MCF7_GSK J1_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description GSK J1 10nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_GSK J1_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 0.10617
DSPP dentin sialophosphoprotein 0.0835068
RPL37A ribosomal protein L37a 0.0812273
TPM4 tropomyosin 4 0.0776473
PAWR PRKC, apoptosis, WT1, regulator 0.0731512
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0688082
LMBR1 limb development membrane protein 1 0.0655632
H3-3B H3.3 histone B 0.065499
KRT8 keratin 8, type II 0.0639593
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0638596
NCOA3 nuclear receptor coactivator 3 0.0598358
CST3 cystatin C 0.0566342
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0545443
KRT19 keratin 19, type I 0.0539657
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0514833
FTH1 ferritin, heavy polypeptide 1 0.0514433
TSPAN12 tetraspanin 12 0.0510856
RPLP0 ribosomal protein, large, P0 0.0502687
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0474339
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0464925
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.0463929
SETD5 SET domain containing 5 0.04555
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0455494
USP32 ubiquitin specific peptidase 32 0.0451443
MYO5C myosin VC 0.044821
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.0444139
ABHD2 abhydrolase domain containing 2 0.0442654
RPL18 ribosomal protein L18 0.0442412
AGR2 anterior gradient 2 0.0442208
DSTN destrin (actin depolymerizing factor) 0.0435808
ESR1 estrogen receptor 1 0.0432541
APOD apolipoprotein D 0.0432122
ANKRD17 ankyrin repeat domain 17 0.0428386
TRIM37 tripartite motif containing 37 0.0426718
IQGAP1 IQ motif containing GTPase activating protein 1 0.0417832
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0416739
RPS17 ribosomal protein S17 0.0414919
STC2 stanniocalcin 2 0.0414083
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0408406
LRP1B low density lipoprotein receptor-related protein 1B 0.0401985
RPS19 ribosomal protein S19 0.0392302
DSCAM Down syndrome cell adhesion molecule 0.0390318
NEO1 neogenin 1 0.0389738
PACS1 phosphofurin acidic cluster sorting protein 1 0.0384214
EMP2 epithelial membrane protein 2 0.0383041
JMJD1C jumonji domain containing 1C 0.0381832
CENPB centromere protein B, 80kDa 0.0381589
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0381303
XBP1 X-box binding protein 1 0.0378941
RPL28 ribosomal protein L28 0.0378893
TOB1 transducer of ERBB2, 1 0.0374295
CAPNS1 calpain, small subunit 1 0.0374114
BCAS3 breast carcinoma amplified sequence 3 0.0373584
NCKAP5 NCK-associated protein 5 0.036654
SULF2 sulfatase 2 0.0365395
BCL2L1 BCL2-like 1 0.0361635
RPSA ribosomal protein SA 0.0359288
FREM2 FRAS1 related extracellular matrix protein 2 0.0358325
MALRD1 MAM and LDL receptor class A domain containing 1 0.0356313
GRN granulin 0.0355853
PLEC plectin 0.0351369
CPT1A carnitine palmitoyltransferase 1A (liver) 0.03509
COL4A5 collagen, type IV, alpha 5 0.0342956
TLK2 tousled-like kinase 2 0.0342752
MYOF myoferlin 0.0341116
CLASP2 cytoplasmic linker associated protein 2 0.0336763
KPNB1 karyopherin (importin) beta 1 0.0335287
POGZ pogo transposable element with ZNF domain 0.0335086
CXXC5 CXXC finger protein 5 0.0332575
RPLP1 ribosomal protein, large, P1 0.0330152
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0324572
SAMD8 sterile alpha motif domain containing 8 0.0323774
RPS27 ribosomal protein S27 0.0322399
BCAP31 B-cell receptor-associated protein 31 0.0321994
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0320847
MAML3 mastermind-like 3 (Drosophila) 0.0315052
CHD4 chromodomain helicase DNA binding protein 4 0.0312657
RERE arginine-glutamic acid dipeptide (RE) repeats 0.031188
CD63 CD63 molecule 0.0310111
RPS10 ribosomal protein S10 0.0308589
TPM1 tropomyosin 1 (alpha) 0.0306812
UGCG UDP-glucose ceramide glucosyltransferase 0.0303252
GSK3B glycogen synthase kinase 3 beta 0.0303
ADIPOR2 adiponectin receptor 2 0.0300237
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0299996
RNF115 ring finger protein 115 0.0299856
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0299831
IRS1 insulin receptor substrate 1 0.0299771
MBTD1 mbt domain containing 1 0.0298771
GATAD2B GATA zinc finger domain containing 2B 0.0298355
TRIM33 tripartite motif containing 33 0.0298249
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0294285
ESYT2 extended synaptotagmin-like protein 2 0.0293307
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0289917
R3HDM1 R3H domain containing 1 0.0289734
GLCCI1 glucocorticoid induced 1 0.0288309
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0287525
CTSD cathepsin D 0.0285859
RPL18A ribosomal protein L18a 0.0285769
TMEM164 transmembrane protein 164 0.0285108
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0284575
LARS1 leucyl-tRNA synthetase 1 0.0284167
CLSTN1 calsyntenin 1 0.0278188
ZBTB7A zinc finger and BTB domain containing 7A 0.0275043
SIL1 SIL1 nucleotide exchange factor 0.0274021
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.0273999
RACK1 receptor for activated C kinase 1 0.0273397
PKM pyruvate kinase, muscle 0.0271794
RABEPK Rab9 effector protein with kelch motifs 0.0271258
CLDN3 claudin 3 0.0270937
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0270021
PATJ PATJ crumbs cell polarity complex component 0.0270018
SH3D19 SH3 domain containing 19 0.0269469
NRP1 neuropilin 1 0.0268065
AHNAK AHNAK nucleoprotein 0.0264511
RPS18 ribosomal protein S18 0.0264455
THBS1 thrombospondin 1 0.0263874
ETF1 eukaryotic translation termination factor 1 0.0261599
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0259258
GTF2IRD1 GTF2I repeat domain containing 1 0.0258958
KMT2E lysine (K)-specific methyltransferase 2E 0.0258947
RAB6A RAB6A, member RAS oncogene family 0.025808
NIBAN2 niban apoptosis regulator 2 0.0257881
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0257023
ANXA4 annexin A4 0.0256849
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0254624
SAMD12 sterile alpha motif domain containing 12 0.0254548
IQANK1 IQ motif and ankyrin repeat containing 1 0.0253949
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0253132
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.025136
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0250554
PKP4 plakophilin 4 0.0250482
ACTN4 actinin, alpha 4 0.0249189
UBE2H ubiquitin-conjugating enzyme E2H 0.0248585
MAP2K1 mitogen-activated protein kinase kinase 1 0.0248409
PGR progesterone receptor 0.02477
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0246678
FHIT fragile histidine triad 0.0246459
SFT2D2 SFT2 domain containing 2 0.0245835
FNBP1 formin binding protein 1 0.0245559
CHD7 chromodomain helicase DNA binding protein 7 0.0243884
H2AC6 H2A clustered histone 6 0.0243865
COL18A1 collagen, type XVIII, alpha 1 0.0243684
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0241374
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0241185
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0241143
MICU1 mitochondrial calcium uptake 1 0.0240753
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0239757
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0238948
PFKP phosphofructokinase, platelet 0.0238771
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 0.0235303
TGOLN2 trans-golgi network protein 2 0.0234868
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0234589
SCFD1 sec1 family domain containing 1 0.0233566
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0233298
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0233225
PTK2 protein tyrosine kinase 2 0.0232824
RPS2 ribosomal protein S2 0.0232739
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0230799
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0230794
RPL19 ribosomal protein L19 0.0228531
TPD52 tumor protein D52 0.0228366
ARSG arylsulfatase G 0.022821
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227576
PRICKLE2 prickle homolog 2 (Drosophila) 0.0226694
FOXO1 forkhead box O1 0.0226645
KRT18 keratin 18, type I 0.02266
RPN2 ribophorin II 0.0226468
PTPRF protein tyrosine phosphatase, receptor type, F 0.0225395
TRIM28 tripartite motif containing 28 0.0224934
RPL29 ribosomal protein L29 0.0224504
SUFU suppressor of fused homolog (Drosophila) 0.0224236
MICALL2 MICAL-like 2 0.0224196
UGDH UDP-glucose 6-dehydrogenase 0.0224014
LDLR low density lipoprotein receptor 0.0223891
TNRC18 trinucleotide repeat containing 18 0.0223433
SPTSSB serine palmitoyltransferase, small subunit B 0.0223009
LOC102724023 ES1 protein homolog, mitochondrial 0.0222803
FXYD3 FXYD domain containing ion transport regulator 3 0.0222254
RPL23A ribosomal protein L23a 0.0221924
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.0221402
SELENOS selenoprotein S 0.0220935
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0220651
VCP valosin containing protein 0.0219705
HDGF hepatoma-derived growth factor 0.0219304
BABAM2 BRISC and BRCA1 A complex member 2 0.021857
HELZ helicase with zinc finger 0.021803
MYO1D myosin ID 0.021753
RPL3 ribosomal protein L3 0.0217325
AFF1 AF4/FMR2 family, member 1 0.0216857
KDM4B lysine (K)-specific demethylase 4B 0.0216856
PDIA6 protein disulfide isomerase family A, member 6 0.0216709
GPC6 glypican 6 0.0216328
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0215593
FBXW11 F-box and WD repeat domain containing 11 0.0214709
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0214544
ATRNL1 attractin-like 1 0.0212451
URM1 ubiquitin related modifier 1 0.0212173
SCAMP2 secretory carrier membrane protein 2 0.0212139
MTREX Mtr4 exosome RNA helicase 0.0212118
CCNT2 cyclin T2 0.021185
CHD3 chromodomain helicase DNA binding protein 3 0.0211767
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0211185
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0211081
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.0210101
TPI1 triosephosphate isomerase 1 0.0210045
SCD5 stearoyl-CoA desaturase 5 0.0209434
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0208303
OSBPL9 oxysterol binding protein-like 9 0.0208164
ATXN7 ataxin 7 0.0207829
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0207662
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0.0207337
GLB1 galactosidase, beta 1 0.0206316
LMF1 lipase maturation factor 1 0.0205595
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0205267
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.020516
PEBP1 phosphatidylethanolamine binding protein 1 0.0203687
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0203378
LTBP1 latent transforming growth factor beta binding protein 1 0.0202229
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.0202154
TMSB10 thymosin beta 10 0.020209
ATP13A3 ATPase type 13A3 0.020175
PSD3 pleckstrin and Sec7 domain containing 3 0.020107
RPL21 ribosomal protein L21 0.0200039
DLG5 discs, large homolog 5 (Drosophila) 0.0199128
RPS3A ribosomal protein S3A 0.0199096
MBOAT1 membrane bound O-acyltransferase domain containing 1 0.0198947
COX5B cytochrome c oxidase subunit Vb 0.0198922
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.019838
FAM120AOS family with sequence similarity 120A opposite strand 0.0197892
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0197855
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0196082
ANKRD46 ankyrin repeat domain 46 0.0194625
CLIC4 chloride intracellular channel 4 0.019458
DPY19L3 dpy-19-like 3 (C. elegans) 0.0193911
TLE5 TLE family member 5, transcriptional modulator 0.0193627
TMEM245 transmembrane protein 245 0.019341
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0193402
TACC2 transforming, acidic coiled-coil containing protein 2 0.019294
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0192887
SNX29 sorting nexin 29 0.0192447
ECPAS Ecm29 proteasome adaptor and scaffold 0.0192432
JMY junction mediating and regulatory protein, p53 cofactor 0.0192286
APRT adenine phosphoribosyltransferase 0.0191176
RRP1B ribosomal RNA processing 1B 0.0190931
LARP1 La ribonucleoprotein domain family, member 1 0.0190872
PUS7 pseudouridylate synthase 7 (putative) 0.019072
FLNA filamin A, alpha 0.0190296
TMEM223 transmembrane protein 223 0.0190137
CLINT1 clathrin interactor 1 0.0190017
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0189932
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0189731
ACTN1 actinin, alpha 1 0.0189716
ATRN attractin 0.0189683
RABGAP1 RAB GTPase activating protein 1 0.0189212
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.018889
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0188818
STX6 syntaxin 6 0.0188577
CALR calreticulin 0.0188521
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.018846
TDP1 tyrosyl-DNA phosphodiesterase 1 0.0188007
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0187642
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0187273
WEE1 WEE1 G2 checkpoint kinase 0.0187029
SSH1 slingshot protein phosphatase 1 0.018673
RBM14-RBM4 RBM14-RBM4 readthrough 0.0186669
TSG101 tumor susceptibility 101 0.0186309
TMEM150C transmembrane protein 150C 0.0186002
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0185922
RPL23 ribosomal protein L23 0.018544
HLA-E major histocompatibility complex, class I, E 0.0185148
SGMS1 sphingomyelin synthase 1 0.0185058
ITGB4 integrin, beta 4 0.0184857
L2HGDH L-2-hydroxyglutarate dehydrogenase 0.0184355
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0183914
FBL fibrillarin 0.0183825
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0183588
S100A11 S100 calcium binding protein A11 0.0183539
PDLIM7 PDZ and LIM domain 7 (enigma) 0.018353
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0183425
CCND3 cyclin D3 0.0183204
STK38L serine/threonine kinase 38 like 0.0183202
RPS15A ribosomal protein S15a 0.0182918
KIAA0319L KIAA0319-like 0.0182882
CLCN4 chloride channel, voltage-sensitive 4 0.0182814
OSBPL8 oxysterol binding protein-like 8 0.0182761
CTSA cathepsin A 0.0182747
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0182484
SURF4 surfeit 4 0.0182284
ZCCHC7 zinc finger, CCHC domain containing 7 0.0182082
WDFY3 WD repeat and FYVE domain containing 3 0.0182004
RAB31 RAB31, member RAS oncogene family 0.0181537
TAOK3 TAO kinase 3 0.0181531
PAXBP1 PAX3 and PAX7 binding protein 1 0.0181521
TACC1 transforming, acidic coiled-coil containing protein 1 0.0180511
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0179642
MAST4 microtubule associated serine/threonine kinase family member 4 0.0178478
VCL vinculin 0.0178126
DEK DEK proto-oncogene 0.0177482
SSBP3 single stranded DNA binding protein 3 0.0177336
ZNF280C zinc finger protein 280C 0.0177267
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0177027
GOLGB1 golgin B1 0.0176474
LMBRD1 LMBR1 domain containing 1 0.0175981
RBMX RNA binding motif protein, X-linked 0.0175938
LARP4 La ribonucleoprotein domain family, member 4 0.0175787
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.0175622
KIDINS220 kinase D-interacting substrate, 220kDa 0.0175569
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.0175308
MYO9A myosin IXA 0.0175301
VMP1 vacuole membrane protein 1 0.0175266
METTL16 methyltransferase like 16 0.0174833
RNF13 ring finger protein 13 0.0174769
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 0.0174496
DOCK6 dedicator of cytokinesis 6 0.0174237
MRPS18B mitochondrial ribosomal protein S18B 0.0174221
OSBPL10 oxysterol binding protein-like 10 0.0173813
MSH2 mutS homolog 2 0.0173785
SETD2 SET domain containing 2 0.0173317
NELFCD negative elongation factor complex member C/D 0.0173176
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0173065
MARVELD2 MARVEL domain containing 2 0.0172385
ODF2 outer dense fiber of sperm tails 2 0.0171888
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.0171851
PTMS parathymosin 0.0171706
PGRMC1 progesterone receptor membrane component 1 0.0171045
NBPF12 neuroblastoma breakpoint family, member 12 0.0170788
CADM1 cell adhesion molecule 1 0.0170045
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.0169982
ZNF609 zinc finger protein 609 0.0169893
DMWD dystrophia myotonica, WD repeat containing 0.0169854
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.0169463
HIP1 huntingtin interacting protein 1 0.016912
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0168782
MIDEAS mitotic deacetylase associated SANT domain protein 0.0168775
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0168422
TOGARAM1 TOG array regulator of axonemal microtubules 1 0.0168358
WASF2 WAS protein family, member 2 0.01675
LGALS12 lectin, galactoside-binding, soluble, 12 0.016724
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0167193
PLXND1 plexin D1 0.0167184
TMEM14C transmembrane protein 14C 0.016709
NINJ1 ninjurin 1 0.0166735
NRCAM neuronal cell adhesion molecule 0.0166583
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.0166121
LPP LIM domain containing preferred translocation partner in lipoma 0.0165958
ASXL1 additional sex combs like transcriptional regulator 1 0.0165932
FAM168A family with sequence similarity 168, member A 0.0165399
AURKAIP1 aurora kinase A interacting protein 1 0.0165223
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.0165149
SLC39A9 solute carrier family 39, member 9 0.0165064
TADA2A transcriptional adaptor 2A 0.0165058
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0164678
CAPRIN1 cell cycle associated protein 1 0.0164384
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0164321
MAP4 microtubule-associated protein 4 0.0164291
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.0164279
RPS20 ribosomal protein S20 0.0164082
CSDE1 cold shock domain containing E1, RNA-binding 0.0164035
CLTC clathrin, heavy chain (Hc) 0.0163844
TM7SF3 transmembrane 7 superfamily member 3 0.0163597
CCND1 cyclin D1 0.0163142
M6PR mannose-6-phosphate receptor (cation dependent) 0.0163106
SNX24 sorting nexin 24 0.0162942
ADGRG6 adhesion G protein-coupled receptor G6 0.0162711
ZNF451 zinc finger protein 451 0.0162416
MYO16 myosin XVI 0.0162118
WDR45 WD repeat domain 45 0.0162002
EP300 E1A binding protein p300 0.0161906
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.016189
GREB1L growth regulation by estrogen in breast cancer-like 0.0161798
INTS2 integrator complex subunit 2 0.0161728
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0161605
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.0161599
TUBA1B tubulin, alpha 1b 0.0161272
KIAA0232 KIAA0232 0.016012
IP6K1 inositol hexakisphosphate kinase 1 0.016002
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.01598
RAB1B RAB1B, member RAS oncogene family 0.0159696
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0159682
DNM1 dynamin 1 0.0159634
RPS27A ribosomal protein S27a 0.0159557
GOLM2 golgi membrane protein 2 0.0159444
TRPS1 trichorhinophalangeal syndrome I 0.0159198
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0159187
MAPK1 mitogen-activated protein kinase 1 0.0159013
CDC5L cell division cycle 5-like 0.0158954
CERT1 ceramide transporter 1 0.0158823
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0158727
SQSTM1 sequestosome 1 0.015868
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0157686
LEPROT leptin receptor overlapping transcript 0.0157548
RHOC ras homolog family member C 0.0157429
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0156972
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0156935
BSG basigin (Ok blood group) 0.0156847
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0156619
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0156382
NIPAL2 NIPA-like domain containing 2 0.0156294
PHF20 PHD finger protein 20 0.0156227
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0156218
RPS21 ribosomal protein S21 0.0156214
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0156154
OTUD5 OTU deubiquitinase 5 0.0156117
PCBP2 poly(rC) binding protein 2 0.0156039
ZFYVE1 zinc finger, FYVE domain containing 1 0.0155599
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0155465
PRR14L proline rich 14-like 0.0155291
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0155151
CA4 carbonic anhydrase IV 0.0155142
DDTL D-dopachrome tautomerase-like 0.0155062
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0152922
KRT80 keratin 80, type II 0.0152787
RUNX1 runt-related transcription factor 1 0.0152546
BOD1 biorientation of chromosomes in cell division 1 0.0152495
YEATS2 YEATS domain containing 2 0.0152485
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0152426
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0152382
TMEM268 transmembrane protein 268 0.0152245
KIF5B kinesin family member 5B 0.015206
ITGB5 integrin, beta 5 0.0152052
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.0151987
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.0151877
CAND1 cullin-associated and neddylation-dissociated 1 0.0151753
CFDP1 craniofacial development protein 1 0.0151727
SCARB2 scavenger receptor class B, member 2 0.0151638
PKN2 protein kinase N2 0.0151577
IRS2 insulin receptor substrate 2 0.0151422
TMEM123 transmembrane protein 123 0.0151163
WDR20 WD repeat domain 20 0.0150885
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0149692
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0149606
EXOC2 exocyst complex component 2 0.0149542
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0149512
LYST lysosomal trafficking regulator 0.0149459
PGPEP1 pyroglutamyl-peptidase I 0.0149368
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.0149031
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0149003
FOXK1 forkhead box K1 0.0148412
RILPL2 Rab interacting lysosomal protein-like 2 0.0148187
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0148079
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.0147715
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0147703
SYPL1 synaptophysin-like 1 0.0147532
PER2 period circadian clock 2 0.0147466
EIF4A1 eukaryotic translation initiation factor 4A1 0.0147439
SCAF4 SR-related CTD-associated factor 4 0.0147168
NOL8 nucleolar protein 8 0.0147148
SYNGR2 synaptogyrin 2 0.0146806
CD24 CD24 molecule 0.01462
BICDL1 BICD family like cargo adaptor 1 0.0146194
RBBP8 retinoblastoma binding protein 8 0.0146076
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.0146008
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0145779
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0145604
RNF216 ring finger protein 216 0.0145561
KRTAP11-1 keratin associated protein 11-1 0.0145544
VAV2 vav 2 guanine nucleotide exchange factor 0.0145524
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0145499
CREBRF CREB3 regulatory factor 0.0145339
LARP1B La ribonucleoprotein domain family, member 1B 0.0145188
RNF10 ring finger protein 10 0.0145146
ARF1 ADP-ribosylation factor 1 0.0145063
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0145007
SCAF1 SR-related CTD-associated factor 1 0.0144854
PLSCR1 phospholipid scramblase 1 0.0144725
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 0.0144444
ABI2 abl-interactor 2 0.01444
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.0143872
BTBD2 BTB (POZ) domain containing 2 0.0143713
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0143513
BMP2K BMP2 inducible kinase 0.0143177
ANAPC1 anaphase promoting complex subunit 1 0.0143163
CUL3 cullin 3 0.0143121
RPLP2 ribosomal protein, large, P2 0.0143075
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0142903
PRSS23 protease, serine, 23 0.0142866
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0142756
MSRA methionine sulfoxide reductase A 0.0142745
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 0.0142604
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0142601
IQCB1 IQ motif containing B1 0.014225
RC3H1 ring finger and CCCH-type domains 1 0.014221
RER1 retention in endoplasmic reticulum sorting receptor 1 0.014207
TCEA2 transcription elongation factor A (SII), 2 0.0141877
ERCC3 excision repair cross-complementation group 3 0.014186
CTSB cathepsin B 0.01415
ACOT7 acyl-CoA thioesterase 7 0.0141474
ZCCHC10 zinc finger, CCHC domain containing 10 0.0141441
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0141427
TPCN1 two pore segment channel 1 0.014129
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 0.0141277
DAND5 DAN domain family member 5, BMP antagonist 0.0141167
LSR lipolysis stimulated lipoprotein receptor 0.0141148
SOAT1 sterol O-acyltransferase 1 0.0140673
ZFHX3 zinc finger homeobox 3 0.0140545
ORC3 origin recognition complex, subunit 3 0.0140327
UCK2 uridine-cytidine kinase 2 0.0140187
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.014012
COPS2 COP9 signalosome subunit 2 0.0140021

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.10537
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.100744
SYTL2 synaptotagmin-like 2 -0.0914744
GFRA1 GDNF family receptor alpha 1 -0.0811441
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0772533
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0746694
MSI2 musashi RNA-binding protein 2 -0.0703865
WWOX WW domain containing oxidoreductase -0.0703787
RPS6 ribosomal protein S6 -0.0635999
EVL Enah/Vasp-like -0.063576
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0612955
HIPK2 homeodomain interacting protein kinase 2 -0.0584722
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0583988
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0572821
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0560933
MACROD2 MACRO domain containing 2 -0.0554773
GSE1 Gse1 coiled-coil protein -0.0546194
R3HDM2 R3H domain containing 2 -0.0493519
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0489207
CANX calnexin -0.0484957
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0477851
PDS5A PDS5 cohesin associated factor A -0.0468022
ANKRD11 ankyrin repeat domain 11 -0.0458409
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0457991
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0454385
FAM222B family with sequence similarity 222, member B -0.0454206
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0446982
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0445419
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0436069
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0436066
AGO2 argonaute RISC catalytic component 2 -0.0431942
CHD8 chromodomain helicase DNA binding protein 8 -0.042779
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0425329
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -0.041829
CELF1 CUGBP, Elav-like family member 1 -0.0415916
RNF213 ring finger protein 213 -0.041305
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0408548
DTNA dystrobrevin, alpha -0.0402712
ATXN7L1 ataxin 7-like 1 -0.040269
GNAS GNAS complex locus -0.0402094
UBC ubiquitin C -0.0401716
ZNF638 zinc finger protein 638 -0.038371
SKA2 spindle and kinetochore associated complex subunit 2 -0.0377465
RHOBTB3 Rho-related BTB domain containing 3 -0.0372637
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.03691
GREB1 growth regulation by estrogen in breast cancer 1 -0.0368692
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0366417
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0362996
RPL37 ribosomal protein L37 -0.0357599
CENPP centromere protein P -0.0354589
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0349176
BRI3BP BRI3 binding protein -0.0348557
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0348287
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0345687
GRHL2 grainyhead-like 2 (Drosophila) -0.0343654
PFDN4 prefoldin subunit 4 -0.0342386
ZNF217 zinc finger protein 217 -0.0338669
PTGES2 prostaglandin E synthase 2 -0.0337789
RBM47 RNA binding motif protein 47 -0.03314
GSPT1 G1 to S phase transition 1 -0.0330501
TBL1X transducin (beta)-like 1X-linked -0.0326328
RPS24 ribosomal protein S24 -0.0323364
GRB2 growth factor receptor-bound protein 2 -0.0320675
STK24 serine/threonine kinase 24 -0.0319105
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0318428
CLSTN2 calsyntenin 2 -0.0317452
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0316525
CDK6 cyclin-dependent kinase 6 -0.0315746
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -0.0314755
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0314269
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0312195
BRCA2 breast cancer 2, early onset -0.0311048
QKI QKI, KH domain containing, RNA binding -0.0308513
RANBP17 RAN binding protein 17 -0.0308136
ZMYND8 zinc finger, MYND-type containing 8 -0.030728
TUBD1 tubulin, delta 1 -0.0307118
NEBL nebulette -0.0306211
ATAD2 ATPase family, AAA domain containing 2 -0.0305915
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0304771
KYNU kynureninase -0.0302933
TPX2 TPX2, microtubule-associated -0.0302551
LRRC58 leucine rich repeat containing 58 -0.0302126
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0300597
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.030021
PRRC2B proline-rich coiled-coil 2B -0.0299995
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0298698
MARCHF6 membrane associated ring-CH-type finger 6 -0.0296985
HIPK1 homeodomain interacting protein kinase 1 -0.0296602
ABR active BCR-related -0.0295238
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0294683
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -0.029185
COX6C cytochrome c oxidase subunit VIc -0.029044
TMOD3 tropomodulin 3 (ubiquitous) -0.0290236
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0288664
GIPC1 GIPC PDZ domain containing family, member 1 -0.0287644
PUM2 pumilio RNA-binding family member 2 -0.0286531
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0284973
MRPL13 mitochondrial ribosomal protein L13 -0.0284615
BTBD9 BTB (POZ) domain containing 9 -0.0283371
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0282027
ARID4A AT rich interactive domain 4A (RBP1-like) -0.0280209
RPL13A ribosomal protein L13a -0.0280137
KHSRP KH-type splicing regulatory protein -0.0279415
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0278892
PARD3 par-3 family cell polarity regulator -0.027828
AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.0278247
RGS6 regulator of G-protein signaling 6 -0.0277149
TFF1 trefoil factor 1 -0.0276404
DLG1 discs, large homolog 1 (Drosophila) -0.0273822
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0270664
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.027046
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0269791
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -0.026965
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0269334
UBE2O ubiquitin-conjugating enzyme E2O -0.02691
DGKH diacylglycerol kinase, eta -0.0267263
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0267107
PRKD2 protein kinase D2 -0.0266841
CBX5 chromobox homolog 5 -0.0265225
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -0.0264602
DNASE1L1 deoxyribonuclease I-like 1 -0.0263649
PCDH7 protocadherin 7 -0.0262791
INVS inversin -0.0261597
BIRC6 baculoviral IAP repeat containing 6 -0.0261486
CYRIB CYFIP related Rac1 interactor B -0.0261368
TMSB4X thymosin beta 4, X-linked -0.0261173
CDK13 cyclin-dependent kinase 13 -0.0261032
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0260585
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0260461
PHF21A PHD finger protein 21A -0.0259536
MED13L mediator complex subunit 13-like -0.0258904
BPTF bromodomain PHD finger transcription factor -0.025844
GTF2I general transcription factor IIi -0.0257193
RPS12 ribosomal protein S12 -0.0256522
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.025627
PHF12 PHD finger protein 12 -0.0255885
LRP10 low density lipoprotein receptor-related protein 10 -0.0255145
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0254865
CCDC7 coiled-coil domain containing 7 -0.0254794
SNW1 SNW domain containing 1 -0.025422
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0253534
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0253326
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.0252736
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0252544
SMAD3 SMAD family member 3 -0.0252541
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0252243
ARHGAP11B Rho GTPase activating protein 11B -0.0251707
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0250603
SHROOM3 shroom family member 3 -0.0250581
ZNF518A zinc finger protein 518A -0.024987
MAP7 microtubule-associated protein 7 -0.02492
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.0247691
HMCN1 hemicentin 1 -0.0245694
RAB10 RAB10, member RAS oncogene family -0.0245015
RORA RAR-related orphan receptor A -0.0244231
NRIP1 nuclear receptor interacting protein 1 -0.024419
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0243811
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0243106
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0241821
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0241771
NECAB1 N-terminal EF-hand calcium binding protein 1 -0.0241576
SOS1 son of sevenless homolog 1 (Drosophila) -0.0240548
TRIM56 tripartite motif containing 56 -0.0239167
AFAP1 actin filament associated protein 1 -0.0238548
PPA2 pyrophosphatase (inorganic) 2 -0.0237776
ZFAND3 zinc finger, AN1-type domain 3 -0.0237476
MRTFB myocardin related transcription factor B -0.0237034
FANCI Fanconi anemia, complementation group I -0.0236859
AOPEP aminopeptidase O (putative) -0.0236788
GATA3 GATA binding protein 3 -0.0236379
CCDC57 coiled-coil domain containing 57 -0.0236363
KIF1B kinesin family member 1B -0.0236298
SOS2 son of sevenless homolog 2 (Drosophila) -0.0235435
PFKL phosphofructokinase, liver -0.0235195
STX8 syntaxin 8 -0.0235166
BCLAF1 BCL2-associated transcription factor 1 -0.0234089
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0233641
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.023351
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0232324
RPS14 ribosomal protein S14 -0.0231941
SYT1 synaptotagmin I -0.023168
TMCC1 transmembrane and coiled-coil domain family 1 -0.0231557
HMGB1 high mobility group box 1 -0.0231526
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.0231342
ATP5F1B ATP synthase F1 subunit beta -0.0231305
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.023113
ZMYM5 zinc finger, MYM-type 5 -0.023058
TBC1D32 TBC1 domain family, member 32 -0.0229798
SETX senataxin -0.0229663
MICU2 mitochondrial calcium uptake 2 -0.0229021
SYCP2 synaptonemal complex protein 2 -0.0228216
RFWD3 ring finger and WD repeat domain 3 -0.0227598
CD59 CD59 molecule, complement regulatory protein -0.0227327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0226931
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0226345
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0226335
PXDN peroxidasin -0.022595
LAMP2 lysosomal-associated membrane protein 2 -0.0225799
SNX6 sorting nexin 6 -0.0225295
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0225269
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0224945
PSEN1 presenilin 1 -0.0224051
MTG2 mitochondrial ribosome-associated GTPase 2 -0.022388
SPPL2A signal peptide peptidase like 2A -0.0223841
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0223417
NUP205 nucleoporin 205kDa -0.0223357
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.02216
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0220696
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0220553
RAB28 RAB28, member RAS oncogene family -0.0220292
SREBF2 sterol regulatory element binding transcription factor 2 -0.0219921
MBD5 methyl-CpG binding domain protein 5 -0.0217402
EDRF1 erythroid differentiation regulatory factor 1 -0.021737
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0217329
DOCK5 dedicator of cytokinesis 5 -0.0216963
SCAPER S-phase cyclin A-associated protein in the ER -0.0216562
IVD isovaleryl-CoA dehydrogenase -0.021633
YTHDC1 YTH domain containing 1 -0.0216245
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0216237
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0215819
RNF130 ring finger protein 130 -0.0215381
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.0215251
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0215026
HOOK3 hook microtubule-tethering protein 3 -0.021472
SENP5 SUMO1/sentrin specific peptidase 5 -0.0213321
TUT7 terminal uridylyl transferase 7 -0.0212442
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0212375
BLTP2 bridge-like lipid transfer protein family member 2 -0.0212005
RBM25 RNA binding motif protein 25 -0.021198
KTN1 kinectin 1 (kinesin receptor) -0.0211898
AP2A1 adaptor-related protein complex 2, alpha 1 subunit -0.0211429
ACYP2 acylphosphatase 2, muscle type -0.0211231
MIA3 melanoma inhibitory activity family, member 3 -0.0211214
PCYOX1 prenylcysteine oxidase 1 -0.0210659
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0210436
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0210423
UBA1 ubiquitin-like modifier activating enzyme 1 -0.0210402
NCOR1 nuclear receptor corepressor 1 -0.0210009
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0209918
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.020981
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0209311
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0209172
WWC2 WW and C2 domain containing 2 -0.0208671
TRIP12 thyroid hormone receptor interactor 12 -0.0208412
NPDC1 neural proliferation, differentiation and control, 1 -0.0208315
SRRM1 serine/arginine repetitive matrix 1 -0.0208087
DHCR24 24-dehydrocholesterol reductase -0.0206896
SPICE1 spindle and centriole associated protein 1 -0.0206484
DNMBP dynamin binding protein -0.0206326
DCAKD dephospho-CoA kinase domain containing -0.0206216
NCKAP1 NCK-associated protein 1 -0.0204498
EIF4B eukaryotic translation initiation factor 4B -0.0204236
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0203836
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -0.0203801
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0203629
MYO1B myosin IB -0.0202467
PCM1 pericentriolar material 1 -0.0202133
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0202041
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.0201922
HELLS helicase, lymphoid-specific -0.0200979
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0200799
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.020047
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -0.0200426
TMEM59 transmembrane protein 59 -0.0200396
TMEM178B transmembrane protein 178B -0.019982
SENP6 SUMO1/sentrin specific peptidase 6 -0.0199781
ZXDC ZXD family zinc finger C -0.0199714
ANO6 anoctamin 6 -0.0199708
DHDDS dehydrodolichyl diphosphate synthase -0.0199659
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.0199658
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0199055
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0199017
SEC16A SEC16 homolog A (S. cerevisiae) -0.019893
ANKRD36C ankyrin repeat domain 36C -0.0198833
MCM7 minichromosome maintenance complex component 7 -0.0198554
ATP11B ATPase, class VI, type 11B -0.0198386
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0197966
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0197669
CALCR calcitonin receptor -0.0197584
SDC1 syndecan 1 -0.0197191
PTBP2 polypyrimidine tract binding protein 2 -0.0196703
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0196631
NALF1 NALCN channel auxiliary factor 1 -0.0196286
FANCM Fanconi anemia, complementation group M -0.0195474
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0195172
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0194708
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.019417
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -0.0194004
ZNF260 zinc finger protein 260 -0.0193787
IFI6 interferon, alpha-inducible protein 6 -0.0193649
S100A14 S100 calcium binding protein A14 -0.0193599
YAP1 Yes-associated protein 1 -0.0192837
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0192727
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0192578
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0192265
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0191834
TICRR TOPBP1-interacting checkpoint and replication regulator -0.0191707
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0191592
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0191397
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0191234
IMMT inner membrane protein, mitochondrial -0.0190644
TTF1 transcription termination factor, RNA polymerase I -0.0190267
FOXK2 forkhead box K2 -0.019
AHI1 Abelson helper integration site 1 -0.0189066
SOX4 SRY (sex determining region Y)-box 4 -0.0189056
STRBP spermatid perinuclear RNA binding protein -0.0188823
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0188689
GATAD1 GATA zinc finger domain containing 1 -0.0187966
EVPL envoplakin -0.0187841
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -0.0187237
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0186652
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0186468
ALCAM activated leukocyte cell adhesion molecule -0.0186284
UBE3C ubiquitin protein ligase E3C -0.0186257
C1ORF21 chromosome 1 open reading frame 21 -0.0186106
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0185706
RPS8 ribosomal protein S8 -0.0185614
C21ORF58 chromosome 21 open reading frame 58 -0.0185458
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0185166
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0185152
PSPC1 paraspeckle component 1 -0.0185075
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.018496
SLF2 SMC5-SMC6 complex localization factor 2 -0.0184879
TRIM44 tripartite motif containing 44 -0.0184767
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0184369
PCLO piccolo presynaptic cytomatrix protein -0.0183731
RNF169 ring finger protein 169 -0.0183706
TBC1D16 TBC1 domain family, member 16 -0.0183445
EIF3I eukaryotic translation initiation factor 3, subunit I -0.0183294
INIP INTS3 and NABP interacting protein -0.0183222
FASN fatty acid synthase -0.0182691
TPST1 tyrosylprotein sulfotransferase 1 -0.0182506
RPAP2 RNA polymerase II associated protein 2 -0.0181992
XPC xeroderma pigmentosum, complementation group C -0.0181946
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0181726
KANK2 KN motif and ankyrin repeat domains 2 -0.0181452
SIN3A SIN3 transcription regulator family member A -0.0181371
ANKRD26 ankyrin repeat domain 26 -0.0181295
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0181267
SMC5 structural maintenance of chromosomes 5 -0.0181245
NBEA neurobeachin -0.0181229
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0181115
TBRG4 transforming growth factor beta regulator 4 -0.0180996
KDM6B lysine (K)-specific demethylase 6B -0.0180905
WAPL WAPL cohesin release factor -0.0179846
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0179119
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 -0.0178988
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -0.0178898
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0178804
ANO10 anoctamin 10 -0.0178778
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0178356
KCNK6 potassium channel, two pore domain subfamily K, member 6 -0.0178186
PBX1 pre-B-cell leukemia homeobox 1 -0.0178114
N4BP1 NEDD4 binding protein 1 -0.0178051
PLXNA4 plexin A4 -0.0177065
RPL31 ribosomal protein L31 -0.0176851
BCAS1 breast carcinoma amplified sequence 1 -0.0176679
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0175983
ACTG1 actin gamma 1 -0.0175901
MED13 mediator complex subunit 13 -0.0175463
PBX3 pre-B-cell leukemia homeobox 3 -0.0175324
CLDN7 claudin 7 -0.0175275
ZHX3 zinc fingers and homeoboxes 3 -0.0175155
EPCAM epithelial cell adhesion molecule -0.0175006
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0174785
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0174552
SPTBN2 spectrin, beta, non-erythrocytic 2 -0.0174355
TFRC transferrin receptor -0.0174343
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0174263
FGF13 fibroblast growth factor 13 -0.0174216
STRN3 striatin, calmodulin binding protein 3 -0.0173655
VPS35L VPS35 endosomal protein sorting factor like -0.0173601
RABL6 RAB, member RAS oncogene family-like 6 -0.0173436
USP1 ubiquitin specific peptidase 1 -0.0173155
USP25 ubiquitin specific peptidase 25 -0.0172888
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0172857
DMXL2 Dmx-like 2 -0.0172725
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0172658
RNASEK ribonuclease, RNase K -0.0172276
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -0.0172214
GOLGA3 golgin A3 -0.0171671
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -0.0171605
IWS1 IWS1 homolog (S. cerevisiae) -0.0171375
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.0171328
PTOV1 prostate tumor overexpressed 1 -0.0171256
DIAPH1 diaphanous-related formin 1 -0.0170326
RAP1A RAP1A, member of RAS oncogene family -0.0170191
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0170084
NRDC nardilysin convertase -0.017005
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0169977
MON2 MON2 homolog (S. cerevisiae) -0.0169599
HAT1 histone acetyltransferase 1 -0.0169512
ZNF37A zinc finger protein 37A -0.0169247
UVRAG UV radiation resistance associated -0.0168682
DENND1B DENN/MADD domain containing 1B -0.0168507
DENR density-regulated protein -0.0168033
BCL2 B-cell CLL/lymphoma 2 -0.0167913
ITCH itchy E3 ubiquitin protein ligase -0.0167899
SUMF1 sulfatase modifying factor 1 -0.0167867
GIGYF2 GRB10 interacting GYF protein 2 -0.0167778
ATG7 autophagy related 7 -0.0167598
ZFP64 ZFP64 zinc finger protein -0.0167251
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -0.0167164
PLXDC2 plexin domain containing 2 -0.016705
KMT2C lysine (K)-specific methyltransferase 2C -0.0166647
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0166387
ICA1 islet cell autoantigen 1, 69kDa -0.0166136
TMEM131 transmembrane protein 131 -0.0166129
COG6 component of oligomeric golgi complex 6 -0.0165941
ZNF652 zinc finger protein 652 -0.0165667
RGS17 regulator of G-protein signaling 17 -0.0165296
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0165028
ZNF398 zinc finger protein 398 -0.0164189
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0164039
NRG3 neuregulin 3 -0.0164031
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.016309
RIN2 Ras and Rab interactor 2 -0.0161814
TXNRD3 thioredoxin reductase 3 -0.0161374
TRIP11 thyroid hormone receptor interactor 11 -0.0161349
TAPBP TAP binding protein (tapasin) -0.0161344
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0161311
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.0160856
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0160849
ANAPC11 anaphase promoting complex subunit 11 -0.0160584
IDS iduronate 2-sulfatase -0.0160581
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.0160369
PRRC2C proline-rich coiled-coil 2C -0.0160318
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0160104
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0160062
GPATCH2 G patch domain containing 2 -0.0160051
ERBIN erbb2 interacting protein -0.0159872
SUMO2 small ubiquitin-like modifier 2 -0.0159564
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -0.0159182
TMEM87A transmembrane protein 87A -0.0158935
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0158455
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0158408
KEAP1 kelch-like ECH-associated protein 1 -0.0158077
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0157892
DNA2 DNA replication helicase/nuclease 2 -0.0157775
LYPD6B LY6/PLAUR domain containing 6B -0.0157712
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.015767
AUTS2 autism susceptibility candidate 2 -0.0157626
RAP1B RAP1B, member of RAS oncogene family -0.0157571
AKAP13 A kinase (PRKA) anchor protein 13 -0.0157171
DCPH1 damage control phosphatase 1 -0.0156591
MARCHF7 membrane associated ring-CH-type finger 7 -0.0156457
MSH6 mutS homolog 6 -0.0156416
NSD2 nuclear receptor binding SET domain protein 2 -0.0156354
JARID2 jumonji, AT rich interactive domain 2 -0.0156026
SETBP1 SET binding protein 1 -0.0155982
LNPEP leucyl/cystinyl aminopeptidase -0.0155728
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0155598
RPL27A ribosomal protein L27a -0.0155284
XPO4 exportin 4 -0.0154856
CCNY cyclin Y -0.0154694
KDM6A lysine (K)-specific demethylase 6A -0.0154604
USP9X ubiquitin specific peptidase 9, X-linked -0.0154503
NCKAP5L NCK-associated protein 5-like -0.0154492
ARHGAP24 Rho GTPase activating protein 24 -0.0154434
MYO6 myosin VI -0.0154341
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0154329
TOP3A topoisomerase (DNA) III alpha -0.0154322
SMIM14 small integral membrane protein 14 -0.0154146
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0154143
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0154034
VEZF1 vascular endothelial zinc finger 1 -0.015403
TMPRSS4 transmembrane protease, serine 4 -0.0154026
HOMER2 homer scaffolding protein 2 -0.0153998
PBRM1 polybromo 1 -0.0153842
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0153483
LONP1 lon peptidase 1, mitochondrial -0.0153343
HCFC1 host cell factor C1 -0.0153127
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0152646
MYO1E myosin IE -0.0152121
CARS1 cysteinyl-tRNA synthetase 1 -0.0152086
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -0.0151736
AHCTF1 AT hook containing transcription factor 1 -0.0151715
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0151493
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0151298
ZCCHC8 zinc finger, CCHC domain containing 8 -0.0151213
RPL35A ribosomal protein L35a -0.0151077
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0151028
TK1 thymidine kinase 1, soluble -0.0150806
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0150803
NSD3 nuclear receptor binding SET domain protein 3 -0.0150545
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0150455
ARL3 ADP-ribosylation factor-like 3 -0.0150287
CDK4 cyclin-dependent kinase 4 -0.0150247
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.014999
PRCC papillary renal cell carcinoma (translocation-associated) -0.0149846
ZNF594 zinc finger protein 594 -0.0149764
SEC24C SEC24 family member C -0.0149722
ACLY ATP citrate lyase -0.0149556
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0149311
REXO2 RNA exonuclease 2 -0.0149143
DEPDC1B DEP domain containing 1B -0.0148989
TFG TRK-fused gene -0.0148738
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0148694
ZMYND11 zinc finger, MYND-type containing 11 -0.0148358
RSRP1 arginine/serine-rich protein 1 -0.0148322