MCF7_Alendronate sodium trihydrate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 100nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_Alendronate sodium trihydrate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.197911
KRT8 keratin 8, type II 0.14086
KRT19 keratin 19, type I 0.131473
DSPP dentin sialophosphoprotein 0.116796
HSPB1 heat shock 27kDa protein 1 0.109047
FDPS farnesyl diphosphate synthase 0.0941338
SQLE squalene epoxidase 0.0878224
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0775539
BCAS3 breast carcinoma amplified sequence 3 0.0761324
RPLP1 ribosomal protein, large, P1 0.0746529
MRPL13 mitochondrial ribosomal protein L13 0.0690538
RPL28 ribosomal protein L28 0.0643813
RPS8 ribosomal protein S8 0.0640379
NPNT nephronectin 0.0623509
DTNA dystrobrevin, alpha 0.0616773
MVD mevalonate (diphospho) decarboxylase 0.0613519
TENM3 teneurin transmembrane protein 3 0.0609043
RPL12 ribosomal protein L12 0.0591429
RPL18 ribosomal protein L18 0.059086
KRT18 keratin 18, type I 0.0584752
NCOA3 nuclear receptor coactivator 3 0.057794
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0567194
RACK1 receptor for activated C kinase 1 0.0546912
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0540363
RPS9 ribosomal protein S9 0.0512538
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0512226
USP32 ubiquitin specific peptidase 32 0.0509897
LDLR low density lipoprotein receptor 0.0481731
MYH14 myosin, heavy chain 14, non-muscle 0.0470195
RPS2 ribosomal protein S2 0.0463075
CLTC clathrin, heavy chain (Hc) 0.0454138
ENSA endosulfine alpha 0.0450108
RPS16 ribosomal protein S16 0.0438875
NEBL nebulette 0.0434145
SREBF2 sterol regulatory element binding transcription factor 2 0.0412029
RPL13A ribosomal protein L13a 0.0411126
RPL15 ribosomal protein L15 0.0406396
EVL Enah/Vasp-like 0.0405925
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0400309
INSIG1 insulin induced gene 1 0.0396545
TFF1 trefoil factor 1 0.0394175
RPS18 ribosomal protein S18 0.0383479
S100A10 S100 calcium binding protein A10 0.0380935
UBE2H ubiquitin-conjugating enzyme E2H 0.0378917
AHNAK AHNAK nucleoprotein 0.0375588
KRT80 keratin 80, type II 0.0373175
FOXO3 forkhead box O3 0.037266
NEMF nuclear export mediator factor 0.0367511
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0367246
RPS19 ribosomal protein S19 0.0366774
DCDC2 doublecortin domain containing 2 0.0362701
XBP1 X-box binding protein 1 0.0361367
RIGI RNA sensor RIG-I 0.0356138
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0354864
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0351314
SMIM14 small integral membrane protein 14 0.0348396
CCSER1 coiled-coil serine-rich protein 1 0.0347807
NRCAM neuronal cell adhesion molecule 0.0342801
PTPRF protein tyrosine phosphatase, receptor type, F 0.0336557
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.033642
PTPRK protein tyrosine phosphatase, receptor type, K 0.0331466
SPPL3 signal peptide peptidase like 3 0.0330392
LMBR1 limb development membrane protein 1 0.0329246
TACC2 transforming, acidic coiled-coil containing protein 2 0.0327292
RPL30 ribosomal protein L30 0.0327034
RPL35A ribosomal protein L35a 0.0321894
UBL4A ubiquitin-like 4A 0.0321666
ATXN2 ataxin 2 0.0319951
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0318118
CUX1 cut-like homeobox 1 0.0316445
BRWD1 bromodomain and WD repeat domain containing 1 0.0315882
BCAS1 breast carcinoma amplified sequence 1 0.031574
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0315197
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0314062
RPS6 ribosomal protein S6 0.0312769
ELOVL6 ELOVL fatty acid elongase 6 0.0307402
IGF1R insulin-like growth factor 1 receptor 0.030602
SUN1 Sad1 and UNC84 domain containing 1 0.0305442
RPLP0 ribosomal protein, large, P0 0.0303541
TPR translocated promoter region, nuclear basket protein 0.0302411
MACF1 microtubule-actin crosslinking factor 1 0.0301021
VGLL4 vestigial-like family member 4 0.030067
SERINC5 serine incorporator 5 0.0299842
PATJ PATJ crumbs cell polarity complex component 0.0299036
TNRC6B trinucleotide repeat containing 6B 0.0298783
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0298528
RPS21 ribosomal protein S21 0.029607
IQGAP1 IQ motif containing GTPase activating protein 1 0.0295555
NRP1 neuropilin 1 0.029471
SLTM SAFB-like, transcription modulator 0.029425
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0293868
UBC ubiquitin C 0.0293866
TRIM56 tripartite motif containing 56 0.0293051
BCAS4 breast carcinoma amplified sequence 4 0.0290496
RPL37A ribosomal protein L37a 0.0289959
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0286737
RPS5 ribosomal protein S5 0.0285671
KDM5B lysine (K)-specific demethylase 5B 0.0285545
OGA O-GlcNAcase 0.0285465
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0285075
SYTL2 synaptotagmin-like 2 0.0284334
SOS2 son of sevenless homolog 2 (Drosophila) 0.0282883
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0282291
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0281161
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0281052
BICRAL BICRA like chromatin remodeling complex associated protein 0.0280101
CDK19 cyclin-dependent kinase 19 0.027911
DNM2 dynamin 2 0.0278126
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0277364
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0273494
RPS29 ribosomal protein S29 0.0272628
RAD9A RAD9 homolog A (S. pombe) 0.0272306
ZNF33A zinc finger protein 33A 0.0271445
RPS24 ribosomal protein S24 0.0270972
RPL7A ribosomal protein L7a 0.0268623
MYOF myoferlin 0.0268566
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0266869
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0266362
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0265281
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.026244
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0262044
CHD6 chromodomain helicase DNA binding protein 6 0.0261328
NXNL2 nucleoredoxin-like 2 0.0261201
MSMO1 methylsterol monooxygenase 1 0.026067
ABHD18 abhydrolase domain containing 18 0.0257577
ALCAM activated leukocyte cell adhesion molecule 0.025718
AKAP9 A kinase (PRKA) anchor protein 9 0.0256583
TRIO trio Rho guanine nucleotide exchange factor 0.0254656
NUP210L nucleoporin 210kDa-like 0.0252124
TMED8 transmembrane emp24 protein transport domain containing 8 0.0251362
ATXN3 ataxin 3 0.0249116
GOLM2 golgi membrane protein 2 0.0248621
SQSTM1 sequestosome 1 0.0248369
ZBTB20 zinc finger and BTB domain containing 20 0.0248133
TMOD3 tropomodulin 3 (ubiquitous) 0.0248092
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0247758
MXD4 MAX dimerization protein 4 0.0247394
LPIN1 lipin 1 0.0246644
ACLY ATP citrate lyase 0.024502
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0244064
ACSS2 acyl-CoA synthetase short-chain family member 2 0.024333
UBE2B ubiquitin-conjugating enzyme E2B 0.0242378
CERCAM cerebral endothelial cell adhesion molecule 0.0241769
RPL37 ribosomal protein L37 0.0241618
ZSWIM5 zinc finger, SWIM-type containing 5 0.0241521
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0240851
RPL6 ribosomal protein L6 0.0240693
HIP1 huntingtin interacting protein 1 0.0240429
SLC38A2 solute carrier family 38, member 2 0.0240131
DST dystonin 0.0239209
LGALS3 lectin, galactoside-binding, soluble, 3 0.0238796
MRTFB myocardin related transcription factor B 0.0238738
RPS3 ribosomal protein S3 0.0236511
EXOC6B exocyst complex component 6B 0.0236078
NAV1 neuron navigator 1 0.0235828
TTC3 tetratricopeptide repeat domain 3 0.0235066
FHIT fragile histidine triad 0.0234903
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0234488
PXDN peroxidasin 0.0233299
MLXIP MLX interacting protein 0.023288
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0232485
ABR active BCR-related 0.0231719
YIPF4 Yip1 domain family, member 4 0.0229073
CUTA cutA divalent cation tolerance homolog (E. coli) 0.0228791
DEPTOR DEP domain containing MTOR-interacting protein 0.0227338
TXNIP thioredoxin interacting protein 0.0227315
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0227239
LARP1 La ribonucleoprotein domain family, member 1 0.0226856
RPL31 ribosomal protein L31 0.0226741
GIPC1 GIPC PDZ domain containing family, member 1 0.0225363
MYO15B myosin XVB 0.0224519
MARCHF6 membrane associated ring-CH-type finger 6 0.0223771
RPS20 ribosomal protein S20 0.0222418
PAWR PRKC, apoptosis, WT1, regulator 0.0221989
MIA3 melanoma inhibitory activity family, member 3 0.0221159
TUBA1A tubulin, alpha 1a 0.0221058
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0221036
RGS6 regulator of G-protein signaling 6 0.022012
TTC17 tetratricopeptide repeat domain 17 0.0219568
EMB embigin 0.021923
CLU clusterin 0.0217971
TNRC6A trinucleotide repeat containing 6A 0.0217434
DNM1 dynamin 1 0.0216996
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0216742
MCC mutated in colorectal cancers 0.0214478
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0214093
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0213825
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.021354
MAVS mitochondrial antiviral signaling protein 0.0213498
SAE1 SUMO1 activating enzyme subunit 1 0.0213259
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0212457
RSRP1 arginine/serine-rich protein 1 0.0211913
RNF115 ring finger protein 115 0.0210728
EFR3A EFR3 homolog A (S. cerevisiae) 0.0209917
MYO5A myosin VA (heavy chain 12, myoxin) 0.0208675
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0.0208537
GTF2IRD1 GTF2I repeat domain containing 1 0.0207751
KMT2A lysine (K)-specific methyltransferase 2A 0.0205529
PEDS1 plasmanylethanolamine desaturase 1 0.0205296
NRIP1 nuclear receptor interacting protein 1 0.0205073
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0204455
PRKCH protein kinase C, eta 0.0204233
GRN granulin 0.0203528
RPS15 ribosomal protein S15 0.0202671
ERG28 ergosterol biosynthesis 28 homolog 0.0202568
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0201616
MUC1 mucin 1, cell surface associated 0.0201396
USP9X ubiquitin specific peptidase 9, X-linked 0.0201161
RPL35 ribosomal protein L35 0.020074
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0200386
RGS12 regulator of G-protein signaling 12 0.020027
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0200019
TLK2 tousled-like kinase 2 0.0198361
SYNRG synergin, gamma 0.0198241
TM7SF2 transmembrane 7 superfamily member 2 0.019775
KLF6 Kruppel-like factor 6 0.0197526
MYO9A myosin IXA 0.0197071
ACIN1 apoptotic chromatin condensation inducer 1 0.0195912
ZFP64 ZFP64 zinc finger protein 0.0194613
RDX radixin 0.0194485
KYNU kynureninase 0.0194105
ELOVL1 ELOVL fatty acid elongase 1 0.0193556
RPS27 ribosomal protein S27 0.0193237
FTL ferritin, light polypeptide 0.0193175
RPL32 ribosomal protein L32 0.0192117
RPL18A ribosomal protein L18a 0.0191962
PHACTR4 phosphatase and actin regulator 4 0.0191802
PHF21A PHD finger protein 21A 0.0191135
SFTPA2 surfactant protein A2 0.019071
ZNF430 zinc finger protein 430 0.0189827
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0189796
BAG3 BCL2-associated athanogene 3 0.0189424
FAM13B family with sequence similarity 13, member B 0.0189383
GSN gelsolin 0.018907
RUFY1 RUN and FYVE domain containing 1 0.0188662
OSBPL10 oxysterol binding protein-like 10 0.0188645
RPS7 ribosomal protein S7 0.0188641
CDV3 CDV3 homolog (mouse) 0.0186784
CLDN4 claudin 4 0.0186704
MARK3 MAP/microtubule affinity-regulating kinase 3 0.018649
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0185698
TRIP4 thyroid hormone receptor interactor 4 0.0185411
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0185015
TM9SF3 transmembrane 9 superfamily member 3 0.0184257
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.018377
HBP1 HMG-box transcription factor 1 0.0183749
RPS17 ribosomal protein S17 0.018239
LRMDA leucine rich melanocyte differentiation associated 0.0182199
POGZ pogo transposable element with ZNF domain 0.0182114
ITPKC inositol-trisphosphate 3-kinase C 0.0181807
UBE2K ubiquitin-conjugating enzyme E2K 0.0181681
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.0180606
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0179971
CTCF CCCTC-binding factor (zinc finger protein) 0.0179856
SLC35E1 solute carrier family 35, member E1 0.0179622
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0179548
IREB2 iron-responsive element binding protein 2 0.0179295
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0179262
PANK3 pantothenate kinase 3 0.0178378
CCDC148 coiled-coil domain containing 148 0.0177223
MUC16 mucin 16, cell surface associated 0.0176506
RPS14 ribosomal protein S14 0.0176438
CYB5D2 cytochrome b5 domain containing 2 0.0176233
DHCR24 24-dehydrocholesterol reductase 0.0176109
HDGF hepatoma-derived growth factor 0.0174795
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.0174704
PSD3 pleckstrin and Sec7 domain containing 3 0.0173917
MYO1D myosin ID 0.0173531
RBM6 RNA binding motif protein 6 0.0173199
CYBA cytochrome b-245, alpha polypeptide 0.0172834
NRBP1 nuclear receptor binding protein 1 0.0172642
BCAR3 breast cancer anti-estrogen resistance 3 0.017245
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0172362
WDR44 WD repeat domain 44 0.0172123
KIF16B kinesin family member 16B 0.0171962
PRDX2 peroxiredoxin 2 0.0170687
TACC1 transforming, acidic coiled-coil containing protein 1 0.0170318
STAU1 staufen double-stranded RNA binding protein 1 0.0170301
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0170052
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0170051
DDIT4 DNA-damage-inducible transcript 4 0.0169723
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0169608
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0169213
S100A14 S100 calcium binding protein A14 0.0168793
COP1 COP1 E3 ubiquitin ligase 0.0168595
PRSS8 protease, serine, 8 0.0168486
WASF2 WAS protein family, member 2 0.016788
CREBBP CREB binding protein 0.0167356
LTBP1 latent transforming growth factor beta binding protein 1 0.0167285
TMEM44 transmembrane protein 44 0.0167111
FLNB filamin B, beta 0.0166614
NFE2L1 nuclear factor, erythroid 2-like 1 0.0166604
ZNF789 zinc finger protein 789 0.0165947
CERS4 ceramide synthase 4 0.0165317
GSTM3 glutathione S-transferase mu 3 (brain) 0.0164906
ARRB1 arrestin, beta 1 0.0164726
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0164602
BOK BCL2-related ovarian killer 0.016384
GNS glucosamine (N-acetyl)-6-sulfatase 0.016362
TOM1L2 target of myb1-like 2 (chicken) 0.0163586
CRYBG1 crystallin beta-gamma domain containing 1 0.0163426
RNF213 ring finger protein 213 0.0163239
UTRN utrophin 0.0163166
MBNL1 muscleblind-like splicing regulator 1 0.0162907
TMEM150C transmembrane protein 150C 0.016285
RPLP2 ribosomal protein, large, P2 0.0162558
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0162341
BASP1 brain abundant, membrane attached signal protein 1 0.0161795
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0161742
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.0161218
C14ORF132 chromosome 14 open reading frame 132 0.016058
TAPBP TAP binding protein (tapasin) 0.0159812
ITGB4 integrin, beta 4 0.0159356
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0159092
CAMTA1 calmodulin binding transcription activator 1 0.0158356
TBC1D17 TBC1 domain family, member 17 0.0158077
RPS11 ribosomal protein S11 0.0158031
RHOA ras homolog family member A 0.0157218
WDR26 WD repeat domain 26 0.015689
PHTF2 putative homeodomain transcription factor 2 0.0156117
PCGF3 polycomb group ring finger 3 0.0155644
SCAPER S-phase cyclin A-associated protein in the ER 0.0155508
FLOT2 flotillin 2 0.0155406
RPL27 ribosomal protein L27 0.015534
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0154614
AFF4 AF4/FMR2 family, member 4 0.0154367
RYBP RING1 and YY1 binding protein 0.0154313
FAM217B family with sequence similarity 217, member B 0.0153883
ASXL2 additional sex combs like transcriptional regulator 2 0.0153591
TMPRSS4 transmembrane protease, serine 4 0.0153214
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0152666
CCDC14 coiled-coil domain containing 14 0.0152347
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0152277
PRKCZ protein kinase C, zeta 0.0151934
TBCE tubulin folding cofactor E 0.0151632
NUCB1 nucleobindin 1 0.0151207
EGFL7 EGF-like-domain, multiple 7 0.0151019
UBXN2A UBX domain protein 2A 0.0150892
APP amyloid beta (A4) precursor protein 0.0150538
KLHL24 kelch-like family member 24 0.0150264
EP400 E1A binding protein p400 0.0150057
ATXN7 ataxin 7 0.014969
SRSF9 serine/arginine-rich splicing factor 9 0.0149117
CCDC125 coiled-coil domain containing 125 0.0149006
EFCAB14 EF-hand calcium binding domain 14 0.0148934
RSL24D1 ribosomal L24 domain containing 1 0.0148793
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0148753
STK38 serine/threonine kinase 38 0.0148656
KCNK15 potassium channel, two pore domain subfamily K, member 15 0.0148175
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.014763
WDFY1 WD repeat and FYVE domain containing 1 0.0147253
PRUNE2 prune homolog 2 (Drosophila) 0.0147228
ZMYM5 zinc finger, MYM-type 5 0.0146986
DCAKD dephospho-CoA kinase domain containing 0.0146759
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.0146431
DNAH14 dynein, axonemal, heavy chain 14 0.0146159
FTH1 ferritin, heavy polypeptide 1 0.0145816
LURAP1L leucine rich adaptor protein 1-like 0.0145423
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0145242
PRMT2 protein arginine methyltransferase 2 0.0145138
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0145054
WASHC2C WASH complex subunit 2C 0.0145027
FYCO1 FYVE and coiled-coil domain containing 1 0.0144731
TGIF1 TGFB-induced factor homeobox 1 0.0144699
TXNRD1 thioredoxin reductase 1 0.0144515
LRRC58 leucine rich repeat containing 58 0.0144471
GPR107 G protein-coupled receptor 107 0.0144304
HDAC1 histone deacetylase 1 0.0143681
SOX4 SRY (sex determining region Y)-box 4 0.0143602
HEATR5B HEAT repeat containing 5B 0.0143559
WASHC4 WASH complex subunit 4 0.0143275
CFLAR CASP8 and FADD-like apoptosis regulator 0.0142531
PTPRE protein tyrosine phosphatase, receptor type, E 0.01419
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.0141815
ELP4 elongator acetyltransferase complex subunit 4 0.0141751
ARTN artemin 0.0141598
CLIC3 chloride intracellular channel 3 0.014137
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.0141296
PACS1 phosphofurin acidic cluster sorting protein 1 0.0141008
FBXO28 F-box protein 28 0.0140976
MVK mevalonate kinase 0.0140819
CPA6 carboxypeptidase A6 0.0140727
DENND4A DENN/MADD domain containing 4A 0.0140421
RAB2A RAB2A, member RAS oncogene family 0.013986
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.0139116
RNF10 ring finger protein 10 0.0138578
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0138368
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.013818
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0137933
PLEC plectin 0.0137578
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0137471
TAOK1 TAO kinase 1 0.0137086
TMEM135 transmembrane protein 135 0.0137078
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0136948
INTS12 integrator complex subunit 12 0.0136749
POLK polymerase (DNA directed) kappa 0.0136434
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0136368
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0136116
STAG2 stromal antigen 2 0.013606
TAGLN2 transgelin 2 0.0135796
CCNG2 cyclin G2 0.0135654
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.0135211
MYO1E myosin IE 0.0134804
QPRT quinolinate phosphoribosyltransferase 0.0134726
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0134426
GALC galactosylceramidase 0.0134385
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0134219
GPR137C G protein-coupled receptor 137C 0.0133963
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0133407
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.0133368
ANXA2 annexin A2 0.0133185
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0132928
PCYOX1 prenylcysteine oxidase 1 0.0132911
ZNF91 zinc finger protein 91 0.0132894
UBE4B ubiquitination factor E4B 0.013288
UBAP2 ubiquitin associated protein 2 0.0132869
RPL19 ribosomal protein L19 0.0132578
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 0.0132367
INSR insulin receptor 0.0132338
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0132245
SSBP3 single stranded DNA binding protein 3 0.0131951
ZNFX1 zinc finger, NFX1-type containing 1 0.0131704
GATAD2B GATA zinc finger domain containing 2B 0.0131612
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0131602
PMP22 peripheral myelin protein 22 0.0131377
FNBP4 formin binding protein 4 0.0131357
ZNF254 zinc finger protein 254 0.0131295
RPS15A ribosomal protein S15a 0.0131159
FRK fyn-related Src family tyrosine kinase 0.0130714
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 0.0130153
TRNAU1AP tRNA selenocysteine 1 associated protein 1 0.0130141
WDR20 WD repeat domain 20 0.0129975
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 0.0129918
PRRC2C proline-rich coiled-coil 2C 0.0129918
CALU calumenin 0.0129917
GATAD1 GATA zinc finger domain containing 1 0.0129901
AK8 adenylate kinase 8 0.0129889
CACUL1 CDK2-associated, cullin domain 1 0.0129491
TTBK2 tau tubulin kinase 2 0.0129469
FLNA filamin A, alpha 0.0129393
TAOK3 TAO kinase 3 0.012927
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0129228
RHOD ras homolog family member D 0.0128902
EZR ezrin 0.0128838
GOLGA2 golgin A2 0.0128775
RAB3D RAB3D, member RAS oncogene family 0.0128631
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0128416
TTC1 tetratricopeptide repeat domain 1 0.012824
ZMYND11 zinc finger, MYND-type containing 11 0.0128162
CBX5 chromobox homolog 5 0.0128134
MTPN myotrophin 0.0128046
TMEM205 transmembrane protein 205 0.0128019
BICD2 bicaudal D homolog 2 (Drosophila) 0.0127949
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0127745
MUSK muscle, skeletal, receptor tyrosine kinase 0.0127619
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0127537
TRAK2 trafficking protein, kinesin binding 2 0.0127219
STC1 stanniocalcin 1 0.01271
GOLPH3L golgi phosphoprotein 3-like 0.0127089
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0127048
CTPS2 CTP synthase 2 0.0126913
PKN2 protein kinase N2 0.0126725
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0126682
MVP major vault protein 0.0126115
C17ORF67 chromosome 17 open reading frame 67 0.0125998
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.0125821
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0125812
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0125622
ABLIM1 actin binding LIM protein 1 0.0125559
STX8 syntaxin 8 0.0125417
ANKRD12 ankyrin repeat domain 12 0.0125352
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0125281
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0125135
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0124905
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.0124809
TTC28 tetratricopeptide repeat domain 28 0.0124747
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.0124702
STAP2 signal transducing adaptor family member 2 0.0124637
PLXNA3 plexin A3 0.0124482
DNA2 DNA replication helicase/nuclease 2 0.0124339
DHRS7B dehydrogenase/reductase (SDR family) member 7B 0.0124336
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 0.0124114
RPS12 ribosomal protein S12 0.0123909
KRIT1 KRIT1, ankyrin repeat containing 0.0123819
BFAR bifunctional apoptosis regulator 0.01238
MTSS1 metastasis suppressor 1 0.0123647
WDR82 WD repeat domain 82 0.0123634
STK4 serine/threonine kinase 4 0.0123555
RNF114 ring finger protein 114 0.0123495
ZER1 zyg-11 related, cell cycle regulator 0.0123123
RPL26 ribosomal protein L26 0.0123105
UBN2 ubinuclein 2 0.0122615
DMD dystrophin 0.0122579
SHROOM2 shroom family member 2 0.0122521
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.0122507
MRPS11 mitochondrial ribosomal protein S11 0.0122352
PKP4 plakophilin 4 0.012231
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0122246
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 0.0121999
TM9SF2 transmembrane 9 superfamily member 2 0.0121969

decreased expression

Symbol Name Standardized Value
SULF2 sulfatase 2 -0.16812
GFRA1 GDNF family receptor alpha 1 -0.141734
ESR1 estrogen receptor 1 -0.1149
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0867499
THSD4 thrombospondin, type I, domain containing 4 -0.0862419
LRP1B low density lipoprotein receptor-related protein 1B -0.08242
WWOX WW domain containing oxidoreductase -0.0814345
TRIM37 tripartite motif containing 37 -0.0810037
JARID2 jumonji, AT rich interactive domain 2 -0.0779951
PKM pyruvate kinase, muscle -0.0698589
MKI67 marker of proliferation Ki-67 -0.0658635
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0643633
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0611511
GREB1 growth regulation by estrogen in breast cancer 1 -0.0599121
SMYD3 SET and MYND domain containing 3 -0.0592544
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0577226
BMP7 bone morphogenetic protein 7 -0.0567963
MED13 mediator complex subunit 13 -0.0557543
GPC6 glypican 6 -0.0554294
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0552357
TPM4 tropomyosin 4 -0.0542939
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0539479
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0527329
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0510714
ZMYND8 zinc finger, MYND-type containing 8 -0.0482574
PARD6B par-6 family cell polarity regulator beta -0.0476118
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0455524
BPTF bromodomain PHD finger transcription factor -0.0452826
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0447965
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0446526
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0442195
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0436219
ZFHX3 zinc finger homeobox 3 -0.0428957
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0428756
ATAD2 ATPase family, AAA domain containing 2 -0.0424655
TMEM164 transmembrane protein 164 -0.0423275
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0420818
PUM2 pumilio RNA-binding family member 2 -0.0417082
CCND1 cyclin D1 -0.0410706
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0404736
TPM3 tropomyosin 3 -0.040175
CTSD cathepsin D -0.0398889
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0398233
MCM7 minichromosome maintenance complex component 7 -0.0396982
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.0396816
ENO1 enolase 1, (alpha) -0.0390947
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0390702
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0390569
PTPRG protein tyrosine phosphatase, receptor type, G -0.038531
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0381986
PTPRA protein tyrosine phosphatase, receptor type, A -0.0381456
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0379536
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0373394
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0358792
PRR11 proline rich 11 -0.0352456
THADA thyroid adenoma associated -0.0348731
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.0346068
WWC1 WW and C2 domain containing 1 -0.0341303
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0340778
AMZ1 archaelysin family metallopeptidase 1 -0.0339596
NOP58 NOP58 ribonucleoprotein -0.0337307
RAB10 RAB10, member RAS oncogene family -0.0336779
SPIDR scaffolding protein involved in DNA repair -0.0331283
NEO1 neogenin 1 -0.0329994
MYH9 myosin, heavy chain 9, non-muscle -0.032929
PCDH7 protocadherin 7 -0.0328749
ACTG1 actin gamma 1 -0.0326763
CKAP5 cytoskeleton associated protein 5 -0.032475
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0320901
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0319753
TAC4 tachykinin 4 (hemokinin) -0.0318017
REPS1 RALBP1 associated Eps domain containing 1 -0.0316957
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.031613
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0314534
UGDH UDP-glucose 6-dehydrogenase -0.0312968
AGR2 anterior gradient 2 -0.0312193
FGF13 fibroblast growth factor 13 -0.0312119
PTK2 protein tyrosine kinase 2 -0.031031
GRHL2 grainyhead-like 2 (Drosophila) -0.0307218
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0305246
SND1 staphylococcal nuclease and tudor domain containing 1 -0.03041
IGFBP5 insulin-like growth factor binding protein 5 -0.0302687
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0298907
ZNF609 zinc finger protein 609 -0.0298493
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0292078
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0291415
GSE1 Gse1 coiled-coil protein -0.0291138
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.028758
PBX3 pre-B-cell leukemia homeobox 3 -0.0287179
MED13L mediator complex subunit 13-like -0.028642
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.028511
CENPP centromere protein P -0.0284787
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0283619
NHSL1 NHS-like 1 -0.0283435
CENPB centromere protein B, 80kDa -0.0282338
TOP1 topoisomerase (DNA) I -0.0278853
MED12L mediator complex subunit 12-like -0.0277078
RBM39 RNA binding motif protein 39 -0.0276815
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0269258
SPOPL speckle-type POZ protein-like -0.0267556
PARD3 par-3 family cell polarity regulator -0.026753
VMP1 vacuole membrane protein 1 -0.0265738
CDC27 cell division cycle 27 -0.0265142
SMC4 structural maintenance of chromosomes 4 -0.0265035
ACTN4 actinin, alpha 4 -0.0264887
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0262088
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0260875
ANKRD17 ankyrin repeat domain 17 -0.0260661
TRPS1 trichorhinophalangeal syndrome I -0.0260284
WEE1 WEE1 G2 checkpoint kinase -0.0259536
RTN4 reticulon 4 -0.0258318
CLDN7 claudin 7 -0.0258255
SON SON DNA binding protein -0.0256206
NSD1 nuclear receptor binding SET domain protein 1 -0.0255622
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0255525
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0254719
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0254
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0252804
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0250829
ZFAND6 zinc finger, AN1-type domain 6 -0.0250481
DHDDS dehydrodolichyl diphosphate synthase -0.024843
JPT1 Jupiter microtubule associated homolog 1 -0.0246573
MIDEAS mitotic deacetylase associated SANT domain protein -0.0246487
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0246059
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0245798
ZHX3 zinc fingers and homeoboxes 3 -0.0245457
SET SET nuclear proto-oncogene -0.0244977
RUNX1 runt-related transcription factor 1 -0.0243716
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.024182
APOD apolipoprotein D -0.0240909
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0236458
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0236303
CALCR calcitonin receptor -0.0235988
FRYL FRY-like -0.0235783
ZFR zinc finger RNA binding protein -0.0234094
KIF20B kinesin family member 20B -0.0234091
PDZRN3 PDZ domain containing ring finger 3 -0.0232738
TASOR2 transcription activation suppressor family member 2 -0.023262
LOC112694756 uncharaterized LOC112694756 -0.0232249
KDM2A lysine (K)-specific demethylase 2A -0.023138
PSPC1 paraspeckle component 1 -0.0231361
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.0231264
XPO1 exportin 1 -0.0230409
CALR calreticulin -0.0229531
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.0228869
HCFC1 host cell factor C1 -0.0228561
EIF3H eukaryotic translation initiation factor 3, subunit H -0.022765
PDE7A phosphodiesterase 7A -0.0226783
TPD52L1 tumor protein D52-like 1 -0.0226232
RPAP2 RNA polymerase II associated protein 2 -0.0225443
AURKAIP1 aurora kinase A interacting protein 1 -0.0225331
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0225299
DBF4 DBF4 zinc finger -0.0224866
POTEF POTE ankyrin domain family, member F -0.0224832
PFN1 profilin 1 -0.0222586
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0222274
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0221468
SHTN1 shootin 1 -0.022107
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0220333
CMIP c-Maf inducing protein -0.0220236
CSDE1 cold shock domain containing E1, RNA-binding -0.0220062
DTNB dystrobrevin, beta -0.0219651
RANBP17 RAN binding protein 17 -0.021958
VCL vinculin -0.0218718
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0218605
TPM1 tropomyosin 1 (alpha) -0.0218462
TUG1 taurine up-regulated 1 (non-protein coding) -0.0217067
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0217006
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.021682
RSRC1 arginine/serine-rich coiled-coil 1 -0.0216479
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0216178
CUL3 cullin 3 -0.0215669
NCOA2 nuclear receptor coactivator 2 -0.0214744
CENPF centromere protein F, 350/400kDa -0.0214666
EPHA6 EPH receptor A6 -0.0213626
ZNRF3 zinc and ring finger 3 -0.0213463
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0213218
SDK1 sidekick cell adhesion molecule 1 -0.0211666
SRPK1 SRSF protein kinase 1 -0.021112
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0209977
TNPO2 transportin 2 -0.020984
PRC1 protein regulator of cytokinesis 1 -0.0209637
AKAP1 A kinase (PRKA) anchor protein 1 -0.0209032
PRKCE protein kinase C, epsilon -0.0208174
FANCC Fanconi anemia, complementation group C -0.0208117
ABI2 abl-interactor 2 -0.0207684
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0206866
TRAPPC9 trafficking protein particle complex 9 -0.0206529
CLASP1 cytoplasmic linker associated protein 1 -0.0206081
PHF14 PHD finger protein 14 -0.0205636
MED27 mediator complex subunit 27 -0.0205459
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0205234
REEP5 receptor accessory protein 5 -0.0205006
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.0204311
GMDS GDP-mannose 4,6-dehydratase -0.0203083
ANLN anillin, actin binding protein -0.0202758
TIAM1 T-cell lymphoma invasion and metastasis 1 -0.0202101
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.020121
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.0201098
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0201066
SCFD2 sec1 family domain containing 2 -0.0201062
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0200973
H3-3B H3.3 histone B -0.0200607
CD9 CD9 molecule -0.0200475
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.0200403
CEP78 centrosomal protein 78kDa -0.02004
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0199306
FAF1 Fas (TNFRSF6) associated factor 1 -0.0198576
BTBD7 BTB (POZ) domain containing 7 -0.0197742
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -0.0197326
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -0.0197064
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0196891
TMEM178B transmembrane protein 178B -0.0196585
TUBB tubulin, beta class I -0.0196348
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0195987
CNKSR3 CNKSR family member 3 -0.0195905
DLG1 discs, large homolog 1 (Drosophila) -0.0194112
SMIM44 small integral membrane protein 44 -0.0193494
SOS1 son of sevenless homolog 1 (Drosophila) -0.019286
BLTP2 bridge-like lipid transfer protein family member 2 -0.0192121
TGFB2 transforming growth factor, beta 2 -0.0191967
UBB ubiquitin B -0.0190778
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0190626
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0190488
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0190349
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0190085
BSG basigin (Ok blood group) -0.0189955
DICER1 dicer 1, ribonuclease type III -0.0189885
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0189797
GPATCH2 G patch domain containing 2 -0.0189661
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0189476
FTSJ3 FtsJ homolog 3 (E. coli) -0.0189178
AKT1 v-akt murine thymoma viral oncogene homolog 1 -0.0188877
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0188566
ARMC9 armadillo repeat containing 9 -0.0187915
UVRAG UV radiation resistance associated -0.0187779
BRCA1 breast cancer 1, early onset -0.018745
BRD2 bromodomain containing 2 -0.018714
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -0.0186911
USP37 ubiquitin specific peptidase 37 -0.0186909
TUBA1B tubulin, alpha 1b -0.0186293
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0185864
PLXDC2 plexin domain containing 2 -0.018578
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.018558
TLN1 talin 1 -0.0185248
SLMAP sarcolemma associated protein -0.018502
KNL1 kinetochore scaffold 1 -0.0184817
FCHSD2 FCH and double SH3 domains 2 -0.0184243
PRCC papillary renal cell carcinoma (translocation-associated) -0.0184222
AOPEP aminopeptidase O (putative) -0.0184152
DLC1 DLC1 Rho GTPase activating protein -0.0183017
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.0183012
ADGRV1 adhesion G protein-coupled receptor V1 -0.0182874
RFWD3 ring finger and WD repeat domain 3 -0.0182229
PERP PERP, TP53 apoptosis effector -0.0182094
SRSF4 serine/arginine-rich splicing factor 4 -0.0181852
KMT5B lysine methyltransferase 5B -0.0181743
ARHGAP11B Rho GTPase activating protein 11B -0.0181333
PICALM phosphatidylinositol binding clathrin assembly protein -0.0180206
ORC5 origin recognition complex, subunit 5 -0.018018
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.017996
DPP7 dipeptidyl-peptidase 7 -0.0179923
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0179577
MREG melanoregulin -0.0178499
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.0178258
WAC WW domain containing adaptor with coiled-coil -0.0178121
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -0.0178082
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0177306
PTRH2 peptidyl-tRNA hydrolase 2 -0.017709
STRBP spermatid perinuclear RNA binding protein -0.0177046
MAPK14 mitogen-activated protein kinase 14 -0.0176914
ZNF407 zinc finger protein 407 -0.0176868
SHISA9 shisa family member 9 -0.0176697
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0175936
THRB thyroid hormone receptor, beta -0.0174695
SVIL supervillin -0.0174373
COX6C cytochrome c oxidase subunit VIc -0.0174158
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0174152
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -0.0173888
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0173291
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.0173085
BCAS2 breast carcinoma amplified sequence 2 -0.0172343
TRAF3 TNF receptor-associated factor 3 -0.0172064
SIK3 SIK family kinase 3 -0.0171534
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0170959
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0170562
EDC3 enhancer of mRNA decapping 3 -0.0170417
NCOA1 nuclear receptor coactivator 1 -0.0170352
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0169779
LSG1 large 60S subunit nuclear export GTPase 1 -0.0169703
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0169225
WDR43 WD repeat domain 43 -0.0168541
ZNF652 zinc finger protein 652 -0.0168496
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0168399
DEK DEK proto-oncogene -0.016836
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) -0.0168232
CMC2 C-x(9)-C motif containing 2 -0.0168009
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0167826
NPDC1 neural proliferation, differentiation and control, 1 -0.016762
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0167423
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0167262
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0167194
LIN9 lin-9 DREAM MuvB core complex component -0.0166966
CERS6 ceramide synthase 6 -0.0166849
IRAK1 interleukin-1 receptor-associated kinase 1 -0.016563
USP3 ubiquitin specific peptidase 3 -0.0165584
BRI3BP BRI3 binding protein -0.0165366
SKA2 spindle and kinetochore associated complex subunit 2 -0.0165134
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0165035
MACROD2 MACRO domain containing 2 -0.0164679
PUS7 pseudouridylate synthase 7 (putative) -0.0164331
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0164324
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0164306
NELFB negative elongation factor complex member B -0.0163361
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0163089
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0162997
TSG101 tumor susceptibility 101 -0.016271
ZNF148 zinc finger protein 148 -0.016266
TXN2 thioredoxin 2 -0.0162264
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0161596
SH3RF1 SH3 domain containing ring finger 1 -0.016073
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0160721
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0160638
ZMYM2 zinc finger, MYM-type 2 -0.0160472
SSH2 slingshot protein phosphatase 2 -0.0160373
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0160263
AFG2A AFG2 AAA ATPase homolog A -0.0160202
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0160071
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0159962
CHD1 chromodomain helicase DNA binding protein 1 -0.0159743
TRIM33 tripartite motif containing 33 -0.0159704
MICU2 mitochondrial calcium uptake 2 -0.0159695
SSR1 signal sequence receptor, alpha -0.0159484
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0159181
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0159179
TMED3 transmembrane emp24 protein transport domain containing 3 -0.0158628
CEP350 centrosomal protein 350kDa -0.015842
RPL3 ribosomal protein L3 -0.015825
MTA3 metastasis associated 1 family, member 3 -0.0157452
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0157319
HAT1 histone acetyltransferase 1 -0.0157122
HM13 histocompatibility (minor) 13 -0.0156901
TNRC18 trinucleotide repeat containing 18 -0.0156505
MRPS25 mitochondrial ribosomal protein S25 -0.0156503
SPATA7 spermatogenesis associated 7 -0.0156478
PTBP1 polypyrimidine tract binding protein 1 -0.0156425
FRS2 fibroblast growth factor receptor substrate 2 -0.0156413
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0156288
DENND1A DENN/MADD domain containing 1A -0.0155937
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0155647
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0155467
ZMPSTE24 zinc metallopeptidase STE24 -0.0155434
TLK1 tousled-like kinase 1 -0.0155266
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0154819
EIPR1 EARP complex and GARP complex interacting protein 1 -0.0154641
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0154283
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0154203
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0154144
XXYLT1 xyloside xylosyltransferase 1 -0.0154133
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0154059
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -0.0153869
EEA1 early endosome antigen 1 -0.0153786
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 -0.0153611
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0153461
NUDC nudC nuclear distribution protein -0.015332
SAPCD2 suppressor APC domain containing 2 -0.0153174
LARP4 La ribonucleoprotein domain family, member 4 -0.0152977
H2AZ2 H2A.Z variant histone 2 -0.0152956
PARP1 poly (ADP-ribose) polymerase 1 -0.0152916
ZNF217 zinc finger protein 217 -0.0152728
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0152172
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0152112
INTS2 integrator complex subunit 2 -0.0151624
TNPO3 transportin 3 -0.0151229
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -0.0151071
SFXN1 sideroflexin 1 -0.0151001
MBNL3 muscleblind-like splicing regulator 3 -0.0150979
TTLL10 tubulin tyrosine ligase-like family member 10 -0.0150958
SRSF2 serine/arginine-rich splicing factor 2 -0.0150932
ATF6 activating transcription factor 6 -0.0150322
ANKRD28 ankyrin repeat domain 28 -0.0150312
PCNT pericentrin -0.0150303
USP34 ubiquitin specific peptidase 34 -0.0150134
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0149921
CHD3 chromodomain helicase DNA binding protein 3 -0.0149849
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0149163
PTBP2 polypyrimidine tract binding protein 2 -0.0148934
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.014866
CBX4 chromobox homolog 4 -0.0148577
LMAN2 lectin, mannose-binding 2 -0.0148185
LMNB1 lamin B1 -0.0148064
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0147669
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0147657
THOC2 THO complex 2 -0.0147285
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.0147046
FOXJ3 forkhead box J3 -0.0146513
HDLBP high density lipoprotein binding protein -0.0146455
CUEDC1 CUE domain containing 1 -0.0146334
ANAPC11 anaphase promoting complex subunit 11 -0.0146332
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -0.0146249
MRFAP1 Morf4 family associated protein 1 -0.0146002
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0145896
HMGB1 high mobility group box 1 -0.0145884
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -0.0145598
CD151 CD151 molecule (Raph blood group) -0.0145237
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0144802
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0144637
XPC xeroderma pigmentosum, complementation group C -0.0144407
PHB1 prohibitin 1 -0.0144262
MEIS1 Meis homeobox 1 -0.0144259
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0143885
MORF4L1 mortality factor 4 like 1 -0.014369
INO80 INO80 complex subunit -0.0143391
GTPBP4 GTP binding protein 4 -0.0143088
AAGAB alpha- and gamma-adaptin binding protein -0.0142972
RBL1 retinoblastoma-like 1 -0.0142634
FGF12 fibroblast growth factor 12 -0.0142321
RBM8A RNA binding motif protein 8A -0.014201
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0141904
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -0.0141823
CENPE centromere protein E, 312kDa -0.0141797
ANGEL1 angel homolog 1 (Drosophila) -0.0141666
FUS FUS RNA binding protein -0.0141623
CCNF cyclin F -0.014162
DNMBP dynamin binding protein -0.0141004
STK24 serine/threonine kinase 24 -0.0140904
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.0140616
SPOP speckle-type POZ protein -0.0140259
IL4R interleukin 4 receptor -0.0140038
KIAA0586 KIAA0586 -0.0139749
H2AJ H2A.J histone -0.0139564
NCOA6 nuclear receptor coactivator 6 -0.0139486
VRK1 vaccinia related kinase 1 -0.0139347
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -0.0139307
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0139292
ZNF710 zinc finger protein 710 -0.0139229
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0139117
GDE1 glycerophosphodiester phosphodiesterase 1 -0.0138994
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0138737
TTC27 tetratricopeptide repeat domain 27 -0.0138585
SERF2 small EDRK-rich factor 2 -0.0138518
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -0.0138104
DYM dymeclin -0.0138089
NIBAN2 niban apoptosis regulator 2 -0.0137824
EMP2 epithelial membrane protein 2 -0.0137711
DTYMK deoxythymidylate kinase (thymidylate kinase) -0.013771
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.0137523
ZNF146 zinc finger protein 146 -0.0137464
SLC35B1 solute carrier family 35, member B1 -0.0137447
COG8 component of oligomeric golgi complex 8 -0.0137413
FERMT2 fermitin family member 2 -0.0137087
SNX17 sorting nexin 17 -0.0136845
C9ORF78 chromosome 9 open reading frame 78 -0.0136713
SARS2 seryl-tRNA synthetase 2, mitochondrial -0.0136704
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0136384
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0136365
LPP LIM domain containing preferred translocation partner in lipoma -0.0135721
EEF2 eukaryotic translation elongation factor 2 -0.0135709
ADAM10 ADAM metallopeptidase domain 10 -0.0135562
RTF2 replication termination factor 2 -0.0135549
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0135276
STC2 stanniocalcin 2 -0.0135223
IGFBP4 insulin-like growth factor binding protein 4 -0.0135184
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0135125
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.0135065
FRAS1 Fraser extracellular matrix complex subunit 1 -0.013467
H1-10 H1.10 linker histone -0.0134421
FUCA2 fucosidase, alpha-L- 2, plasma -0.0134118
ZNF703 zinc finger protein 703 -0.0133902
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0133338
GPD1L glycerol-3-phosphate dehydrogenase 1-like -0.0133304
ADGRL1 adhesion G protein-coupled receptor L1 -0.0133246
FBXO11 F-box protein 11 -0.0133009
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0132765
TRIP11 thyroid hormone receptor interactor 11 -0.0132695
BIRC6 baculoviral IAP repeat containing 6 -0.013264
LAMP1 lysosomal-associated membrane protein 1 -0.0132633
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.0132603
TRAPPC10 trafficking protein particle complex 10 -0.0132485
DIAPH1 diaphanous-related formin 1 -0.0132354
RCC1 regulator of chromosome condensation 1 -0.0132268
SERBP1 SERPINE1 mRNA binding protein 1 -0.0132084
PARN poly(A)-specific ribonuclease -0.013196
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0131583
UBE2M ubiquitin-conjugating enzyme E2M -0.0131544
UBE3A ubiquitin protein ligase E3A -0.0131374
CGGBP1 CGG triplet repeat binding protein 1 -0.0130952
MYDGF myeloid-derived growth factor -0.0130803
DCPH1 damage control phosphatase 1 -0.0130536
AMBRA1 autophagy/beclin-1 regulator 1 -0.0130434
PARD3B par-3 family cell polarity regulator beta -0.013038
TULP4 tubby like protein 4 -0.0130226
OLA1 Obg-like ATPase 1 -0.0129962
RHEB Ras homolog enriched in brain -0.0129452
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.0129449
ZNF367 zinc finger protein 367 -0.0129208
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.0128982
MESD mesoderm development LRP chaperone -0.0128863
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -0.0128859
ECT2 epithelial cell transforming 2 -0.012882