MCF7_NVP-BSK805 2HCl_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 10nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_NVP-BSK805 2HCl_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 0.147557
DSPP dentin sialophosphoprotein 0.126002
DSCAM Down syndrome cell adhesion molecule 0.109131
TPM4 tropomyosin 4 0.103781
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0985606
CSDE1 cold shock domain containing E1, RNA-binding 0.0783553
EPHA4 EPH receptor A4 0.0783064
BMP7 bone morphogenetic protein 7 0.0774552
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0704317
PAWR PRKC, apoptosis, WT1, regulator 0.0669703
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0614443
RPS3 ribosomal protein S3 0.0611193
GREB1 growth regulation by estrogen in breast cancer 1 0.0606184
H3-3B H3.3 histone B 0.0600279
COL4A5 collagen, type IV, alpha 5 0.0596831
SLC38A1 solute carrier family 38, member 1 0.0592482
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0587901
BPTF bromodomain PHD finger transcription factor 0.0580474
MYH9 myosin, heavy chain 9, non-muscle 0.0556733
PTPRK protein tyrosine phosphatase, receptor type, K 0.0555742
LPP LIM domain containing preferred translocation partner in lipoma 0.0545289
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0529353
MTSS1 metastasis suppressor 1 0.0524482
SRPK2 SRSF protein kinase 2 0.051914
TMEM150C transmembrane protein 150C 0.0515173
IRS1 insulin receptor substrate 1 0.0510562
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0503045
AREG amphiregulin 0.0501649
BASP1 brain abundant, membrane attached signal protein 1 0.0495085
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0492178
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0491097
RPS21 ribosomal protein S21 0.048257
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0465336
ADNP activity-dependent neuroprotector homeobox 0.0457688
STC2 stanniocalcin 2 0.0454978
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0448818
CHD6 chromodomain helicase DNA binding protein 6 0.043782
RAD23B RAD23 homolog B (S. cerevisiae) 0.0434824
SGMS1 sphingomyelin synthase 1 0.0426876
TRPS1 trichorhinophalangeal syndrome I 0.0423751
IQANK1 IQ motif and ankyrin repeat containing 1 0.0422086
RPS8 ribosomal protein S8 0.0421321
MYO9A myosin IXA 0.0415153
MRPL13 mitochondrial ribosomal protein L13 0.0415054
SERINC5 serine incorporator 5 0.0412638
SPTSSB serine palmitoyltransferase, small subunit B 0.040505
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.0396836
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0395052
LOC102724023 ES1 protein homolog, mitochondrial 0.0393984
PERP PERP, TP53 apoptosis effector 0.0392318
ITPRID2 ITPR interacting domain containing 2 0.0391221
DST dystonin 0.0390314
CDV3 CDV3 homolog (mouse) 0.038674
GOLGB1 golgin B1 0.0385615
KIDINS220 kinase D-interacting substrate, 220kDa 0.0384507
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0381685
SULF2 sulfatase 2 0.038061
PDS5A PDS5 cohesin associated factor A 0.037829
LRP1B low density lipoprotein receptor-related protein 1B 0.0373774
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0373489
MACF1 microtubule-actin crosslinking factor 1 0.0373105
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0372141
FOXP1 forkhead box P1 0.0366326
CXXC5 CXXC finger protein 5 0.0366257
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0366254
RPS6 ribosomal protein S6 0.0364769
SKA2 spindle and kinetochore associated complex subunit 2 0.036247
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0356636
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0355024
UTRN utrophin 0.0351354
MED13 mediator complex subunit 13 0.0351187
MYO5C myosin VC 0.0351072
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.0344367
CLIP1 CAP-GLY domain containing linker protein 1 0.0341071
RPS4X ribosomal protein S4, X-linked 0.0340591
HSPB1 heat shock 27kDa protein 1 0.0340308
JMJD1C jumonji domain containing 1C 0.0339236
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0336019
CST3 cystatin C 0.0333063
ITGB4 integrin, beta 4 0.0332476
MBNL1 muscleblind-like splicing regulator 1 0.0332472
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0331672
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0330368
JAK2 Janus kinase 2 0.0329284
BCL2 B-cell CLL/lymphoma 2 0.0325525
SYT1 synaptotagmin I 0.0321638
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0314333
CELF1 CUGBP, Elav-like family member 1 0.0313489
VGLL4 vestigial-like family member 4 0.0312979
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0312552
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.0311589
HOOK2 hook microtubule-tethering protein 2 0.031103
ZMYM2 zinc finger, MYM-type 2 0.0309906
GNAS GNAS complex locus 0.0308191
TOP1 topoisomerase (DNA) I 0.0308016
RPS16 ribosomal protein S16 0.030526
THOC2 THO complex 2 0.0301737
EEF2 eukaryotic translation elongation factor 2 0.0300545
BCL2L1 BCL2-like 1 0.0299598
MAPK9 mitogen-activated protein kinase 9 0.0298691
THSD4 thrombospondin, type I, domain containing 4 0.0297118
BRI3BP BRI3 binding protein 0.0295925
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.0293098
TFF3 trefoil factor 3 (intestinal) 0.0292876
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0289083
CD9 CD9 molecule 0.0288449
FLNA filamin A, alpha 0.0287171
TRIR telomerase RNA component interacting RNase 0.028627
RPL34 ribosomal protein L34 0.0285818
TRAPPC9 trafficking protein particle complex 9 0.0282197
SBF2 SET binding factor 2 0.0280207
TTC3 tetratricopeptide repeat domain 3 0.0280203
OSBPL10 oxysterol binding protein-like 10 0.0279995
RPL6 ribosomal protein L6 0.0279798
ENO1 enolase 1, (alpha) 0.0279144
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0278574
RPL7A ribosomal protein L7a 0.0276428
MTREX Mtr4 exosome RNA helicase 0.027577
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0275474
RYBP RING1 and YY1 binding protein 0.0273346
SMAD3 SMAD family member 3 0.0273313
PHACTR2 phosphatase and actin regulator 2 0.0271507
ZHX2 zinc fingers and homeoboxes 2 0.0270328
HSF1 heat shock transcription factor 1 0.0269998
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0269757
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0265808
CLDN3 claudin 3 0.0265655
RPL4 ribosomal protein L4 0.0263601
ECE1 endothelin converting enzyme 1 0.0263369
TFF1 trefoil factor 1 0.0262698
PODXL podocalyxin-like 0.0262048
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0258723
PALLD palladin, cytoskeletal associated protein 0.0258276
EPHA7 EPH receptor A7 0.0257168
SP3 Sp3 transcription factor 0.0253998
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0253517
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0253447
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0252948
MED13L mediator complex subunit 13-like 0.0251525
TUFT1 tuftelin 1 0.0250801
FGF12 fibroblast growth factor 12 0.0249781
LMBR1 limb development membrane protein 1 0.0249437
NBEA neurobeachin 0.0248382
STRN3 striatin, calmodulin binding protein 3 0.0248046
CCAR1 cell division cycle and apoptosis regulator 1 0.0246333
RAB10 RAB10, member RAS oncogene family 0.024589
PDLIM5 PDZ and LIM domain 5 0.0244918
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0244439
ZER1 zyg-11 related, cell cycle regulator 0.0243883
RPS11 ribosomal protein S11 0.0243834
PRRC2C proline-rich coiled-coil 2C 0.0242984
MYO9B myosin IXB 0.0242872
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.024226
GLI3 GLI family zinc finger 3 0.0242015
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0241853
SCRN1 secernin 1 0.024145
PRPF3 pre-mRNA processing factor 3 0.0240031
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0240021
LRP10 low density lipoprotein receptor-related protein 10 0.0239979
ZFP64 ZFP64 zinc finger protein 0.0237977
PEBP1 phosphatidylethanolamine binding protein 1 0.0236134
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0235964
RPS18 ribosomal protein S18 0.0235702
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0235477
ADGRG6 adhesion G protein-coupled receptor G6 0.0234585
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0233546
RSU1 Ras suppressor protein 1 0.0233007
TPD52 tumor protein D52 0.023287
RPS15 ribosomal protein S15 0.0232628
KDM5A lysine (K)-specific demethylase 5A 0.0232353
DYNLL2 dynein, light chain, LC8-type 2 0.0231409
THBS1 thrombospondin 1 0.0231203
RIGI RNA sensor RIG-I 0.0230898
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.0230071
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0229944
KLHL36 kelch-like family member 36 0.0229219
TLK1 tousled-like kinase 1 0.0228395
RPL12 ribosomal protein L12 0.0228214
MAP4 microtubule-associated protein 4 0.022658
FIGN fidgetin 0.0225712
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0225496
RHOA ras homolog family member A 0.022457
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0224187
MXD4 MAX dimerization protein 4 0.0223867
TXNIP thioredoxin interacting protein 0.0223691
AHNAK AHNAK nucleoprotein 0.0223087
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.022283
MYO5A myosin VA (heavy chain 12, myoxin) 0.0222583
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0222532
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0221057
ECHDC2 enoyl CoA hydratase domain containing 2 0.0220968
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0220781
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.022049
TAPBP TAP binding protein (tapasin) 0.0220211
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.0219935
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0219845
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0219601
MBTD1 mbt domain containing 1 0.0219388
TPM1 tropomyosin 1 (alpha) 0.0219062
HRNR hornerin 0.0218949
ZFHX3 zinc finger homeobox 3 0.0218326
TLE5 TLE family member 5, transcriptional modulator 0.0218174
SHISA9 shisa family member 9 0.0218161
TTLL10 tubulin tyrosine ligase-like family member 10 0.0217816
FAM13B family with sequence similarity 13, member B 0.0217515
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.02171
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0216408
RAB2A RAB2A, member RAS oncogene family 0.021622
XRN1 5'-3' exoribonuclease 1 0.0216077
KLF3 Kruppel-like factor 3 (basic) 0.0215206
RPS20 ribosomal protein S20 0.0214664
OSBPL8 oxysterol binding protein-like 8 0.0214615
AQR aquarius intron-binding spliceosomal factor 0.0214261
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0213779
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0213399
DPH6 diphthamine biosynthesis 6 0.0212331
PTMA prothymosin, alpha 0.0211986
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0211819
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.0211813
CPNE3 copine III 0.0211813
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0211742
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0211207
RDX radixin 0.0210901
LDLR low density lipoprotein receptor 0.0210297
FNBP4 formin binding protein 4 0.0210175
CADM1 cell adhesion molecule 1 0.0209996
AHCY adenosylhomocysteinase 0.0208847
DGKH diacylglycerol kinase, eta 0.0207604
WIPF1 WAS/WASL interacting protein family, member 1 0.02076
MYO1D myosin ID 0.0207014
RPL11 ribosomal protein L11 0.0206312
LATS2 large tumor suppressor kinase 2 0.0206031
RCL1 RNA terminal phosphate cyclase-like 1 0.0205904
FAM234A family with sequence similarity 234 member A 0.0205405
RPSA ribosomal protein SA 0.020534
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0205237
CLEC16A C-type lectin domain family 16, member A 0.0205071
PBX1 pre-B-cell leukemia homeobox 1 0.0204433
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0204159
RNF149 ring finger protein 149 0.0203852
BABAM2 BRISC and BRCA1 A complex member 2 0.0203575
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0203087
PTPRE protein tyrosine phosphatase, receptor type, E 0.0202551
TMEM87B transmembrane protein 87B 0.0202401
HDLBP high density lipoprotein binding protein 0.0201606
SPATS2 spermatogenesis associated, serine-rich 2 0.0201251
RSF1 remodeling and spacing factor 1 0.0201
KCTD20 potassium channel tetramerization domain containing 20 0.0200157
NIPBL Nipped-B homolog (Drosophila) 0.0199978
CARM1 coactivator-associated arginine methyltransferase 1 0.0199767
UBA2 ubiquitin-like modifier activating enzyme 2 0.0199356
CAV1 caveolin 1, caveolae protein, 22kDa 0.0199264
PRR11 proline rich 11 0.0198791
PHACTR4 phosphatase and actin regulator 4 0.0198664
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0198652
TSPAN15 tetraspanin 15 0.0198481
DCP1A decapping mRNA 1A 0.0198089
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0197947
SETD5 SET domain containing 5 0.0197308
TBC1D30 TBC1 domain family, member 30 0.0196591
ACTG1 actin gamma 1 0.019633
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0196229
HMCN1 hemicentin 1 0.019482
DOCK4 dedicator of cytokinesis 4 0.0194738
POTEF POTE ankyrin domain family, member F 0.0194587
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0194367
LOC112694756 uncharaterized LOC112694756 0.0194249
UBE2H ubiquitin-conjugating enzyme E2H 0.0194044
ZNF721 zinc finger protein 721 0.0193601
DUSP5 dual specificity phosphatase 5 0.0193541
WWC2 WW and C2 domain containing 2 0.0193256
NOCT nocturnin 0.0192463
KDM5B lysine (K)-specific demethylase 5B 0.019182
SUSD6 sushi domain containing 6 0.0191673
CCDC47 coiled-coil domain containing 47 0.0191067
BTG1 B-cell translocation gene 1, anti-proliferative 0.0190878
AK3 adenylate kinase 3 0.0190674
ELF4 E74-like factor 4 (ets domain transcription factor) 0.0189652
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0189591
MGA MGA, MAX dimerization protein 0.0188608
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0188549
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.018831
NEK4 NIMA-related kinase 4 0.0187842
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0187776
PRTG protogenin 0.0187446
ANKRD44 ankyrin repeat domain 44 0.018668
MACC1 metastasis associated in colon cancer 1 0.0186633
USP9X ubiquitin specific peptidase 9, X-linked 0.018593
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0185723
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 0.0185519
SIKE1 suppressor of IKBKE 1 0.018517
ATRNL1 attractin-like 1 0.0184963
ACAD10 acyl-CoA dehydrogenase family, member 10 0.0184628
ESD esterase D 0.0184477
PCSK2 proprotein convertase subtilisin/kexin type 2 0.0184438
TSPAN12 tetraspanin 12 0.0184208
POGZ pogo transposable element with ZNF domain 0.0183916
DLG5 discs, large homolog 5 (Drosophila) 0.0183605
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0183604
REST RE1-silencing transcription factor 0.0183132
EGR1 early growth response 1 0.0182743
NFE2L2 nuclear factor, erythroid 2-like 2 0.0182653
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0182058
DNAH14 dynein, axonemal, heavy chain 14 0.0181665
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0181642
IQGAP1 IQ motif containing GTPase activating protein 1 0.0181226
COBL cordon-bleu WH2 repeat protein 0.018113
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0181119
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0181075
MCC mutated in colorectal cancers 0.0181001
SSH2 slingshot protein phosphatase 2 0.0180955
GAB2 GRB2-associated binding protein 2 0.0180452
TET3 tet methylcytosine dioxygenase 3 0.0180373
SIDT1 SID1 transmembrane family, member 1 0.0180069
TMEM131L transmembrane 131 like 0.0180024
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.0179956
GTF2I general transcription factor IIi 0.0179951
CANX calnexin 0.0179918
CTNNBL1 catenin, beta like 1 0.0179809
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0179494
SNX4 sorting nexin 4 0.0179482
BZW2 basic leucine zipper and W2 domains 2 0.0179451
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.017944
NEBL nebulette 0.0179349
TPR translocated promoter region, nuclear basket protein 0.017878
RHBDD1 rhomboid domain containing 1 0.0178776
STK38 serine/threonine kinase 38 0.0178395
KRT80 keratin 80, type II 0.0177945
ZNF148 zinc finger protein 148 0.0177779
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0177713
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0177383
CLU clusterin 0.0177254
ABHD17C abhydrolase domain containing 17C 0.0177158
FUS FUS RNA binding protein 0.0176897
FAF2 Fas associated factor family member 2 0.0176543
KIF14 kinesin family member 14 0.0176352
RNF13 ring finger protein 13 0.0176216
ETF1 eukaryotic translation termination factor 1 0.017617
EML5 echinoderm microtubule associated protein like 5 0.0176133
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0175586
ARID1A AT rich interactive domain 1A (SWI-like) 0.0175147
YEATS2 YEATS domain containing 2 0.0174893
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 0.0174745
IGSF1 immunoglobulin superfamily, member 1 0.0174715
ZNF518A zinc finger protein 518A 0.0174701
NSD3 nuclear receptor binding SET domain protein 3 0.0174686
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0174657
RNASE7 ribonuclease, RNase A family, 7 0.017443
RPS27 ribosomal protein S27 0.0174297
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.017409
TTC39C tetratricopeptide repeat domain 39C 0.0173738
ATP5F1B ATP synthase F1 subunit beta 0.0173312
TMEM165 transmembrane protein 165 0.0173141
NRF1 nuclear respiratory factor 1 0.0173091
USP1 ubiquitin specific peptidase 1 0.0172887
BRD3 bromodomain containing 3 0.0172805
VCL vinculin 0.0172414
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0172131
TAOK1 TAO kinase 1 0.0171941
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0171121
FOXN3 forkhead box N3 0.01704
MTFR1 mitochondrial fission regulator 1 0.0170125
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0169718
RPL18 ribosomal protein L18 0.0169217
LITAF lipopolysaccharide-induced TNF factor 0.0169177
NALF1 NALCN channel auxiliary factor 1 0.0168603
PGR progesterone receptor 0.0168517
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 0.0168117
TPT1 tumor protein, translationally-controlled 1 0.0168016
HDAC7 histone deacetylase 7 0.0167857
CREBBP CREB binding protein 0.0167834
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0167791
ZNF251 zinc finger protein 251 0.0167526
BIRC6 baculoviral IAP repeat containing 6 0.0167405
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0167279
FBXL17 F-box and leucine-rich repeat protein 17 0.0167053
RPL27A ribosomal protein L27a 0.0166895
FZD6 frizzled class receptor 6 0.0166843
ANO6 anoctamin 6 0.0166728
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0166699
UBTF upstream binding transcription factor, RNA polymerase I 0.0166664
CAPNS1 calpain, small subunit 1 0.0165994
LDOC1 leucine zipper, down-regulated in cancer 1 0.0165801
EDA ectodysplasin A 0.0165648
KCTD3 potassium channel tetramerization domain containing 3 0.0165463
METTL8 methyltransferase like 8 0.0165415
ENAH enabled homolog (Drosophila) 0.0164954
CCDC122 coiled-coil domain containing 122 0.0164953
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0164782
KYNU kynureninase 0.0164758
ZFYVE16 zinc finger, FYVE domain containing 16 0.0164501
GTF2IRD2B GTF2I repeat domain containing 2B 0.016442
FRMD4A FERM domain containing 4A 0.0164246
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.01642
FERMT2 fermitin family member 2 0.016385
CLTC clathrin, heavy chain (Hc) 0.0163517
UBE2B ubiquitin-conjugating enzyme E2B 0.0162916
SEC62 SEC62 homolog (S. cerevisiae) 0.0162752
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0162562
NPC1 Niemann-Pick disease, type C1 0.0162519
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0162371
KIAA0319L KIAA0319-like 0.0161768
ANAPC1 anaphase promoting complex subunit 1 0.016174
SNF8 SNF8, ESCRT-II complex subunit 0.0161692
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0161544
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0161219
LUC7L LUC7-like (S. cerevisiae) 0.0161019
PCDHB16 protocadherin beta 16 0.0160757
OAZ1 ornithine decarboxylase antizyme 1 0.0160568
MRPS18B mitochondrial ribosomal protein S18B 0.0160524
FBXL18 F-box and leucine-rich repeat protein 18 0.0160052
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0159901
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0159604
RAB40C RAB40C, member RAS oncogene family 0.0159083
RPLP2 ribosomal protein, large, P2 0.0158881
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0158837
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0158769
ARB2A ARB2 cotranscriptional regulator A 0.0158682
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0158525
CDYL2 chromodomain protein, Y-like 2 0.0158209
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 0.0158061
ACIN1 apoptotic chromatin condensation inducer 1 0.0157886
MTG2 mitochondrial ribosome-associated GTPase 2 0.0157855
REEP5 receptor accessory protein 5 0.0157703
EFHC1 EF-hand domain (C-terminal) containing 1 0.0157421
WDR45 WD repeat domain 45 0.0157072
IL13RA1 interleukin 13 receptor, alpha 1 0.0157062
SON SON DNA binding protein 0.0156992
DENND2C DENN/MADD domain containing 2C 0.0156685
ZNF789 zinc finger protein 789 0.0156681
CSRP1 cysteine and glycine-rich protein 1 0.0156216
SETDB1 SET domain, bifurcated 1 0.0156146
PKP4 plakophilin 4 0.0155965
ARSD arylsulfatase D 0.0155941
SHTN1 shootin 1 0.0155466
SET SET nuclear proto-oncogene 0.0155425
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0155421
VPS50 VPS50 subunit of EARP/GARPII complex 0.0155293
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.0154967
UBXN4 UBX domain protein 4 0.0154911
MEIS1 Meis homeobox 1 0.0154656
URGCP upregulator of cell proliferation 0.0154478
LUZP1 leucine zipper protein 1 0.0154325
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.015402
PEX16 peroxisomal biogenesis factor 16 0.0153984
LRRC58 leucine rich repeat containing 58 0.0153851
FAM217B family with sequence similarity 217, member B 0.0153603
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.0153212
CATSPERG catsper channel auxiliary subunit gamma 0.0153154
FOXO1 forkhead box O1 0.0153113
CLIC4 chloride intracellular channel 4 0.0153045
ENDOD1 endonuclease domain containing 1 0.0152807
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0152805
RPL35A ribosomal protein L35a 0.0152755
ZBTB10 zinc finger and BTB domain containing 10 0.0152701
ARMC9 armadillo repeat containing 9 0.0152449
SERINC3 serine incorporator 3 0.0152358
OSBPL1A oxysterol binding protein-like 1A 0.0151869
USP42 ubiquitin specific peptidase 42 0.0151857
NIN ninein (GSK3B interacting protein) 0.0151463
GRTP1 growth hormone regulated TBC protein 1 0.0151388
TRIM56 tripartite motif containing 56 0.0151375
BARD1 BRCA1 associated RING domain 1 0.0151177
CDH18 cadherin 18, type 2 0.0151011
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0150657
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.0150617
RBSN rabenosyn, RAB effector 0.0150557
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 0.0150238
BCLAF1 BCL2-associated transcription factor 1 0.0149764
NUAK1 NUAK family, SNF1-like kinase, 1 0.0149661
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.0149607
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.01496
CCDC159 coiled-coil domain containing 159 0.0148889
LAMP2 lysosomal-associated membrane protein 2 0.0148656
BCAS1 breast carcinoma amplified sequence 1 0.014851
SCAMP1 secretory carrier membrane protein 1 0.0147985
RBM14-RBM4 RBM14-RBM4 readthrough 0.0147835
PUM1 pumilio RNA-binding family member 1 0.0147651
CAAP1 caspase activity and apoptosis inhibitor 1 0.0147516
FRYL FRY-like 0.0147078
FOCAD focadhesin 0.0147066
ABI2 abl-interactor 2 0.0146947
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0146768
DPP8 dipeptidyl-peptidase 8 0.0146555
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0146543
RPL13A ribosomal protein L13a 0.0146215
LCORL ligand dependent nuclear receptor corepressor-like 0.0146173
BRD2 bromodomain containing 2 0.0145964
TNRC6C trinucleotide repeat containing 6C 0.0145785
MBD4 methyl-CpG binding domain protein 4 0.014542
ATP5MF ATP synthase membrane subunit f 0.0145251
LGALS3 lectin, galactoside-binding, soluble, 3 0.0145251
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0145092
NBPF15 neuroblastoma breakpoint family, member 15 0.0145087
RNF139 ring finger protein 139 0.0144906
EMC2 ER membrane protein complex subunit 2 0.0144866
CLSTN2 calsyntenin 2 0.0144864
MAST4 microtubule associated serine/threonine kinase family member 4 0.014484
ARHGAP29 Rho GTPase activating protein 29 0.0144741
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.0144703

decreased expression

Symbol Name Standardized Value
BCAS3 breast carcinoma amplified sequence 3 -0.12478
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.122918
WWOX WW domain containing oxidoreductase -0.113597
MSI2 musashi RNA-binding protein 2 -0.0871785
CUX1 cut-like homeobox 1 -0.0797029
AGR2 anterior gradient 2 -0.0686076
ESR1 estrogen receptor 1 -0.0682812
ELP2 elongator acetyltransferase complex subunit 2 -0.0679625
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0668801
CTSD cathepsin D -0.0658001
GFRA1 GDNF family receptor alpha 1 -0.0657167
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.065023
NCOA3 nuclear receptor coactivator 3 -0.0603109
PARD6B par-6 family cell polarity regulator beta -0.0582215
PKM pyruvate kinase, muscle -0.0554336
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.053893
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0524337
GRHL2 grainyhead-like 2 (Drosophila) -0.0501974
DLG1 discs, large homolog 1 (Drosophila) -0.0498827
SMYD3 SET and MYND domain containing 3 -0.0496404
KRT8 keratin 8, type II -0.0486922
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0482874
COX6C cytochrome c oxidase subunit VIc -0.0472163
KRT18 keratin 18, type I -0.0469727
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0464694
NRCAM neuronal cell adhesion molecule -0.0461001
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0434595
CNKSR3 CNKSR family member 3 -0.0430843
KRT19 keratin 19, type I -0.0429068
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0423423
KAT6B K(lysine) acetyltransferase 6B -0.0422536
ATXN2 ataxin 2 -0.0420606
FGF13 fibroblast growth factor 13 -0.0407859
GOLGA4 golgin A4 -0.0406477
KMT2C lysine (K)-specific methyltransferase 2C -0.0402688
VDAC2 voltage-dependent anion channel 2 -0.0395811
RABGAP1L RAB GTPase activating protein 1-like -0.0380266
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0372434
NCAM2 neural cell adhesion molecule 2 -0.0368723
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0368027
PSD3 pleckstrin and Sec7 domain containing 3 -0.0361927
EMP2 epithelial membrane protein 2 -0.0359479
GPC6 glypican 6 -0.0352536
CCDC170 coiled-coil domain containing 170 -0.0341849
BCAS4 breast carcinoma amplified sequence 4 -0.0341568
MIS18BP1 MIS18 binding protein 1 -0.0341033
COPE coatomer protein complex, subunit epsilon -0.0339246
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0337896
KIAA1671 KIAA1671 -0.0336157
RPL37A ribosomal protein L37a -0.0335988
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0330329
TOM1L2 target of myb1-like 2 (chicken) -0.0322321
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.032041
KDM2A lysine (K)-specific demethylase 2A -0.0316202
RGS6 regulator of G-protein signaling 6 -0.0314462
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311486
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0310929
RPS24 ribosomal protein S24 -0.0310167
CCND1 cyclin D1 -0.0305867
FANCI Fanconi anemia, complementation group I -0.0305233
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.030511
PTGES2 prostaglandin E synthase 2 -0.0302166
TUBB tubulin, beta class I -0.0295702
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0295255
FHIT fragile histidine triad -0.0293484
DTNA dystrobrevin, alpha -0.0293379
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0290489
TMSB10 thymosin beta 10 -0.0289562
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0289055
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0288129
BSG basigin (Ok blood group) -0.0287964
TRIM33 tripartite motif containing 33 -0.0286486
FANCD2 Fanconi anemia, complementation group D2 -0.0284518
IFI6 interferon, alpha-inducible protein 6 -0.0279039
PDE8A phosphodiesterase 8A -0.0278339
RFX7 regulatory factor X, 7 -0.0276618
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0276429
WASHC5 WASH complex subunit 5 -0.0274676
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0273424
UGDH UDP-glucose 6-dehydrogenase -0.0273278
MAP7 microtubule-associated protein 7 -0.0273161
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0271051
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.027066
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0267561
TPX2 TPX2, microtubule-associated -0.0266796
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0266345
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0265432
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -0.0263073
CHLSN cholesin -0.0262126
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0261863
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0261091
ABHD2 abhydrolase domain containing 2 -0.0259611
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0257928
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0257538
ANKRD11 ankyrin repeat domain 11 -0.0253147
CPA6 carboxypeptidase A6 -0.0253063
RAD51B RAD51 paralog B -0.0251285
MLPH melanophilin -0.0250889
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0250836
MAPK6 mitogen-activated protein kinase 6 -0.0250766
TMED8 transmembrane emp24 protein transport domain containing 8 -0.025052
KAZN kazrin, periplakin interacting protein -0.0248605
MANBA mannosidase, beta A, lysosomal -0.0248101
GPHN gephyrin -0.0244287
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0240654
EHBP1 EH domain binding protein 1 -0.0238847
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -0.0238171
HID1 HID1 domain containing -0.0234135
PRKCA protein kinase C, alpha -0.0232125
CDCA4 cell division cycle associated 4 -0.0231363
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -0.0231302
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0231079
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.023048
ABI1 abl-interactor 1 -0.0229692
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0229032
UBL3 ubiquitin-like 3 -0.0228872
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0228426
RUFY1 RUN and FYVE domain containing 1 -0.0227173
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0227066
HM13 histocompatibility (minor) 13 -0.0226728
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0226556
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.0226297
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0225904
KATNBL1 katanin p80 subunit B-like 1 -0.0225578
ADCY9 adenylate cyclase 9 -0.0225036
TMEM192 transmembrane protein 192 -0.0224703
PHF14 PHD finger protein 14 -0.0224664
ERI3 ERI1 exoribonuclease family member 3 -0.0224577
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0223872
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0223714
GDI2 GDP dissociation inhibitor 2 -0.0223539
ABHD12 abhydrolase domain containing 12 -0.0223245
NRIP1 nuclear receptor interacting protein 1 -0.0223194
MCM7 minichromosome maintenance complex component 7 -0.0220555
TMPRSS4 transmembrane protease, serine 4 -0.021964
SSR4 signal sequence receptor, delta -0.0219251
EIF4B eukaryotic translation initiation factor 4B -0.0218946
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0218749
RPS19 ribosomal protein S19 -0.0217426
FKBP3 FK506 binding protein 3, 25kDa -0.0216963
ZC3H14 zinc finger CCCH-type containing 14 -0.021694
VTA1 vesicle (multivesicular body) trafficking 1 -0.0215304
RC3H2 ring finger and CCCH-type domains 2 -0.0214743
GREB1L growth regulation by estrogen in breast cancer-like -0.0214602
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.021413
MUC16 mucin 16, cell surface associated -0.0214013
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0213095
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0212986
IFI27 interferon, alpha-inducible protein 27 -0.0212117
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -0.0211858
DENND4C DENN/MADD domain containing 4C -0.0211647
NUP210 nucleoporin 210kDa -0.0211604
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0211536
PLK2 polo-like kinase 2 -0.0211459
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0210587
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0209591
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0209436
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.0208598
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0207633
PDE7A phosphodiesterase 7A -0.0205913
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0205912
PRLR prolactin receptor -0.0205725
PARN poly(A)-specific ribonuclease -0.0205702
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0205537
BAG3 BCL2-associated athanogene 3 -0.0204929
TLN2 talin 2 -0.0204757
STARD10 StAR-related lipid transfer (START) domain containing 10 -0.0204594
STRBP spermatid perinuclear RNA binding protein -0.0204508
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0203847
MKI67 marker of proliferation Ki-67 -0.0203259
IGFBP4 insulin-like growth factor binding protein 4 -0.0202615
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -0.0200053
DENND1B DENN/MADD domain containing 1B -0.0199816
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing -0.0199625
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0199238
UBC ubiquitin C -0.0199166
COG5 component of oligomeric golgi complex 5 -0.0199016
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0198109
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0198073
DCTN4 dynactin 4 (p62) -0.0197126
ASXL2 additional sex combs like transcriptional regulator 2 -0.0196035
WDR59 WD repeat domain 59 -0.0195714
STRN striatin, calmodulin binding protein -0.0195419
ZNF277 zinc finger protein 277 -0.019465
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0194625
WAPL WAPL cohesin release factor -0.0194065
ZNF3 zinc finger protein 3 -0.0193788
URI1 URI1, prefoldin-like chaperone -0.019176
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0191474
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.01914
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -0.0191321
TMED3 transmembrane emp24 protein transport domain containing 3 -0.0191135
CENPB centromere protein B, 80kDa -0.0190984
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0190954
CLDN7 claudin 7 -0.0190913
DOCK1 dedicator of cytokinesis 1 -0.019077
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.019071
TNPO2 transportin 2 -0.0190505
TAOK3 TAO kinase 3 -0.0190407
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -0.0190246
SETD1B SET domain containing 1B -0.0190206
FDPS farnesyl diphosphate synthase -0.0189914
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0188339
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0187772
YTHDC1 YTH domain containing 1 -0.0187747
DCDC2 doublecortin domain containing 2 -0.0187721
MECOM MDS1 and EVI1 complex locus -0.0187056
SAMTOR S-adenosylmethionine sensor upstream of mTORC1 -0.0186323
RPL35 ribosomal protein L35 -0.0185873
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0185624
RNF216 ring finger protein 216 -0.0184776
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.0184361
CLTA clathrin, light chain A -0.0184257
KCNK6 potassium channel, two pore domain subfamily K, member 6 -0.0184178
GID8 GID complex subunit 8 -0.0184104
PRC1 protein regulator of cytokinesis 1 -0.0183798
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.0183797
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0183793
SPAG9 sperm associated antigen 9 -0.0183757
CEP95 centrosomal protein 95kDa -0.0183386
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0183191
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -0.018283
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0182311
COPS3 COP9 signalosome subunit 3 -0.0181948
RAB21 RAB21, member RAS oncogene family -0.0181568
PCDH7 protocadherin 7 -0.0181561
SPATA7 spermatogenesis associated 7 -0.0181168
JARID2 jumonji, AT rich interactive domain 2 -0.0180589
PRKD2 protein kinase D2 -0.0180562
TELO2 telomere maintenance 2 -0.0180305
ARHGAP11B Rho GTPase activating protein 11B -0.0179497
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.017932
CIAO1 cytosolic iron-sulfur assembly component 1 -0.0178868
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -0.0178715
TUFM Tu translation elongation factor, mitochondrial -0.0178708
WAC WW domain containing adaptor with coiled-coil -0.0177447
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0177313
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0177061
ATP5F1E ATP synthase F1 subunit epsilon -0.0175899
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -0.0175134
PLXDC2 plexin domain containing 2 -0.0175121
ENOSF1 enolase superfamily member 1 -0.0174599
COX5A cytochrome c oxidase subunit Va -0.01743
SHROOM2 shroom family member 2 -0.0174297
RAD51C RAD51 paralog C -0.0174297
APP amyloid beta (A4) precursor protein -0.0174244
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0174236
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.017369
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.0172885
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0172805
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -0.0172064
MCM10 minichromosome maintenance complex component 10 -0.0171972
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0171596
RCOR1 REST corepressor 1 -0.017151
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0170738
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -0.0169857
GPATCH8 G patch domain containing 8 -0.0169598
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0167707
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -0.016756
DSG2 desmoglein 2 -0.016737
SEC16A SEC16 homolog A (S. cerevisiae) -0.0167252
EXOC6B exocyst complex component 6B -0.0167238
KPNB1 karyopherin (importin) beta 1 -0.0167128
IRF2BPL interferon regulatory factor 2 binding protein-like -0.0166191
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.016614
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0166131
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0166065
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0166012
TULP4 tubby like protein 4 -0.0165964
ACLY ATP citrate lyase -0.0165914
KIF5B kinesin family member 5B -0.0165303
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0164978
CTCF CCCTC-binding factor (zinc finger protein) -0.0164816
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0164586
RPL7 ribosomal protein L7 -0.0164471
SLC38A9 solute carrier family 38, member 9 -0.0164283
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0164156
PICALM phosphatidylinositol binding clathrin assembly protein -0.0163683
TMCC1 transmembrane and coiled-coil domain family 1 -0.016346
FLNB filamin B, beta -0.0163196
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0162967
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -0.016292
LAMP1 lysosomal-associated membrane protein 1 -0.0162915
PHF19 PHD finger protein 19 -0.016263
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.016261
RBBP8 retinoblastoma binding protein 8 -0.0162197
TASOR2 transcription activation suppressor family member 2 -0.0162176
PRPF6 pre-mRNA processing factor 6 -0.0162103
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0161548
ATAD1 ATPase family, AAA domain containing 1 -0.0161467
EXOC2 exocyst complex component 2 -0.0160881
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.0160545
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0160522
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0160149
DPY19L4 dpy-19-like 4 (C. elegans) -0.0160066
TMEM167A transmembrane protein 167A -0.0159632
CYBA cytochrome b-245, alpha polypeptide -0.0159459
EDF1 endothelial differentiation-related factor 1 -0.015941
AMZ1 archaelysin family metallopeptidase 1 -0.0158577
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0158509
PLCB4 phospholipase C, beta 4 -0.0158499
DIAPH3 diaphanous-related formin 3 -0.0158058
ICA1 islet cell autoantigen 1, 69kDa -0.0157869
STK39 serine threonine kinase 39 -0.015781
UBXN7 UBX domain protein 7 -0.0157809
R3HDM1 R3H domain containing 1 -0.0157418
SNW1 SNW domain containing 1 -0.0157218
MECP2 methyl CpG binding protein 2 -0.0156718
ZFAND3 zinc finger, AN1-type domain 3 -0.0156611
ATRN attractin -0.0156452
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0156416
SCARB1 scavenger receptor class B, member 1 -0.0156352
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0156165
ICMT isoprenylcysteine carboxyl methyltransferase -0.0156103
ATXN1 ataxin 1 -0.0155969
MACROD2 MACRO domain containing 2 -0.0155773
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0155721
WSB1 WD repeat and SOCS box containing 1 -0.0155601
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0155046
CCDC57 coiled-coil domain containing 57 -0.0154877
ATAD2 ATPase family, AAA domain containing 2 -0.0154636
ATG14 autophagy related 14 -0.0154634
TUBGCP2 tubulin, gamma complex associated protein 2 -0.0154599
IRAK1 interleukin-1 receptor-associated kinase 1 -0.0154554
PCNT pericentrin -0.0154409
FOXK2 forkhead box K2 -0.0154228
PRKCE protein kinase C, epsilon -0.0154051
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0153615
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0153544
SYTL4 synaptotagmin-like 4 -0.0153369
CUL5 cullin 5 -0.0153237
DCAF7 DDB1 and CUL4 associated factor 7 -0.0153201
TRIP11 thyroid hormone receptor interactor 11 -0.0152872
SLX4IP SLX4 interacting protein -0.0152739
CALR calreticulin -0.0152209
YBX1 Y box binding protein 1 -0.0152001
NELFB negative elongation factor complex member B -0.0151906
NRP1 neuropilin 1 -0.0151747
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -0.015152
CLSPN claspin -0.015127
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0151089
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.0150955
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0150479
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0150054
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.0149757
MYO6 myosin VI -0.0149696
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -0.0149554
CFAP44 cilia and flagella associated protein 44 -0.0149493
TFRC transferrin receptor -0.0149462
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -0.0149441
TSPAN14 tetraspanin 14 -0.0149396
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0149251
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0148958
RPN2 ribophorin II -0.0148813
TMEM214 transmembrane protein 214 -0.0148698
RPS29 ribosomal protein S29 -0.0148509
VSIG10 V-set and immunoglobulin domain containing 10 -0.0148428
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0148396
SCN8A sodium channel, voltage gated, type VIII alpha subunit -0.014819
GOLGA2 golgin A2 -0.0148158
ZBTB1 zinc finger and BTB domain containing 1 -0.0148136
INO80 INO80 complex subunit -0.0147932
ADPGK ADP-dependent glucokinase -0.0147903
SIRT2 sirtuin 2 -0.0147471
B2M beta-2-microglobulin -0.0147404
RPL41 ribosomal protein L41 -0.014726
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0147216
NOL11 nucleolar protein 11 -0.0146759
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0146603
IGSF3 immunoglobulin superfamily, member 3 -0.0146088
TOR1AIP1 torsin A interacting protein 1 -0.014573
TMLHE trimethyllysine hydroxylase, epsilon -0.0145374
DROSHA drosha, ribonuclease type III -0.0145243
CRTC3 CREB regulated transcription coactivator 3 -0.0145026
AK1 adenylate kinase 1 -0.0144939
GPR107 G protein-coupled receptor 107 -0.0144459
CRIP2 cysteine-rich protein 2 -0.014441
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0143868
TRIM66 tripartite motif containing 66 -0.0143864
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -0.0143528
DOCK7 dedicator of cytokinesis 7 -0.0143279
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0142812
SSH3 slingshot protein phosphatase 3 -0.0142528
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0142492
MYH14 myosin, heavy chain 14, non-muscle -0.0142481
ITPKC inositol-trisphosphate 3-kinase C -0.0142409
NIPAL2 NIPA-like domain containing 2 -0.0142259
LNPEP leucyl/cystinyl aminopeptidase -0.0141809
EVI5 ecotropic viral integration site 5 -0.0141384
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0141293
COPB1 coatomer protein complex, subunit beta 1 -0.0141095
BRCA1 breast cancer 1, early onset -0.0140453
ANXA7 annexin A7 -0.0139946
UNK unkempt family zinc finger -0.0139894
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0139843
FBXO42 F-box protein 42 -0.0139773
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0139322
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0139279
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -0.0139216
ECT2 epithelial cell transforming 2 -0.0139199
RAB7A RAB7A, member RAS oncogene family -0.013917
RBM4B RNA binding motif protein 4B -0.0139158
ZNF106 zinc finger protein 106 -0.0139114
SKIC3 SKI3 subunit of superkiller complex -0.0139084
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -0.0139023
UBE2K ubiquitin-conjugating enzyme E2K -0.0138775
ANKRD50 ankyrin repeat domain 50 -0.0138681
FRMD3 FERM domain containing 3 -0.0138671
C2CD5 C2 calcium-dependent domain containing 5 -0.0138511
HMGB1 high mobility group box 1 -0.0138308
TMEM184B transmembrane protein 184B -0.0137888
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0137446
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -0.0137391
RBM39 RNA binding motif protein 39 -0.0137249
CAMTA1 calmodulin binding transcription activator 1 -0.0137217
KIF18B kinesin family member 18B -0.0136995
LY6E lymphocyte antigen 6 complex, locus E -0.0136968
YBX3 Y box binding protein 3 -0.0136964
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -0.0136455
TARS1 threonyl-tRNA synthetase 1 -0.0136157
FPGS folylpolyglutamate synthase -0.0136106
CDK4 cyclin-dependent kinase 4 -0.0135923
RPN1 ribophorin I -0.0135867
COPS6 COP9 signalosome subunit 6 -0.0135755
NECAB1 N-terminal EF-hand calcium binding protein 1 -0.0135675
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.0135388
CCDC7 coiled-coil domain containing 7 -0.0135358
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -0.013534
NCOA2 nuclear receptor coactivator 2 -0.0135026
TRA2A transformer 2 alpha homolog (Drosophila) -0.0134722
ZMYND8 zinc finger, MYND-type containing 8 -0.013466
SNX27 sorting nexin family member 27 -0.0134422
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0134006
KAT6A K(lysine) acetyltransferase 6A -0.0133953
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0133905
NELFA negative elongation factor complex member A -0.0133622
RCC1L RCC1 like -0.0133593
HAUS1 HAUS augmin-like complex, subunit 1 -0.0133535
FAM120B family with sequence similarity 120B -0.0133376
SF1 splicing factor 1 -0.0133082
RTN4RL1 reticulon 4 receptor-like 1 -0.0133055
TOGARAM1 TOG array regulator of axonemal microtubules 1 -0.0132803
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0132638
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.0132508
CHPT1 choline phosphotransferase 1 -0.0132345
SLC71A2 solute carrier family 71 member 2 -0.0132327
TMPO thymopoietin -0.0132312
INTS12 integrator complex subunit 12 -0.0132167
LATS1 large tumor suppressor kinase 1 -0.013211
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.013208
WDR81 WD repeat domain 81 -0.0131958
FASN fatty acid synthase -0.0131954
SEC11A SEC11 homolog A (S. cerevisiae) -0.0131829
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0131773
SHARPIN SHANK-associated RH domain interactor -0.0131753
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0131706
SACK1H scaffolding CK1 anchoring protein H -0.0131613
FRMD5 FERM domain containing 5 -0.0131569
SLC35D4 solute carrier family 35 member D4 -0.013142
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0131339
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0131125
UNC13B unc-13 homolog B (C. elegans) -0.0130923
DYNLL1 dynein, light chain, LC8-type 1 -0.0130732
RNF115 ring finger protein 115 -0.0130617
RAB25 RAB25, member RAS oncogene family -0.0130563
TPST1 tyrosylprotein sulfotransferase 1 -0.0130559
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0130477
XPOT exportin, tRNA -0.0130465
NUP62 nucleoporin 62kDa -0.0130057
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0129805
SPIRE1 spire-type actin nucleation factor 1 -0.0129634
ADCY8 adenylate cyclase 8 (brain) -0.0129463
IPO9 importin 9 -0.0129367
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0129264
TRIM65 tripartite motif containing 65 -0.0129143
CRLF3 cytokine receptor-like factor 3 -0.0129099
FBXW11 F-box and WD repeat domain containing 11 -0.0129039
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0129004
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0128887
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0128861
CYREN cell cycle regulator of NHEJ -0.0128557
MCMBP minichromosome maintenance complex binding protein -0.0128502
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -0.012834
REPS1 RALBP1 associated Eps domain containing 1 -0.0128112
BCR breakpoint cluster region -0.0127999
SASH1 SAM and SH3 domain containing 1 -0.0127738
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0126813
NBPF12 neuroblastoma breakpoint family, member 12 -0.0126651
TMF1 TATA element modulatory factor 1 -0.0126605
ALG12 ALG12, alpha-1,6-mannosyltransferase -0.0126514
ZMPSTE24 zinc metallopeptidase STE24 -0.0126383
TMEM184A transmembrane protein 184A -0.0126377
GON4L gon-4-like (C. elegans) -0.0126348
KDM3B lysine (K)-specific demethylase 3B -0.0126317
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -0.0126293
YAP1 Yes-associated protein 1 -0.0126198
ITM2B integral membrane protein 2B -0.0126184
GSK3B glycogen synthase kinase 3 beta -0.012613
ZNF100 zinc finger protein 100 -0.0126009
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -0.0125923