MCF7_NVP-BSK805 2HCl_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 1µM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_NVP-BSK805 2HCl_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.120642
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.114242
DSPP dentin sialophosphoprotein 0.108969
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.098139
RPL37A ribosomal protein L37a 0.0900859
CALR calreticulin 0.0883788
CSDE1 cold shock domain containing E1, RNA-binding 0.0874438
RPS3 ribosomal protein S3 0.086453
H3-3B H3.3 histone B 0.0861471
ZNF217 zinc finger protein 217 0.0785458
RPL15 ribosomal protein L15 0.073882
CTSD cathepsin D 0.0732417
TPM4 tropomyosin 4 0.0728347
TRIM37 tripartite motif containing 37 0.0660696
RPL30 ribosomal protein L30 0.0637083
PARD6B par-6 family cell polarity regulator beta 0.0636196
RPS17 ribosomal protein S17 0.0628536
MRPL13 mitochondrial ribosomal protein L13 0.0623622
RPL13A ribosomal protein L13a 0.0620725
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0583757
RPLP0 ribosomal protein, large, P0 0.057512
SDK1 sidekick cell adhesion molecule 1 0.0569387
PLEC plectin 0.0560235
ARTN artemin 0.0559095
PTPRK protein tyrosine phosphatase, receptor type, K 0.0550281
TFF1 trefoil factor 1 0.0539896
SPTSSB serine palmitoyltransferase, small subunit B 0.0536038
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0528845
CLDN3 claudin 3 0.0521472
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.0516023
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.051321
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0503884
TXNIP thioredoxin interacting protein 0.0489983
LDLR low density lipoprotein receptor 0.0487425
MLPH melanophilin 0.0481812
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0479488
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0476471
RPL18 ribosomal protein L18 0.0465386
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0462673
RPLP1 ribosomal protein, large, P1 0.0461354
KDM5B lysine (K)-specific demethylase 5B 0.0448101
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0442827
HDGF hepatoma-derived growth factor 0.0441897
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0436395
RDX radixin 0.0430748
TRPS1 trichorhinophalangeal syndrome I 0.0430692
RPS8 ribosomal protein S8 0.0423175
PDS5A PDS5 cohesin associated factor A 0.0420315
RPS2 ribosomal protein S2 0.0417646
CXXC5 CXXC finger protein 5 0.0416763
DTNA dystrobrevin, alpha 0.0403747
FLNB filamin B, beta 0.0398279
CLTC clathrin, heavy chain (Hc) 0.0392961
BSG basigin (Ok blood group) 0.0392309
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0388863
RPS9 ribosomal protein S9 0.0388663
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0386992
DSCAM Down syndrome cell adhesion molecule 0.0386145
S100A11 S100 calcium binding protein A11 0.0385601
LOC112694756 uncharaterized LOC112694756 0.0379364
GLCCI1 glucocorticoid induced 1 0.037921
DHCR7 7-dehydrocholesterol reductase 0.03722
SLC38A1 solute carrier family 38, member 1 0.0370899
ACTN4 actinin, alpha 4 0.0368279
RPS12 ribosomal protein S12 0.0365339
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0361915
THBS1 thrombospondin 1 0.0361168
RPL37 ribosomal protein L37 0.0348209
MACC1 metastasis associated in colon cancer 1 0.03441
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.034337
IER3 immediate early response 3 0.0342572
PTMA prothymosin, alpha 0.0342297
ZMYND8 zinc finger, MYND-type containing 8 0.0341114
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0338183
MYH9 myosin, heavy chain 9, non-muscle 0.0337724
NFIB nuclear factor I/B 0.0334683
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0333302
SQLE squalene epoxidase 0.0330105
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0329027
HELZ helicase with zinc finger 0.032641
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0324423
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0324174
CSNK1A1 casein kinase 1, alpha 1 0.0324005
RSL1D1 ribosomal L1 domain containing 1 0.0322693
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0322362
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0319375
RABL6 RAB, member RAS oncogene family-like 6 0.031768
PRRC2B proline-rich coiled-coil 2B 0.0316986
HSPB1 heat shock 27kDa protein 1 0.0316717
EMCN endomucin 0.0313893
RPS6 ribosomal protein S6 0.0312443
SSR4 signal sequence receptor, delta 0.0312085
ATP5F1E ATP synthase F1 subunit epsilon 0.0307769
PEDS1 plasmanylethanolamine desaturase 1 0.0307384
PTPRF protein tyrosine phosphatase, receptor type, F 0.0307025
CST3 cystatin C 0.0305508
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0304977
CEMIP2 cell migration inducing hyaluronidase 2 0.0304774
IQGAP1 IQ motif containing GTPase activating protein 1 0.0304706
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0302578
PCED1B PC-esterase domain containing 1B 0.0302562
DAAM1 dishevelled associated activator of morphogenesis 1 0.0299997
RYBP RING1 and YY1 binding protein 0.0295863
ATP9A ATPase, class II, type 9A 0.0294935
ITM2B integral membrane protein 2B 0.0294213
CUEDC1 CUE domain containing 1 0.029361
NRP1 neuropilin 1 0.0291692
ULK1 unc-51 like autophagy activating kinase 1 0.0290857
RPS4X ribosomal protein S4, X-linked 0.0290412
AHNAK AHNAK nucleoprotein 0.0288947
PFN1 profilin 1 0.0288724
RPS21 ribosomal protein S21 0.0287604
RPL12 ribosomal protein L12 0.0287447
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0287407
RACK1 receptor for activated C kinase 1 0.028725
SHTN1 shootin 1 0.0284724
HSF1 heat shock transcription factor 1 0.0284197
BTBD1 BTB (POZ) domain containing 1 0.0283627
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0283151
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0282286
FBP1 fructose-1,6-bisphosphatase 1 0.028196
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0280045
IGFBP5 insulin-like growth factor binding protein 5 0.02794
CCDC170 coiled-coil domain containing 170 0.0279099
FXYD3 FXYD domain containing ion transport regulator 3 0.0277425
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0277402
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0275939
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0274558
BRI3BP BRI3 binding protein 0.0274314
ATAD2 ATPase family, AAA domain containing 2 0.0273558
RNF115 ring finger protein 115 0.0272849
FTH1 ferritin, heavy polypeptide 1 0.0269338
CCND1 cyclin D1 0.0268487
VAV3 vav 3 guanine nucleotide exchange factor 0.0268251
SPPL2A signal peptide peptidase like 2A 0.0267188
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0267165
GNAS GNAS complex locus 0.0265271
MRPS34 mitochondrial ribosomal protein S34 0.0264993
RPS7 ribosomal protein S7 0.0264879
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0264614
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0264112
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0263686
MYO9A myosin IXA 0.0262
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0261962
RSL24D1 ribosomal L24 domain containing 1 0.0261419
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0261159
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0261142
FOXA1 forkhead box A1 0.0258997
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0258681
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0258442
BCAS2 breast carcinoma amplified sequence 2 0.0257837
RPL32 ribosomal protein L32 0.0257684
RPL8 ribosomal protein L8 0.0257497
NFE2L2 nuclear factor, erythroid 2-like 2 0.0256881
KIF1B kinesin family member 1B 0.0255689
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255261
SRSF4 serine/arginine-rich splicing factor 4 0.0254953
DLG5 discs, large homolog 5 (Drosophila) 0.0254198
SYNGR2 synaptogyrin 2 0.0253248
RPS5 ribosomal protein S5 0.0253236
UBE4A ubiquitination factor E4A 0.0253116
ENSA endosulfine alpha 0.0251607
THRAP3 thyroid hormone receptor associated protein 3 0.0251516
NAV2 neuron navigator 2 0.02513
TBC1D22A TBC1 domain family, member 22A 0.0248421
RREB1 ras responsive element binding protein 1 0.0247626
PRR11 proline rich 11 0.0247536
RPL9 ribosomal protein L9 0.0247106
MYADM myeloid-associated differentiation marker 0.0246092
SYT1 synaptotagmin I 0.0245591
CHURC1 churchill domain containing 1 0.0245308
SOX13 SRY (sex determining region Y)-box 13 0.0244631
TRAM2 translocation associated membrane protein 2 0.0244536
ECPAS Ecm29 proteasome adaptor and scaffold 0.0241965
ACTG1 actin gamma 1 0.0240728
DCAF7 DDB1 and CUL4 associated factor 7 0.0240239
PSPC1 paraspeckle component 1 0.0239416
EPHA6 EPH receptor A6 0.0238616
HDGFL3 HDGF like 3 0.0238316
LRP10 low density lipoprotein receptor-related protein 10 0.0237893
GOLGB1 golgin B1 0.0236228
RAB10 RAB10, member RAS oncogene family 0.0234657
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0234486
RPL6 ribosomal protein L6 0.0234437
TMSB10 thymosin beta 10 0.0232763
SPNS1 spinster homolog 1 (Drosophila) 0.0232344
ACBD3 acyl-CoA binding domain containing 3 0.0232219
SNX27 sorting nexin family member 27 0.023171
RPL21 ribosomal protein L21 0.0230998
PRRC2C proline-rich coiled-coil 2C 0.0230725
LOC102724023 ES1 protein homolog, mitochondrial 0.02303
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0229256
PRPF38B pre-mRNA processing factor 38B 0.0229128
VGLL4 vestigial-like family member 4 0.022861
QRICH1 glutamine-rich 1 0.0228015
CLSTN1 calsyntenin 1 0.0227574
TMX1 thioredoxin-related transmembrane protein 1 0.0227414
RPL7A ribosomal protein L7a 0.0226665
FERMT2 fermitin family member 2 0.0226449
RPL10A ribosomal protein L10a 0.0226199
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.022613
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0224523
FTL ferritin, light polypeptide 0.0224128
PUM1 pumilio RNA-binding family member 1 0.0223286
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.022319
RPSA ribosomal protein SA 0.0223183
BMP7 bone morphogenetic protein 7 0.0223129
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0223082
LITAF lipopolysaccharide-induced TNF factor 0.0222349
STK39 serine threonine kinase 39 0.0221975
NEBL nebulette 0.0221916
DSTN destrin (actin depolymerizing factor) 0.0220931
NRIP1 nuclear receptor interacting protein 1 0.0219476
NECTIN1 nectin cell adhesion molecule 1 0.0219021
MUSK muscle, skeletal, receptor tyrosine kinase 0.0217737
PER2 period circadian clock 2 0.0217701
RAD23B RAD23 homolog B (S. cerevisiae) 0.0217657
RYK receptor-like tyrosine kinase 0.0217543
URI1 URI1, prefoldin-like chaperone 0.02168
ERRFI1 ERBB receptor feedback inhibitor 1 0.0216792
BMPR1B bone morphogenetic protein receptor, type IB 0.0215968
PARK7 parkinson protein 7 0.0215906
TUBB tubulin, beta class I 0.0214854
NHP2 NHP2 ribonucleoprotein 0.0213814
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.021322
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.0212834
ADNP activity-dependent neuroprotector homeobox 0.0212516
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.0212475
ZNF804B zinc finger protein 804B 0.0211808
CLIP1 CAP-GLY domain containing linker protein 1 0.0211624
MACROD2 MACRO domain containing 2 0.0211139
PAXBP1 PAX3 and PAX7 binding protein 1 0.0211025
GMEB1 glucocorticoid modulatory element binding protein 1 0.0210244
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0209817
ATP11B ATPase, class VI, type 11B 0.0209652
VCP valosin containing protein 0.0209306
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0208893
ARB2A ARB2 cotranscriptional regulator A 0.0208389
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0208058
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0207757
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.0206694
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0206565
VCL vinculin 0.0206453
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0206441
APOD apolipoprotein D 0.0206332
TXN2 thioredoxin 2 0.0206259
SEPTIN9 septin 9 0.0205961
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0205791
CD47 CD47 molecule 0.0204932
CD9 CD9 molecule 0.0204518
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.020437
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0203895
GSK3B glycogen synthase kinase 3 beta 0.0203651
CLIC4 chloride intracellular channel 4 0.0203271
NCOA6 nuclear receptor coactivator 6 0.0202937
DCAF4 DDB1 and CUL4 associated factor 4 0.0202797
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0202533
CENPB centromere protein B, 80kDa 0.0202471
RPL14 ribosomal protein L14 0.020243
TACC1 transforming, acidic coiled-coil containing protein 1 0.020188
TUBA1B tubulin, alpha 1b 0.020179
RPL23A ribosomal protein L23a 0.0201212
SINHCAF SIN3-HDAC complex associated factor 0.02009
ATOSA atos homolog A 0.0200562
IGF2R insulin-like growth factor 2 receptor 0.0200238
PLCB4 phospholipase C, beta 4 0.019971
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0199312
MIPEP mitochondrial intermediate peptidase 0.019928
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0198593
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0198379
FLOT2 flotillin 2 0.0197721
CEP290 centrosomal protein 290kDa 0.0197524
DOCK8 dedicator of cytokinesis 8 0.0197093
INSIG1 insulin induced gene 1 0.0195786
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0195571
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0194844
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0194266
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0194216
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0194172
CHD6 chromodomain helicase DNA binding protein 6 0.0193473
SLC2A4RG SLC2A4 regulator 0.0193369
COL18A1 collagen, type XVIII, alpha 1 0.0192945
NOTCH3 notch 3 0.0192778
BCLAF1 BCL2-associated transcription factor 1 0.0192647
UBXN4 UBX domain protein 4 0.0192527
MAPK9 mitogen-activated protein kinase 9 0.0192188
RPL36A ribosomal protein L36a 0.0191602
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0191599
MTSS1 metastasis suppressor 1 0.0191549
TOR1AIP2 torsin A interacting protein 2 0.019116
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0190505
CD81 CD81 molecule 0.0189616
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.0188951
SLC35E3 solute carrier family 35, member E3 0.0188143
SETD2 SET domain containing 2 0.0188001
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 0.018794
PKN2 protein kinase N2 0.0187811
ITSN2 intersectin 2 0.0187691
JAK1 Janus kinase 1 0.0187616
LPP LIM domain containing preferred translocation partner in lipoma 0.0187614
RPL18A ribosomal protein L18a 0.0187613
CYBC1 cytochrome b-245 chaperone 1 0.0187443
ANAPC5 anaphase promoting complex subunit 5 0.018736
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0186898
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0186768
FAM120A family with sequence similarity 120A 0.0186742
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.0186721
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.018662
RNF43 ring finger protein 43 0.0186349
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0185035
FMR1 fragile X mental retardation 1 0.018489
OSBPL1A oxysterol binding protein-like 1A 0.0184791
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.0184475
GOLGA4 golgin A4 0.0184088
CORO1B coronin, actin binding protein, 1B 0.0183684
TAOK1 TAO kinase 1 0.0183347
MKI67 marker of proliferation Ki-67 0.0183141
DUSP16 dual specificity phosphatase 16 0.0182632
ARSD arylsulfatase D 0.0182352
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.018128
LIMD1 LIM domains containing 1 0.0181249
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0181109
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.0180889
ETF1 eukaryotic translation termination factor 1 0.0180864
TRIP12 thyroid hormone receptor interactor 12 0.0180206
PHACTR2 phosphatase and actin regulator 2 0.0180167
NPY1R neuropeptide Y receptor Y1 0.0179744
SIVA1 SIVA1, apoptosis-inducing factor 0.0179511
H1-10 H1.10 linker histone 0.0179478
ATRNL1 attractin-like 1 0.0179301
MCM4 minichromosome maintenance complex component 4 0.0178997
BRCA2 breast cancer 2, early onset 0.0178985
PGR progesterone receptor 0.0178916
KIDINS220 kinase D-interacting substrate, 220kDa 0.0178765
NCKAP5 NCK-associated protein 5 0.0178568
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0178403
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0177219
NT5DC3 5'-nucleotidase domain containing 3 0.017708
HLTF helicase-like transcription factor 0.0176926
SELENOI selenoprotein I 0.017685
EGR1 early growth response 1 0.0176293
TRIR telomerase RNA component interacting RNase 0.017627
RNF111 ring finger protein 111 0.0175974
TLK1 tousled-like kinase 1 0.0175956
COL4A5 collagen, type IV, alpha 5 0.0175853
EAPP E2F-associated phosphoprotein 0.0175768
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0175563
SET SET nuclear proto-oncogene 0.017552
AARS1 alanyl-tRNA synthetase 1 0.0175463
CENPC centromere protein C 0.0175278
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0175003
NONO non-POU domain containing, octamer-binding 0.0174188
ESYT1 extended synaptotagmin-like protein 1 0.0174076
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0173845
PDIA4 protein disulfide isomerase family A, member 4 0.0173317
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0172935
AMIGO2 adhesion molecule with Ig-like domain 2 0.0171945
IREB2 iron-responsive element binding protein 2 0.0171428
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.0171409
BLVRB biliverdin reductase B 0.0171202
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0170795
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0170498
NAP1L1 nucleosome assembly protein 1-like 1 0.0170092
TPT1 tumor protein, translationally-controlled 1 0.0170071
FN1 fibronectin 1 0.0169892
FOXJ3 forkhead box J3 0.0169736
TAGLN2 transgelin 2 0.01696
ZNF518A zinc finger protein 518A 0.016953
LAMP2 lysosomal-associated membrane protein 2 0.0169297
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0168857
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0168845
SELENOS selenoprotein S 0.0168788
CENPO centromere protein O 0.0168595
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.0168514
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0168215
TPM3 tropomyosin 3 0.0168084
FAM234A family with sequence similarity 234 member A 0.0167989
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.0167969
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0167878
SDC1 syndecan 1 0.0167231
SREBF1 sterol regulatory element binding transcription factor 1 0.0167111
FOXO3 forkhead box O3 0.0166842
VASP vasodilator-stimulated phosphoprotein 0.0166474
PRLR prolactin receptor 0.0166099
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.0165909
RPS10 ribosomal protein S10 0.0165707
EP300 E1A binding protein p300 0.016541
OSBPL8 oxysterol binding protein-like 8 0.0165165
KLHL28 kelch-like family member 28 0.0164418
OGA O-GlcNAcase 0.0164074
SERF2 small EDRK-rich factor 2 0.0163206
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 0.0162709
SUMF2 sulfatase modifying factor 2 0.0162499
MYL12B myosin, light chain 12B, regulatory 0.0162449
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.0162186
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0161819
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.016157
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.0161483
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0161155
YY1 YY1 transcription factor 0.0161037
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0160938
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0160937
APP amyloid beta (A4) precursor protein 0.0160614
CLEC16A C-type lectin domain family 16, member A 0.0160205
SFXN1 sideroflexin 1 0.0160151
WSB1 WD repeat and SOCS box containing 1 0.0159987
PDAP1 PDGFA associated protein 1 0.0159739
SMAD5 SMAD family member 5 0.0159466
PWWP2A PWWP domain containing 2A 0.0159012
TSC22D1 TSC22 domain family, member 1 0.0158912
ZC3H13 zinc finger CCCH-type containing 13 0.0158893
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0158877
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0158475
RBM23 RNA binding motif protein 23 0.0157509
TMEM248 transmembrane protein 248 0.0157386
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.0157136
SPIRE1 spire-type actin nucleation factor 1 0.015711
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0156955
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0156915
CHD9 chromodomain helicase DNA binding protein 9 0.0156891
DST dystonin 0.0156724
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0.0156667
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0156608
SMG7 SMG7 nonsense mediated mRNA decay factor 0.01566
RECQL5 RecQ protein-like 5 0.0156519
IWS1 IWS1 homolog (S. cerevisiae) 0.0156102
MAX MYC associated factor X 0.0155889
THOC7 THO complex 7 0.0155457
PTBP3 polypyrimidine tract binding protein 3 0.0155109
SLC38A6 solute carrier family 38, member 6 0.0154727
KMT5B lysine methyltransferase 5B 0.0154588
CRYBG1 crystallin beta-gamma domain containing 1 0.0154467
EML4 echinoderm microtubule associated protein like 4 0.0154283
CDC123 cell division cycle 123 0.0154168
ZNF292 zinc finger protein 292 0.0153937
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.01539
PERP PERP, TP53 apoptosis effector 0.0153821
LGALS3 lectin, galactoside-binding, soluble, 3 0.0153694
ATAD2B ATPase family, AAA domain containing 2B 0.0153504
NELFE negative elongation factor complex member E 0.015326
RHEB Ras homolog enriched in brain 0.0153146
PDCD6IP programmed cell death 6 interacting protein 0.0152731
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0152677
GLG1 golgi glycoprotein 1 0.0152641
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0152624
ATXN7L3B ataxin 7-like 3B 0.0152394
SSH2 slingshot protein phosphatase 2 0.0152126
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0151737
GDF15 growth differentiation factor 15 0.0151691
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.015131
ESD esterase D 0.0151255
RPS20 ribosomal protein S20 0.0151129
GLE1 GLE1 RNA export mediator 0.0150145
SERINC5 serine incorporator 5 0.0149955
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.0149914
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0149823
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0149448
DHDDS dehydrodolichyl diphosphate synthase 0.0149362
PLIN4 perilipin 4 0.014927
AXIN1 axin 1 0.014903
TBC1D5 TBC1 domain family, member 5 0.0148601
CEP350 centrosomal protein 350kDa 0.0148276
POM121C POM121 transmembrane nucleoporin C 0.0148185
BCAP29 B-cell receptor-associated protein 29 0.0148057
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0148029
IL13RA1 interleukin 13 receptor, alpha 1 0.0147788
PARN poly(A)-specific ribonuclease 0.0147624
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 0.0147549
CANX calnexin 0.0147313
TXNL4A thioredoxin-like 4A 0.0147279
GOLM2 golgi membrane protein 2 0.0147222
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0147105
DARS1 aspartyl-tRNA synthetase 1 0.0147061
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0146757
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0146559
DMAC2L distal membrane arm assembly component 2 like 0.01456
ZNF43 zinc finger protein 43 0.0145439
ANAPC11 anaphase promoting complex subunit 11 0.0145386
MGLL monoglyceride lipase 0.0145304
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0145299
BLTP2 bridge-like lipid transfer protein family member 2 0.0145149
CENPF centromere protein F, 350/400kDa 0.0145038
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0144978
CDC14A cell division cycle 14A 0.0144855
TIMP3 TIMP metallopeptidase inhibitor 3 0.0144334
USP42 ubiquitin specific peptidase 42 0.0144326
DNAH14 dynein, axonemal, heavy chain 14 0.0144188
IER2 immediate early response 2 0.0144048
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0143823
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.0143768
WDR44 WD repeat domain 44 0.0143625
PUM2 pumilio RNA-binding family member 2 0.0143348
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0143223
SQSTM1 sequestosome 1 0.0143176
RAD23A RAD23 homolog A (S. cerevisiae) 0.0143168
OXA1L oxidase (cytochrome c) assembly 1-like 0.0142778
PCDH7 protocadherin 7 0.0142538
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0142473
SERINC3 serine incorporator 3 0.0142471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0142123

decreased expression

Symbol Name Standardized Value
BCAS3 breast carcinoma amplified sequence 3 -0.127427
GPC6 glypican 6 -0.100151
WWOX WW domain containing oxidoreductase -0.095898
USP32 ubiquitin specific peptidase 32 -0.0892225
IGF1R insulin-like growth factor 1 receptor -0.0787675
IFI6 interferon, alpha-inducible protein 6 -0.0677656
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0655772
AK1 adenylate kinase 1 -0.0642971
KRT18 keratin 18, type I -0.0627669
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0623696
PRKCE protein kinase C, epsilon -0.060822
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0598304
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0585447
GATA3 GATA binding protein 3 -0.0541604
TUBD1 tubulin, delta 1 -0.0532296
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0524764
KRT8 keratin 8, type II -0.0523406
CUX1 cut-like homeobox 1 -0.0513978
NCOA3 nuclear receptor coactivator 3 -0.049441
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0475492
PLXDC2 plexin domain containing 2 -0.0468242
RORA RAR-related orphan receptor A -0.0452307
SULF2 sulfatase 2 -0.0450811
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0439166
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.043763
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0428537
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0423293
NUMB numb homolog (Drosophila) -0.0423037
CCSER1 coiled-coil serine-rich protein 1 -0.042033
CALCR calcitonin receptor -0.0419464
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0407205
MSI2 musashi RNA-binding protein 2 -0.0406058
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0399484
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0383558
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.037987
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0378729
TCF12 transcription factor 12 -0.0371764
ANKRD11 ankyrin repeat domain 11 -0.03713
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0368793
SEC11A SEC11 homolog A (S. cerevisiae) -0.0365775
PBX3 pre-B-cell leukemia homeobox 3 -0.0357599
SIDT1 SID1 transmembrane family, member 1 -0.0357486
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0354756
MCU mitochondrial calcium uniporter -0.0352906
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0350988
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0347509
RNF216 ring finger protein 216 -0.0339657
DGKH diacylglycerol kinase, eta -0.0334978
PKP4 plakophilin 4 -0.0334871
DICER1 dicer 1, ribonuclease type III -0.0328917
RANBP17 RAN binding protein 17 -0.0326216
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0326185
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0324728
JARID2 jumonji, AT rich interactive domain 2 -0.0324017
MED13L mediator complex subunit 13-like -0.0322523
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0316531
FTO fat mass and obesity associated -0.031585
BCAS1 breast carcinoma amplified sequence 1 -0.0311007
KMT2C lysine (K)-specific methyltransferase 2C -0.0309297
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0303928
FBXL17 F-box and leucine-rich repeat protein 17 -0.0301929
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0301066
LRP1B low density lipoprotein receptor-related protein 1B -0.0296453
TM9SF3 transmembrane 9 superfamily member 3 -0.029549
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0291341
ZFAND3 zinc finger, AN1-type domain 3 -0.0290876
PTRH2 peptidyl-tRNA hydrolase 2 -0.0290122
GDI2 GDP dissociation inhibitor 2 -0.0290024
CFDP1 craniofacial development protein 1 -0.028959
MACF1 microtubule-actin crosslinking factor 1 -0.0289205
ZMYM2 zinc finger, MYM-type 2 -0.0287223
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0286677
AKAP13 A kinase (PRKA) anchor protein 13 -0.028647
NCOA2 nuclear receptor coactivator 2 -0.0284762
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.028415
TPI1 triosephosphate isomerase 1 -0.0284035
NSD2 nuclear receptor binding SET domain protein 2 -0.0282471
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0281007
SPIDR scaffolding protein involved in DNA repair -0.0280932
FANCA Fanconi anemia, complementation group A -0.0280153
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.027476
STRBP spermatid perinuclear RNA binding protein -0.027319
ANKRD17 ankyrin repeat domain 17 -0.0273002
RPS19 ribosomal protein S19 -0.0271997
FCHSD2 FCH and double SH3 domains 2 -0.0271273
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0270772
PATJ PATJ crumbs cell polarity complex component -0.0269497
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0268749
MAPK6 mitogen-activated protein kinase 6 -0.0266671
KDM2A lysine (K)-specific demethylase 2A -0.0265619
TENM3 teneurin transmembrane protein 3 -0.0265261
FRYL FRY-like -0.0264931
MAP2K1 mitogen-activated protein kinase kinase 1 -0.026355
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.026343
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.0262925
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0260891
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0259629
AGFG1 ArfGAP with FG repeats 1 -0.0259613
PAWR PRKC, apoptosis, WT1, regulator -0.0255801
DHRS7B dehydrogenase/reductase (SDR family) member 7B -0.0254714
TOM1L1 target of myb1 (chicken)-like 1 -0.0254161
ATP5F1C ATP synthase F1 subunit gamma -0.0252938
TBL1X transducin (beta)-like 1X-linked -0.0251042
TOP3A topoisomerase (DNA) III alpha -0.025068
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0249234
TET3 tet methylcytosine dioxygenase 3 -0.0249033
MYO5C myosin VC -0.0248912
ATXN1 ataxin 1 -0.0248887
CADM1 cell adhesion molecule 1 -0.0246314
ARID1A AT rich interactive domain 1A (SWI-like) -0.0246218
CMIP c-Maf inducing protein -0.0244792
TMEM150C transmembrane protein 150C -0.0243928
FANCM Fanconi anemia, complementation group M -0.0243248
TRIM33 tripartite motif containing 33 -0.0242653
FAM193B family with sequence similarity 193, member B -0.024228
DCDC2 doublecortin domain containing 2 -0.0239992
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -0.0239121
TASP1 taspase, threonine aspartase, 1 -0.0237844
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.023596
C1ORF21 chromosome 1 open reading frame 21 -0.0235374
GMDS GDP-mannose 4,6-dehydratase -0.0235234
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.023374
MIS18BP1 MIS18 binding protein 1 -0.0233032
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0232495
EFNA5 ephrin-A5 -0.0232399
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.0232311
NT5C2 5'-nucleotidase, cytosolic II -0.0232172
ACACA acetyl-CoA carboxylase alpha -0.0230343
ENAH enabled homolog (Drosophila) -0.0229726
MAP7 microtubule-associated protein 7 -0.0227948
EZR ezrin -0.0227842
ATE1 arginyltransferase 1 -0.0226978
TRERF1 transcriptional regulating factor 1 -0.0225796
COPE coatomer protein complex, subunit epsilon -0.0225584
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0225217
C21ORF58 chromosome 21 open reading frame 58 -0.022265
IFI27 interferon, alpha-inducible protein 27 -0.0222421
PICALM phosphatidylinositol binding clathrin assembly protein -0.0222339
SFMBT2 Scm-like with four mbt domains 2 -0.0222084
TRIM28 tripartite motif containing 28 -0.0221088
NHSL1 NHS-like 1 -0.0220952
RCOR1 REST corepressor 1 -0.0219835
SEPTIN6 septin 6 -0.0219398
SPATS2 spermatogenesis associated, serine-rich 2 -0.0219097
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0218378
PHF21A PHD finger protein 21A -0.0217578
SMYD3 SET and MYND domain containing 3 -0.0217075
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -0.0216178
ZFHX3 zinc finger homeobox 3 -0.0213054
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0211941
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0210046
CNKSR3 CNKSR family member 3 -0.0210006
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0208779
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -0.0208611
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0208541
ARID4A AT rich interactive domain 4A (RBP1-like) -0.0208123
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0206589
STX8 syntaxin 8 -0.0206432
ADCY9 adenylate cyclase 9 -0.0206229
GTF2I general transcription factor IIi -0.0205184
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0204663
RTN3 reticulon 3 -0.0203721
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.020344
MECOM MDS1 and EVI1 complex locus -0.0203232
TMPRSS4 transmembrane protease, serine 4 -0.0203214
WDR20 WD repeat domain 20 -0.020281
SNX4 sorting nexin 4 -0.0202129
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0201317
CDC42SE2 CDC42 small effector 2 -0.0201053
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.02001
PRKCA protein kinase C, alpha -0.0200066
RAB22A RAB22A, member RAS oncogene family -0.0199687
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0199145
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0198859
GPD1L glycerol-3-phosphate dehydrogenase 1-like -0.0198578
UBE3A ubiquitin protein ligase E3A -0.0198311
FAM120B family with sequence similarity 120B -0.0197362
HAT1 histone acetyltransferase 1 -0.01972
UGDH UDP-glucose 6-dehydrogenase -0.0196992
ZNF367 zinc finger protein 367 -0.0196679
EVL Enah/Vasp-like -0.019667
ARHGAP10 Rho GTPase activating protein 10 -0.0196631
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.019607
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0194956
CKAP5 cytoskeleton associated protein 5 -0.0194827
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0194186
PHC3 polyhomeotic homolog 3 (Drosophila) -0.019351
FRS2 fibroblast growth factor receptor substrate 2 -0.0193231
DCAF10 DDB1 and CUL4 associated factor 10 -0.0192853
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0192426
SACK1B scaffolding CK1 anchoring protein B -0.0191077
GPHN gephyrin -0.0190315
NPAS3 neuronal PAS domain protein 3 -0.0189712
NCOA1 nuclear receptor coactivator 1 -0.0189259
MB21D2 Mab-21 domain containing 2 -0.0188681
KATNIP katanin interacting protein -0.0188502
FHIT fragile histidine triad -0.0188412
GPATCH8 G patch domain containing 8 -0.0187786
SLC38A12 solute carrier family 38 member 12 -0.0187754
ATXN10 ataxin 10 -0.0186677
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0186303
RASGEF1B RasGEF domain family, member 1B -0.0186153
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.0185957
GRB2 growth factor receptor-bound protein 2 -0.018547
GPSM2 G-protein signaling modulator 2 -0.0185035
DOCK1 dedicator of cytokinesis 1 -0.0184689
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -0.0184156
PSEN1 presenilin 1 -0.0184081
PKM pyruvate kinase, muscle -0.018376
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0183706
SCAF11 SR-related CTD-associated factor 11 -0.0183419
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0182634
ABR active BCR-related -0.0182211
TANGO6 transport and golgi organization 6 homolog (Drosophila) -0.018208
FER fer (fps/fes related) tyrosine kinase -0.0182075
ZNF644 zinc finger protein 644 -0.0182015
NOL4L nucleolar protein 4-like -0.0181419
RTN4RL1 reticulon 4 receptor-like 1 -0.0180388
SCARB1 scavenger receptor class B, member 1 -0.0180022
MRFAP1 Morf4 family associated protein 1 -0.017966
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0179444
TMEM164 transmembrane protein 164 -0.0179337
ELOVL6 ELOVL fatty acid elongase 6 -0.0178323
PLXNA4 plexin A4 -0.0178312
WWC1 WW and C2 domain containing 1 -0.0177667
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0177538
RFX7 regulatory factor X, 7 -0.0176971
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0176722
NRCAM neuronal cell adhesion molecule -0.0176641
TOB2 transducer of ERBB2, 2 -0.0176548
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0176052
EXD3 exonuclease 3'-5' domain containing 3 -0.0175842
PDZRN3 PDZ domain containing ring finger 3 -0.0175727
ADCY1 adenylate cyclase 1 (brain) -0.017565
ADAM10 ADAM metallopeptidase domain 10 -0.0175005
SFXN2 sideroflexin 2 -0.0174751
H2AJ H2A.J histone -0.0174531
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0174387
ARSG arylsulfatase G -0.017431
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -0.0174096
WARS1 tryptophanyl-tRNA synthetase 1 -0.0173992
SIL1 SIL1 nucleotide exchange factor -0.0173836
LCLAT1 lysocardiolipin acyltransferase 1 -0.0173701
CNOT6 CCR4-NOT transcription complex, subunit 6 -0.0173618
ESR1 estrogen receptor 1 -0.0173525
MBD4 methyl-CpG binding domain protein 4 -0.0173394
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0173216
MARCHF5 membrane associated ring-CH-type finger 5 -0.0173184
NBEA neurobeachin -0.0172897
ZNF207 zinc finger protein 207 -0.0172717
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0172655
INVS inversin -0.0172519
RAD51B RAD51 paralog B -0.0172349
SRPK1 SRSF protein kinase 1 -0.0171899
RAB1A RAB1A, member RAS oncogene family -0.0171869
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0171293
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -0.0171057
SLF2 SMC5-SMC6 complex localization factor 2 -0.0170909
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0170793
PRKD3 protein kinase D3 -0.0170609
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0170235
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0169975
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0169841
DPH6 diphthamine biosynthesis 6 -0.0169687
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0169584
XBP1 X-box binding protein 1 -0.0169518
TRAPPC9 trafficking protein particle complex 9 -0.0169196
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -0.0169155
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -0.0169117
KDM2B lysine (K)-specific demethylase 2B -0.0168998
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0168793
ZNF714 zinc finger protein 714 -0.0168571
CAPN7 calpain 7 -0.0168459
STX6 syntaxin 6 -0.0168456
KMT2E lysine (K)-specific methyltransferase 2E -0.016841
ACLY ATP citrate lyase -0.0168241
STAT5B signal transducer and activator of transcription 5B -0.0168164
SEC31A SEC31 homolog A (S. cerevisiae) -0.0168128
VSIG10 V-set and immunoglobulin domain containing 10 -0.0168065
BZW2 basic leucine zipper and W2 domains 2 -0.0168042
PRKCI protein kinase C, iota -0.0167939
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0167913
PACS2 phosphofurin acidic cluster sorting protein 2 -0.0167908
STK38 serine/threonine kinase 38 -0.0167642
GPBP1 GC-rich promoter binding protein 1 -0.0167574
KPNB1 karyopherin (importin) beta 1 -0.0167537
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0167043
RFWD3 ring finger and WD repeat domain 3 -0.016696
KIF4A kinesin family member 4A -0.0166951
UNK unkempt family zinc finger -0.016574
GATAD2A GATA zinc finger domain containing 2A -0.0165353
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0165307
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0164948
BLTP1 bridge-like lipid transfer protein family member 1 -0.0164465
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0164108
PHF14 PHD finger protein 14 -0.0163859
MRS2 MRS2 magnesium transporter -0.0163132
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0163067
FAM168A family with sequence similarity 168, member A -0.0162775
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0162618
CRTC3 CREB regulated transcription coactivator 3 -0.0162519
LIN52 lin-52 DREAM MuvB core complex component -0.0162258
EDRF1 erythroid differentiation regulatory factor 1 -0.0162099
CDCA8 cell division cycle associated 8 -0.0161477
SMAD3 SMAD family member 3 -0.016145
ZNFX1 zinc finger, NFX1-type containing 1 -0.0161387
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0160516
EMC3 ER membrane protein complex subunit 3 -0.015988
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.015974
ZNF638 zinc finger protein 638 -0.0159739
MUC16 mucin 16, cell surface associated -0.0159717
TBCK TBC1 domain containing kinase -0.0159619
CBX3 chromobox homolog 3 -0.0159562
EPHA4 EPH receptor A4 -0.0159427
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -0.0159112
WHRN whirlin -0.0158894
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0158856
NUDC nudC nuclear distribution protein -0.0158633
C2ORF68 chromosome 2 open reading frame 68 -0.0158492
CCDC12 coiled-coil domain containing 12 -0.015829
MACO1 macoilin 1 -0.0158022
NCOR1 nuclear receptor corepressor 1 -0.0157924
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0157917
ZHX3 zinc fingers and homeoboxes 3 -0.0157756
RNF213 ring finger protein 213 -0.0157645
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0157622
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -0.0157519
UBE2K ubiquitin-conjugating enzyme E2K -0.0157407
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -0.0156813
MCC mutated in colorectal cancers -0.0156294
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0156177
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0155597
KMT2A lysine (K)-specific methyltransferase 2A -0.0155414
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.0155152
PDIA6 protein disulfide isomerase family A, member 6 -0.0155077
SYT12 synaptotagmin XII -0.0154721
HIP1 huntingtin interacting protein 1 -0.0154356
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.015421
NUBPL nucleotide binding protein-like -0.0153624
CLASP1 cytoplasmic linker associated protein 1 -0.0153377
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0153263
TMEM65 transmembrane protein 65 -0.0153263
ZNF407 zinc finger protein 407 -0.0153233
MED13 mediator complex subunit 13 -0.0152645
RBM4 RNA binding motif protein 4 -0.0152143
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0151864
MAP4 microtubule-associated protein 4 -0.0151397
GREB1 growth regulation by estrogen in breast cancer 1 -0.0151319
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.0151049
KCMF1 potassium channel modulatory factor 1 -0.0150779
DNM2 dynamin 2 -0.0150652
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0149786
FLII flightless I homolog (Drosophila) -0.0149747
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.014963
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0149351
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -0.0148945
MFSD12 major facilitator superfamily domain containing 12 -0.0148434
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0147773
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0147662
ZNF83 zinc finger protein 83 -0.0147514
BAG3 BCL2-associated athanogene 3 -0.0147223
NBPF12 neuroblastoma breakpoint family, member 12 -0.014698
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0146978
PCLO piccolo presynaptic cytomatrix protein -0.0146917
SNED1 sushi, nidogen and EGF-like domains 1 -0.0146869
ADGRV1 adhesion G protein-coupled receptor V1 -0.0146802
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.0146642
SH3KBP1 SH3-domain kinase binding protein 1 -0.014659
ELMOD3 ELMO/CED-12 domain containing 3 -0.0146372
RB1CC1 RB1-inducible coiled-coil 1 -0.0146368
SHISA9 shisa family member 9 -0.0145472
TPD52L2 tumor protein D52-like 2 -0.0145385
ANKRD52 ankyrin repeat domain 52 -0.0145298
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -0.0145115
DDHD1 DDHD domain containing 1 -0.0144845
EPB41 erythrocyte membrane protein band 4.1 -0.0144565
RPTOR regulatory associated protein of MTOR, complex 1 -0.0144418
POMT1 protein-O-mannosyltransferase 1 -0.0144034
LYPD6 LY6/PLAUR domain containing 6 -0.0143954
CENPP centromere protein P -0.0143919
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.0143856
PTPRA protein tyrosine phosphatase, receptor type, A -0.0143617
YTHDC1 YTH domain containing 1 -0.0143169
RC3H1 ring finger and CCCH-type domains 1 -0.0142884
BTBD9 BTB (POZ) domain containing 9 -0.0142755
ACBD6 acyl-CoA binding domain containing 6 -0.0142574
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0142537
RHBDD2 rhomboid domain containing 2 -0.0142452
COXFA4 cytochrome c oxidase associated subunit FA4 -0.0142404
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0142383
KDM6A lysine (K)-specific demethylase 6A -0.0142366
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0141939
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -0.01418
FCF1 FCF1 rRNA-processing protein -0.0141555
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0141216
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0141167
UBXN7 UBX domain protein 7 -0.0141158
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0141108
CGGBP1 CGG triplet repeat binding protein 1 -0.0141048
ARHGAP32 Rho GTPase activating protein 32 -0.0140858
FGF12 fibroblast growth factor 12 -0.0140777
CDK12 cyclin-dependent kinase 12 -0.0140562
PPME1 protein phosphatase methylesterase 1 -0.014056
PGCKA1 PDCD10 and GCKIII kinases associated 1 -0.0140232
C1ORF159 chromosome 1 open reading frame 159 -0.0140059
SEC24A SEC24 family member A -0.013978
HDAC8 histone deacetylase 8 -0.0139541
DENND4C DENN/MADD domain containing 4C -0.0139514
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.0139176
WNK1 WNK lysine deficient protein kinase 1 -0.0138531
TES testin LIM domain protein -0.01385
PARD3B par-3 family cell polarity regulator beta -0.0138349
FBXW4 F-box and WD repeat domain containing 4 -0.0138286
BACE1 beta-site APP-cleaving enzyme 1 -0.0138182
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0137897
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.0137761
LATS1 large tumor suppressor kinase 1 -0.0137719
COPS3 COP9 signalosome subunit 3 -0.0137349
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0137271
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0137204
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0137169
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0137122
ASCC2 activating signal cointegrator 1 complex subunit 2 -0.0137039
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0136859
EEF2K eukaryotic elongation factor 2 kinase -0.0136814
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0136735
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.0136587
DPY19L4 dpy-19-like 4 (C. elegans) -0.0136515
TBCD tubulin folding cofactor D -0.0136357
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.013628
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -0.0136225
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0136131
PSD3 pleckstrin and Sec7 domain containing 3 -0.013606
KIAA1958 KIAA1958 -0.0136012
XPOT exportin, tRNA -0.013597
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0135935
KLHL20 kelch-like family member 20 -0.0135812
MIDEAS mitotic deacetylase associated SANT domain protein -0.0135742
MARCHF1 membrane associated ring-CH-type finger 1 -0.0135663
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0135643
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0135573
PRSS23 protease, serine, 23 -0.0135567
IFITM3 interferon induced transmembrane protein 3 -0.0135523
ATXN7L1 ataxin 7-like 1 -0.0135513
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.0135083
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0134934
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -0.0134905
BCAR3 breast cancer anti-estrogen resistance 3 -0.0134578
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.0134294
HEXB hexosaminidase B (beta polypeptide) -0.013392
BIRC6 baculoviral IAP repeat containing 6 -0.0133892
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0133877
PUM3 pumilio RNA binding family member 3 -0.0133241
LMAN2 lectin, mannose-binding 2 -0.013323
VDAC1 voltage-dependent anion channel 1 -0.0132952
SORT1 sortilin 1 -0.0132623
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0132618
PHF12 PHD finger protein 12 -0.01326
MED27 mediator complex subunit 27 -0.0132284
AFTPH aftiphilin -0.0132088
ZC3H18 zinc finger CCCH-type containing 18 -0.0132031
TSC22D2 TSC22 domain family, member 2 -0.0132002
USP45 ubiquitin specific peptidase 45 -0.0131984
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0131551
FAM149B1 family with sequence similarity 149, member B1 -0.0131247
RSBN1L round spermatid basic protein 1-like -0.0131093
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0130991
GIGYF2 GRB10 interacting GYF protein 2 -0.0130963
RBM39 RNA binding motif protein 39 -0.0130806
TEX14 testis expressed 14 -0.0130778
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.013073
CDK4 cyclin-dependent kinase 4 -0.0130549
EFCAB14 EF-hand calcium binding domain 14 -0.0130491
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0130279
RUNDC1 RUN domain containing 1 -0.0129914
MAML3 mastermind-like 3 (Drosophila) -0.0129708
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.0129347
VAV2 vav 2 guanine nucleotide exchange factor -0.0129257
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -0.01292
ARHGAP17 Rho GTPase activating protein 17 -0.0129145
WIPF1 WAS/WASL interacting protein family, member 1 -0.0128932
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0128926
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -0.0128909
PML promyelocytic leukemia -0.0128819
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0128589
PRC1 protein regulator of cytokinesis 1 -0.0128439
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.0128345
HOOK3 hook microtubule-tethering protein 3 -0.0128271
RPN1 ribophorin I -0.0128151
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.0128051
PTK2 protein tyrosine kinase 2 -0.0127956
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0127919
SYNJ2 synaptojanin 2 -0.0127684
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0127602
MAU2 MAU2 sister chromatid cohesion factor -0.0127102
SUFU suppressor of fused homolog (Drosophila) -0.0127097
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -0.0127013
PARD3 par-3 family cell polarity regulator -0.0126637
PDS5B PDS5 cohesin associated factor B -0.0126573
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0126534