeat containing 1 -0.0133888
WDR43 WD repeat domain 43 -0.0133818
PSD4 pleckstrin and Sec7 domain containing 4 -0.0133731
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0133511
MRPL20 mitochondrial ribosomal protein L20 -0.0133489
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -0.013325
KIAA1671 KIAA1671 -0.0132587
GLE1 GLE1 RNA export mediator -0.0132241
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.013203
PDZRN3 PDZ domain containing ring finger 3 -0.0131977
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0131642
GPSM2 G-protein signaling modulator 2 -0.013152
RPL36A ribosomal protein L36a -0.0131206
STIL SCL/TAL1 interrupting locus -0.0131169
AMBRA1 autophagy/beclin-1 regulator 1 -0.0131082
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0130912
PRKCA protein kinase C, alpha -0.0130896
LCOR ligand dependent nuclear receptor corepressor -0.0130888
SSR4 signal sequence receptor, delta -0.0130676
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0130209
EPHA6 EPH receptor A6 -0.0130203
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0130042
SCFD2 sec1 family domain containing 2 -0.0129832
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0129651
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0129626
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.012943
PHB1 prohibitin 1 -0.0129201
PCDH7 protocadherin 7 -0.0129076
CCNI cyclin I -0.0128919
GTPBP4 GTP binding protein 4 -0.0128896
RCOR1 REST corepressor 1 -0.0128714
TEX2 testis expressed 2 -0.0128521
PRPF38B pre-mRNA processing factor 38B -0.0128508
CCND1 cyclin D1 -0.0128404
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.0128298
NELFCD negative elongation factor complex member C/D -0.0128283
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -0.0127681
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0127462
RANGAP1 Ran GTPase activating protein 1 -0.0127423
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0127253
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -0.0126519
BRD1 bromodomain containing 1 -0.0126071
PHIP pleckstrin homology domain interacting protein -0.0126039
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0125796
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0125689
RAB8A RAB8A, member RAS oncogene family -0.0125606
XXYLT1 xyloside xylosyltransferase 1 -0.012544
UVRAG UV radiation resistance associated -0.0125369
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.012532
TMPO thymopoietin -0.0125089
CDK13 cyclin-dependent kinase 13 -0.0125062
KNL1 kinetochore scaffold 1 -0.0125009
TCERG1 transcription elongation regulator 1 -0.0124711
PHTF1 putative homeodomain transcription factor 1 -0.0124677
RPL23A ribosomal protein L23a -0.0124676
DEK DEK proto-oncogene -0.0124593
TATDN1 TatD DNase domain containing 1 -0.0124482
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0124426
SHLD2 shieldin complex subunit 2 -0.0124374
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0124305
PTDSS1 phosphatidylserine synthase 1 -0.0124154
STK39 serine threonine kinase 39 -0.0123984
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0123885
PARD3B par-3 family cell polarity regulator beta -0.0123855
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.01238
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.0123618
BCAS2 breast carcinoma amplified sequence 2 -0.0123618
GSPT1 G1 to S phase transition 1 -0.0123541
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0123457
PDE7A phosphodiesterase 7A -0.0123427
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0123274
WDR4 WD repeat domain 4 -0.0123233
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0123215
NBAS neuroblastoma amplified sequence -0.0123175
MTCH2 mitochondrial carrier 2 -0.0123037
SLC39A9 solute carrier family 39, member 9 -0.0122711
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0122598
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0122087
KNTC1 kinetochore associated 1 -0.0122039
ADAR adenosine deaminase, RNA-specific -0.0121751
GMNN geminin, DNA replication inhibitor -0.012163
EPCAM epithelial cell adhesion molecule -0.0121471
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -0.0121334
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0121243
KDM6A lysine (K)-specific demethylase 6A -0.012102
COG4 component of oligomeric golgi complex 4 -0.0120911
PTPRK protein tyrosine phosphatase, receptor type, K -0.0120554
TSEN54 TSEN54 tRNA splicing endonuclease subunit -0.0120461
TOP2A topoisomerase (DNA) II alpha 170kDa -0.012035
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0120337
TOP3A topoisomerase (DNA) III alpha -0.0120118
CTSD cathepsin D -0.0120081
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -0.0119853
CUL5 cullin 5 -0.0119731
PSPC1 paraspeckle component 1 -0.0119527
ZNF367 zinc finger protein 367 -0.0119504
H2AJ H2A.J histone -0.0119492
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0119428
RBM39 RNA binding motif protein 39 -0.0119313
WHRN whirlin -0.0119174
MRPS21 mitochondrial ribosomal protein S21 -0.0119122
SNX4 sorting nexin 4 -0.0119119
NHSL1 NHS-like 1 -0.0119068
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0119006
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0118963
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -0.0118848
UBE2K ubiquitin-conjugating enzyme E2K -0.0118812
IGFBP5 insulin-like growth factor binding protein 5 -0.0118752