MCF7_Obatoclax Mesylate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 1µM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_Obatoclax Mesylate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.283293
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.278664
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.183551
DSPP dentin sialophosphoprotein 0.0982706
LOC112694756 uncharaterized LOC112694756 0.0981207
ENO1 enolase 1, (alpha) 0.0947653
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0916387
KRT19 keratin 19, type I 0.0900222
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0860341
PKM pyruvate kinase, muscle 0.0831515
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0830304
CSDE1 cold shock domain containing E1, RNA-binding 0.0795855
THSD4 thrombospondin, type I, domain containing 4 0.0744324
DTNA dystrobrevin, alpha 0.0704892
TTC3 tetratricopeptide repeat domain 3 0.0661019
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0643492
POTEF POTE ankyrin domain family, member F 0.0624308
SDK1 sidekick cell adhesion molecule 1 0.0610963
AK1 adenylate kinase 1 0.0589327
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0570403
RPL13A ribosomal protein L13a 0.0552871
TPI1 triosephosphate isomerase 1 0.0533272
RPL15 ribosomal protein L15 0.0524762
DAAM1 dishevelled associated activator of morphogenesis 1 0.0507897
SET SET nuclear proto-oncogene 0.0507044
KMT2C lysine (K)-specific methyltransferase 2C 0.0483698
LDHA lactate dehydrogenase A 0.0467474
PTPRK protein tyrosine phosphatase, receptor type, K 0.0467459
HSPB1 heat shock 27kDa protein 1 0.0455633
USP32 ubiquitin specific peptidase 32 0.0439655
ANKRD17 ankyrin repeat domain 17 0.0426132
H3-3B H3.3 histone B 0.0424115
TRIM37 tripartite motif containing 37 0.04125
SOX4 SRY (sex determining region Y)-box 4 0.0411253
SQLE squalene epoxidase 0.0410532
MRPL13 mitochondrial ribosomal protein L13 0.0409786
RPLP0 ribosomal protein, large, P0 0.0409565
EEF2 eukaryotic translation elongation factor 2 0.0407141
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0398282
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0392034
FDPS farnesyl diphosphate synthase 0.0386321
TMSB10 thymosin beta 10 0.0383332
RPL8 ribosomal protein L8 0.0382889
ACTG1 actin gamma 1 0.0376622
RPS8 ribosomal protein S8 0.0370632
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.036878
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0360625
PTMA prothymosin, alpha 0.0357358
IGF1R insulin-like growth factor 1 receptor 0.0357279
LRRC58 leucine rich repeat containing 58 0.0351802
DSCAM Down syndrome cell adhesion molecule 0.035066
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0348699
CUX1 cut-like homeobox 1 0.0345876
BRD4 bromodomain containing 4 0.0342955
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0341775
NRIP1 nuclear receptor interacting protein 1 0.0338173
RPS2 ribosomal protein S2 0.0333278
COL4A5 collagen, type IV, alpha 5 0.0329017
MLPH melanophilin 0.0325976
RPL7A ribosomal protein L7a 0.0325636
SMYD3 SET and MYND domain containing 3 0.032392
MALRD1 MAM and LDL receptor class A domain containing 1 0.03211
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0315945
CCSER1 coiled-coil serine-rich protein 1 0.0311847
SQSTM1 sequestosome 1 0.0311682
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0310586
S100A11 S100 calcium binding protein A11 0.0309313
SREBF2 sterol regulatory element binding transcription factor 2 0.0305346
USP48 ubiquitin specific peptidase 48 0.0304535
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0303466
SERINC5 serine incorporator 5 0.0303125
IFI27 interferon, alpha-inducible protein 27 0.0291919
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0291691
BRWD1 bromodomain and WD repeat domain containing 1 0.0289099
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0287895
KRT80 keratin 80, type II 0.0287507
RPS23 ribosomal protein S23 0.0286838
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.028604
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0283914
RUNX1 runt-related transcription factor 1 0.0281187
ADAR adenosine deaminase, RNA-specific 0.0279868
TMEM164 transmembrane protein 164 0.0279865
HMGN1 high mobility group nucleosome binding domain 1 0.0274811
SPTSSB serine palmitoyltransferase, small subunit B 0.0274217
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0272617
MYO9A myosin IXA 0.0269823
NRP1 neuropilin 1 0.0269728
NAV1 neuron navigator 1 0.0269397
MED13L mediator complex subunit 13-like 0.0268627
CMYA5 cardiomyopathy associated 5 0.0267965
SFXN1 sideroflexin 1 0.0267582
FOXO3 forkhead box O3 0.0260581
RPS6 ribosomal protein S6 0.02603
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.0258219
RPS17 ribosomal protein S17 0.0258198
HDLBP high density lipoprotein binding protein 0.0256354
ISG15 ISG15 ubiquitin-like modifier 0.0255479
SPIRE1 spire-type actin nucleation factor 1 0.0255147
MUSK muscle, skeletal, receptor tyrosine kinase 0.0254915
HEATR6 HEAT repeat containing 6 0.0254845
RABGAP1 RAB GTPase activating protein 1 0.0252155
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0252023
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0251465
SYTL2 synaptotagmin-like 2 0.0249524
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0249156
GREB1 growth regulation by estrogen in breast cancer 1 0.0248723
RPS16 ribosomal protein S16 0.0248716
RPS7 ribosomal protein S7 0.0247955
RAB7A RAB7A, member RAS oncogene family 0.0245133
ARTN artemin 0.0243742
AREG amphiregulin 0.0242086
RPS27 ribosomal protein S27 0.0241807
ENOSF1 enolase superfamily member 1 0.0241291
ZFP36L1 ZFP36 ring finger protein-like 1 0.0240053
BPTF bromodomain PHD finger transcription factor 0.0238516
ANXA2 annexin A2 0.0237373
KPNB1 karyopherin (importin) beta 1 0.0236906
AMZ1 archaelysin family metallopeptidase 1 0.0235242
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0234089
STRBP spermatid perinuclear RNA binding protein 0.023255
MACROD2 MACRO domain containing 2 0.0230873
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0230593
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.023056
CCND1 cyclin D1 0.0230338
FGF13 fibroblast growth factor 13 0.0229899
RPS21 ribosomal protein S21 0.0227532
TRIO trio Rho guanine nucleotide exchange factor 0.0225697
LGALS3 lectin, galactoside-binding, soluble, 3 0.0223993
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0223772
PGK1 phosphoglycerate kinase 1 0.0222968
GIPC1 GIPC PDZ domain containing family, member 1 0.0222676
BMP7 bone morphogenetic protein 7 0.0222245
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0221791
PFKP phosphofructokinase, platelet 0.0220835
TFRC transferrin receptor 0.022054
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0219641
RTN4 reticulon 4 0.0218859
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0218511
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0217815
GNAS GNAS complex locus 0.0216559
CEMIP2 cell migration inducing hyaluronidase 2 0.0216439
RSL24D1 ribosomal L24 domain containing 1 0.0215657
TMEM120B transmembrane protein 120B 0.0215551
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0215298
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0213436
DST dystonin 0.0213173
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0210181
MACC1 metastasis associated in colon cancer 1 0.0209982
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0209217
SERBP1 SERPINE1 mRNA binding protein 1 0.0205191
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0204076
RPL5 ribosomal protein L5 0.0203259
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0201394
TRPS1 trichorhinophalangeal syndrome I 0.0201141
REST RE1-silencing transcription factor 0.0199006
VCP valosin containing protein 0.0198814
KLF6 Kruppel-like factor 6 0.0198471
SUMF1 sulfatase modifying factor 1 0.0198446
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0197881
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0197796
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0197345
IGSF1 immunoglobulin superfamily, member 1 0.0197285
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0197248
KIF21A kinesin family member 21A 0.019634
SP100 SP100 nuclear antigen 0.0196123
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0195517
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0194588
CDYL2 chromodomain protein, Y-like 2 0.0193295
SAMD1 sterile alpha motif domain containing 1 0.0192288
PKN2 protein kinase N2 0.0192186
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0189487
LTBP1 latent transforming growth factor beta binding protein 1 0.0188706
EPHA4 EPH receptor A4 0.0188567
TRIM25 tripartite motif containing 25 0.0188179
CBX3 chromobox homolog 3 0.0187877
CLTC clathrin, heavy chain (Hc) 0.0187861
CTNND2 catenin (cadherin-associated protein), delta 2 0.0187271
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0186482
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0186465
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0186138
NRCAM neuronal cell adhesion molecule 0.0186005
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0185921
RPL34 ribosomal protein L34 0.0185551
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0184959
LARP1 La ribonucleoprotein domain family, member 1 0.018469
COPE coatomer protein complex, subunit epsilon 0.0184225
IER3 immediate early response 3 0.0184007
MYO1B myosin IB 0.0183663
MYH14 myosin, heavy chain 14, non-muscle 0.0182543
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.0182526
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0182312
RPL14 ribosomal protein L14 0.0182264
LARP4B La ribonucleoprotein domain family, member 4B 0.0181044
SYT1 synaptotagmin I 0.0180503
NBEAL1 neurobeachin-like 1 0.0180134
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0180094
ARLN allregulin 0.0179298
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0179215
ANKRD12 ankyrin repeat domain 12 0.0178889
RRBP1 ribosome binding protein 1 0.0178827
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0178484
FHIT fragile histidine triad 0.0178206
RPL3 ribosomal protein L3 0.0177806
ARFGEF3 ARFGEF family member 3 0.0177687
QPRT quinolinate phosphoribosyltransferase 0.0177346
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.0176976
RPL12 ribosomal protein L12 0.0176824
ULK1 unc-51 like autophagy activating kinase 1 0.0176512
TASOR2 transcription activation suppressor family member 2 0.0176477
DICER1 dicer 1, ribonuclease type III 0.0176198
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0175146
FAM174B family with sequence similarity 174, member B 0.0175081
RACK1 receptor for activated C kinase 1 0.0174999
BBX bobby sox homolog (Drosophila) 0.0174753
ZNHIT1 zinc finger, HIT-type containing 1 0.0174268
RPL10A ribosomal protein L10a 0.0173817
ATP11C ATPase, class VI, type 11C 0.0173605
SPRED2 sprouty-related, EVH1 domain containing 2 0.0172778
BTBD7 BTB (POZ) domain containing 7 0.0172473
RPL11 ribosomal protein L11 0.0172466
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0168707
IDE insulin-degrading enzyme 0.0168279
PRR14L proline rich 14-like 0.0168199
ARHGAP12 Rho GTPase activating protein 12 0.0167891
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.016627
TET3 tet methylcytosine dioxygenase 3 0.0166081
INSIG1 insulin induced gene 1 0.0166057
RPS9 ribosomal protein S9 0.0165845
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0165622
BLTP2 bridge-like lipid transfer protein family member 2 0.0165439
S100A10 S100 calcium binding protein A10 0.0165073
THOC2 THO complex 2 0.016483
RLF rearranged L-myc fusion 0.0163734
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0162234
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0161953
SPPL3 signal peptide peptidase like 3 0.01619
FTL ferritin, light polypeptide 0.0161381
TRAP1 TNF receptor-associated protein 1 0.0161239
COX6C cytochrome c oxidase subunit VIc 0.0160043
OTUD4 OTU deubiquitinase 4 0.0160035
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0158973
PCNT pericentrin 0.0158555
DAZAP1 DAZ associated protein 1 0.0158456
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.015834
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.015801
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0157917
ZFR zinc finger RNA binding protein 0.0157807
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0157759
ARL8B ADP-ribosylation factor-like 8B 0.0157674
SINHCAF SIN3-HDAC complex associated factor 0.0157238
NIN ninein (GSK3B interacting protein) 0.0156026
RPSA ribosomal protein SA 0.0154999
AFDN afadin, adherens junction formation factor 0.0154957
DLG1 discs, large homolog 1 (Drosophila) 0.0154956
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.015453
IGF2R insulin-like growth factor 2 receptor 0.0154455
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.0154391
RPS13 ribosomal protein S13 0.0154265
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.015397
KLHL24 kelch-like family member 24 0.0153833
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.0153731
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0153662
PRXL2A peroxiredoxin like 2A 0.0153284
POU2F1 POU class 2 homeobox 1 0.0152795
SFTPA2 surfactant protein A2 0.0152718
CPA6 carboxypeptidase A6 0.0152559
RPS5 ribosomal protein S5 0.0151914
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0151463
SEC31A SEC31 homolog A (S. cerevisiae) 0.0151188
ELOVL6 ELOVL fatty acid elongase 6 0.0149589
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0149494
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0149377
HDGFL3 HDGF like 3 0.0149241
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.014866
KYNU kynureninase 0.014852
EGR1 early growth response 1 0.0148209
RAD23B RAD23 homolog B (S. cerevisiae) 0.014771
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0147555
YEATS2 YEATS domain containing 2 0.0147542
CMIP c-Maf inducing protein 0.0147496
GRAMD1A GRAM domain containing 1A 0.0147439
ANKRD50 ankyrin repeat domain 50 0.0147039
TRIM56 tripartite motif containing 56 0.0146529
SECISBP2 SECIS binding protein 2 0.0145784
CHD4 chromodomain helicase DNA binding protein 4 0.0145464
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0145225
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0145127
TLN2 talin 2 0.01449
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.0144556
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0143921
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0143805
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0143615
BCL2 B-cell CLL/lymphoma 2 0.0143583
PRMT1 protein arginine methyltransferase 1 0.0143291
RNF43 ring finger protein 43 0.0143001
ZFP36L2 ZFP36 ring finger protein-like 2 0.0142723
RIGI RNA sensor RIG-I 0.0142274
CBX5 chromobox homolog 5 0.0142039
MBTD1 mbt domain containing 1 0.0141787
LDLR low density lipoprotein receptor 0.0141601
SSR1 signal sequence receptor, alpha 0.0141516
LNX2 ligand of numb-protein X 2 0.0141255
MPV17 MpV17 mitochondrial inner membrane protein 0.0141217
IQGAP1 IQ motif containing GTPase activating protein 1 0.0141091
CDK4 cyclin-dependent kinase 4 0.0140847
TNRC6A trinucleotide repeat containing 6A 0.014078
ATOSA atos homolog A 0.014075
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.0139797
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0139575
NKTR natural killer cell triggering receptor 0.0139334
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 0.0139132
ACER3 alkaline ceramidase 3 0.0139126
INO80D INO80 complex subunit D 0.0138941
SRRM2 serine/arginine repetitive matrix 2 0.0138453
ZNF638 zinc finger protein 638 0.0138437
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.0138214
MYO1D myosin ID 0.0138212
PCNX4 pecanex 4 0.0137291
TUBA1A tubulin, alpha 1a 0.0136943
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0136894
RPL23A ribosomal protein L23a 0.013673
UTRN utrophin 0.013671
MBD4 methyl-CpG binding domain protein 4 0.0136627
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.01366
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0136245
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0136164
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0135803
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0135639
RPL4 ribosomal protein L4 0.0135177
TBK1 TANK-binding kinase 1 0.0135066
ARL15 ADP-ribosylation factor-like 15 0.0134982
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0134916
DOCK5 dedicator of cytokinesis 5 0.01349
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.0134757
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0134483
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0134378
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0134191
LCOR ligand dependent nuclear receptor corepressor 0.0134173
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.013398
RPS19 ribosomal protein S19 0.0133927
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0133322
NPC2 Niemann-Pick disease, type C2 0.0133236
IREB2 iron-responsive element binding protein 2 0.0133175
GDI2 GDP dissociation inhibitor 2 0.0133121
MCM4 minichromosome maintenance complex component 4 0.013294
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0132557
PUS7 pseudouridylate synthase 7 (putative) 0.0132407
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0131715
FMNL2 formin-like 2 0.0131601
KLHL22 kelch-like family member 22 0.0131345
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.0131273
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0131269
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.0131111
GCLC glutamate-cysteine ligase, catalytic subunit 0.0130597
NUP62 nucleoporin 62kDa 0.0130103
ZNF292 zinc finger protein 292 0.0130092
SRBD1 S1 RNA binding domain 1 0.0130064
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0129973
N4BP3 NEDD4 binding protein 3 0.0129896
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0129863
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.012965
MPZ myelin protein zero 0.0129369
NINL ninein-like 0.0128911
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0128657
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.0128635
SSH1 slingshot protein phosphatase 1 0.0128482
BRD3 bromodomain containing 3 0.0128384
SRPK2 SRSF protein kinase 2 0.0127886
USP54 ubiquitin specific peptidase 54 0.0127794
DDIT4 DNA-damage-inducible transcript 4 0.012771
FBRSL1 fibrosin-like 1 0.0127556
PHGDH phosphoglycerate dehydrogenase 0.0127375
PALB2 partner and localizer of BRCA2 0.012729
ESYT2 extended synaptotagmin-like protein 2 0.0127108
NOL8 nucleolar protein 8 0.0127077
AXIN1 axin 1 0.0126834
MAP7 microtubule-associated protein 7 0.0126278
SETX senataxin 0.0126259
SMIM14 small integral membrane protein 14 0.0126012
RPL30 ribosomal protein L30 0.0125634
GAB2 GRB2-associated binding protein 2 0.0125499
ILF3 interleukin enhancer binding factor 3, 90kDa 0.012532
CDYL chromodomain protein, Y-like 0.0125006
COP1 COP1 E3 ubiquitin ligase 0.0124632
RBBP6 retinoblastoma binding protein 6 0.0124602
THRAP3 thyroid hormone receptor associated protein 3 0.0124563
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0124532
L2HGDH L-2-hydroxyglutarate dehydrogenase 0.0124282
MREG melanoregulin 0.0124229
SCAF11 SR-related CTD-associated factor 11 0.0123979
FKBP8 FK506 binding protein 8, 38kDa 0.0123936
SNX9 sorting nexin 9 0.0123811
TAOK1 TAO kinase 1 0.0123627
ZHX1 zinc fingers and homeoboxes 1 0.0123624
AHCYL2 adenosylhomocysteinase-like 2 0.0123312
RNF223 ring finger protein 223 0.012328
TCEAL4 transcription elongation factor A (SII)-like 4 0.0123222
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0122958
SYT12 synaptotagmin XII 0.0122849
ZNF24 zinc finger protein 24 0.0122827
BMS1 BMS1 ribosome biogenesis factor 0.0122739
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0122689
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 0.0122587
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0122504
NXNL2 nucleoredoxin-like 2 0.0122392
RPL27A ribosomal protein L27a 0.0122318
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0122278
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.012199
EIF4B eukaryotic translation initiation factor 4B 0.012197
FOXO1 forkhead box O1 0.0121529
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.0121435
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0121416
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0121357
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0121336
OSBPL2 oxysterol binding protein-like 2 0.0120982
RPS20 ribosomal protein S20 0.0120652
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0120238
KIDINS220 kinase D-interacting substrate, 220kDa 0.0119943
NAV2 neuron navigator 2 0.0119929
ZSWIM5 zinc finger, SWIM-type containing 5 0.0119729
C14ORF132 chromosome 14 open reading frame 132 0.0119671
MIPOL1 mirror-image polydactyly 1 0.0119035
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 0.0118854
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.0118686
PRKCE protein kinase C, epsilon 0.0118337
DCAF5 DDB1 and CUL4 associated factor 5 0.0118152
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0117858
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0117415
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0117376
MPG N-methylpurine-DNA glycosylase 0.0117337
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.0117325
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.0117287
GOLGA3 golgin A3 0.0116968
NOL11 nucleolar protein 11 0.0116948
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0116646
NSD3 nuclear receptor binding SET domain protein 3 0.011664
ATP5MJ ATP synthase membrane subunit j 0.0116552
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 0.0116511
KNOP1 lysine-rich nucleolar protein 1 0.0116472
COMMD10 COMM domain containing 10 0.011644
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 0.011635
MLXIP MLX interacting protein 0.0116311
SNX5 sorting nexin 5 0.0116218
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0116015
TPM4 tropomyosin 4 0.0115616
ZNF714 zinc finger protein 714 0.0115029
MBD5 methyl-CpG binding domain protein 5 0.0114828
CALCR calcitonin receptor 0.0114629
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0114552
DTD1 D-tyrosyl-tRNA deacylase 1 0.0114184
MAPT microtubule-associated protein tau 0.0114134
EIF3I eukaryotic translation initiation factor 3, subunit I 0.011399
SUGP1 SURP and G patch domain containing 1 0.0113838
ATP5F1E ATP synthase F1 subunit epsilon 0.0113752
INSR insulin receptor 0.0113681
AK4 adenylate kinase 4 0.0113681
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0113557
MROH1 maestro heat-like repeat family member 1 0.0113513
MESD mesoderm development LRP chaperone 0.0113324
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.011328
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0113267
CHML choroideremia-like (Rab escort protein 2) 0.011322
ZC3H15 zinc finger CCCH-type containing 15 0.0113063
KLHL5 kelch-like family member 5 0.0112875
JPT1 Jupiter microtubule associated homolog 1 0.0112679
MTDH metadherin 0.0112558
INF2 inverted formin, FH2 and WH2 domain containing 0.0112339
RPS24 ribosomal protein S24 0.0112294
MVD mevalonate (diphospho) decarboxylase 0.0112213
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0112107
EPS8 epidermal growth factor receptor pathway substrate 8 0.0111922
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0111694
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.0111288
HDGF hepatoma-derived growth factor 0.0110761
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.011073
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.0110575
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.0110568
FEM1B fem-1 homolog b (C. elegans) 0.01104
ZC3H4 zinc finger CCCH-type containing 4 0.0110357
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0110289
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0110201
CKAP4 cytoskeleton-associated protein 4 0.0110124
SENP5 SUMO1/sentrin specific peptidase 5 0.0110092
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0109982
TBL1X transducin (beta)-like 1X-linked 0.0109855
STC1 stanniocalcin 1 0.0109709
SNU13 small nuclear ribonucleoprotein 13 0.0109673
C19ORF53 chromosome 19 open reading frame 53 0.0109531
TKT transketolase 0.01095
SETD2 SET domain containing 2 0.010944
RPL37A ribosomal protein L37a 0.0109425
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 0.0109328
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0109243
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0109203
SFXN2 sideroflexin 2 0.010858
FAM20B family with sequence similarity 20, member B 0.010856
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.0108475
EPS15 epidermal growth factor receptor pathway substrate 15 0.0108416
MCM9 minichromosome maintenance complex component 9 0.0108176
PRPF38B pre-mRNA processing factor 38B 0.0108127

decreased expression

Symbol Name Standardized Value
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.154892
KRT8 keratin 8, type II -0.11493
WWOX WW domain containing oxidoreductase -0.113798
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.106669
ESR1 estrogen receptor 1 -0.102309
GFRA1 GDNF family receptor alpha 1 -0.0915044
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0827861
NCOA3 nuclear receptor coactivator 3 -0.0825355
AGR2 anterior gradient 2 -0.07887
VMP1 vacuole membrane protein 1 -0.0774799
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0768069
TUBD1 tubulin, delta 1 -0.0727076
CNKSR3 CNKSR family member 3 -0.0723945
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0662973
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0598956
TMEM64 transmembrane protein 64 -0.0584785
BSG basigin (Ok blood group) -0.0517625
JARID2 jumonji, AT rich interactive domain 2 -0.0516041
IGFBP5 insulin-like growth factor binding protein 5 -0.0510503
SULF2 sulfatase 2 -0.0508554
XBP1 X-box binding protein 1 -0.0507935
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0482117
KRT18 keratin 18, type I -0.0481389
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0473759
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0467875
GSE1 Gse1 coiled-coil protein -0.0457933
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0454279
PRR11 proline rich 11 -0.0443354
TOM1L2 target of myb1-like 2 (chicken) -0.0439122
KAT6B K(lysine) acetyltransferase 6B -0.0436082
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0435813
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.043544
TMCC1 transmembrane and coiled-coil domain family 1 -0.0434543
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0420524
ELP2 elongator acetyltransferase complex subunit 2 -0.041543
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.0411517
MKI67 marker of proliferation Ki-67 -0.0402602
TNRC18 trinucleotide repeat containing 18 -0.039431
EMP2 epithelial membrane protein 2 -0.037745
EVL Enah/Vasp-like -0.0377302
GLG1 golgi glycoprotein 1 -0.0375039
CCNI cyclin I -0.0374431
CALR calreticulin -0.0364301
EXOC6B exocyst complex component 6B -0.036255
LRP1B low density lipoprotein receptor-related protein 1B -0.036014
TPX2 TPX2, microtubule-associated -0.0359209
SIDT1 SID1 transmembrane family, member 1 -0.0354923
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0349644
GRHL2 grainyhead-like 2 (Drosophila) -0.0345973
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -0.0344468
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0338506
THRB thyroid hormone receptor, beta -0.0330883
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0329369
TLK2 tousled-like kinase 2 -0.0327296
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0326938
TOP1 topoisomerase (DNA) I -0.0326831
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.032264
GPC6 glypican 6 -0.0322443
LMBR1 limb development membrane protein 1 -0.0316556
CA12 carbonic anhydrase XII -0.0316107
GATA3 GATA binding protein 3 -0.0313773
LY6E lymphocyte antigen 6 complex, locus E -0.0311313
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0310904
RTN3 reticulon 3 -0.0308341
FOXP1 forkhead box P1 -0.0307802
TFF1 trefoil factor 1 -0.0307065
TTC28 tetratricopeptide repeat domain 28 -0.0305598
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0305595
STK24 serine/threonine kinase 24 -0.0304268
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.030191
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0298624
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -0.0295262
STRN3 striatin, calmodulin binding protein 3 -0.0295076
SEPTIN9 septin 9 -0.0293381
CST3 cystatin C -0.0288387
MSI2 musashi RNA-binding protein 2 -0.0287535
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0286728
FLNB filamin B, beta -0.0286123
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0284353
HMCN1 hemicentin 1 -0.0283099
POLK polymerase (DNA directed) kappa -0.0281662
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0280714
PBX3 pre-B-cell leukemia homeobox 3 -0.0279691
NPAS3 neuronal PAS domain protein 3 -0.0278833
BASP1 brain abundant, membrane attached signal protein 1 -0.0278293
SOGA1 suppressor of glucose, autophagy associated 1 -0.0278107
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0275651
APOD apolipoprotein D -0.0268674
CLDN3 claudin 3 -0.0267583
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0260814
PCDH7 protocadherin 7 -0.0259525
YLPM1 YLP motif containing 1 -0.0256583
SASH1 SAM and SH3 domain containing 1 -0.0255548
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0253909
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0253278
PTPRG protein tyrosine phosphatase, receptor type, G -0.02516
LCORL ligand dependent nuclear receptor corepressor-like -0.025106
PARD6B par-6 family cell polarity regulator beta -0.0250991
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0246666
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0246305
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0239013
ZNRF3 zinc and ring finger 3 -0.0237884
DCDC2 doublecortin domain containing 2 -0.0237326
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0236243
NRBP1 nuclear receptor binding protein 1 -0.0235871
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0235162
PCLO piccolo presynaptic cytomatrix protein -0.0234374
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0233047
NCOA2 nuclear receptor coactivator 2 -0.0232968
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0232119
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.023175
JMJD1C jumonji domain containing 1C -0.0229314
ATAD2 ATPase family, AAA domain containing 2 -0.022867
DHDDS dehydrodolichyl diphosphate synthase -0.0226615
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0226568
ZMYM2 zinc finger, MYM-type 2 -0.0226312
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0224714
BICRAL BICRA like chromatin remodeling complex associated protein -0.0222771
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0220364
SYNGR2 synaptogyrin 2 -0.021976
FAM234A family with sequence similarity 234 member A -0.0219242
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0219136
LRP10 low density lipoprotein receptor-related protein 10 -0.0217257
TAPBP TAP binding protein (tapasin) -0.0217083
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0216963
CD9 CD9 molecule -0.0216844
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0214892
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0214667
C1ORF21 chromosome 1 open reading frame 21 -0.0214629
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0213329
UBE2H ubiquitin-conjugating enzyme E2H -0.0210561
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -0.0207125
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0206773
EMC3 ER membrane protein complex subunit 3 -0.0206678
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0206523
CENPF centromere protein F, 350/400kDa -0.0204476
TRIM33 tripartite motif containing 33 -0.020444
FANCI Fanconi anemia, complementation group I -0.0204424
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0203307
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0202272
ZER1 zyg-11 related, cell cycle regulator -0.0201554
SACK1B scaffolding CK1 anchoring protein B -0.0201456
SYAP1 synapse associated protein 1 -0.0201285
CCDC170 coiled-coil domain containing 170 -0.0200718
XXYLT1 xyloside xylosyltransferase 1 -0.0200347
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0200222
FLNA filamin A, alpha -0.0200196
TUBA1B tubulin, alpha 1b -0.019964
PFN1 profilin 1 -0.0199364
VSIG10 V-set and immunoglobulin domain containing 10 -0.0198525
XPO1 exportin 1 -0.0197771
H1-10 H1.10 linker histone -0.0197396
NSD2 nuclear receptor binding SET domain protein 2 -0.0197319
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0197207
TUBB tubulin, beta class I -0.0196724
ADNP activity-dependent neuroprotector homeobox -0.0196601
CHD8 chromodomain helicase DNA binding protein 8 -0.0196488
DLG5 discs, large homolog 5 (Drosophila) -0.0196436
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0196007
BCAS3 breast carcinoma amplified sequence 3 -0.0195089
RPL28 ribosomal protein L28 -0.0194752
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0193988
APOLD1 apolipoprotein L domain containing 1 -0.0193653
ZNF609 zinc finger protein 609 -0.0193448
COXFA4 cytochrome c oxidase associated subunit FA4 -0.0193428
UVRAG UV radiation resistance associated -0.0192725
KDM3B lysine (K)-specific demethylase 3B -0.0192364
CD151 CD151 molecule (Raph blood group) -0.0192028
TMEM178B transmembrane protein 178B -0.0191828
ESRP1 epithelial splicing regulatory protein 1 -0.0190287
ABHD2 abhydrolase domain containing 2 -0.0190154
NIPBL Nipped-B homolog (Drosophila) -0.0189579
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0189511
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0188824
MZT2B mitotic spindle organizing protein 2B -0.0187609
SYTL4 synaptotagmin-like 4 -0.0186984
ARSG arylsulfatase G -0.0186889
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0186289
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0185658
FAM193B family with sequence similarity 193, member B -0.0185549
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0185415
GIGYF2 GRB10 interacting GYF protein 2 -0.0185293
RAD9A RAD9 homolog A (S. pombe) -0.018515
RPL39 ribosomal protein L39 -0.0184503
NT5C2 5'-nucleotidase, cytosolic II -0.0184404
TOB1 transducer of ERBB2, 1 -0.0184195
NCOA1 nuclear receptor coactivator 1 -0.0183817
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0182582
CLASP1 cytoplasmic linker associated protein 1 -0.0182498
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0182108
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0181226
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.018105
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0181016
RAD51C RAD51 paralog C -0.0180604
TUBB4B tubulin, beta 4B class IVb -0.0179581
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.017842
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0177325
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0177129
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0176334
FERMT2 fermitin family member 2 -0.0175963
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0175533
NTN1 netrin 1 -0.0174974
SEPTIN7 septin 7 -0.0174628
HDAC8 histone deacetylase 8 -0.0174542
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0174006
NRG3 neuregulin 3 -0.0173088
BMPR1A bone morphogenetic protein receptor, type IA -0.0172365
NCOR1 nuclear receptor corepressor 1 -0.0171995
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0171836
ITM2B integral membrane protein 2B -0.0171461
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0170294
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0170186
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0170045
WDR26 WD repeat domain 26 -0.0169293
RPS29 ribosomal protein S29 -0.0169083
PUM1 pumilio RNA-binding family member 1 -0.0168841
ADGRG6 adhesion G protein-coupled receptor G6 -0.0167501
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0167189
ABHD12 abhydrolase domain containing 12 -0.0167091
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0166932
CAMKMT calmodulin-lysine N-methyltransferase -0.0166493
SGMS1 sphingomyelin synthase 1 -0.0165785
SKA2 spindle and kinetochore associated complex subunit 2 -0.0165745
FAM222B family with sequence similarity 222, member B -0.0165641
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.016553
PDS5A PDS5 cohesin associated factor A -0.016523
ARMC9 armadillo repeat containing 9 -0.0164745
CYBA cytochrome b-245, alpha polypeptide -0.0164576
RSRC1 arginine/serine-rich coiled-coil 1 -0.0164375
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0164334
RGS3 regulator of G-protein signaling 3 -0.0164302
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0164259
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0164124
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0164012
CTSD cathepsin D -0.0163722
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.0162992
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0162982
IST1 increased sodium tolerance 1 homolog (yeast) -0.0162444
PRC1 protein regulator of cytokinesis 1 -0.0162405
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0162094
MRPS34 mitochondrial ribosomal protein S34 -0.0161499
CTBP2 C-terminal binding protein 2 -0.0161227
TRA2A transformer 2 alpha homolog (Drosophila) -0.0160795
ARHGAP11B Rho GTPase activating protein 11B -0.016075
MYADM myeloid-associated differentiation marker -0.0160738
FKBP4 FK506 binding protein 4, 59kDa -0.0160162
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0159806
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0159799
GPR137 G protein-coupled receptor 137 -0.0159648
TRAPPC6B trafficking protein particle complex 6B -0.0159552
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0159431
DOCK1 dedicator of cytokinesis 1 -0.0158619
CYRIB CYFIP related Rac1 interactor B -0.0158382
ITGB4 integrin, beta 4 -0.0157743
GOLPH3L golgi phosphoprotein 3-like -0.0157687
BCL2L1 BCL2-like 1 -0.0157439
PLEC plectin -0.015738
TRAPPC12 trafficking protein particle complex 12 -0.0157206
BBLN bublin coiled coil protein -0.0157185
PDIA6 protein disulfide isomerase family A, member 6 -0.0156921
BLVRB biliverdin reductase B -0.0156907
CPEB3 cytoplasmic polyadenylation element binding protein 3 -0.0156016
PCNX1 pecanex 1 -0.0155728
IL17RA interleukin 17 receptor A -0.0155656
IQANK1 IQ motif and ankyrin repeat containing 1 -0.0155538
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.0155377
NEBL nebulette -0.0155253
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.0154949
GALC galactosylceramidase -0.0154704
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0153827
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0153764
PTPRF protein tyrosine phosphatase, receptor type, F -0.015361
EPCAM epithelial cell adhesion molecule -0.0153352
LURAP1L leucine rich adaptor protein 1-like -0.0153339
ATRAID all-trans retinoic acid-induced differentiation factor -0.0152844
DEGS2 delta(4)-desaturase, sphingolipid 2 -0.0152603
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0152498
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0152396
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0152349
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.015212
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0152087
NVL nuclear VCP-like -0.01516
FAF2 Fas associated factor family member 2 -0.0150857
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0150336
SORT1 sortilin 1 -0.0150297
FBXO11 F-box protein 11 -0.0150217
CLIC4 chloride intracellular channel 4 -0.0150073
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0149994
ZNF821 zinc finger protein 821 -0.0149478
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0149302
LIMK2 LIM domain kinase 2 -0.0148989
SRP54 signal recognition particle 54kDa -0.0148739
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0148344
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.0148239
SOS2 son of sevenless homolog 2 (Drosophila) -0.0148198
MTSS1 metastasis suppressor 1 -0.0148155
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -0.0148122
PTBP2 polypyrimidine tract binding protein 2 -0.0147879
NUP98 nucleoporin 98kDa -0.0146932
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -0.0146928
ANO10 anoctamin 10 -0.0146514
ARHGAP24 Rho GTPase activating protein 24 -0.0146498
SNW1 SNW domain containing 1 -0.0146483
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0146481
THEM6 thioesterase superfamily member 6 -0.0146343
TGOLN2 trans-golgi network protein 2 -0.0146311
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0146235
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0146114
PNKD paroxysmal nonkinesigenic dyskinesia -0.0146008
PRRC2B proline-rich coiled-coil 2B -0.0145875
TXN2 thioredoxin 2 -0.0145581
ZNF148 zinc finger protein 148 -0.0145411
TOR1AIP1 torsin A interacting protein 1 -0.0145183
KIF4A kinesin family member 4A -0.0144938
GATAD2A GATA zinc finger domain containing 2A -0.0144501
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0144288
PHB2 prohibitin 2 -0.0143957
STK10 serine/threonine kinase 10 -0.0143846
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0143716
PRKD2 protein kinase D2 -0.01434
CAPNS1 calpain, small subunit 1 -0.0143229
YAP1 Yes-associated protein 1 -0.0142948
MPHOSPH9 M-phase phosphoprotein 9 -0.0142789
EFCAB14 EF-hand calcium binding domain 14 -0.0142711
TMEM205 transmembrane protein 205 -0.014258
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0142297
PDS5B PDS5 cohesin associated factor B -0.0141743
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.014152
AURKAIP1 aurora kinase A interacting protein 1 -0.0141273
PICALM phosphatidylinositol binding clathrin assembly protein -0.014101
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.014027
TRAPPC9 trafficking protein particle complex 9 -0.0140218
DGCR2 DiGeorge syndrome critical region gene 2 -0.0139376
CMC2 C-x(9)-C motif containing 2 -0.0139196
VDAC2 voltage-dependent anion channel 2 -0.01391
TMX1 thioredoxin-related transmembrane protein 1 -0.0138535
HIP1 huntingtin interacting protein 1 -0.0138181
HELZ helicase with zinc finger -0.0138098
SECISBP2L SECIS binding protein 2-like -0.0138063
ESYT1 extended synaptotagmin-like protein 1 -0.0137734
GSN gelsolin -0.0137647
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0137435
RHBDD2 rhomboid domain containing 2 -0.0137185
CCNF cyclin F -0.0137123
EAPP E2F-associated phosphoprotein -0.0136696
PDE7A phosphodiesterase 7A -0.0136572
RGS17 regulator of G-protein signaling 17 -0.0136482
WDR37 WD repeat domain 37 -0.0136348
TUFM Tu translation elongation factor, mitochondrial -0.0136275
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0136113
ODF2 outer dense fiber of sperm tails 2 -0.0135832
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0135665
SH3BGRL SH3 domain binding glutamate-rich protein like -0.0135482
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0134904
LITAF lipopolysaccharide-induced TNF factor -0.013486
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0134835
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.0134721
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -0.0134609
COG5 component of oligomeric golgi complex 5 -0.01345
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0134232
NUCB1 nucleobindin 1 -0.0133821
GOLGA1 golgin A1 -0.013376
KLHL28 kelch-like family member 28 -0.0133712
VASP vasodilator-stimulated phosphoprotein -0.013323
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0133081
RAD51B RAD51 paralog B -0.013293
KNL1 kinetochore scaffold 1 -0.0132848
LAMP2 lysosomal-associated membrane protein 2 -0.0132846
DIAPH1 diaphanous-related formin 1 -0.0132683
UBE2B ubiquitin-conjugating enzyme E2B -0.0132592
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.013257
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0132396
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -0.0132331
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.0132319
PDZRN3 PDZ domain containing ring finger 3 -0.0132103
WDR33 WD repeat domain 33 -0.013199
CKAP5 cytoskeleton associated protein 5 -0.0131635
COPA coatomer protein complex, subunit alpha -0.0131617
LIN52 lin-52 DREAM MuvB core complex component -0.0131536
MACF1 microtubule-actin crosslinking factor 1 -0.0131451
MARCHF6 membrane associated ring-CH-type finger 6 -0.0131394
NIBAN2 niban apoptosis regulator 2 -0.013117
KIAA1671 KIAA1671 -0.013113
PHACTR4 phosphatase and actin regulator 4 -0.0130959
R3HDM1 R3H domain containing 1 -0.0130905
FANCD2 Fanconi anemia, complementation group D2 -0.0130404
GPSM2 G-protein signaling modulator 2 -0.0130311
GDE1 glycerophosphodiester phosphodiesterase 1 -0.0130207
SIRT1 sirtuin 1 -0.0130094
RPL27 ribosomal protein L27 -0.0130043
DCAF10 DDB1 and CUL4 associated factor 10 -0.0129885
PLK2 polo-like kinase 2 -0.0129792
SIK3 SIK family kinase 3 -0.0129776
PUM2 pumilio RNA-binding family member 2 -0.0129278
JAK1 Janus kinase 1 -0.0129081
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -0.0128962
KIF13A kinesin family member 13A -0.0128522
KIF20B kinesin family member 20B -0.0128352
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.0128215
LAMA5 laminin, alpha 5 -0.0128079
PITPNA phosphatidylinositol transfer protein, alpha -0.0127594
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.0127569
SKP1 S-phase kinase-associated protein 1 -0.0127369
PIKFYVE phosphoinositide kinase, FYVE finger containing -0.0127166
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -0.0126919
MAP2K3 mitogen-activated protein kinase kinase 3 -0.0126877
MED12L mediator complex subunit 12-like -0.0126768
SRSF4 serine/arginine-rich splicing factor 4 -0.0126698
IFNAR1 interferon (alpha, beta and omega) receptor 1 -0.012643
RTN4RL1 reticulon 4 receptor-like 1 -0.0126271
SCYL2 SCY1-like 2 (S. cerevisiae) -0.0126233
TSC22D1 TSC22 domain family, member 1 -0.0126071
SCAP SREBF chaperone -0.0125773
FAF1 Fas (TNFRSF6) associated factor 1 -0.0125746
FOXK1 forkhead box K1 -0.0125731
RFWD3 ring finger and WD repeat domain 3 -0.0125698
UNC45A unc-45 homolog A (C. elegans) -0.0125663
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0125639
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0125625
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.0125496
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -0.0125351
EP400 E1A binding protein p400 -0.0125134
PTK2 protein tyrosine kinase 2 -0.0124856
PRICKLE2 prickle homolog 2 (Drosophila) -0.0124854
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0124843
OSTF1 osteoclast stimulating factor 1 -0.0124739
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -0.0124736
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0124721
EDRF1 erythroid differentiation regulatory factor 1 -0.0124689
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -0.0124483
RPL31 ribosomal protein L31 -0.0124178
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -0.0124154
FN1 fibronectin 1 -0.0123867
WWC3 WWC family member 3 -0.0123627
SLC38A10 solute carrier family 38, member 10 -0.0123569
SUMF2 sulfatase modifying factor 2 -0.0123377
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0123238
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0123194
NINJ1 ninjurin 1 -0.0123142
VAV2 vav 2 guanine nucleotide exchange factor -0.0123007
CCDC47 coiled-coil domain containing 47 -0.0122889
KIF14 kinesin family member 14 -0.0122536
TRIP12 thyroid hormone receptor interactor 12 -0.0122514
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0122437
GTF2IRD1 GTF2I repeat domain containing 1 -0.0122286
LETMD1 LETM1 domain containing 1 -0.0122033
ANKRD13D ankyrin repeat domain 13 family, member D -0.0121868
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.01218
PDE8A phosphodiesterase 8A -0.0121506
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -0.0121465
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0121232
CDH18 cadherin 18, type 2 -0.0121111
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -0.0120932
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.012083
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0120743
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0120663
MYLIP myosin regulatory light chain interacting protein -0.0120237
TPM3 tropomyosin 3 -0.0120205
RANBP9 RAN binding protein 9 -0.0120137
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0119992
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -0.0119823
RPL38 ribosomal protein L38 -0.0119756
YY1 YY1 transcription factor -0.0119742
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -0.0119533
ACTN1 actinin, alpha 1 -0.0119506
ZDHHC12 zinc finger, DHHC-type containing 12 -0.0119331
TTLL10 tubulin tyrosine ligase-like family member 10 -0.0119116
MIS18BP1 MIS18 binding protein 1 -0.0119083
ATXN7L1 ataxin 7-like 1 -0.0118926
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0118853
SPTBN2 spectrin, beta, non-erythrocytic 2 -0.0118433
GPATCH2L G patch domain containing 2-like -0.0118385
ATXN1 ataxin 1 -0.0118196
MARCHF5 membrane associated ring-CH-type finger 5 -0.011815
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0118128
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0118112
FCHO2 FCH domain only 2 -0.0118005
SAR1B secretion associated, Ras related GTPase 1B -0.011769
NIPAL3 NIPA-like domain containing 3 -0.0117316
G6PC3 glucose 6 phosphatase, catalytic, 3 -0.0117029
NHSL1 NHS-like 1 -0.0116933
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.011646
DENND1B DENN/MADD domain containing 1B -0.0116427
NRDC nardilysin convertase -0.0116384
DERL1 derlin 1 -0.0116361
RASAL2 RAS protein activator like 2 -0.011622
TUG1 taurine up-regulated 1 (non-protein coding) -0.0116096
MTMR3 myotubularin related protein 3 -0.0116075
FBP1 fructose-1,6-bisphosphatase 1 -0.0116039
MAML3 mastermind-like 3 (Drosophila) -0.0115979
ADIPOR2 adiponectin receptor 2 -0.0115719
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0115589
MRPS11 mitochondrial ribosomal protein S11 -0.0115523
FCHSD2 FCH and double SH3 domains 2 -0.0115522
TEX14 testis expressed 14 -0.0115444
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0115431
FBXL18 F-box and leucine-rich repeat protein 18 -0.0115416
CD58 CD58 molecule -0.0115236
N4BP2 NEDD4 binding protein 2 -0.0115223
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -0.0115194