MCF7_SGI-1776 free base_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SGI-1776 free base 100nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_SGI-1776 free base_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
TPM4 tropomyosin 4 0.13326
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.129126
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.084836
H3-3B H3.3 histone B 0.080643
PARD6B par-6 family cell polarity regulator beta 0.0782036
VMP1 vacuole membrane protein 1 0.0754611
SPTSSB serine palmitoyltransferase, small subunit B 0.0737395
BPTF bromodomain PHD finger transcription factor 0.0722758
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0699108
TRPS1 trichorhinophalangeal syndrome I 0.0662985
ZNF217 zinc finger protein 217 0.0647613
TRIM37 tripartite motif containing 37 0.0643885
TFF1 trefoil factor 1 0.063426
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0628155
MALRD1 MAM and LDL receptor class A domain containing 1 0.0590633
GATA3 GATA binding protein 3 0.0582124
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0576183
BSG basigin (Ok blood group) 0.0573359
LDLR low density lipoprotein receptor 0.0546387
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0535656
KMT5B lysine methyltransferase 5B 0.0497062
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0495669
USP32 ubiquitin specific peptidase 32 0.0481374
PAWR PRKC, apoptosis, WT1, regulator 0.0477576
CTNND2 catenin (cadherin-associated protein), delta 2 0.0475443
NCKAP5 NCK-associated protein 5 0.0464236
ERBB3 erb-b2 receptor tyrosine kinase 3 0.046291
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0453996
AK1 adenylate kinase 1 0.04534
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0448386
UBE2H ubiquitin-conjugating enzyme E2H 0.0443976
ZNF91 zinc finger protein 91 0.0443335
RPL30 ribosomal protein L30 0.0441571
RPL13A ribosomal protein L13a 0.0437451
LRP10 low density lipoprotein receptor-related protein 10 0.0436353
PTPRK protein tyrosine phosphatase, receptor type, K 0.0432713
LOC112694756 uncharaterized LOC112694756 0.0425297
MYO1E myosin IE 0.0417826
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0417575
RPL10A ribosomal protein L10a 0.041054
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0409131
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0408763
TMEM64 transmembrane protein 64 0.0401073
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0396429
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0395425
DSPP dentin sialophosphoprotein 0.039358
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0391691
KRT8 keratin 8, type II 0.0391592
MED13L mediator complex subunit 13-like 0.0391565
MACC1 metastasis associated in colon cancer 1 0.038993
ZFP36L2 ZFP36 ring finger protein-like 2 0.0379713
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.0377721
RPS21 ribosomal protein S21 0.0374854
RPL18 ribosomal protein L18 0.0374105
MLPH melanophilin 0.0373791
CST3 cystatin C 0.037094
LY6E lymphocyte antigen 6 complex, locus E 0.0369426
SLC38A1 solute carrier family 38, member 1 0.0368824
ATP9A ATPase, class II, type 9A 0.0366854
CNKSR3 CNKSR family member 3 0.0363059
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0360585
RAP1A RAP1A, member of RAS oncogene family 0.0358721
KMT2C lysine (K)-specific methyltransferase 2C 0.035808
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.0356997
VCL vinculin 0.0355156
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0344847
WAC WW domain containing adaptor with coiled-coil 0.0344111
KYNU kynureninase 0.0343066
CDV3 CDV3 homolog (mouse) 0.0340135
USP34 ubiquitin specific peptidase 34 0.0340023
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0337464
CREBBP CREB binding protein 0.0337048
PTGES2 prostaglandin E synthase 2 0.0333009
EEIG1 estrogen-induced osteoclastogenesis regulator 1 0.0327527
CLU clusterin 0.032458
SQLE squalene epoxidase 0.0322658
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0322129
JAK1 Janus kinase 1 0.0318573
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0317081
MAVS mitochondrial antiviral signaling protein 0.0310541
NPAS3 neuronal PAS domain protein 3 0.0310128
ARTN artemin 0.030865
SSBP2 single-stranded DNA binding protein 2 0.0307301
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0306119
SNX14 sorting nexin 14 0.0305272
ACTN4 actinin, alpha 4 0.0305102
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030343
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0303174
CD63 CD63 molecule 0.0297121
PHACTR2 phosphatase and actin regulator 2 0.0293997
CCND1 cyclin D1 0.0293047
MICU2 mitochondrial calcium uptake 2 0.0292693
PATJ PATJ crumbs cell polarity complex component 0.0291554
UBL3 ubiquitin-like 3 0.0290938
MTA3 metastasis associated 1 family, member 3 0.0290589
GMPS guanine monphosphate synthase 0.0288419
ARHGAP5 Rho GTPase activating protein 5 0.0287938
PTMA prothymosin, alpha 0.0287725
MAP4 microtubule-associated protein 4 0.0287218
SPIDR scaffolding protein involved in DNA repair 0.0284923
RPS3 ribosomal protein S3 0.0282881
PARD3 par-3 family cell polarity regulator 0.0279773
EPS8 epidermal growth factor receptor pathway substrate 8 0.0277755
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0277182
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.027672
TIMP3 TIMP metallopeptidase inhibitor 3 0.0276533
ARHGAP21 Rho GTPase activating protein 21 0.0276245
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0275664
TRERF1 transcriptional regulating factor 1 0.027562
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.0275365
BBX bobby sox homolog (Drosophila) 0.0274087
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0273775
JMJD1C jumonji domain containing 1C 0.027308
ATOSA atos homolog A 0.0272232
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0271954
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0271797
CSDE1 cold shock domain containing E1, RNA-binding 0.0269801
KAT6B K(lysine) acetyltransferase 6B 0.0268191
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0268028
AHNAK AHNAK nucleoprotein 0.0267537
FLNB filamin B, beta 0.0267121
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0266821
RC3H1 ring finger and CCCH-type domains 1 0.0265634
WASHC5 WASH complex subunit 5 0.0265026
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0263926
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0263848
ARMC9 armadillo repeat containing 9 0.0263471
RBM15 RNA binding motif protein 15 0.0263174
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0262214
EIF4B eukaryotic translation initiation factor 4B 0.0262177
STIL SCL/TAL1 interrupting locus 0.0261686
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0259563
ITGB4 integrin, beta 4 0.0258315
MRPL13 mitochondrial ribosomal protein L13 0.025668
NPDC1 neural proliferation, differentiation and control, 1 0.0256662
GPC6 glypican 6 0.0256662
ALCAM activated leukocyte cell adhesion molecule 0.0255103
FIGN fidgetin 0.0254742
UBC ubiquitin C 0.0253359
BCAP31 B-cell receptor-associated protein 31 0.0252867
ZNF148 zinc finger protein 148 0.0252354
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0252002
MAML3 mastermind-like 3 (Drosophila) 0.0251603
RTN4 reticulon 4 0.0249543
SLMAP sarcolemma associated protein 0.0249409
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0248958
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0248836
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248603
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0248562
TFF3 trefoil factor 3 (intestinal) 0.0247358
NCOA3 nuclear receptor coactivator 3 0.024602
ITM2B integral membrane protein 2B 0.0244615
ZDHHC24 zinc finger, DHHC-type containing 24 0.024422
ASTN2 astrotactin 2 0.0243672
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0239618
ANKRD28 ankyrin repeat domain 28 0.0238183
PDE8A phosphodiesterase 8A 0.023805
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0237918
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0237668
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 0.0237317
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0237271
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0236013
NOXA1 NADPH oxidase activator 1 0.0235877
TLK2 tousled-like kinase 2 0.0235704
SYNPO2 synaptopodin 2 0.0235086
HLA-E major histocompatibility complex, class I, E 0.0234331
KLHDC10 kelch domain containing 10 0.0233929
ZMYND8 zinc finger, MYND-type containing 8 0.0231527
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.0230641
TTC3 tetratricopeptide repeat domain 3 0.0230436
DSTN destrin (actin depolymerizing factor) 0.0230362
PSPC1 paraspeckle component 1 0.0229999
RBM47 RNA binding motif protein 47 0.0229398
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0228795
NRCAM neuronal cell adhesion molecule 0.0228641
IQANK1 IQ motif and ankyrin repeat containing 1 0.0227885
CDK12 cyclin-dependent kinase 12 0.0227874
CLIC4 chloride intracellular channel 4 0.0227788
STX8 syntaxin 8 0.0227753
GSTM3 glutathione S-transferase mu 3 (brain) 0.0227271
CDC42SE2 CDC42 small effector 2 0.0226952
SEPTIN11 septin 11 0.0226546
RUSC2 RUN and SH3 domain containing 2 0.0225579
TUFT1 tuftelin 1 0.0225183
CTCF CCCTC-binding factor (zinc finger protein) 0.0225007
IQGAP1 IQ motif containing GTPase activating protein 1 0.0224589
ZHX2 zinc fingers and homeoboxes 2 0.0224038
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0223271
CD24 CD24 molecule 0.0223046
PRPF8 pre-mRNA processing factor 8 0.0222818
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0222619
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0222223
MARCKSL1 MARCKS-like 1 0.0221914
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0221667
SFXN5 sideroflexin 5 0.0221009
TSPAN13 tetraspanin 13 0.022083
RHOBTB3 Rho-related BTB domain containing 3 0.0220484
BCL2 B-cell CLL/lymphoma 2 0.0220011
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0219421
QRICH1 glutamine-rich 1 0.0218326
LITAF lipopolysaccharide-induced TNF factor 0.0217994
SEC13 SEC13 homolog (S. cerevisiae) 0.0217862
FAM234A family with sequence similarity 234 member A 0.0217152
CAPNS1 calpain, small subunit 1 0.0216399
RAB20 RAB20, member RAS oncogene family 0.0216073
CCDC125 coiled-coil domain containing 125 0.021594
RPL35A ribosomal protein L35a 0.0215811
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0215305
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0214695
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.021399
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0213889
IARS1 isoleucyl-tRNA synthetase 1 0.0213874
EGR1 early growth response 1 0.0213663
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213009
BMP7 bone morphogenetic protein 7 0.0212819
GRID1 glutamate receptor, ionotropic, delta 1 0.0211886
UFL1 UFM1-specific ligase 1 0.0210796
SCAF11 SR-related CTD-associated factor 11 0.0210547
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.0210312
SSR1 signal sequence receptor, alpha 0.0210053
PCNX4 pecanex 4 0.020964
AATF apoptosis antagonizing transcription factor 0.0208753
RHEB Ras homolog enriched in brain 0.0208688
MAST4 microtubule associated serine/threonine kinase family member 4 0.0207881
NCOR2 nuclear receptor corepressor 2 0.0207613
LRP1B low density lipoprotein receptor-related protein 1B 0.0207396
H2AZ2 H2A.Z variant histone 2 0.0206641
SDC4 syndecan 4 0.0206203
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0205871
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.020543
ATP5MJ ATP synthase membrane subunit j 0.0205016
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0204697
MYH9 myosin, heavy chain 9, non-muscle 0.0204677
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0204599
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0204053
SKP1 S-phase kinase-associated protein 1 0.0203583
EZR ezrin 0.0203229
TM9SF2 transmembrane 9 superfamily member 2 0.0202981
MDM4 MDM4, p53 regulator 0.0202632
FHIT fragile histidine triad 0.0202537
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0202507
NECTIN2 nectin cell adhesion molecule 2 0.0202
HP1BP3 heterochromatin protein 1, binding protein 3 0.0201896
RAB22A RAB22A, member RAS oncogene family 0.0200955
RPL7 ribosomal protein L7 0.0200598
BIRC6 baculoviral IAP repeat containing 6 0.0200388
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0200305
DGKH diacylglycerol kinase, eta 0.0199827
DENND2C DENN/MADD domain containing 2C 0.0199451
MAGT1 magnesium transporter 1 0.0199436
RPAP3 RNA polymerase II associated protein 3 0.0198885
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.0198853
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0198655
TNRC18 trinucleotide repeat containing 18 0.0197906
IFI6 interferon, alpha-inducible protein 6 0.0196722
ITGB5 integrin, beta 5 0.0196669
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0196544
EXOC4 exocyst complex component 4 0.0196397
MED13 mediator complex subunit 13 0.0196376
TNPO1 transportin 1 0.0195661
CLDN3 claudin 3 0.0194979
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.019415
PARK7 parkinson protein 7 0.0193839
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.019371
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0193672
RPL11 ribosomal protein L11 0.0193256
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0193203
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0192995
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0192675
RYK receptor-like tyrosine kinase 0.0192397
PKM pyruvate kinase, muscle 0.0192057
CBX1 chromobox homolog 1 0.0191305
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0191156
RPSA ribosomal protein SA 0.0190875
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.0190793
FASN fatty acid synthase 0.0190533
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0190417
RMDN1 regulator of microtubule dynamics 1 0.0190268
PHIP pleckstrin homology domain interacting protein 0.0190002
GPHN gephyrin 0.0189878
PALLD palladin, cytoskeletal associated protein 0.0188594
SIL1 SIL1 nucleotide exchange factor 0.0188477
DTNBP1 dystrobrevin binding protein 1 0.0187493
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0187232
RINT1 RAD50 interactor 1 0.0186768
LAMP2 lysosomal-associated membrane protein 2 0.018657
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 0.0186545
BASP1 brain abundant, membrane attached signal protein 1 0.0186457
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0185779
NCOA6 nuclear receptor coactivator 6 0.0185393
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.018512
ARRB1 arrestin, beta 1 0.0184912
GUSB glucuronidase, beta 0.0184861
VEZT vezatin, adherens junctions transmembrane protein 0.0184723
S100A11 S100 calcium binding protein A11 0.0184597
ACIN1 apoptotic chromatin condensation inducer 1 0.0184068
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0183784
SERINC5 serine incorporator 5 0.0183747
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0183594
TLE5 TLE family member 5, transcriptional modulator 0.0183522
ADNP activity-dependent neuroprotector homeobox 0.018348
METAP2 methionyl aminopeptidase 2 0.0183178
ANXA7 annexin A7 0.0183102
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0182332
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0181836
EVI5 ecotropic viral integration site 5 0.0181405
NSD1 nuclear receptor binding SET domain protein 1 0.0180726
SLC25A39 solute carrier family 25, member 39 0.0179773
RBM33 RNA binding motif protein 33 0.0179485
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 0.0179259
TFRC transferrin receptor 0.0178632
ZZZ3 zinc finger, ZZ-type containing 3 0.0178258
MRRF mitochondrial ribosome recycling factor 0.0177871
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.0177713
TRAPPC9 trafficking protein particle complex 9 0.0177612
YIPF4 Yip1 domain family, member 4 0.0176731
TSC2 tuberous sclerosis 2 0.0176229
PUM2 pumilio RNA-binding family member 2 0.0175688
GLO1 glyoxalase I 0.0175191
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0175098
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0174798
PFKP phosphofructokinase, platelet 0.0174469
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 0.017446
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0174287
SUMO2 small ubiquitin-like modifier 2 0.0174187
GTF2IRD1 GTF2I repeat domain containing 1 0.017389
NUP214 nucleoporin 214kDa 0.0173706
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0173704
GOSR1 golgi SNAP receptor complex member 1 0.0173272
PRC1 protein regulator of cytokinesis 1 0.0173211
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0173056
UBE3C ubiquitin protein ligase E3C 0.0173032
SDF4 stromal cell derived factor 4 0.0172809
LMNA lamin A/C 0.0172711
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.017259
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0172418
TUBA1C tubulin, alpha 1c 0.0172165
IP6K2 inositol hexakisphosphate kinase 2 0.0172075
DCAF4 DDB1 and CUL4 associated factor 4 0.0172027
PER3 period circadian clock 3 0.0171818
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0171228
LGALS3 lectin, galactoside-binding, soluble, 3 0.0170795
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0169949
RPS13 ribosomal protein S13 0.0169944
YY1 YY1 transcription factor 0.0169878
NVL nuclear VCP-like 0.0169389
ULK1 unc-51 like autophagy activating kinase 1 0.0169144
CCND3 cyclin D3 0.0168179
RAB31 RAB31, member RAS oncogene family 0.0167548
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.0167467
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.016737
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0166988
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.0166781
JUN jun proto-oncogene 0.0166726
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0166299
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0166116
CEP15 centrosomal protein 15 0.0165898
UBTF upstream binding transcription factor, RNA polymerase I 0.0165677
TIMP1 TIMP metallopeptidase inhibitor 1 0.0164989
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0164839
IFI27 interferon, alpha-inducible protein 27 0.0164761
GTF2A1 general transcription factor IIA, 1, 19/37kDa 0.0164632
SCAP SREBF chaperone 0.0164389
ZNF66 zinc finger protein 66 0.0164355
ANKAR ankyrin and armadillo repeat containing 0.0164206
FRS2 fibroblast growth factor receptor substrate 2 0.0164062
SCFD2 sec1 family domain containing 2 0.0163999
PTRH2 peptidyl-tRNA hydrolase 2 0.0162945
RPL35 ribosomal protein L35 0.0162821
SLC38A9 solute carrier family 38, member 9 0.0162813
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0162796
PLCB4 phospholipase C, beta 4 0.0162664
SYAP1 synapse associated protein 1 0.0162314
RABEPK Rab9 effector protein with kelch motifs 0.0162248
SYNGR2 synaptogyrin 2 0.0162203
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0161915
TMEM150C transmembrane protein 150C 0.0161682
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.016163
NUMA1 nuclear mitotic apparatus protein 1 0.0161378
REXO2 RNA exonuclease 2 0.0161277
UBE2I ubiquitin-conjugating enzyme E2I 0.0161217
IST1 increased sodium tolerance 1 homolog (yeast) 0.0160244
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0159995
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0159988
TAOK1 TAO kinase 1 0.0159813
COPE coatomer protein complex, subunit epsilon 0.0159712
ZHX3 zinc fingers and homeoboxes 3 0.0159591
FAF1 Fas (TNFRSF6) associated factor 1 0.0159577
ZDHHC20 zinc finger, DHHC-type containing 20 0.0159366
TMEM165 transmembrane protein 165 0.0159142
TRIM33 tripartite motif containing 33 0.0158847
MRPL10 mitochondrial ribosomal protein L10 0.0158751
CENPB centromere protein B, 80kDa 0.0158626
STAP2 signal transducing adaptor family member 2 0.0158541
BMPR1B bone morphogenetic protein receptor, type IB 0.0158382
CEP135 centrosomal protein 135kDa 0.0158076
NONO non-POU domain containing, octamer-binding 0.0158048
MIPEP mitochondrial intermediate peptidase 0.0157924
ARF4 ADP-ribosylation factor 4 0.0157426
MFSD12 major facilitator superfamily domain containing 12 0.0157332
SURF4 surfeit 4 0.0157321
MSI2 musashi RNA-binding protein 2 0.0157118
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 0.0157094
COP1 COP1 E3 ubiquitin ligase 0.0156711
PTPRD protein tyrosine phosphatase, receptor type, D 0.0156272
SPAST spastin 0.0155819
STX12 syntaxin 12 0.01553
RPS18 ribosomal protein S18 0.0155123
SINHCAF SIN3-HDAC complex associated factor 0.0155122
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.0155045
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0155037
CLIP1 CAP-GLY domain containing linker protein 1 0.0155031
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 0.015487
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.015485
SAP30BP SAP30 binding protein 0.0153851
ABLIM1 actin binding LIM protein 1 0.0153843
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0153671
LMTK2 lemur tyrosine kinase 2 0.0153479
PBX1 pre-B-cell leukemia homeobox 1 0.0153395
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0153365
PHF3 PHD finger protein 3 0.0153107
TMEM120A transmembrane protein 120A 0.0153028
KDM5C lysine (K)-specific demethylase 5C 0.0152994
RSU1 Ras suppressor protein 1 0.0152944
OSBP oxysterol binding protein 0.015281
SENP6 SUMO1/sentrin specific peptidase 6 0.0152652
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0152546
RNASE3 ribonuclease, RNase A family, 3 0.0152366
TRAM1 translocation associated membrane protein 1 0.0152358
CEMIP2 cell migration inducing hyaluronidase 2 0.0152255
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0151964
TOM1L2 target of myb1-like 2 (chicken) 0.0151823
CORO1C coronin, actin binding protein, 1C 0.015167
THRAP3 thyroid hormone receptor associated protein 3 0.015157
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0151544
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.0151527
MYADM myeloid-associated differentiation marker 0.0151444
RPL32 ribosomal protein L32 0.0151418
CSTB cystatin B (stefin B) 0.0151289
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0151188
UBE2B ubiquitin-conjugating enzyme E2B 0.0151016
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.015082
PSD4 pleckstrin and Sec7 domain containing 4 0.0150447
GLE1 GLE1 RNA export mediator 0.0150367
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0150175
EGR3 early growth response 3 0.0150127
CUL3 cullin 3 0.0150118
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.0150105
COL4A5 collagen, type IV, alpha 5 0.014961
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0149234
TRIQK triple QxxK/R motif containing 0.0149176
CTSH cathepsin H 0.0148669
COMMD1 copper metabolism (Murr1) domain containing 1 0.0148437
EPS15 epidermal growth factor receptor pathway substrate 15 0.014773
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0147178
PLCD3 phospholipase C, delta 3 0.0147113
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0146988
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0146955
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0146737
STMN1 stathmin 1 0.0146712
MRPS21 mitochondrial ribosomal protein S21 0.0146695
FNBP1 formin binding protein 1 0.0146607
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.0146593
METTL26 methyltransferase like 26 0.014651
GSR glutathione reductase 0.0146305
KIDINS220 kinase D-interacting substrate, 220kDa 0.0146253
GFUS GDP-L-fucose synthase 0.0146227
TRIP12 thyroid hormone receptor interactor 12 0.0145931
FOXK1 forkhead box K1 0.0145808
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0145568
RUNDC1 RUN domain containing 1 0.0145378
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0145376
CSPP1 centrosome and spindle pole associated protein 1 0.0144992
FOXO1 forkhead box O1 0.0144957
FBXL17 F-box and leucine-rich repeat protein 17 0.0144772
SETD5 SET domain containing 5 0.0144762
DPYD dihydropyrimidine dehydrogenase 0.0144685
CEP95 centrosomal protein 95kDa 0.0144666
EXOC3 exocyst complex component 3 0.0144428
LURAP1L leucine rich adaptor protein 1-like 0.0144266
MXD4 MAX dimerization protein 4 0.0143993
AEBP2 AE binding protein 2 0.0143869
HEATR1 HEAT repeat containing 1 0.0143732
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.0143469
TXNIP thioredoxin interacting protein 0.0143295
NPEPPS aminopeptidase puromycin sensitive 0.01432
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.014298
SLC35F5 solute carrier family 35, member F5 0.0142953
PRXL2A peroxiredoxin like 2A 0.0142797
DCTN1 dynactin 1 0.014258
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0142493
WWC1 WW and C2 domain containing 1 0.0142357
DST dystonin 0.0142232
COL5A1 collagen, type V, alpha 1 0.0141966
MTUS1 microtubule associated tumor suppressor 1 0.0141942
TIMM29 translocase of inner mitochondrial membrane 29 0.0141938
EXOC6 exocyst complex component 6 0.0141782
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0141572
CLDN7 claudin 7 0.0141547
RAD52 RAD52 homolog (S. cerevisiae) 0.0141433

decreased expression

Symbol Name Standardized Value
IGF1R insulin-like growth factor 1 receptor -0.20302
GFRA1 GDNF family receptor alpha 1 -0.113525
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.109423
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0899862
RAD51B RAD51 paralog B -0.0799787
KRT18 keratin 18, type I -0.0715747
CTSD cathepsin D -0.0659677
THSD4 thrombospondin, type I, domain containing 4 -0.0631864
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0583184
GRHL2 grainyhead-like 2 (Drosophila) -0.0562947
GSE1 Gse1 coiled-coil protein -0.0560461
PBX3 pre-B-cell leukemia homeobox 3 -0.0543348
CUX1 cut-like homeobox 1 -0.0531012
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0530945
AGR2 anterior gradient 2 -0.0519058
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0484756
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0482182
PRKCE protein kinase C, epsilon -0.0482072
HSPB1 heat shock 27kDa protein 1 -0.0480976
TRIO trio Rho guanine nucleotide exchange factor -0.0467422
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0454678
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.043245
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0427354
TPD52L1 tumor protein D52-like 1 -0.0424332
UBAP2 ubiquitin associated protein 2 -0.0424201
SMYD3 SET and MYND domain containing 3 -0.0424086
BRCA1 breast cancer 1, early onset -0.0422361
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0416506
LARP1 La ribonucleoprotein domain family, member 1 -0.0403136
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0400366
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0400136
AKAP13 A kinase (PRKA) anchor protein 13 -0.0398825
ACACA acetyl-CoA carboxylase alpha -0.0398069
VAV2 vav 2 guanine nucleotide exchange factor -0.03961
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0392401
GPATCH8 G patch domain containing 8 -0.0390588
NUP160 nucleoporin 160kDa -0.0383621
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0382173
PLXDC2 plexin domain containing 2 -0.0377273
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0376994
TUBD1 tubulin, delta 1 -0.0369259
AFF4 AF4/FMR2 family, member 4 -0.0368633
SVIL supervillin -0.0368199
BCAS4 breast carcinoma amplified sequence 4 -0.0366789
ATXN7L1 ataxin 7-like 1 -0.0366454
GREB1 growth regulation by estrogen in breast cancer 1 -0.0364042
SULF2 sulfatase 2 -0.0357896
RPL6 ribosomal protein L6 -0.035782
KDM2A lysine (K)-specific demethylase 2A -0.0353941
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.035008
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0349683
TPT1 tumor protein, translationally-controlled 1 -0.0346783
CKAP5 cytoskeleton associated protein 5 -0.0346338
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.0344864
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0343536
ADCY1 adenylate cyclase 1 (brain) -0.0342131
HDGFL3 HDGF like 3 -0.0342059
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0341941
WDR33 WD repeat domain 33 -0.0341062
SYTL2 synaptotagmin-like 2 -0.0339964
DIDO1 death inducer-obliterator 1 -0.0334521
SPIRE1 spire-type actin nucleation factor 1 -0.0333964
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0333275
WWOX WW domain containing oxidoreductase -0.0330726
IGFBP5 insulin-like growth factor binding protein 5 -0.0325805
EMCN endomucin -0.0323213
HMCN1 hemicentin 1 -0.0319253
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0318885
NCOA2 nuclear receptor coactivator 2 -0.0314284
DENR density-regulated protein -0.0312121
EEA1 early endosome antigen 1 -0.030993
HIP1 huntingtin interacting protein 1 -0.0304825
ATAD2 ATPase family, AAA domain containing 2 -0.0303393
THRB thyroid hormone receptor, beta -0.0300443
CENPP centromere protein P -0.0298859
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.0298706
PKN2 protein kinase N2 -0.0296404
MTSS1 metastasis suppressor 1 -0.0294101
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0291768
BTBD7 BTB (POZ) domain containing 7 -0.0287031
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0286199
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0283996
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0281735
RNF216 ring finger protein 216 -0.0281351
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0280402
SKA2 spindle and kinetochore associated complex subunit 2 -0.0280167
FOXP1 forkhead box P1 -0.0277802
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0276346
CPA6 carboxypeptidase A6 -0.0274776
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.027475
RPL39 ribosomal protein L39 -0.0273
PRRC2B proline-rich coiled-coil 2B -0.0270897
SH3RF1 SH3 domain containing ring finger 1 -0.0270136
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0269927
TMEM131 transmembrane protein 131 -0.0269615
LPP LIM domain containing preferred translocation partner in lipoma -0.0269535
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.0267778
NAP1L1 nucleosome assembly protein 1-like 1 -0.0267284
RDX radixin -0.0266927
ARHGAP11B Rho GTPase activating protein 11B -0.0266066
SLTM SAFB-like, transcription modulator -0.026316
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.026157
DLG1 discs, large homolog 1 (Drosophila) -0.0261458
CALCR calcitonin receptor -0.0260328
RAD23A RAD23 homolog A (S. cerevisiae) -0.0260298
SYCP2 synaptonemal complex protein 2 -0.0259678
RNF213 ring finger protein 213 -0.0259354
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0258622
MAP7 microtubule-associated protein 7 -0.0257313
TASOR2 transcription activation suppressor family member 2 -0.0257155
ANKRD17 ankyrin repeat domain 17 -0.0256656
FAM222B family with sequence similarity 222, member B -0.0255579
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0254911
RPS16 ribosomal protein S16 -0.0254077
TPD52 tumor protein D52 -0.0252895
HIPK2 homeodomain interacting protein kinase 2 -0.0252276
H2AJ H2A.J histone -0.0252004
AK8 adenylate kinase 8 -0.0251475
TRIP11 thyroid hormone receptor interactor 11 -0.0251118
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0250259
CLASP1 cytoplasmic linker associated protein 1 -0.0249863
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -0.0249135
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0248931
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0248892
CCSER1 coiled-coil serine-rich protein 1 -0.0247643
GTF2I general transcription factor IIi -0.0245244
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0243518
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0242317
DIAPH3 diaphanous-related formin 3 -0.0241587
INO80 INO80 complex subunit -0.0240152
DIAPH2 diaphanous-related formin 2 -0.0240116
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0239321
MACF1 microtubule-actin crosslinking factor 1 -0.0239013
ZNF638 zinc finger protein 638 -0.023839
PRR11 proline rich 11 -0.0237275
MBD5 methyl-CpG binding domain protein 5 -0.023702
EPHA4 EPH receptor A4 -0.0236846
CC2D1A coiled-coil and C2 domain containing 1A -0.0236025
PDE7A phosphodiesterase 7A -0.0235855
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.0233961
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0233872
ZFHX3 zinc finger homeobox 3 -0.0232687
TMEM63A transmembrane protein 63A -0.023266
SLC12A9 solute carrier family 12, member 9 -0.0232421
SEPTIN7 septin 7 -0.0231755
FGF13 fibroblast growth factor 13 -0.0231727
NOTCH2 notch 2 -0.0231264
RPL38 ribosomal protein L38 -0.0231255
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0230294
EPHB4 EPH receptor B4 -0.0229438
CADM1 cell adhesion molecule 1 -0.0229434
RPL27A ribosomal protein L27a -0.0225871
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -0.0224647
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.022416
PCBP3 poly(rC) binding protein 3 -0.0224155
KIF5B kinesin family member 5B -0.0223211
HSDL2 hydroxysteroid dehydrogenase like 2 -0.022228
RBM39 RNA binding motif protein 39 -0.0222217
FANCI Fanconi anemia, complementation group I -0.0221421
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0221199
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0220333
INTS6 integrator complex subunit 6 -0.0217655
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0217064
EEIG2 EEIG family member 2 -0.0216175
RNF121 ring finger protein 121 -0.0216073
DNMBP dynamin binding protein -0.0215594
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0215254
MRTFA myocardin related transcription factor A -0.0214987
FBXL20 F-box and leucine-rich repeat protein 20 -0.0214075
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -0.0213058
TBK1 TANK-binding kinase 1 -0.0211
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0210958
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0210488
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0209806
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0209561
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0209329
CMIP c-Maf inducing protein -0.0209102
MACROD1 MACRO domain containing 1 -0.0209012
RPL37 ribosomal protein L37 -0.0208925
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0208872
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0208252
CDT1 chromatin licensing and DNA replication factor 1 -0.0206386
RCOR1 REST corepressor 1 -0.0205547
IGSF3 immunoglobulin superfamily, member 3 -0.0205505
WDFY3 WD repeat and FYVE domain containing 3 -0.020534
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -0.0204627
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0204467
ZNF804B zinc finger protein 804B -0.0204443
AURKA aurora kinase A -0.0203849
BCR breakpoint cluster region -0.0203496
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.0203287
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0203083
TMED8 transmembrane emp24 protein transport domain containing 8 -0.0203046
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0202257
CD2AP CD2-associated protein -0.0201872
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0201835
MCU mitochondrial calcium uniporter -0.0201443
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0200694
GMDS GDP-mannose 4,6-dehydratase -0.0200292
MBD4 methyl-CpG binding domain protein 4 -0.0199868
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0199215
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.019878
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0198656
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0198514
EVPL envoplakin -0.0198205
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0197823
NCOA1 nuclear receptor coactivator 1 -0.0197781
LTBP1 latent transforming growth factor beta binding protein 1 -0.0196821
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0196407
GATAD2A GATA zinc finger domain containing 2A -0.019623
SAP130 Sin3A-associated protein, 130kDa -0.0195891
DOP1B DOP1 leucine zipper like protein B -0.0195705
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0195413
FAM120C family with sequence similarity 120C -0.0194213
IGFBP4 insulin-like growth factor binding protein 4 -0.0194132
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.019343
KDM3B lysine (K)-specific demethylase 3B -0.0193389
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0192941
PGCKA1 PDCD10 and GCKIII kinases associated 1 -0.0192754
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0192538
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0192146
HOMER2 homer scaffolding protein 2 -0.0192097
ZNF367 zinc finger protein 367 -0.0191657
QSER1 glutamine and serine rich 1 -0.0191575
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.019134
HSPA8 heat shock 70kDa protein 8 -0.0190849
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0190788
CBX3 chromobox homolog 3 -0.0190523
TTC27 tetratricopeptide repeat domain 27 -0.0190327
PRKCA protein kinase C, alpha -0.0190233
DLG5 discs, large homolog 5 (Drosophila) -0.0189847
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0189635
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -0.0189568
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0189508
TRIM25 tripartite motif containing 25 -0.0188882
TET2 tet methylcytosine dioxygenase 2 -0.0188127
GLCCI1 glucocorticoid induced 1 -0.0187617
R3HDM2 R3H domain containing 2 -0.0187309
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0187196
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0187103
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0186958
KIF4A kinesin family member 4A -0.0186957
LUZP1 leucine zipper protein 1 -0.0186732
KIAA1671 KIAA1671 -0.0186469
N4BP2 NEDD4 binding protein 2 -0.0185629
EXOC1 exocyst complex component 1 -0.0185235
WDR73 WD repeat domain 73 -0.0185084
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -0.018392
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) -0.0183786
TNRC6A trinucleotide repeat containing 6A -0.0183666
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0183324
CMC2 C-x(9)-C motif containing 2 -0.0183284
CRYBG1 crystallin beta-gamma domain containing 1 -0.0183244
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0182182
PSD3 pleckstrin and Sec7 domain containing 3 -0.018183
ZDHHC12 zinc finger, DHHC-type containing 12 -0.0181778
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0181622
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0181507
KIF18B kinesin family member 18B -0.0181437
TLN2 talin 2 -0.0181178
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0181077
MRTFB myocardin related transcription factor B -0.0180646
DNA2 DNA replication helicase/nuclease 2 -0.0180427
HYOU1 hypoxia up-regulated 1 -0.0180417
RPTOR regulatory associated protein of MTOR, complex 1 -0.0179034
DCTN2 dynactin 2 (p50) -0.0178899
REPS1 RALBP1 associated Eps domain containing 1 -0.0178773
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0178347
NHSL1 NHS-like 1 -0.0178314
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0177971
HDLBP high density lipoprotein binding protein -0.0177929
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0177899
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0177871
CHD8 chromodomain helicase DNA binding protein 8 -0.0177583
PTCD3 pentatricopeptide repeat domain 3 -0.0177298
FCHO2 FCH domain only 2 -0.0176974
NOP58 NOP58 ribonucleoprotein -0.0176877
POM121C POM121 transmembrane nucleoporin C -0.0176861
MORF4L1 mortality factor 4 like 1 -0.0176493
STXBP5 syntaxin binding protein 5 (tomosyn) -0.017494
RPS12 ribosomal protein S12 -0.0174331
TRRAP transformation/transcription domain-associated protein -0.017432
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0174163
FNBP4 formin binding protein 4 -0.0173898
NUP98 nucleoporin 98kDa -0.0173758
RBPMS RNA binding protein with multiple splicing -0.0173444
RRBP1 ribosome binding protein 1 -0.0173415
NINL ninein-like -0.0173346
NF1 neurofibromin 1 -0.0173228
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0172997
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0172554
THOC2 THO complex 2 -0.0172475
LRMDA leucine rich melanocyte differentiation associated -0.0172376
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0171718
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0171699
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0171616
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.0171576
BRWD1 bromodomain and WD repeat domain containing 1 -0.017154
TMEM131L transmembrane 131 like -0.0171322
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0170756
NUP210 nucleoporin 210kDa -0.0170716
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0170301
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0170299
CENPE centromere protein E, 312kDa -0.0169701
VWA8 von Willebrand factor A domain containing 8 -0.0169481
RAD51C RAD51 paralog C -0.0169358
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0169326
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -0.0169126
TXNRD1 thioredoxin reductase 1 -0.0168663
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -0.0168419
GDI2 GDP dissociation inhibitor 2 -0.0167884
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0167662
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.0166736
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -0.0166534
PTEN phosphatase and tensin homolog -0.0166174
ANKRD11 ankyrin repeat domain 11 -0.0165849
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0165814
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -0.0165654
RANBP17 RAN binding protein 17 -0.0165303
PTPRS protein tyrosine phosphatase, receptor type, S -0.0164627
DRC4 dynein regulatory complex subunit 4 -0.0164338
ERBIN erbb2 interacting protein -0.0164013
TBCK TBC1 domain containing kinase -0.0163884
KIF13A kinesin family member 13A -0.016362
ZGRF1 zinc finger, GRF-type containing 1 -0.0163574
MYO5C myosin VC -0.0163206
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0162612
KANSL3 KAT8 regulatory NSL complex subunit 3 -0.0162598
ELOB elongin B -0.0162587
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -0.0162348
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.0162284
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -0.0161873
MRPS18B mitochondrial ribosomal protein S18B -0.0161413
COX6C cytochrome c oxidase subunit VIc -0.0161334
TMEM65 transmembrane protein 65 -0.0161325
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0161149
BBS9 Bardet-Biedl syndrome 9 -0.0161106
TTC17 tetratricopeptide repeat domain 17 -0.0161046
TMSB10 thymosin beta 10 -0.0161027
SRSF10 serine/arginine-rich splicing factor 10 -0.0161008
RPL8 ribosomal protein L8 -0.0160544
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0160498
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -0.0160472
SEC11A SEC11 homolog A (S. cerevisiae) -0.016046
NIPSNAP1 nipsnap homolog 1 (C. elegans) -0.0160446
BRPF3 bromodomain and PHD finger containing, 3 -0.0160419
SOGA1 suppressor of glucose, autophagy associated 1 -0.0160344
NANS N-acetylneuraminic acid synthase -0.0160305
FAF2 Fas associated factor family member 2 -0.0159764
RUFY1 RUN and FYVE domain containing 1 -0.015972
USP6NL USP6 N-terminal like -0.0159078
ZCCHC7 zinc finger, CCHC domain containing 7 -0.015903
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -0.0158428
SFXN2 sideroflexin 2 -0.0158427
DNPEP aspartyl aminopeptidase -0.0157756
RPAP2 RNA polymerase II associated protein 2 -0.0157587
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.0157537
SLC19A1 solute carrier family 19 (folate transporter), member 1 -0.0157366
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0157193
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0156947
PIAS1 protein inhibitor of activated STAT, 1 -0.0156335
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -0.0156251
INTS2 integrator complex subunit 2 -0.0155896
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0155711
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0155585
XPO4 exportin 4 -0.0155419
POLK polymerase (DNA directed) kappa -0.0155203
SPAG9 sperm associated antigen 9 -0.0155033
ZNF75A zinc finger protein 75a -0.0155016
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -0.0154997
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0154929
EAPP E2F-associated phosphoprotein -0.0154844
ECE1 endothelin converting enzyme 1 -0.015411
RAB1A RAB1A, member RAS oncogene family -0.0153967
DICER1 dicer 1, ribonuclease type III -0.0153808
RPS17 ribosomal protein S17 -0.0153424
USP22 ubiquitin specific peptidase 22 -0.0153358
SDF2 stromal cell-derived factor 2 -0.0153203
KATNBL1 katanin p80 subunit B-like 1 -0.0153149
MIDN midnolin -0.0153022
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.015279
UBE3D ubiquitin protein ligase E3D -0.0152028
GPSM2 G-protein signaling modulator 2 -0.0151421
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0151313
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0151213
HIPK1 homeodomain interacting protein kinase 1 -0.0151152
INHBA inhibin, beta A -0.0151046
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0150939
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.0150707
SRSF4 serine/arginine-rich splicing factor 4 -0.0150383
CCDC47 coiled-coil domain containing 47 -0.0150203
LMNB1 lamin B1 -0.0150181
RALGDS ral guanine nucleotide dissociation stimulator -0.0150034
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.014989
MLXIP MLX interacting protein -0.0149373
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0149335
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.0149234
PARD3B par-3 family cell polarity regulator beta -0.0149147
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0149127
DCAF10 DDB1 and CUL4 associated factor 10 -0.0149028
JADE2 jade family PHD finger 2 -0.0148781
SPIRE2 spire-type actin nucleation factor 2 -0.0148748
TSC22D2 TSC22 domain family, member 2 -0.0148728
UBN2 ubinuclein 2 -0.0148518
CDK19 cyclin-dependent kinase 19 -0.0148447
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0148371
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0148309
MED12L mediator complex subunit 12-like -0.0148304
SAMD4B sterile alpha motif domain containing 4B -0.0148268
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0148182
FMN1 formin 1 -0.0148047
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0147996
TM2D1 TM2 domain containing 1 -0.0147963
SCARB2 scavenger receptor class B, member 2 -0.0147687
ATMIN ATM interactor -0.0147661
ULK2 unc-51 like autophagy activating kinase 2 -0.014764
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0147591
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.0147542
MIS18BP1 MIS18 binding protein 1 -0.0147339
HOOK2 hook microtubule-tethering protein 2 -0.0147306
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0146181
ZFP90 ZFP90 zinc finger protein -0.0146109
XBP1 X-box binding protein 1 -0.0145999
SLC38A2 solute carrier family 38, member 2 -0.014574
ORC4 origin recognition complex, subunit 4 -0.0145683
PELP1 proline, glutamate and leucine rich protein 1 -0.0145435
CKAP4 cytoskeleton-associated protein 4 -0.0145313
KMT2A lysine (K)-specific methyltransferase 2A -0.0145298
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0145221
FLOT1 flotillin 1 -0.0145204
AAK1 AP2 associated kinase 1 -0.0144958
RBM12B RNA binding motif protein 12B -0.0144814
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.0144718
MYO9B myosin IXB -0.0144548
CDC73 cell division cycle 73 -0.0144509
NUCB1 nucleobindin 1 -0.0144473
PHGDH phosphoglycerate dehydrogenase -0.0144466
CDC27 cell division cycle 27 -0.0144032
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0143912
ORC5 origin recognition complex, subunit 5 -0.0143837
ATF7IP activating transcription factor 7 interacting protein -0.0143707
MPZL1 myelin protein zero-like 1 -0.0143673
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.014353
HOOK1 hook microtubule-tethering protein 1 -0.0143509
ZNF512B zinc finger protein 512B -0.0143477
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.0143243
ADAM10 ADAM metallopeptidase domain 10 -0.0143055
ITPRID2 ITPR interacting domain containing 2 -0.0142808
GPATCH1 G patch domain containing 1 -0.014248
TP53 tumor protein p53 -0.0142393
ISG15 ISG15 ubiquitin-like modifier -0.0142321
UQCRC1 ubiquinol-cytochrome c reductase core protein I -0.0142051
PLPP1 phospholipid phosphatase 1 -0.0141819
PTGR1 prostaglandin reductase 1 -0.0141305
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0141262
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0141131
GON4L gon-4-like (C. elegans) -0.0140973
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0140842
ZNF141 zinc finger protein 141 -0.0140742
IPO7 importin 7 -0.0140136
ZFAND3 zinc finger, AN1-type domain 3 -0.0139996
MACO1 macoilin 1 -0.0139917
SOS1 son of sevenless homolog 1 (Drosophila) -0.0139738
NFX1 nuclear transcription factor, X-box binding 1 -0.0139707
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.0139607
ECPAS Ecm29 proteasome adaptor and scaffold -0.0139462
TMEM50B transmembrane protein 50B -0.0139459
NRP1 neuropilin 1 -0.0139251
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0138938
PNKD paroxysmal nonkinesigenic dyskinesia -0.0138906
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0138723
TPD52L2 tumor protein D52-like 2 -0.0138552
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0138399
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0138067
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0137961
FOXA1 forkhead box A1 -0.0137934
ATAD2B ATPase family, AAA domain containing 2B -0.0137519
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0137425
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0137383
NSD3 nuclear receptor binding SET domain protein 3 -0.01373
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 -0.0137254
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.0137218
MYO5A myosin VA (heavy chain 12, myoxin) -0.0137048
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0137045
MGMT O-6-methylguanine-DNA methyltransferase -0.0136944
ADGRG6 adhesion G protein-coupled receptor G6 -0.0136922
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0136778
UBE2O ubiquitin-conjugating enzyme E2O -0.0136587
IPO11 importin 11 -0.0136542
NME1 NME/NM23 nucleoside diphosphate kinase 1 -0.0136246
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0136209
PSKH1 protein serine kinase H1 -0.0136174
SRSF11 serine/arginine-rich splicing factor 11 -0.013611
VCP valosin containing protein -0.0136047
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0135948
HEATR5B HEAT repeat containing 5B -0.0135938
PARG poly (ADP-ribose) glycohydrolase -0.013593
DOCK9 dedicator of cytokinesis 9 -0.0135647
PRPF38B pre-mRNA processing factor 38B -0.0135585
UBAC2 UBA domain containing 2 -0.0135515