MCF7_GSK J1_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK J1 100nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_GSK J1_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
CTSD cathepsin D 0.0917913
TPM4 tropomyosin 4 0.0869234
THSD4 thrombospondin, type I, domain containing 4 0.0865828
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0848618
VMP1 vacuole membrane protein 1 0.0843194
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0840003
KRT8 keratin 8, type II 0.0825515
MSI2 musashi RNA-binding protein 2 0.0744443
UGDH UDP-glucose 6-dehydrogenase 0.0665079
USP32 ubiquitin specific peptidase 32 0.0664064
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0650537
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.063796
MALRD1 MAM and LDL receptor class A domain containing 1 0.0623057
CDV3 CDV3 homolog (mouse) 0.0615363
LITAF lipopolysaccharide-induced TNF factor 0.0598249
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0597045
TRIM37 tripartite motif containing 37 0.0550294
MLPH melanophilin 0.0531173
MYO1E myosin IE 0.0529741
ATXN1 ataxin 1 0.04798
COP1 COP1 E3 ubiquitin ligase 0.0479393
RGS6 regulator of G-protein signaling 6 0.0476365
RPS4X ribosomal protein S4, X-linked 0.0476213
RPLP1 ribosomal protein, large, P1 0.0467461
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0466191
BCL2 B-cell CLL/lymphoma 2 0.0455877
ZHX3 zinc fingers and homeoboxes 3 0.0454645
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0453985
RACK1 receptor for activated C kinase 1 0.0449723
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0443512
RPS11 ribosomal protein S11 0.0437602
TENM3 teneurin transmembrane protein 3 0.0432296
RPL15 ribosomal protein L15 0.0424928
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0417546
PARD6B par-6 family cell polarity regulator beta 0.0417228
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0408554
DSTN destrin (actin depolymerizing factor) 0.0405649
SACK1B scaffolding CK1 anchoring protein B 0.0397838
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0395215
HSPB1 heat shock 27kDa protein 1 0.039485
QRICH1 glutamine-rich 1 0.038467
CORO1B coronin, actin binding protein, 1B 0.0382987
RPL28 ribosomal protein L28 0.037783
APOD apolipoprotein D 0.0369657
PDE8A phosphodiesterase 8A 0.0366539
MYO9A myosin IXA 0.0354333
RPL30 ribosomal protein L30 0.0353223
TCF12 transcription factor 12 0.035167
RPS2 ribosomal protein S2 0.0351287
CLDN4 claudin 4 0.0351054
RTN3 reticulon 3 0.0348573
CLSTN1 calsyntenin 1 0.0348248
ARFGEF3 ARFGEF family member 3 0.034551
PTPRK protein tyrosine phosphatase, receptor type, K 0.0344189
GAN gigaxonin 0.034291
PLEC plectin 0.0342819
PHF21A PHD finger protein 21A 0.034091
CUX1 cut-like homeobox 1 0.0337304
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0337121
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0336608
SLTM SAFB-like, transcription modulator 0.0336309
ENO1 enolase 1, (alpha) 0.0335001
TAPBP TAP binding protein (tapasin) 0.0334302
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.0333808
ANKRD28 ankyrin repeat domain 28 0.0333605
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0332266
LARP4B La ribonucleoprotein domain family, member 4B 0.032896
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.032817
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0326373
NECAB1 N-terminal EF-hand calcium binding protein 1 0.0324941
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.032247
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0317245
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0317191
RPS5 ribosomal protein S5 0.0317148
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0315773
ARF4 ADP-ribosylation factor 4 0.0313607
MIDEAS mitotic deacetylase associated SANT domain protein 0.0309492
UBL4A ubiquitin-like 4A 0.0306744
UBP1 upstream binding protein 1 (LBP-1a) 0.0306127
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0305093
WDR44 WD repeat domain 44 0.0304216
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0304023
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0300792
RBM47 RNA binding motif protein 47 0.0299367
MLXIP MLX interacting protein 0.0298839
BSG basigin (Ok blood group) 0.0294862
TK1 thymidine kinase 1, soluble 0.029448
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0293921
R3HDM2 R3H domain containing 2 0.0291309
ALCAM activated leukocyte cell adhesion molecule 0.0291087
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0290438
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0288738
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0287809
EEF2 eukaryotic translation elongation factor 2 0.0287169
ZCCHC7 zinc finger, CCHC domain containing 7 0.0287091
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0286146
NSD1 nuclear receptor binding SET domain protein 1 0.0285738
UBE3A ubiquitin protein ligase E3A 0.0285317
ZNF292 zinc finger protein 292 0.0285303
GSPT1 G1 to S phase transition 1 0.0283216
H2AC6 H2A clustered histone 6 0.0282739
SET SET nuclear proto-oncogene 0.0282382
BCL2L1 BCL2-like 1 0.0280209
SETD2 SET domain containing 2 0.0279829
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.027717
DAPK3 death-associated protein kinase 3 0.0276204
KMT2C lysine (K)-specific methyltransferase 2C 0.0276197
CLDN3 claudin 3 0.027433
SORT1 sortilin 1 0.0273145
LAMP1 lysosomal-associated membrane protein 1 0.0272209
AREG amphiregulin 0.0269609
PRKCE protein kinase C, epsilon 0.0269211
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0268998
SLC38A10 solute carrier family 38, member 10 0.0266582
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.0265361
CERS6 ceramide synthase 6 0.0264626
ABI2 abl-interactor 2 0.0262771
VAV3 vav 3 guanine nucleotide exchange factor 0.026147
DENND4C DENN/MADD domain containing 4C 0.026127
S100A11 S100 calcium binding protein A11 0.0260964
RPL23A ribosomal protein L23a 0.0259688
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0259201
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0258672
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.0258183
MYH9 myosin, heavy chain 9, non-muscle 0.0257801
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.025743
RPS16 ribosomal protein S16 0.0257166
AFF1 AF4/FMR2 family, member 1 0.0254323
RAB10 RAB10, member RAS oncogene family 0.0253224
TMEM150C transmembrane protein 150C 0.0252181
ITPRID2 ITPR interacting domain containing 2 0.0251616
NOL8 nucleolar protein 8 0.0250749
SSBP2 single-stranded DNA binding protein 2 0.0250399
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.0249291
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0248602
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0247917
TECPR2 tectonin beta-propeller repeat containing 2 0.0247545
SSH2 slingshot protein phosphatase 2 0.0247277
STARD10 StAR-related lipid transfer (START) domain containing 10 0.0246158
FRS2 fibroblast growth factor receptor substrate 2 0.0244401
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0244357
SFXN1 sideroflexin 1 0.0243438
LMBR1 limb development membrane protein 1 0.0243267
CBR4 carbonyl reductase 4 0.0242015
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0241302
UBE4A ubiquitination factor E4A 0.0241052
STAU1 staufen double-stranded RNA binding protein 1 0.0240434
USP42 ubiquitin specific peptidase 42 0.0240377
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0239778
STYXL1 serine/threonine/tyrosine interacting-like 1 0.0236932
GPHN gephyrin 0.0236856
RPS25 ribosomal protein S25 0.0236784
PHIP pleckstrin homology domain interacting protein 0.0236636
NOL10 nucleolar protein 10 0.0236065
SEPTIN7 septin 7 0.0235667
WWC3 WWC family member 3 0.0235047
PTPRF protein tyrosine phosphatase, receptor type, F 0.0234788
CLEC16A C-type lectin domain family 16, member A 0.0234608
ATAD2B ATPase family, AAA domain containing 2B 0.0232758
UBE2B ubiquitin-conjugating enzyme E2B 0.0232489
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.023238
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0231467
MACROD2 MACRO domain containing 2 0.0231144
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0230026
MRTFB myocardin related transcription factor B 0.022978
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0229624
SUMF1 sulfatase modifying factor 1 0.0229618
PRXL2A peroxiredoxin like 2A 0.022923
ABHD2 abhydrolase domain containing 2 0.0228991
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 0.0228729
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.022768
TUFT1 tuftelin 1 0.0227507
PDZD8 PDZ domain containing 8 0.0227141
DHCR7 7-dehydrocholesterol reductase 0.0227008
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0226897
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0226236
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0224981
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.02233
NELFCD negative elongation factor complex member C/D 0.0222747
PPL periplakin 0.0222522
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0222186
ZFHX3 zinc finger homeobox 3 0.0221904
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.0221558
SLC38A2 solute carrier family 38, member 2 0.0221549
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0221098
DENND1A DENN/MADD domain containing 1A 0.0220985
LRP10 low density lipoprotein receptor-related protein 10 0.022081
GTF3A general transcription factor IIIA 0.0220774
RPL4 ribosomal protein L4 0.0219394
ZMYND8 zinc finger, MYND-type containing 8 0.0219325
LMBRD1 LMBR1 domain containing 1 0.0218732
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0218665
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0218462
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0218007
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0217556
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.021698
MAPK8 mitogen-activated protein kinase 8 0.0216639
TTC28 tetratricopeptide repeat domain 28 0.0214912
TAOK3 TAO kinase 3 0.0214783
DEK DEK proto-oncogene 0.0213792
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.0212263
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0211919
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0211859
SQLE squalene epoxidase 0.0211198
PGR progesterone receptor 0.021088
ZMIZ1 zinc finger, MIZ-type containing 1 0.0210564
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0210327
NOP58 NOP58 ribonucleoprotein 0.0210295
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0209869
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0209461
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0209393
IL13RA1 interleukin 13 receptor, alpha 1 0.0209297
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0208997
LCA5L Leber congenital amaurosis 5-like 0.0208794
RPL12 ribosomal protein L12 0.0207887
TLE5 TLE family member 5, transcriptional modulator 0.0207819
EZR ezrin 0.0207591
RRP1B ribosomal RNA processing 1B 0.0207053
PCNX1 pecanex 1 0.0206473
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0206439
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0205203
ZFC3H1 zinc finger, C3H1-type containing 0.0204796
UBE2H ubiquitin-conjugating enzyme E2H 0.0204459
ACBD3 acyl-CoA binding domain containing 3 0.0204384
HEATR1 HEAT repeat containing 1 0.0204006
TMEM127 transmembrane protein 127 0.020369
MTPN myotrophin 0.0202893
BMP7 bone morphogenetic protein 7 0.0202853
RAD9A RAD9 homolog A (S. pombe) 0.020282
MICU2 mitochondrial calcium uptake 2 0.0202448
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0202428
OPHN1 oligophrenin 1 0.0200925
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0200714
CCNT1 cyclin T1 0.0200618
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0200065
NBEAL1 neurobeachin-like 1 0.0198896
ZMYM5 zinc finger, MYM-type 5 0.0198731
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.0198369
EP300 E1A binding protein p300 0.0198356
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.0198278
CLCN7 chloride channel, voltage-sensitive 7 0.0198203
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.0197732
LTBP1 latent transforming growth factor beta binding protein 1 0.0197681
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.0196946
JUP junction plakoglobin 0.019672
IGFBP5 insulin-like growth factor binding protein 5 0.0196695
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0196334
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0196331
TRIM24 tripartite motif containing 24 0.0196322
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0196152
SCFD1 sec1 family domain containing 1 0.0196082
SH3D19 SH3 domain containing 19 0.0195954
AK1 adenylate kinase 1 0.0195683
MTREX Mtr4 exosome RNA helicase 0.0195488
LMNA lamin A/C 0.0195474
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0195266
CTSA cathepsin A 0.0195005
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0194727
NUP107 nucleoporin 107kDa 0.0194689
PTMS parathymosin 0.0193883
H2AZ1 H2A.Z variant histone 1 0.0193611
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0193493
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0192971
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 0.0192452
TBX2 T-box 2 0.0192068
SENP5 SUMO1/sentrin specific peptidase 5 0.0191915
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0191695
FNBP4 formin binding protein 4 0.0191399
RPL13A ribosomal protein L13a 0.0191245
UBQLN1 ubiquilin 1 0.0191066
DYNC2I2 dynein 2 intermediate chain 2 0.0189911
LOC102724023 ES1 protein homolog, mitochondrial 0.0189787
SREBF2 sterol regulatory element binding transcription factor 2 0.018971
RFWD3 ring finger and WD repeat domain 3 0.0189609
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0189411
FAF1 Fas (TNFRSF6) associated factor 1 0.0189335
KYNU kynureninase 0.0189013
MON2 MON2 homolog (S. cerevisiae) 0.0188844
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 0.0188153
NSD2 nuclear receptor binding SET domain protein 2 0.0187801
TMEM131 transmembrane protein 131 0.0187698
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.0187635
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0187584
SERINC5 serine incorporator 5 0.0187466
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 0.0187411
R3HCC1L R3H domain and coiled-coil containing 1-like 0.0187353
EVI5 ecotropic viral integration site 5 0.0187162
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.0186753
RAP1A RAP1A, member of RAS oncogene family 0.0186592
TXNIP thioredoxin interacting protein 0.0185875
CCAR1 cell division cycle and apoptosis regulator 1 0.0185644
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0185618
STX12 syntaxin 12 0.0185219
FAXDC2 fatty acid hydroxylase domain containing 2 0.0185211
YEATS2 YEATS domain containing 2 0.0184915
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0184744
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0184562
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa 0.0184438
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0184429
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.0184416
CCND3 cyclin D3 0.0183598
CHPT1 choline phosphotransferase 1 0.0183588
PAWR PRKC, apoptosis, WT1, regulator 0.0183544
CROT carnitine O-octanoyltransferase 0.0183543
OCLN occludin 0.018326
MCM7 minichromosome maintenance complex component 7 0.0182923
ZNF518A zinc finger protein 518A 0.0182538
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.0182243
ANAPC5 anaphase promoting complex subunit 5 0.0182234
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0182207
MRS2 MRS2 magnesium transporter 0.0181969
KIF21A kinesin family member 21A 0.0181694
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0180915
PTBP2 polypyrimidine tract binding protein 2 0.0180856
SPDEF SAM pointed domain containing ETS transcription factor 0.018081
SELENOI selenoprotein I 0.01807
MARVELD2 MARVEL domain containing 2 0.0180588
FERMT2 fermitin family member 2 0.018054
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0180154
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0180083
DEGS2 delta(4)-desaturase, sphingolipid 2 0.0179866
SNX29 sorting nexin 29 0.0179606
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0179585
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0178973
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0178846
TGOLN2 trans-golgi network protein 2 0.0178443
LDAH lipid droplet associated hydrolase 0.0178362
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.01782
FAM91A1 family with sequence similarity 91, member A1 0.0178182
OXR1 oxidation resistance 1 0.0178119
KAZN kazrin, periplakin interacting protein 0.0178081
LRP6 low density lipoprotein receptor-related protein 6 0.0177937
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0177647
ZZZ3 zinc finger, ZZ-type containing 3 0.0176993
BAG3 BCL2-associated athanogene 3 0.0176907
H3-3B H3.3 histone B 0.017628
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.0176095
USP37 ubiquitin specific peptidase 37 0.0175962
GNAS GNAS complex locus 0.0175651
FBXL20 F-box and leucine-rich repeat protein 20 0.0175534
SCAI suppressor of cancer cell invasion 0.0175185
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0175112
CHPF chondroitin polymerizing factor 0.0175039
PPCDC phosphopantothenoylcysteine decarboxylase 0.0174676
CMYA5 cardiomyopathy associated 5 0.0174547
DPP9 dipeptidyl-peptidase 9 0.0174516
EMB embigin 0.0174491
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0174196
ZC3H14 zinc finger CCCH-type containing 14 0.0173776
NDRG3 NDRG family member 3 0.0173634
CD24 CD24 molecule 0.0173497
TFF3 trefoil factor 3 (intestinal) 0.0173211
LSG1 large 60S subunit nuclear export GTPase 1 0.0173141
TBC1D22A TBC1 domain family, member 22A 0.0172835
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0172768
FREM2 FRAS1 related extracellular matrix protein 2 0.0171414
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0171359
MAVS mitochondrial antiviral signaling protein 0.0171355
XBP1 X-box binding protein 1 0.0171185
RPS15A ribosomal protein S15a 0.0171082
FZD6 frizzled class receptor 6 0.0171066
SUSD6 sushi domain containing 6 0.017101
MORF4L2 mortality factor 4 like 2 0.017101
FAF2 Fas associated factor family member 2 0.0170669
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.01703
PBX1 pre-B-cell leukemia homeobox 1 0.0170008
SRP54 signal recognition particle 54kDa 0.0169943
DOCK7 dedicator of cytokinesis 7 0.0169907
VCL vinculin 0.0169693
LRRC58 leucine rich repeat containing 58 0.0169412
TANK TRAF family member-associated NFKB activator 0.0169328
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.0169178
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.0169168
PDLIM5 PDZ and LIM domain 5 0.0168989
EBPL emopamil binding protein-like 0.0168423
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.0168263
RUBCN rubicon autophagy regulator 0.0168014
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0167353
ZNF780B zinc finger protein 780B 0.0167315
EP400 E1A binding protein p400 0.0167189
UBXN2A UBX domain protein 2A 0.0167039
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 0.0166945
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0166919
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0166872
ATXN7 ataxin 7 0.0166755
MAP7 microtubule-associated protein 7 0.0166623
NEK7 NIMA-related kinase 7 0.0166193
LY6E lymphocyte antigen 6 complex, locus E 0.0165765
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0165413
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0164932
CREB3L4 cAMP responsive element binding protein 3-like 4 0.0164745
LURAP1L leucine rich adaptor protein 1-like 0.016453
IP6K2 inositol hexakisphosphate kinase 2 0.0164294
RPS27 ribosomal protein S27 0.0164252
VEZF1 vascular endothelial zinc finger 1 0.0163705
ZDHHC5 zinc finger, DHHC-type containing 5 0.0163015
CENPO centromere protein O 0.0162949
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.01629
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.0162546
FKBP8 FK506 binding protein 8, 38kDa 0.0162527
RPS18 ribosomal protein S18 0.0162467
TUBB4B tubulin, beta 4B class IVb 0.0162078
TPM1 tropomyosin 1 (alpha) 0.0161964
FAM107B family with sequence similarity 107, member B 0.0161873
DCPH1 damage control phosphatase 1 0.0161869
CREBBP CREB binding protein 0.0161629
GLMN glomulin, FKBP associated protein 0.0161464
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0161319
SPIDR scaffolding protein involved in DNA repair 0.0161287
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0161201
RICTOR RPTOR independent companion of MTOR, complex 2 0.016084
EMC4 ER membrane protein complex subunit 4 0.016081
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0160774
RPSA ribosomal protein SA 0.0160723
GSTZ1 glutathione S-transferase zeta 1 0.0160682
RNPS1 RNA binding protein S1, serine-rich domain 0.0160606
MARVELD3 MARVEL domain containing 3 0.0160446
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 0.0160275
TMEM268 transmembrane protein 268 0.0160232
OTUD5 OTU deubiquitinase 5 0.0160167
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0159648
TBC1D2B TBC1 domain family, member 2B 0.0159524
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0159513
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.0159131
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 0.0159016
DNM2 dynamin 2 0.0158846
NCAM2 neural cell adhesion molecule 2 0.0158562
ZC3H7A zinc finger CCCH-type containing 7A 0.0158517
WDR26 WD repeat domain 26 0.0158483
ADGRL1 adhesion G protein-coupled receptor L1 0.0158451
BRD4 bromodomain containing 4 0.0158051
FAM177A1 family with sequence similarity 177, member A1 0.0158032
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0157801
OSBPL8 oxysterol binding protein-like 8 0.0157306
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0157305
CRTC1 CREB regulated transcription coactivator 1 0.0156405
RPS8 ribosomal protein S8 0.0156263
ZFR zinc finger RNA binding protein 0.0156047
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.0155594
KLC1 kinesin light chain 1 0.0155503
SATB2 SATB homeobox 2 0.015544
PRPF3 pre-mRNA processing factor 3 0.0155364
RPL7 ribosomal protein L7 0.0154891
PLCD3 phospholipase C, delta 3 0.0154853
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.0154764
TBC1D5 TBC1 domain family, member 5 0.0154673
TBCK TBC1 domain containing kinase 0.0154273
RPS15 ribosomal protein S15 0.0154174
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.0154081
NXNL2 nucleoredoxin-like 2 0.0153929
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0153889
WDR27 WD repeat domain 27 0.0153856
MAPK14 mitogen-activated protein kinase 14 0.0153779
MRPL14 mitochondrial ribosomal protein L14 0.015364
ERMP1 endoplasmic reticulum metallopeptidase 1 0.0153476
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.015299
ZNF438 zinc finger protein 438 0.0152813
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0152673
BRAT1 BRCA1-associated ATM activator 1 0.0152603
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.0152471
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.0152467
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.0152282
SSR1 signal sequence receptor, alpha 0.0152004
ANKRD44 ankyrin repeat domain 44 0.0151931
RPL14 ribosomal protein L14 0.0151789
USP1 ubiquitin specific peptidase 1 0.0151294
ZNF609 zinc finger protein 609 0.0151037
ZNF718 zinc finger protein 718 0.0150953
CALCR calcitonin receptor 0.0150912
SERINC1 serine incorporator 1 0.0150829
PRR12 proline rich 12 0.0150802
GPR157 G protein-coupled receptor 157 0.0150745
MIPOL1 mirror-image polydactyly 1 0.0150373
SAV1 salvador family WW domain containing protein 1 0.0150321
PXDN peroxidasin 0.0150236
ARSG arylsulfatase G 0.0150236
RHOBTB3 Rho-related BTB domain containing 3 0.0150215
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.0150181
HDLBP high density lipoprotein binding protein 0.0150053
KRI1 KRI1 homolog (S. cerevisiae) 0.0149617
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0149424
DDR1 discoidin domain receptor tyrosine kinase 1 0.0149353
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.014923
ERGIC2 ERGIC and golgi 2 0.0149225
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0149085
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.0148985
GOLM2 golgi membrane protein 2 0.0148947
PLPP1 phospholipid phosphatase 1 0.0148794
SNX14 sorting nexin 14 0.0148303
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0147895
TMEM97 transmembrane protein 97 0.0147347
ACOD1 aconitate decarboxylase 1 0.0146984
COPB1 coatomer protein complex, subunit beta 1 0.0146558
GIGYF2 GRB10 interacting GYF protein 2 0.0146123
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.014596
MINK1 misshapen-like kinase 1 0.0145959
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0.0145944
HAT1 histone acetyltransferase 1 0.0145912
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0145761
GDE1 glycerophosphodiester phosphodiesterase 1 0.014572

decreased expression

Symbol Name Standardized Value
IGF1R insulin-like growth factor 1 receptor -0.14424
WWOX WW domain containing oxidoreductase -0.0947733
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0927005
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0878125
TRPS1 trichorhinophalangeal syndrome I -0.0807834
GSE1 Gse1 coiled-coil protein -0.0749839
AGR2 anterior gradient 2 -0.0744997
PRR11 proline rich 11 -0.07341
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0655585
GREB1 growth regulation by estrogen in breast cancer 1 -0.0648358
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614629
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0614557
EXOC4 exocyst complex component 4 -0.0595448
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0586873
JARID2 jumonji, AT rich interactive domain 2 -0.0584246
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0577071
CYRIB CYFIP related Rac1 interactor B -0.0549559
CLTC clathrin, heavy chain (Hc) -0.0540912
KRT18 keratin 18, type I -0.0540551
IFI6 interferon, alpha-inducible protein 6 -0.0522292
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0509956
MKI67 marker of proliferation Ki-67 -0.0491903
PKP4 plakophilin 4 -0.0476734
RUNX1 runt-related transcription factor 1 -0.0461555
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.045685
GFRA1 GDNF family receptor alpha 1 -0.0448357
ERBIN erbb2 interacting protein -0.0446196
POTEF POTE ankyrin domain family, member F -0.0436222
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0431951
ZMYM2 zinc finger, MYM-type 2 -0.0431017
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0419955
GTF2IRD1 GTF2I repeat domain containing 1 -0.0415618
MYOF myoferlin -0.0412368
SKA2 spindle and kinetochore associated complex subunit 2 -0.0412189
TBL1X transducin (beta)-like 1X-linked -0.0412169
SYTL2 synaptotagmin-like 2 -0.0411562
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0404092
GRHL2 grainyhead-like 2 (Drosophila) -0.0401069
NRCAM neuronal cell adhesion molecule -0.0399405
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0396251
CA12 carbonic anhydrase XII -0.0395548
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0395007
THADA thyroid adenoma associated -0.0393504
AGO2 argonaute RISC catalytic component 2 -0.0384504
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.038255
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0379076
TRAPPC9 trafficking protein particle complex 9 -0.0377068
AUTS2 autism susceptibility candidate 2 -0.0374557
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0372311
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0368919
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0367138
CADM1 cell adhesion molecule 1 -0.0363746
CCND1 cyclin D1 -0.0363404
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0353917
TTC3 tetratricopeptide repeat domain 3 -0.0351948
LPP LIM domain containing preferred translocation partner in lipoma -0.0349388
PBX3 pre-B-cell leukemia homeobox 3 -0.0347686
DST dystonin -0.0346502
KTN1 kinectin 1 (kinesin receptor) -0.0345143
CD81 CD81 molecule -0.0344511
PICALM phosphatidylinositol binding clathrin assembly protein -0.0344446
SLC38A1 solute carrier family 38, member 1 -0.0344291
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0335759
CHD7 chromodomain helicase DNA binding protein 7 -0.0325586
TUBD1 tubulin, delta 1 -0.0324332
TPR translocated promoter region, nuclear basket protein -0.0324079
FGF13 fibroblast growth factor 13 -0.0323078
DHDDS dehydrodolichyl diphosphate synthase -0.0323077
MED13L mediator complex subunit 13-like -0.0320079
SPPL3 signal peptide peptidase like 3 -0.0317521
CAND1 cullin-associated and neddylation-dissociated 1 -0.0317177
MACF1 microtubule-actin crosslinking factor 1 -0.0316757
ANKRD11 ankyrin repeat domain 11 -0.0313658
SRRM2 serine/arginine repetitive matrix 2 -0.0313121
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0310467
RBM39 RNA binding motif protein 39 -0.031038
DCAF7 DDB1 and CUL4 associated factor 7 -0.0309098
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.0308108
DNMBP dynamin binding protein -0.03081
PRRC2B proline-rich coiled-coil 2B -0.0306375
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0301267
WASF2 WAS protein family, member 2 -0.0299217
PTPRG protein tyrosine phosphatase, receptor type, G -0.0298995
SIDT1 SID1 transmembrane family, member 1 -0.0297613
EVL Enah/Vasp-like -0.029738
UVRAG UV radiation resistance associated -0.0296555
NMD3 NMD3 ribosome export adaptor -0.0295292
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0294121
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0289942
GMDS GDP-mannose 4,6-dehydratase -0.0288992
CHD6 chromodomain helicase DNA binding protein 6 -0.0287327
CSNK1A1 casein kinase 1, alpha 1 -0.0285944
PRKCA protein kinase C, alpha -0.0285655
PRC1 protein regulator of cytokinesis 1 -0.0284676
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.0283008
CENPF centromere protein F, 350/400kDa -0.0281712
MAP4 microtubule-associated protein 4 -0.0281035
OSBPL10 oxysterol binding protein-like 10 -0.0280626
BCAS4 breast carcinoma amplified sequence 4 -0.0279646
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0278729
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0275719
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0275333
EHBP1 EH domain binding protein 1 -0.0272563
XPO1 exportin 1 -0.0272186
RRBP1 ribosome binding protein 1 -0.0269952
AHCTF1 AT hook containing transcription factor 1 -0.0269723
USP9X ubiquitin specific peptidase 9, X-linked -0.0269666
NF1 neurofibromin 1 -0.0268047
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0267676
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0267181
CCNF cyclin F -0.0267053
RANBP17 RAN binding protein 17 -0.0266563
COMMD10 COMM domain containing 10 -0.0264293
ACACA acetyl-CoA carboxylase alpha -0.0263674
RPL35 ribosomal protein L35 -0.0261656
EFNA5 ephrin-A5 -0.0260879
DHCR24 24-dehydrocholesterol reductase -0.0260685
TMOD3 tropomodulin 3 (ubiquitous) -0.0257599
GPATCH8 G patch domain containing 8 -0.0256936
TPX2 TPX2, microtubule-associated -0.0252943
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0251885
CKAP5 cytoskeleton associated protein 5 -0.0249746
RPL29 ribosomal protein L29 -0.0247469
RPLP0 ribosomal protein, large, P0 -0.0246757
BCAS1 breast carcinoma amplified sequence 1 -0.0246728
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0244549
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0244088
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.024291
MUSK muscle, skeletal, receptor tyrosine kinase -0.0242506
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0240482
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0240315
FBXO11 F-box protein 11 -0.0239938
RXRA retinoid X receptor, alpha -0.023964
TPM3 tropomyosin 3 -0.0239144
NEBL nebulette -0.0237221
PCDH7 protocadherin 7 -0.0237185
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0236213
DSCAM Down syndrome cell adhesion molecule -0.023592
TNRC6B trinucleotide repeat containing 6B -0.0235429
KIF4A kinesin family member 4A -0.0235265
SVIL supervillin -0.023404
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0233692
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0231694
GATAD2A GATA zinc finger domain containing 2A -0.0231208
NUMB numb homolog (Drosophila) -0.0230929
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0230698
VKORC1 vitamin K epoxide reductase complex, subunit 1 -0.0230323
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0229832
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0229536
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0229456
MTSS1 metastasis suppressor 1 -0.0229443
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -0.0228601
AURKA aurora kinase A -0.0227745
INO80 INO80 complex subunit -0.0227328
NCOA3 nuclear receptor coactivator 3 -0.0226956
SNX27 sorting nexin family member 27 -0.0226856
AGO3 argonaute RISC catalytic component 3 -0.0225969
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0225315
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0224954
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0224356
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0224228
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0224151
RPL11 ribosomal protein L11 -0.0223928
SEPTIN9 septin 9 -0.0223854
MEIS1 Meis homeobox 1 -0.0222644
SRSF10 serine/arginine-rich splicing factor 10 -0.0222363
EPHA4 EPH receptor A4 -0.0221855
SMYD3 SET and MYND domain containing 3 -0.0221817
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0221735
KCNK6 potassium channel, two pore domain subfamily K, member 6 -0.0221461
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0220768
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.0219879
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0219851
ADIPOR2 adiponectin receptor 2 -0.0219746
CSDE1 cold shock domain containing E1, RNA-binding -0.0218776
EVPL envoplakin -0.0217971
TMEM164 transmembrane protein 164 -0.0216832
ARHGAP11B Rho GTPase activating protein 11B -0.0216566
ATRNL1 attractin-like 1 -0.0215929
FKBP4 FK506 binding protein 4, 59kDa -0.0215691
PTBP1 polypyrimidine tract binding protein 1 -0.0215656
MED27 mediator complex subunit 27 -0.0215373
ESRP1 epithelial splicing regulatory protein 1 -0.0214847
PUM1 pumilio RNA-binding family member 1 -0.0214822
RHOD ras homolog family member D -0.0214746
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0214277
HLA-E major histocompatibility complex, class I, E -0.0213797
TATDN1 TatD DNase domain containing 1 -0.0213519
RPS28 ribosomal protein S28 -0.0213424
TRIR telomerase RNA component interacting RNase -0.0213205
PRKCI protein kinase C, iota -0.0213075
CNKSR3 CNKSR family member 3 -0.0212572
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0212122
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0211134
ENOSF1 enolase superfamily member 1 -0.0210817
UBAP2 ubiquitin associated protein 2 -0.0210715
DENR density-regulated protein -0.021055
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0210084
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0210024
SRSF11 serine/arginine-rich splicing factor 11 -0.0209775
RCOR1 REST corepressor 1 -0.0209562
TBCD tubulin folding cofactor D -0.0208325
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.020824
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0208111
NIPAL2 NIPA-like domain containing 2 -0.0207052
MYO1B myosin IB -0.0205894
FOXK1 forkhead box K1 -0.0205642
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0205452
SND1 staphylococcal nuclease and tudor domain containing 1 -0.020507
GLG1 golgi glycoprotein 1 -0.0205002
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.020453
CANX calnexin -0.0204283
NDC80 NDC80 kinetochore complex component -0.0204274
LRP1B low density lipoprotein receptor-related protein 1B -0.0203865
C1ORF21 chromosome 1 open reading frame 21 -0.0203674
TUBA1C tubulin, alpha 1c -0.020331
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -0.0203274
ORAI2 ORAI calcium release-activated calcium modulator 2 -0.0202892
MRPS25 mitochondrial ribosomal protein S25 -0.0202388
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0202384
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0202064
RASAL2 RAS protein activator like 2 -0.0201883
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0201588
NADSYN1 NAD synthetase 1 -0.0201587
ADCY1 adenylate cyclase 1 (brain) -0.0201559
ZNF652 zinc finger protein 652 -0.0201303
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0201248
TRAP1 TNF receptor-associated protein 1 -0.0200517
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0199973
MYO5B myosin VB -0.0199905
SSBP1 single-stranded DNA binding protein 1, mitochondrial -0.0199718
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -0.0199202
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.019832
MYADM myeloid-associated differentiation marker -0.0198173
NUDCD1 NudC domain containing 1 -0.0197969
KIF14 kinesin family member 14 -0.0197962
NUP214 nucleoporin 214kDa -0.0197914
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0197233
POLK polymerase (DNA directed) kappa -0.0197031
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -0.0197006
ADAM10 ADAM metallopeptidase domain 10 -0.019697
ESYT1 extended synaptotagmin-like protein 1 -0.0196369
TOP1 topoisomerase (DNA) I -0.0196022
CFDP1 craniofacial development protein 1 -0.0195837
NBPF15 neuroblastoma breakpoint family, member 15 -0.0195736
ERP44 endoplasmic reticulum protein 44 -0.0195481
NCOA2 nuclear receptor coactivator 2 -0.0194529
MAPK6 mitogen-activated protein kinase 6 -0.0193454
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0193403
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0193293
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0192158
TMEM178B transmembrane protein 178B -0.0191994
STK24 serine/threonine kinase 24 -0.0191792
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0191545
SAMD12 sterile alpha motif domain containing 12 -0.0191189
VGLL4 vestigial-like family member 4 -0.0190916
NIN ninein (GSK3B interacting protein) -0.0190078
RB1CC1 RB1-inducible coiled-coil 1 -0.0189588
SDK1 sidekick cell adhesion molecule 1 -0.0188453
FOCAD focadhesin -0.0187858
SHTN1 shootin 1 -0.0187786
TMEM64 transmembrane protein 64 -0.018766
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0187163
CAPRIN1 cell cycle associated protein 1 -0.0187146
ECE1 endothelin converting enzyme 1 -0.0187117
GRN granulin -0.0186538
ATXN3 ataxin 3 -0.0186092
GPATCH2L G patch domain containing 2-like -0.0185446
ZNFX1 zinc finger, NFX1-type containing 1 -0.0185337
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0185118
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.0185106
PLXNA4 plexin A4 -0.0184673
CPA6 carboxypeptidase A6 -0.0184654
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.018447
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0184333
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0184199
DROSHA drosha, ribonuclease type III -0.0184068
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0183329
TMEM59 transmembrane protein 59 -0.0183215
SYAP1 synapse associated protein 1 -0.0182368
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0181244
RABGAP1 RAB GTPase activating protein 1 -0.0181075
DMXL1 Dmx-like 1 -0.0181075
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0181034
CHURC1-FNTB CHURC1-FNTB readthrough -0.0180469
KAT6B K(lysine) acetyltransferase 6B -0.0180184
KIF2C kinesin family member 2C -0.0179998
RPL36A ribosomal protein L36a -0.0179368
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0178703
FAM222B family with sequence similarity 222, member B -0.0178277
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0178053
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0177853
HIPK2 homeodomain interacting protein kinase 2 -0.0177465
STX6 syntaxin 6 -0.0177146
CASZ1 castor zinc finger 1 -0.0177091
SYCP2 synaptonemal complex protein 2 -0.0177004
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0176168
RNF13 ring finger protein 13 -0.017587
PBRM1 polybromo 1 -0.0174947
STK39 serine threonine kinase 39 -0.0174728
ECPAS Ecm29 proteasome adaptor and scaffold -0.0174635
TAOK1 TAO kinase 1 -0.0174046
AKAP13 A kinase (PRKA) anchor protein 13 -0.0173793
RSF1 remodeling and spacing factor 1 -0.0172908
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0172053
DGKH diacylglycerol kinase, eta -0.0171979
CFAP44 cilia and flagella associated protein 44 -0.0171872
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -0.0171579
KLF12 Kruppel-like factor 12 -0.0171462
REEP5 receptor accessory protein 5 -0.0171124
XPO6 exportin 6 -0.0170883
SLC37A3 solute carrier family 37, member 3 -0.0170781
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0170583
LDHA lactate dehydrogenase A -0.0170295
DCP2 decapping mRNA 2 -0.0170192
RNF38 ring finger protein 38 -0.0170004
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0169644
RPLP2 ribosomal protein, large, P2 -0.0169586
FMN1 formin 1 -0.0168891
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0168699
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0168516
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0168426
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0168406
CAB39 calcium binding protein 39 -0.0168314
MACROD1 MACRO domain containing 1 -0.0168255
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -0.0168151
HDGFL3 HDGF like 3 -0.0168121
ERLIN1 ER lipid raft associated 1 -0.016773
AKAP11 A kinase (PRKA) anchor protein 11 -0.0167566
SACK1H scaffolding CK1 anchoring protein H -0.0167325
DIAPH2 diaphanous-related formin 2 -0.01671
POM121C POM121 transmembrane nucleoporin C -0.0166937
RNF149 ring finger protein 149 -0.0166666
COBL cordon-bleu WH2 repeat protein -0.0166655
DNPEP aspartyl aminopeptidase -0.0166505
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0166466
CDK6 cyclin-dependent kinase 6 -0.0165728
FAM120B family with sequence similarity 120B -0.0165587
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0165389
MBNL3 muscleblind-like splicing regulator 3 -0.0165105
EIF1 eukaryotic translation initiation factor 1 -0.0165058
CENPE centromere protein E, 312kDa -0.0164954
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0164787
ATXN2 ataxin 2 -0.0164396
SMC1A structural maintenance of chromosomes 1A -0.0164395
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0164158
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.0163995
KMT5B lysine methyltransferase 5B -0.0163723
DLC1 DLC1 Rho GTPase activating protein -0.0163547
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0163416
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0163275
LOC112694756 uncharaterized LOC112694756 -0.0163185
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0162809
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0162635
FCHO2 FCH domain only 2 -0.0162516
LMAN2 lectin, mannose-binding 2 -0.0162411
GATAD2B GATA zinc finger domain containing 2B -0.0162267
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0161906
WDR33 WD repeat domain 33 -0.0161243
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0160893
NECTIN2 nectin cell adhesion molecule 2 -0.0160647
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0160387
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0160379
CEP55 centrosomal protein 55kDa -0.0160009
ZNF331 zinc finger protein 331 -0.0159944
MREG melanoregulin -0.0159931
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0159841
RBM10 RNA binding motif protein 10 -0.0159828
BFAR bifunctional apoptosis regulator -0.0159641
USP33 ubiquitin specific peptidase 33 -0.0158876
RTF2 replication termination factor 2 -0.0158793
TMED8 transmembrane emp24 protein transport domain containing 8 -0.0158712
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0158593
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.0158351
TRRAP transformation/transcription domain-associated protein -0.015835
NSD3 nuclear receptor binding SET domain protein 3 -0.015826
CD59 CD59 molecule, complement regulatory protein -0.0158028
SCD5 stearoyl-CoA desaturase 5 -0.0157808
TAC4 tachykinin 4 (hemokinin) -0.0157531
SOBP sine oculis binding protein homolog (Drosophila) -0.015753
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) -0.015747
PTPRS protein tyrosine phosphatase, receptor type, S -0.0157255
CDC27 cell division cycle 27 -0.0157099
THRAP3 thyroid hormone receptor associated protein 3 -0.0156899
PKD1 polycystic kidney disease 1 (autosomal dominant) -0.0156846
TGFB2 transforming growth factor, beta 2 -0.0156505
FHIT fragile histidine triad -0.0156501
UBE2I ubiquitin-conjugating enzyme E2I -0.0156312
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0156281
KNL1 kinetochore scaffold 1 -0.015619
GPR107 G protein-coupled receptor 107 -0.0155984
STRN3 striatin, calmodulin binding protein 3 -0.015596
ANXA11 annexin A11 -0.0155822
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.015578
LDLR low density lipoprotein receptor -0.0155588
RPL3 ribosomal protein L3 -0.0155471
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.0155457
ACTL6A actin-like 6A -0.0155284
ATG101 autophagy related 101 -0.0155154
CAMKMT calmodulin-lysine N-methyltransferase -0.0154163
CSNK1D casein kinase 1, delta -0.0153888
SGPP1 sphingosine-1-phosphate phosphatase 1 -0.0153481
CDC25C cell division cycle 25C -0.015336
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -0.015319
SEM1 SEM1 26S proteasome subunit -0.0152755
TXNL4A thioredoxin-like 4A -0.0152172
C6ORF141 chromosome 6 open reading frame 141 -0.015204
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.0151845
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -0.0151371
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -0.0151041
RYK receptor-like tyrosine kinase -0.01508
CLASP2 cytoplasmic linker associated protein 2 -0.0150719
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0150608
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0150243
CLCN3 chloride channel, voltage-sensitive 3 -0.0150074
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.0149997
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0149957
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.014979
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.014931
TM9SF3 transmembrane 9 superfamily member 3 -0.01492
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0148945
TENT4A terminal nucleotidyltransferase 4A -0.0148816
DLG1 discs, large homolog 1 (Drosophila) -0.0148806
GALK2 galactokinase 2 -0.0148661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.014851
KDM4C lysine (K)-specific demethylase 4C -0.0148402
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0148171
PARN poly(A)-specific ribonuclease -0.0148079
TLK2 tousled-like kinase 2 -0.0147882
RBMX RNA binding motif protein, X-linked -0.0147732
CANT1 calcium activated nucleotidase 1 -0.0147596
AKAP10 A kinase (PRKA) anchor protein 10 -0.0147541
TLN1 talin 1 -0.0147276
TROAP trophinin associated protein -0.0147077
SNRPA small nuclear ribonucleoprotein polypeptide A -0.0147012
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -0.0146917
UBB ubiquitin B -0.0146872
ANKRD46 ankyrin repeat domain 46 -0.0146864
ATP5MG ATP synthase membrane subunit g -0.0146689
TM9SF2 transmembrane 9 superfamily member 2 -0.0146484
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -0.0146323
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0146232
CHD4 chromodomain helicase DNA binding protein 4 -0.0145929
NONO non-POU domain containing, octamer-binding -0.0145846
CHD1L chromodomain helicase DNA binding protein 1-like -0.0145653
SCFD2 sec1 family domain containing 2 -0.0145455
TBC1D32 TBC1 domain family, member 32 -0.0145173
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.014496
MEIS2 Meis homeobox 2 -0.0144771
NUP62 nucleoporin 62kDa -0.0144731
ARB2A ARB2 cotranscriptional regulator A -0.0144672
MYO5A myosin VA (heavy chain 12, myoxin) -0.014461
SUCO SUN domain containing ossification factor -0.0144599
ATL2 atlastin GTPase 2 -0.0144552
SETD7 SET domain containing (lysine methyltransferase) 7 -0.0144434
PTEN phosphatase and tensin homolog -0.0144393
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0144322
NCBP3 nuclear cap binding subunit 3 -0.014395
SOGA1 suppressor of glucose, autophagy associated 1 -0.0143775
KAT7 K(lysine) acetyltransferase 7 -0.0143183
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0143161
GATA3 GATA binding protein 3 -0.0143041
CAPN8 calpain 8 -0.0142913
MCM3 minichromosome maintenance complex component 3 -0.0142627
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -0.0142385
PRPF39 pre-mRNA processing factor 39 -0.014225
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -0.0141779
USP6NL USP6 N-terminal like -0.0141686
CLU clusterin -0.0141347
IRF2BPL interferon regulatory factor 2 binding protein-like -0.0141205
PRLR prolactin receptor -0.0141201
SWAP70 SWAP switching B-cell complex 70kDa subunit -0.0141139
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -0.0140997
PCBP2 poly(rC) binding protein 2 -0.0140706
SIK3 SIK family kinase 3 -0.0140686
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0140489
IL10RB interleukin 10 receptor, beta -0.0140485
ATP5MC1 ATP synthase membrane subunit c locus 1 -0.0139966
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -0.0139867
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -0.0139835
ZFP90 ZFP90 zinc finger protein -0.0139645
RUVBL1 RuvB-like AAA ATPase 1 -0.0139616
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.0139485
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0139014
RGS3 regulator of G-protein signaling 3 -0.0138536
TDG thymine-DNA glycosylase -0.0138469
RAB2A RAB2A, member RAS oncogene family -0.0138364
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0138329
ZNF148 zinc finger protein 148 -0.0138311
EEIG2 EEIG family member 2 -0.0138235
ZNF282 zinc finger protein 282 -0.0137986
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0137772
NCOR2 nuclear receptor corepressor 2 -0.0137755
TMSB4X thymosin beta 4, X-linked -0.013763
NOP53 NOP53 ribosome biogenesis factor -0.0137088
PKN1 protein kinase N1 -0.0136684
NOP56 NOP56 ribonucleoprotein -0.0136657
ECI1 enoyl-CoA delta isomerase 1 -0.0136587
SNX17 sorting nexin 17 -0.0136441
MRPS18A mitochondrial ribosomal protein S18A -0.0136335