MCF7_Obatoclax Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 10nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_Obatoclax Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.247779
ERBB4 erb-b2 receptor tyrosine kinase 4 0.11555
SDK1 sidekick cell adhesion molecule 1 0.0962963
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.096114
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0806375
ELP2 elongator acetyltransferase complex subunit 2 0.0762683
JMJD1C jumonji domain containing 1C 0.0740418
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0736301
PABPC1 poly(A) binding protein, cytoplasmic 1 0.073399
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0683299
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0673897
COX6C cytochrome c oxidase subunit VIc 0.0634856
CLTC clathrin, heavy chain (Hc) 0.06063
TFF1 trefoil factor 1 0.0542493
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0520787
TRIM33 tripartite motif containing 33 0.0493224
PBX1 pre-B-cell leukemia homeobox 1 0.0491938
XBP1 X-box binding protein 1 0.0487625
PATJ PATJ crumbs cell polarity complex component 0.0467178
ZCCHC7 zinc finger, CCHC domain containing 7 0.0460793
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.0458226
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0453906
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0452822
CADM1 cell adhesion molecule 1 0.0445768
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0445624
GPC6 glypican 6 0.0439064
DLG1 discs, large homolog 1 (Drosophila) 0.0429313
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.0425545
LARP1 La ribonucleoprotein domain family, member 1 0.0419497
SPPL2A signal peptide peptidase like 2A 0.0413965
THBS1 thrombospondin 1 0.0412987
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0412252
EPCAM epithelial cell adhesion molecule 0.04115
BCAS3 breast carcinoma amplified sequence 3 0.0409665
RPSA ribosomal protein SA 0.0396668
NEBL nebulette 0.0393101
BCAS4 breast carcinoma amplified sequence 4 0.0392142
TLK1 tousled-like kinase 1 0.0389211
RPLP0 ribosomal protein, large, P0 0.0388431
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0372728
GOLGB1 golgin B1 0.0366706
MYO5C myosin VC 0.0366097
RPS16 ribosomal protein S16 0.0362772
ELOVL6 ELOVL fatty acid elongase 6 0.0362433
TTC28 tetratricopeptide repeat domain 28 0.0361138
NRG3 neuregulin 3 0.0360021
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0358817
EPHA4 EPH receptor A4 0.0356794
NT5C2 5'-nucleotidase, cytosolic II 0.0356453
CST3 cystatin C 0.0355562
SULF2 sulfatase 2 0.0354936
PRKCE protein kinase C, epsilon 0.0354095
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0352867
PARD3 par-3 family cell polarity regulator 0.0347883
MECOM MDS1 and EVI1 complex locus 0.0344508
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0342619
GLCCI1 glucocorticoid induced 1 0.033861
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.0337074
DNMBP dynamin binding protein 0.0336732
GREB1 growth regulation by estrogen in breast cancer 1 0.0334433
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0332727
GNAS GNAS complex locus 0.0328731
RPS7 ribosomal protein S7 0.032765
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0323573
TMEM164 transmembrane protein 164 0.0323561
GFRA1 GDNF family receptor alpha 1 0.0322756
MSI2 musashi RNA-binding protein 2 0.031763
MLEC malectin 0.0317278
EEF2 eukaryotic translation elongation factor 2 0.031104
NFIB nuclear factor I/B 0.0309041
BMP7 bone morphogenetic protein 7 0.030251
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.030169
MAST4 microtubule associated serine/threonine kinase family member 4 0.0301413
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0301159
ARL15 ADP-ribosylation factor-like 15 0.0299793
NCOA3 nuclear receptor coactivator 3 0.0298738
SCRN1 secernin 1 0.0298673
UBE2J2 ubiquitin-conjugating enzyme E2, J2 0.0297627
GREB1L growth regulation by estrogen in breast cancer-like 0.0295282
RPL18 ribosomal protein L18 0.0295184
SAE1 SUMO1 activating enzyme subunit 1 0.0293205
VWA8 von Willebrand factor A domain containing 8 0.0292145
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0291867
KIF5B kinesin family member 5B 0.0291208
DPH6 diphthamine biosynthesis 6 0.0290972
COL4A5 collagen, type IV, alpha 5 0.0290362
RPS2 ribosomal protein S2 0.0289751
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0288692
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.0288526
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0287599
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0283985
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0282492
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0280959
MTA3 metastasis associated 1 family, member 3 0.0280835
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.0280313
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0279092
PCED1B PC-esterase domain containing 1B 0.0276958
FAF1 Fas (TNFRSF6) associated factor 1 0.0276412
MED12L mediator complex subunit 12-like 0.0275215
DOP1B DOP1 leucine zipper like protein B 0.0274924
KRT19 keratin 19, type I 0.0272972
CHD4 chromodomain helicase DNA binding protein 4 0.0271605
FRYL FRY-like 0.0270626
ZMYND8 zinc finger, MYND-type containing 8 0.0269012
PTMA prothymosin, alpha 0.0268786
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0264942
PDIA3 protein disulfide isomerase family A, member 3 0.026407
ZMIZ1 zinc finger, MIZ-type containing 1 0.02631
CTNND2 catenin (cadherin-associated protein), delta 2 0.0262635
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0261688
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0261467
TRIP11 thyroid hormone receptor interactor 11 0.0259294
FCHSD2 FCH and double SH3 domains 2 0.0257422
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0257417
NCAM2 neural cell adhesion molecule 2 0.0256258
RAB3D RAB3D, member RAS oncogene family 0.0254107
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0252471
PTPRA protein tyrosine phosphatase, receptor type, A 0.0249182
BABAM2 BRISC and BRCA1 A complex member 2 0.0249064
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0248873
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.024851
UBE2K ubiquitin-conjugating enzyme E2K 0.0247415
ASTN2 astrotactin 2 0.0245758
HM13 histocompatibility (minor) 13 0.0245734
STC2 stanniocalcin 2 0.024358
TACC1 transforming, acidic coiled-coil containing protein 1 0.0243501
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0243431
ARMC9 armadillo repeat containing 9 0.0242204
NRCAM neuronal cell adhesion molecule 0.0242081
THOC2 THO complex 2 0.0241003
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0239187
RICTOR RPTOR independent companion of MTOR, complex 2 0.0239027
PDS5B PDS5 cohesin associated factor B 0.0238874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0238872
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.023757
ACBD6 acyl-CoA binding domain containing 6 0.0236734
NOTCH3 notch 3 0.0236073
RNASE3 ribonuclease, RNase A family, 3 0.0235689
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.023527
HOOK3 hook microtubule-tethering protein 3 0.0234142
MGMT O-6-methylguanine-DNA methyltransferase 0.023385
FNBP1L formin binding protein 1-like 0.0233842
ARHGAP12 Rho GTPase activating protein 12 0.0233033
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0232986
MPHOSPH8 M-phase phosphoprotein 8 0.0232713
RBL1 retinoblastoma-like 1 0.02327
ESYT2 extended synaptotagmin-like protein 2 0.0232686
NACA nascent polypeptide-associated complex alpha subunit 0.0231565
RPN2 ribophorin II 0.0229034
MACROD2 MACRO domain containing 2 0.0228224
CUTA cutA divalent cation tolerance homolog (E. coli) 0.0228215
PEX14 peroxisomal biogenesis factor 14 0.0227974
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0227869
GMPS guanine monphosphate synthase 0.0227635
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0227593
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0226996
SEPTIN9 septin 9 0.0226699
ATXN7 ataxin 7 0.022537
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0224358
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0224056
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0223935
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.0222623
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0221194
ATXN7L1 ataxin 7-like 1 0.0221036
RPS17 ribosomal protein S17 0.0221001
TRIO trio Rho guanine nucleotide exchange factor 0.0219572
PTPRF protein tyrosine phosphatase, receptor type, F 0.0219203
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0218073
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0217088
ADD1 adducin 1 (alpha) 0.0217081
SHISA5 shisa family member 5 0.0216853
CALR calreticulin 0.0216547
PLCB4 phospholipase C, beta 4 0.0216208
CLDN3 claudin 3 0.0215477
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0214627
NUDCD3 NudC domain containing 3 0.0213965
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0213214
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.0212304
MROH1 maestro heat-like repeat family member 1 0.0211854
EXOC6B exocyst complex component 6B 0.0211637
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.021091
RBPMS RNA binding protein with multiple splicing 0.021076
RACK1 receptor for activated C kinase 1 0.0210485
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0209755
APOD apolipoprotein D 0.0209682
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.020956
ANO6 anoctamin 6 0.0209537
R3HDM1 R3H domain containing 1 0.0208651
STK38 serine/threonine kinase 38 0.0207664
SMC4 structural maintenance of chromosomes 4 0.0207446
CD24 CD24 molecule 0.0206907
SRP72 signal recognition particle 72kDa 0.0206758
COMMD1 copper metabolism (Murr1) domain containing 1 0.0206503
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0205693
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0205501
JARID2 jumonji, AT rich interactive domain 2 0.0205422
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.0205346
S100A11 S100 calcium binding protein A11 0.0204795
GAK cyclin G associated kinase 0.0204443
CATSPERB catsper channel auxiliary subunit beta 0.020353
KTN1 kinectin 1 (kinesin receptor) 0.0203427
ABHD18 abhydrolase domain containing 18 0.0203272
MARVELD2 MARVEL domain containing 2 0.0202088
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0202056
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0202003
C2CD5 C2 calcium-dependent domain containing 5 0.0201928
TUFM Tu translation elongation factor, mitochondrial 0.020173
CDC27 cell division cycle 27 0.0201241
EIF3I eukaryotic translation initiation factor 3, subunit I 0.020107
SFMBT2 Scm-like with four mbt domains 2 0.0200531
PRICKLE2 prickle homolog 2 (Drosophila) 0.0200394
IGSF3 immunoglobulin superfamily, member 3 0.0200005
DIAPH2 diaphanous-related formin 2 0.0198689
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0198652
ANKRD17 ankyrin repeat domain 17 0.0197858
ATXN3 ataxin 3 0.0196782
FAF2 Fas associated factor family member 2 0.0196528
ATP9A ATPase, class II, type 9A 0.0196419
SYT1 synaptotagmin I 0.0196404
SCAPER S-phase cyclin A-associated protein in the ER 0.0195558
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0195536
KHSRP KH-type splicing regulatory protein 0.0195394
CDK19 cyclin-dependent kinase 19 0.0195089
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.0195056
MAN1B1 mannosidase, alpha, class 1B, member 1 0.019483
NOL10 nucleolar protein 10 0.0194783
RPL18A ribosomal protein L18a 0.0194205
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0193996
ZDHHC9 zinc finger, DHHC-type containing 9 0.0193985
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0193513
PERP PERP, TP53 apoptosis effector 0.0192855
SLC39A11 solute carrier family 39, member 11 0.0192749
USP48 ubiquitin specific peptidase 48 0.0192682
SAP130 Sin3A-associated protein, 130kDa 0.0191999
PCNX1 pecanex 1 0.0190384
KDM4A lysine (K)-specific demethylase 4A 0.0190253
ORC5 origin recognition complex, subunit 5 0.0190053
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0189805
FBXO22 F-box protein 22 0.0189119
RBM47 RNA binding motif protein 47 0.0188903
WIPF1 WAS/WASL interacting protein family, member 1 0.0188883
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0188412
LARP4 La ribonucleoprotein domain family, member 4 0.0188112
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0188107
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0187699
CLASP2 cytoplasmic linker associated protein 2 0.0186919
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 0.018653
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.018586
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0184394
TRIR telomerase RNA component interacting RNase 0.0184275
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.018422
FGF12 fibroblast growth factor 12 0.0183967
LURAP1L leucine rich adaptor protein 1-like 0.0183932
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0182827
DTNA dystrobrevin, alpha 0.0182637
CMYA5 cardiomyopathy associated 5 0.0182056
BCL7A B-cell CLL/lymphoma 7A 0.0182024
ANAPC5 anaphase promoting complex subunit 5 0.0181661
CEP350 centrosomal protein 350kDa 0.0180814
TTC3 tetratricopeptide repeat domain 3 0.0180799
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0180561
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0180231
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0179919
ZNF678 zinc finger protein 678 0.0178786
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0177766
TOGARAM1 TOG array regulator of axonemal microtubules 1 0.0177756
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0177728
INSIG1 insulin induced gene 1 0.0177677
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177471
WDFY3 WD repeat and FYVE domain containing 3 0.0177332
TRAPPC12 trafficking protein particle complex 12 0.0177294
ERBIN erbb2 interacting protein 0.0177102
ADAM17 ADAM metallopeptidase domain 17 0.0177018
R3HDM2 R3H domain containing 2 0.0176942
THADA thyroid adenoma associated 0.0176907
TIMP2 TIMP metallopeptidase inhibitor 2 0.0176745
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0176654
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0176648
SP3 Sp3 transcription factor 0.0176605
LGALS3 lectin, galactoside-binding, soluble, 3 0.017649
SLC16A6 solute carrier family 16, member 6 0.0176156
HMGN1 high mobility group nucleosome binding domain 1 0.0176062
ARHGAP29 Rho GTPase activating protein 29 0.0175299
TTF2 transcription termination factor, RNA polymerase II 0.017527
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.017519
CA12 carbonic anhydrase XII 0.0174974
BMP2K BMP2 inducible kinase 0.0174849
ABI2 abl-interactor 2 0.0174727
CLIP1 CAP-GLY domain containing linker protein 1 0.017457
CDC42SE2 CDC42 small effector 2 0.0174171
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.0174127
PRMT2 protein arginine methyltransferase 2 0.0173857
CHPF chondroitin polymerizing factor 0.0173549
DCAF11 DDB1 and CUL4 associated factor 11 0.0173388
NCOR1 nuclear receptor corepressor 1 0.0173295
PRC1 protein regulator of cytokinesis 1 0.0172859
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.0172793
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0172768
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.0172632
PCNX4 pecanex 4 0.0172397
CREBBP CREB binding protein 0.0172303
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0171773
KDM4C lysine (K)-specific demethylase 4C 0.0171311
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0171166
DIAPH1 diaphanous-related formin 1 0.0171123
CAPRIN1 cell cycle associated protein 1 0.0170978
PRPF38B pre-mRNA processing factor 38B 0.0170218
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0169719
MYO16 myosin XVI 0.0169365
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0168777
CFDP1 craniofacial development protein 1 0.016877
NRP1 neuropilin 1 0.016857
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0168505
UBE2N ubiquitin-conjugating enzyme E2N 0.0168317
BPTF bromodomain PHD finger transcription factor 0.016786
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0167804
EPS15 epidermal growth factor receptor pathway substrate 15 0.0167455
SLC38A2 solute carrier family 38, member 2 0.0167424
POMP proteasome maturation protein 0.0166801
H3-3B H3.3 histone B 0.0166779
TMOD3 tropomodulin 3 (ubiquitous) 0.0166327
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0165479
PRXL2A peroxiredoxin like 2A 0.0165261
COXFA4 cytochrome c oxidase associated subunit FA4 0.0165051
CCN5 cellular communication network factor 5 0.0164782
FOXJ3 forkhead box J3 0.0164368
TPT1 tumor protein, translationally-controlled 1 0.016426
FAM234B family with sequence similarity 234 member B 0.016421
TTC1 tetratricopeptide repeat domain 1 0.0163948
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0163733
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0163581
NTN1 netrin 1 0.0163482
ELF2 E74-like factor 2 (ets domain transcription factor) 0.016289
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0162792
TTC8 tetratricopeptide repeat domain 8 0.0162071
FBXO34 F-box protein 34 0.0162027
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 0.0161978
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.0161732
AFTPH aftiphilin 0.0161637
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.0161561
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0161516
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.0161295
TSPAN13 tetraspanin 13 0.0161243
TNPO3 transportin 3 0.016107
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0160997
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0160936
MNX1 motor neuron and pancreas homeobox 1 0.0160854
LUC7L LUC7-like (S. cerevisiae) 0.0160355
TOB1 transducer of ERBB2, 1 0.0159809
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0159784
RBL2 retinoblastoma-like 2 0.015965
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0159616
THOC7 THO complex 7 0.0159343
CIZ1 CDKN1A interacting zinc finger protein 1 0.0159127
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0158798
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0158312
RABGAP1L RAB GTPase activating protein 1-like 0.0158143
SMAD2 SMAD family member 2 0.0158021
COX5A cytochrome c oxidase subunit Va 0.0157478
TM9SF2 transmembrane 9 superfamily member 2 0.015736
FBXO31 F-box protein 31 0.0157081
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0156934
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0156872
PTEN phosphatase and tensin homolog 0.0156363
COPB1 coatomer protein complex, subunit beta 1 0.0156269
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0156111
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.0155875
SMC1A structural maintenance of chromosomes 1A 0.0155798
KIDINS220 kinase D-interacting substrate, 220kDa 0.0155701
RPS28 ribosomal protein S28 0.0155422
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.0155292
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0155154
AGR3 anterior gradient 3 0.0155123
RAB9A RAB9A, member RAS oncogene family 0.0154786
RIMS2 regulating synaptic membrane exocytosis 2 0.0154749
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.0153858
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0153824
PPP6C protein phosphatase 6, catalytic subunit 0.0153506
CRTAP cartilage associated protein 0.0153496
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0153419
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.0153359
SRSF4 serine/arginine-rich splicing factor 4 0.0153201
ERGIC3 ERGIC and golgi 3 0.0153187
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0153133
NPEPPS aminopeptidase puromycin sensitive 0.0153072
YAF2 YY1 associated factor 2 0.0152743
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.0152733
IPMK inositol polyphosphate multikinase 0.0151743
GATD1 glutamine amidotransferase class 1 domain containing 1 0.015122
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0151038
RBM41 RNA binding motif protein 41 0.0150986
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0150986
CROCC ciliary rootlet coiled-coil, rootletin 0.0150919
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.015058
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0150383
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0150357
WDR59 WD repeat domain 59 0.0150339
DPYD dihydropyrimidine dehydrogenase 0.0150336
ETNK1 ethanolamine kinase 1 0.0150319
RORA RAR-related orphan receptor A 0.0150202
GAPVD1 GTPase activating protein and VPS9 domains 1 0.01502
COL4A6 collagen, type IV, alpha 6 0.0149886
SUCLG1 succinate-CoA ligase, alpha subunit 0.0149863
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.0149716
SART3 squamous cell carcinoma antigen recognized by T cells 3 0.014967
MCEE methylmalonyl CoA epimerase 0.0149415
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.0149397
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.0149209
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.0148937
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0148816
RANBP17 RAN binding protein 17 0.0148793
SENP5 SUMO1/sentrin specific peptidase 5 0.01481
ZNF675 zinc finger protein 675 0.0147811
ARHGAP21 Rho GTPase activating protein 21 0.0147644
SQLE squalene epoxidase 0.0147456
COG1 component of oligomeric golgi complex 1 0.0147263
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.0146874
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0146509
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 0.0146319
TRIM8 tripartite motif containing 8 0.0146145
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0146108
SMIM44 small integral membrane protein 44 0.0146036
AKAP10 A kinase (PRKA) anchor protein 10 0.0145991
WDR43 WD repeat domain 43 0.0145753
KLHDC10 kelch domain containing 10 0.0145515
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.0145107
RNF149 ring finger protein 149 0.0145028
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.0144732
TSPAN15 tetraspanin 15 0.0144727
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0144718
TTC39C tetratricopeptide repeat domain 39C 0.0144681
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0.0144617
SMG9 SMG9 nonsense mediated mRNA decay factor 0.0144434
CHEK2 checkpoint kinase 2 0.0144409
TPGS2 tubulin polyglutamylase complex subunit 2 0.0144366
MAPK3 mitogen-activated protein kinase 3 0.0144191
TRAPPC10 trafficking protein particle complex 10 0.014418
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0144054
DGKH diacylglycerol kinase, eta 0.0143753
ANKRD36 ankyrin repeat domain 36 0.0142466
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0142377
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0141735
ANKRD12 ankyrin repeat domain 12 0.0141721
SPPL3 signal peptide peptidase like 3 0.0141623
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.0141545
FBL fibrillarin 0.0141317
TET1 tet methylcytosine dioxygenase 1 0.0141146
MTCH2 mitochondrial carrier 2 0.0141097
GPALPP1 GPALPP motifs containing 1 0.0140974
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.014068
EMP2 epithelial membrane protein 2 0.0140672
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0140521
MYO19 myosin XIX 0.0140498
PCDHB16 protocadherin beta 16 0.0140393
NOPCHAP1 NOP protein chaperone 1 0.0140255
AKAP9 A kinase (PRKA) anchor protein 9 0.0140174
RSU1 Ras suppressor protein 1 0.0139982
CRYBG1 crystallin beta-gamma domain containing 1 0.0139955
RAB14 RAB14, member RAS oncogene family 0.0139669
CUL3 cullin 3 0.013949
TMEM117 transmembrane protein 117 0.0139475
GMDS GDP-mannose 4,6-dehydratase 0.0139401
EYA3 EYA transcriptional coactivator and phosphatase 3 0.013935
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0139314
ARRDC1 arrestin domain containing 1 0.0139269
KIAA0586 KIAA0586 0.013924
NDC1 NDC1 transmembrane nucleoporin 0.0139229
ARHGAP24 Rho GTPase activating protein 24 0.0138862
GLG1 golgi glycoprotein 1 0.0138492
LRRC28 leucine rich repeat containing 28 0.0138124
VEZF1 vascular endothelial zinc finger 1 0.0138008
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0138005
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.0137886
ZNF43 zinc finger protein 43 0.0137793
CLOCK clock circadian regulator 0.0137706
MYO9B myosin IXB 0.0137692
CLDN7 claudin 7 0.0137525
MADD MAP-kinase activating death domain 0.0137343
HDAC7 histone deacetylase 7 0.0137176
FAM210B family with sequence similarity 210, member B 0.0137038
ZNF91 zinc finger protein 91 0.0137026
ANKRD50 ankyrin repeat domain 50 0.0136997
TMEM87A transmembrane protein 87A 0.0136816
KIF3C kinesin family member 3C 0.0136807
CHD1 chromodomain helicase DNA binding protein 1 0.0136746
ANKRD13C ankyrin repeat domain 13C 0.0136726
NPR2 natriuretic peptide receptor 2 0.0136359
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0135866
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0135502
FIGN fidgetin 0.0135457
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0135322
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.0135197
CISD2 CDGSH iron sulfur domain 2 0.0135083
CERS6 ceramide synthase 6 0.0134917
RPL36AL ribosomal protein L36a-like 0.0134879
SCAF4 SR-related CTD-associated factor 4 0.0134616
ABHD2 abhydrolase domain containing 2 0.0134508
LTAP1 lipid transport auxiliary protein 1 0.0134359
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0134249
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.0134241

decreased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II -0.107512
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0781913
TPM4 tropomyosin 4 -0.0758046
IFI6 interferon, alpha-inducible protein 6 -0.0737251
HSPB1 heat shock 27kDa protein 1 -0.06986
ACTN4 actinin, alpha 4 -0.064888
PARD6B par-6 family cell polarity regulator beta -0.0647527
POTEF POTE ankyrin domain family, member F -0.0604437
ESR1 estrogen receptor 1 -0.0603357
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.059289
CHD6 chromodomain helicase DNA binding protein 6 -0.058097
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0572514
THSD4 thrombospondin, type I, domain containing 4 -0.056425
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0554006
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0551109
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.0530623
CCND1 cyclin D1 -0.0525156
LOC112694756 uncharaterized LOC112694756 -0.0492902
LMNA lamin A/C -0.049282
TRIM37 tripartite motif containing 37 -0.0491037
AREG amphiregulin -0.0486649
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0482646
GRHL2 grainyhead-like 2 (Drosophila) -0.0479725
NCOA2 nuclear receptor coactivator 2 -0.0478244
LRP1B low density lipoprotein receptor-related protein 1B -0.0461581
OSBPL10 oxysterol binding protein-like 10 -0.0450613
RPLP1 ribosomal protein, large, P1 -0.0438173
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0437513
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0430272
RPL30 ribosomal protein L30 -0.0419722
JUP junction plakoglobin -0.0418386
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0401373
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0397647
TPR translocated promoter region, nuclear basket protein -0.0397562
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0396549
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0393975
SERINC5 serine incorporator 5 -0.0387213
ATXN1 ataxin 1 -0.0386045
RPS21 ribosomal protein S21 -0.0383764
TLK2 tousled-like kinase 2 -0.0382653
YY1 YY1 transcription factor -0.038035
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0378605
SPAG9 sperm associated antigen 9 -0.0368721
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.036644
ENO1 enolase 1, (alpha) -0.0363658
RABL6 RAB, member RAS oncogene family-like 6 -0.0353435
TMSB4X thymosin beta 4, X-linked -0.0345546
EVL Enah/Vasp-like -0.0345075
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0343728
INF2 inverted formin, FH2 and WH2 domain containing -0.0343644
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.034288
HLTF helicase-like transcription factor -0.0340126
CSDE1 cold shock domain containing E1, RNA-binding -0.0337668
MED13 mediator complex subunit 13 -0.0334206
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0331908
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0331659
SPTSSB serine palmitoyltransferase, small subunit B -0.0330358
SMIM14 small integral membrane protein 14 -0.0321463
CBX5 chromobox homolog 5 -0.0320299
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0320152
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.0317839
MYH9 myosin, heavy chain 9, non-muscle -0.0314634
DSCAM Down syndrome cell adhesion molecule -0.0314246
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.031302
GTF2IRD1 GTF2I repeat domain containing 1 -0.0312471
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0311221
SKA2 spindle and kinetochore associated complex subunit 2 -0.0308935
NECAB1 N-terminal EF-hand calcium binding protein 1 -0.030879
VMP1 vacuole membrane protein 1 -0.0308694
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0301476
MRPL13 mitochondrial ribosomal protein L13 -0.0300581
GAN gigaxonin -0.0299476
PHIP pleckstrin homology domain interacting protein -0.0298636
GSPT1 G1 to S phase transition 1 -0.0296623
KIAA1671 KIAA1671 -0.0296128
SPATS2 spermatogenesis associated, serine-rich 2 -0.0295367
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0294816
TPM3 tropomyosin 3 -0.0293792
LMBR1 limb development membrane protein 1 -0.0290417
KRT18 keratin 18, type I -0.0289913
RPS15 ribosomal protein S15 -0.0288735
SVIL supervillin -0.0282994
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0281288
WDR70 WD repeat domain 70 -0.0279143
CFAP44 cilia and flagella associated protein 44 -0.0277522
CLASP1 cytoplasmic linker associated protein 1 -0.0277386
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0277316
LARP4B La ribonucleoprotein domain family, member 4B -0.0276547
NRIP1 nuclear receptor interacting protein 1 -0.0274544
METTL2A methyltransferase like 2A -0.0274216
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0273831
ZNRF3 zinc and ring finger 3 -0.0270767
UBB ubiquitin B -0.0269555
FLNA filamin A, alpha -0.026902
AK1 adenylate kinase 1 -0.0267234
ZNF652 zinc finger protein 652 -0.0267072
BCLAF1 BCL2-associated transcription factor 1 -0.0266864
XPO1 exportin 1 -0.026663
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0266305
TPD52 tumor protein D52 -0.0265365
GRB2 growth factor receptor-bound protein 2 -0.0262241
POLK polymerase (DNA directed) kappa -0.0261903
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0260284
LITAF lipopolysaccharide-induced TNF factor -0.0259863
RAD51C RAD51 paralog C -0.0259045
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0258851
AGR2 anterior gradient 2 -0.0258196
GLI3 GLI family zinc finger 3 -0.0257962
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0256659
ENSA endosulfine alpha -0.0256092
TOM1L2 target of myb1-like 2 (chicken) -0.0253559
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0252495
UBL3 ubiquitin-like 3 -0.0252479
PKP4 plakophilin 4 -0.0252423
MYO6 myosin VI -0.0251473
SMYD3 SET and MYND domain containing 3 -0.025086
SMAD3 SMAD family member 3 -0.0248327
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0248172
SARS2 seryl-tRNA synthetase 2, mitochondrial -0.0247348
RPL12 ribosomal protein L12 -0.0247139
UBAC2 UBA domain containing 2 -0.0246685
ITGB4 integrin, beta 4 -0.0246284
SYNRG synergin, gamma -0.0245617
HMCN1 hemicentin 1 -0.0244776
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0244273
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0244218
KMT5B lysine methyltransferase 5B -0.0243738
NECTIN2 nectin cell adhesion molecule 2 -0.0243667
FAM168A family with sequence similarity 168, member A -0.024305
EP400 E1A binding protein p400 -0.0242621
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0241714
ITPRID2 ITPR interacting domain containing 2 -0.0240988
BCL2 B-cell CLL/lymphoma 2 -0.0240956
HPCAL1 hippocalcin-like 1 -0.0240106
CMC2 C-x(9)-C motif containing 2 -0.0240059
RPL32 ribosomal protein L32 -0.023936
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0239293
GINS1 GINS complex subunit 1 (Psf1 homolog) -0.0239258
RTN4 reticulon 4 -0.023894
SIN3A SIN3 transcription regulator family member A -0.0238736
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0238638
ANXA2 annexin A2 -0.0238052
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0236873
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0236522
TPM1 tropomyosin 1 (alpha) -0.0236229
NSD1 nuclear receptor binding SET domain protein 1 -0.0235074
CC2D1A coiled-coil and C2 domain containing 1A -0.0234782
FDPS farnesyl diphosphate synthase -0.0234128
MYO10 myosin X -0.0234005
CADPS2 Ca++-dependent secretion activator 2 -0.0233485
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -0.0233367
MCM4 minichromosome maintenance complex component 4 -0.0233159
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.023315
TRRAP transformation/transcription domain-associated protein -0.0233091
PRR11 proline rich 11 -0.0232683
UBC ubiquitin C -0.0232678
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.023215
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0231826
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0231722
BTBD7 BTB (POZ) domain containing 7 -0.0231474
FAM91A1 family with sequence similarity 91, member A1 -0.023094
AKIRIN1 akirin 1 -0.0230565
ADGRG6 adhesion G protein-coupled receptor G6 -0.0230355
RPS14 ribosomal protein S14 -0.0230283
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0230249
RPN1 ribophorin I -0.0229914
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -0.0228722
MARCHF7 membrane associated ring-CH-type finger 7 -0.0228488
ARHGAP10 Rho GTPase activating protein 10 -0.0228016
H1-10 H1.10 linker histone -0.022776
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0227189
CAMKMT calmodulin-lysine N-methyltransferase -0.0227134
SQSTM1 sequestosome 1 -0.0226308
CCDC57 coiled-coil domain containing 57 -0.0226276
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0225124
STAU1 staufen double-stranded RNA binding protein 1 -0.0224781
ZNF431 zinc finger protein 431 -0.0224227
PPCDC phosphopantothenoylcysteine decarboxylase -0.0224008
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -0.0222058
SOCS4 suppressor of cytokine signaling 4 -0.0221846
SLF2 SMC5-SMC6 complex localization factor 2 -0.022178
TXN2 thioredoxin 2 -0.0220213
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0219903
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0219227
MTG2 mitochondrial ribosome-associated GTPase 2 -0.021913
EEIG2 EEIG family member 2 -0.0218539
NRBP1 nuclear receptor binding protein 1 -0.0218173
SPIDR scaffolding protein involved in DNA repair -0.0218147
ZNF398 zinc finger protein 398 -0.0217418
KPNB1 karyopherin (importin) beta 1 -0.021739
PKM pyruvate kinase, muscle -0.0216017
WAC WW domain containing adaptor with coiled-coil -0.0215874
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0215474
HIP1 huntingtin interacting protein 1 -0.0215383
TAC4 tachykinin 4 (hemokinin) -0.0215297
VASP vasodilator-stimulated phosphoprotein -0.0215102
NUDCD1 NudC domain containing 1 -0.0215092
ZNF217 zinc finger protein 217 -0.0214934
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0214663
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0212168
DCDC2 doublecortin domain containing 2 -0.0211947
RPL28 ribosomal protein L28 -0.0211724
UNK unkempt family zinc finger -0.0211224
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0210793
RNF13 ring finger protein 13 -0.0210586
EFNA5 ephrin-A5 -0.0210096
RPL38 ribosomal protein L38 -0.020999
CHURC1 churchill domain containing 1 -0.0209672
ANAPC16 anaphase promoting complex subunit 16 -0.020946
LSR lipolysis stimulated lipoprotein receptor -0.0209394
PKNOX1 PBX/knotted 1 homeobox 1 -0.020893
CSRP1 cysteine and glycine-rich protein 1 -0.0208713
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0208038
UBAP2 ubiquitin associated protein 2 -0.0207842
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0207752
CBR4 carbonyl reductase 4 -0.0207725
ABR active BCR-related -0.0207561
FMN1 formin 1 -0.0207504
MVD mevalonate (diphospho) decarboxylase -0.020744
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0207419
SCAF11 SR-related CTD-associated factor 11 -0.0207023
PTRH2 peptidyl-tRNA hydrolase 2 -0.0206844
UBE4A ubiquitination factor E4A -0.0206405
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.0206376
S100A10 S100 calcium binding protein A10 -0.0205706
TMPO thymopoietin -0.0205089
CBX1 chromobox homolog 1 -0.0204968
SRBD1 S1 RNA binding domain 1 -0.0203399
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0203056
USP34 ubiquitin specific peptidase 34 -0.0202737
IVD isovaleryl-CoA dehydrogenase -0.0202249
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -0.0202202
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -0.0202176
MYO1D myosin ID -0.020215
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0202091
OSBPL2 oxysterol binding protein-like 2 -0.0202047
FAM120B family with sequence similarity 120B -0.0201222
ISG15 ISG15 ubiquitin-like modifier -0.0201094
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0200846
MDM4 MDM4, p53 regulator -0.0200022
RPS25 ribosomal protein S25 -0.0199966
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.0199626
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0199355
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0199044
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -0.0198834
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.0198415
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -0.0198109
AFAP1 actin filament associated protein 1 -0.0196875
CDK17 cyclin-dependent kinase 17 -0.0196863
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -0.0196859
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0195716
ADCY9 adenylate cyclase 9 -0.0195583
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0195216
MLXIP MLX interacting protein -0.0194809
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.019475
EXD3 exonuclease 3'-5' domain containing 3 -0.0194583
QKI QKI, KH domain containing, RNA binding -0.0194526
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0194419
NAV1 neuron navigator 1 -0.0194244
ECE1 endothelin converting enzyme 1 -0.0193767
SENP6 SUMO1/sentrin specific peptidase 6 -0.0193739
DST dystonin -0.0193051
SETDB1 SET domain, bifurcated 1 -0.0193047
APP amyloid beta (A4) precursor protein -0.0192648
TNPO1 transportin 1 -0.0192609
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -0.0192241
IGF1R insulin-like growth factor 1 receptor -0.0192185
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0191484
DNAAF9 dynein axonemal assembly factor 9 -0.0191307
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -0.0191158
BRD4 bromodomain containing 4 -0.0190798
SFPQ splicing factor proline/glutamine-rich -0.0190796
SURF4 surfeit 4 -0.0190761
SERF2 small EDRK-rich factor 2 -0.0190478
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0190429
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0188771
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0188036
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0187696
UBE3D ubiquitin protein ligase E3D -0.0187278
KIF21A kinesin family member 21A -0.0186833
UBXN7 UBX domain protein 7 -0.0185967
IQCE IQ motif containing E -0.01855
CLTB clathrin, light chain B -0.0185035
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0184811
DOCK4 dedicator of cytokinesis 4 -0.0184555
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0184434
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.018405
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0183913
SIK3 SIK family kinase 3 -0.0183675
GSE1 Gse1 coiled-coil protein -0.0182705
UQCRC1 ubiquinol-cytochrome c reductase core protein I -0.0182629
CTSA cathepsin A -0.0182189
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -0.0181974
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0181728
SOGA1 suppressor of glucose, autophagy associated 1 -0.0180954
THRB thyroid hormone receptor, beta -0.0180742
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -0.0180529
AOPEP aminopeptidase O (putative) -0.0180505
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0179824
CTSD cathepsin D -0.0179646
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0179633
ZZZ3 zinc finger, ZZ-type containing 3 -0.0178934
GPATCH2L G patch domain containing 2-like -0.0178885
RPS19 ribosomal protein S19 -0.0178851
C6ORF89 chromosome 6 open reading frame 89 -0.017809
TRIM27 tripartite motif containing 27 -0.0178034
H2BC5 H2B clustered histone 5 -0.0178008
PRNP prion protein -0.0177608
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0177374
ZBTB7A zinc finger and BTB domain containing 7A -0.0177137
CLIC4 chloride intracellular channel 4 -0.0176479
FBXO33 F-box protein 33 -0.0176391
CAPNS1 calpain, small subunit 1 -0.0176301
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0176045
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0175939
RRP1B ribosomal RNA processing 1B -0.0175824
MTDH metadherin -0.0175805
TNPO2 transportin 2 -0.0175768
RARS1 arginyl-tRNA synthetase 1 -0.0175563
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0175207
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0174672
DTNBP1 dystrobrevin binding protein 1 -0.0174155
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0173767
IPO11 importin 11 -0.0173416
BCL2L1 BCL2-like 1 -0.0173398
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0173377
THUMPD1 THUMP domain containing 1 -0.0173308
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.017319
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0172721
FAM20B family with sequence similarity 20, member B -0.0172555
TUBGCP2 tubulin, gamma complex associated protein 2 -0.0172445
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0172171
INPP5F inositol polyphosphate-5-phosphatase F -0.0171978
RPL36 ribosomal protein L36 -0.0171511
SEC23A Sec23 homolog A (S. cerevisiae) -0.0171369
TMEM41B transmembrane protein 41B -0.0171349
FBXL20 F-box and leucine-rich repeat protein 20 -0.017117
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0171044
SCCPDH saccharopine dehydrogenase (putative) -0.0171031
APTX aprataxin -0.0170669
EHD1 EH-domain containing 1 -0.0170498
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0170389
SDCCAG8 serologically defined colon cancer antigen 8 -0.0170364
RAB7A RAB7A, member RAS oncogene family -0.0169738
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0169068
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0168864
NPTN neuroplastin -0.0168529
RAB21 RAB21, member RAS oncogene family -0.0168448
HCFC1 host cell factor C1 -0.016733
RARA retinoic acid receptor, alpha -0.0167188
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.0166937
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0166787
SH3D19 SH3 domain containing 19 -0.016661
NDFIP1 Nedd4 family interacting protein 1 -0.0166532
RAB31 RAB31, member RAS oncogene family -0.0166395
GPBP1 GC-rich promoter binding protein 1 -0.0166049
NCKAP5 NCK-associated protein 5 -0.0165993
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.0165771
SORT1 sortilin 1 -0.0165629
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -0.0164927
AHNAK AHNAK nucleoprotein -0.0164656
ZFHX3 zinc finger homeobox 3 -0.0162783
RSL1D1 ribosomal L1 domain containing 1 -0.0162761
EZR ezrin -0.0162709
TMSB10 thymosin beta 10 -0.0162671
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -0.0162404
DCPH1 damage control phosphatase 1 -0.0162394
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -0.0162304
PHF14 PHD finger protein 14 -0.0162208
PGM3 phosphoglucomutase 3 -0.0162038
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0161813
ITSN2 intersectin 2 -0.0161774
C3ORF38 chromosome 3 open reading frame 38 -0.0161742
TJP2 tight junction protein 2 -0.0161723
NGLY1 N-glycanase 1 -0.0161653
PSEN1 presenilin 1 -0.016153
BICD1 bicaudal D homolog 1 (Drosophila) -0.0161367
ZNF33A zinc finger protein 33A -0.0161275
UBA1 ubiquitin-like modifier activating enzyme 1 -0.0161236
TOP1 topoisomerase (DNA) I -0.0161229
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0161134
DPY19L3 dpy-19-like 3 (C. elegans) -0.0160891
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -0.016052
AVL9 AVL9 homolog (S. cerevisiase) -0.0160419
PDZRN3 PDZ domain containing ring finger 3 -0.0160404
TUBA1B tubulin, alpha 1b -0.0160122
SRSF2 serine/arginine-rich splicing factor 2 -0.0159956
NBEAL1 neurobeachin-like 1 -0.0159922
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0159548
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0159354
MRPL57 mitochondrial ribosomal protein L57 -0.0159223
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.015919
NUP210 nucleoporin 210kDa -0.0159126
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -0.0158908
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -0.0158385
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0158229
SKAP2 src kinase associated phosphoprotein 2 -0.0158227
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0158012
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0157835
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0157702
UBE2H ubiquitin-conjugating enzyme E2H -0.0157632
STX8 syntaxin 8 -0.0157178
HRNR hornerin -0.0157108
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -0.0156668
RPL29 ribosomal protein L29 -0.0156375
MED15 mediator complex subunit 15 -0.0156255
TUBB4B tubulin, beta 4B class IVb -0.0156163
CD46 CD46 molecule, complement regulatory protein -0.0155863
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.0155805
NXNL2 nucleoredoxin-like 2 -0.0155741
XRN2 5'-3' exoribonuclease 2 -0.0155416
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -0.0155386
TAPBP TAP binding protein (tapasin) -0.0155163
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0154956
STX4 syntaxin 4 -0.0154737
VCL vinculin -0.0154487
RNASEH1 ribonuclease H1 -0.0154356
ZER1 zyg-11 related, cell cycle regulator -0.0154245
SUMO1 small ubiquitin-like modifier 1 -0.0154044
CRIP2 cysteine-rich protein 2 -0.0154001
ZNF148 zinc finger protein 148 -0.0153995
REPS2 RALBP1 associated Eps domain containing 2 -0.0153935
SFMBT1 Scm-like with four mbt domains 1 -0.0153714
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0153578
RTF2 replication termination factor 2 -0.0152577
MIDN midnolin -0.0152556
USP9X ubiquitin specific peptidase 9, X-linked -0.0152491
TMEM59 transmembrane protein 59 -0.0152486
ZNF367 zinc finger protein 367 -0.0151976
RUSF1 RUS family member 1 -0.0151915
FBXW11 F-box and WD repeat domain containing 11 -0.0151876
KIAA1958 KIAA1958 -0.0151821
KLF6 Kruppel-like factor 6 -0.0151466
SWI5 SWI5 recombination repair homolog (yeast) -0.0151329
RIN2 Ras and Rab interactor 2 -0.0151295
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0151284
SH3GLB2 SH3-domain GRB2-like endophilin B2 -0.0150961
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0150953
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0150537
TP53BP1 tumor protein p53 binding protein 1 -0.0150394
MREG melanoregulin -0.0150267
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0149636
SPATA7 spermatogenesis associated 7 -0.0149576
CLDN4 claudin 4 -0.0149334
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0149047
ARFGEF3 ARFGEF family member 3 -0.0148798
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0148773
KHDC1 KH homology domain containing 1 -0.014868
DLC1 DLC1 Rho GTPase activating protein -0.0148458
ORC3 origin recognition complex, subunit 3 -0.0148386
DMXL1 Dmx-like 1 -0.0148115
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.01479
FBXW4 F-box and WD repeat domain containing 4 -0.0147809
NALF1 NALCN channel auxiliary factor 1 -0.0147352
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0147236
CDK4 cyclin-dependent kinase 4 -0.0147087
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -0.0146902
ITPKC inositol-trisphosphate 3-kinase C -0.0146627
CPA6 carboxypeptidase A6 -0.0146618
LRRC58 leucine rich repeat containing 58 -0.0146599
ZNF260 zinc finger protein 260 -0.0146552
RPS9 ribosomal protein S9 -0.0146489
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.0146267
GPATCH1 G patch domain containing 1 -0.0146213
USP47 ubiquitin specific peptidase 47 -0.0146142
RHOC ras homolog family member C -0.0146115
SYPL1 synaptophysin-like 1 -0.0145787
ZNF638 zinc finger protein 638 -0.0145752
RCOR1 REST corepressor 1 -0.0145704
DOT1L DOT1-like histone H3K79 methyltransferase -0.0145616
ZIC1 Zic family member 1 -0.0145238
ZNF804B zinc finger protein 804B -0.0144745
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0144729
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0144393
CASP8AP2 caspase 8 associated protein 2 -0.0144358
PDE7A phosphodiesterase 7A -0.0144298
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0144252
ATG2B autophagy related 2B -0.0144182
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0143979
ATOSA atos homolog A -0.0143862
MZT2A mitotic spindle organizing protein 2A -0.0143762
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -0.0143692
COG5 component of oligomeric golgi complex 5 -0.0143321
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0143185
WDR41 WD repeat domain 41 -0.0143094
CCDC142 coiled-coil domain containing 142 -0.0142867
USP37 ubiquitin specific peptidase 37 -0.0142864
USP11 ubiquitin specific peptidase 11 -0.0142824
AFG2A AFG2 AAA ATPase homolog A -0.0142752
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0142693
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0142575
RBM14-RBM4 RBM14-RBM4 readthrough -0.0142416
RSRP1 arginine/serine-rich protein 1 -0.0142348
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0142196
CCDC6 coiled-coil domain containing 6 -0.01421
SCAI suppressor of cancer cell invasion -0.0142007
ECPAS Ecm29 proteasome adaptor and scaffold -0.0141556
IQANK1 IQ motif and ankyrin repeat containing 1 -0.0141324
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0141178
NPIPB4 nuclear pore complex interacting protein family, member B4 -0.0141016