MCF7_SNS-314 Mesylate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 1µM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
Similar Terms
Downloads & Tools

Genes

1000 genes differentially expressed following the MCF7_SNS-314 Mesylate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.216658
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.160174
SYTL2 synaptotagmin-like 2 0.122906
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.108027
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0975442
PTPRK protein tyrosine phosphatase, receptor type, K 0.0848983
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0846152
GNAS GNAS complex locus 0.0716825
KRT19 keratin 19, type I 0.0705111
DTNA dystrobrevin, alpha 0.0677743
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.059373
KIAA1217 KIAA1217 0.0580293
NEBL nebulette 0.0578239
RPL15 ribosomal protein L15 0.0570076
ATXN1 ataxin 1 0.0555334
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0547513
MAP4 microtubule-associated protein 4 0.0526034
SULF2 sulfatase 2 0.0508199
TUBA1B tubulin, alpha 1b 0.0505898
RPS2 ribosomal protein S2 0.0505407
CALCR calcitonin receptor 0.0501972
ARL15 ADP-ribosylation factor-like 15 0.0492837
CCND1 cyclin D1 0.0482224
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0479341
AKAP13 A kinase (PRKA) anchor protein 13 0.0469707
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0467304
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0461428
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0457692
PABPC1 poly(A) binding protein, cytoplasmic 1 0.044193
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0439825
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0426421
RPL8 ribosomal protein L8 0.0424811
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0419576
RPS16 ribosomal protein S16 0.0414737
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0409147
FOXO3 forkhead box O3 0.0407385
MSI2 musashi RNA-binding protein 2 0.0403424
RPL10A ribosomal protein L10a 0.0401174
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0397315
SKIL SKI-like proto-oncogene 0.0390713
TMSB10 thymosin beta 10 0.039009
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0385109
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0377644
DNMBP dynamin binding protein 0.0377115
SYT1 synaptotagmin I 0.0373558
RHOD ras homolog family member D 0.0370679
SMAD3 SMAD family member 3 0.0368951
RSL1D1 ribosomal L1 domain containing 1 0.0365812
RPS24 ribosomal protein S24 0.0364838
TRAPPC9 trafficking protein particle complex 9 0.0359441
UBE4B ubiquitination factor E4B 0.0358591
PKN2 protein kinase N2 0.0358192
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0356622
RPS29 ribosomal protein S29 0.0353092
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0352749
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0348408
TPD52 tumor protein D52 0.0346314
MBNL1 muscleblind-like splicing regulator 1 0.0344437
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.0344316
CFAP97D1 CFAP97 domain containing 1 0.0343595
ATP9A ATPase, class II, type 9A 0.0343254
CTSD cathepsin D 0.0343016
RPL38 ribosomal protein L38 0.0342464
RPL13A ribosomal protein L13a 0.0341649
PEAK1 pseudopodium-enriched atypical kinase 1 0.0341257
FTH1 ferritin, heavy polypeptide 1 0.0339484
RPS6 ribosomal protein S6 0.0334302
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0332144
TRIM56 tripartite motif containing 56 0.0332015
GPHN gephyrin 0.0331269
RAB31 RAB31, member RAS oncogene family 0.0327778
HDGFL3 HDGF like 3 0.0322945
FLNA filamin A, alpha 0.0317299
PLXNA4 plexin A4 0.0316331
RPL27A ribosomal protein L27a 0.0310558
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0309596
RPL11 ribosomal protein L11 0.0306637
PAPOLA poly(A) polymerase alpha 0.0303911
MRTFA myocardin related transcription factor A 0.030378
RPS18 ribosomal protein S18 0.0303285
FRMD5 FERM domain containing 5 0.0303055
RPS5 ribosomal protein S5 0.0302042
PTBP3 polypyrimidine tract binding protein 3 0.0300433
ZNF217 zinc finger protein 217 0.0300252
GSK3B glycogen synthase kinase 3 beta 0.0298007
PAWR PRKC, apoptosis, WT1, regulator 0.0297323
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0296948
TAOK3 TAO kinase 3 0.0295592
CXXC5 CXXC finger protein 5 0.0295584
MTDH metadherin 0.029542
KDM4C lysine (K)-specific demethylase 4C 0.029534
WDFY3 WD repeat and FYVE domain containing 3 0.0294274
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0293467
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.02933
ABAT 4-aminobutyrate aminotransferase 0.0291911
RPL35 ribosomal protein L35 0.0291636
MACC1 metastasis associated in colon cancer 1 0.0291297
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0290096
PACS1 phosphofurin acidic cluster sorting protein 1 0.0289697
BCL2L1 BCL2-like 1 0.0289226
ENAH enabled homolog (Drosophila) 0.0288885
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.0282749
MRPL13 mitochondrial ribosomal protein L13 0.0282537
LCOR ligand dependent nuclear receptor corepressor 0.0282035
CELF1 CUGBP, Elav-like family member 1 0.0282035
RPL7L1 ribosomal protein L7-like 1 0.0281314
RPL6 ribosomal protein L6 0.027938
POTEF POTE ankyrin domain family, member F 0.0277456
TRIO trio Rho guanine nucleotide exchange factor 0.0276977
MED13 mediator complex subunit 13 0.0276444
TTC3 tetratricopeptide repeat domain 3 0.0273609
SPIRE1 spire-type actin nucleation factor 1 0.0273431
SPPL3 signal peptide peptidase like 3 0.0272616
MYO1B myosin IB 0.0271821
KRT8 keratin 8, type II 0.0271352
CMYA5 cardiomyopathy associated 5 0.0270691
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0267736
ZNF609 zinc finger protein 609 0.0267604
UBL4A ubiquitin-like 4A 0.0267502
RPL18A ribosomal protein L18a 0.0267093
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0266528
GAPVD1 GTPase activating protein and VPS9 domains 1 0.026454
FBXW11 F-box and WD repeat domain containing 11 0.0262843
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.026201
GREB1 growth regulation by estrogen in breast cancer 1 0.0261483
COG5 component of oligomeric golgi complex 5 0.0260688
FOXK1 forkhead box K1 0.0257707
RGS6 regulator of G-protein signaling 6 0.0257405
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0257193
YME1L1 YME1-like 1 ATPase 0.0256552
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0255896
UIMC1 ubiquitin interaction motif containing 1 0.0255829
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0255626
TNRC18 trinucleotide repeat containing 18 0.0255565
KDM5B lysine (K)-specific demethylase 5B 0.025544
CLMB calcimembrin 0.0254884
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0253547
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0253228
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0253076
PCDH7 protocadherin 7 0.0252926
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0252385
TPD52L1 tumor protein D52-like 1 0.0251767
VGLL4 vestigial-like family member 4 0.0250884
ADGRG6 adhesion G protein-coupled receptor G6 0.0249433
SAP30BP SAP30 binding protein 0.0248481
GIPC1 GIPC PDZ domain containing family, member 1 0.0248308
FBXO22 F-box protein 22 0.0248011
MARVELD2 MARVEL domain containing 2 0.0247727
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0247224
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.0245891
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0244377
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244266
HIPK2 homeodomain interacting protein kinase 2 0.0244243
ADGRV1 adhesion G protein-coupled receptor V1 0.0243307
CSDE1 cold shock domain containing E1, RNA-binding 0.0243171
S100A10 S100 calcium binding protein A10 0.0242165
NRP1 neuropilin 1 0.0241813
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0241631
CUX1 cut-like homeobox 1 0.0241444
RAB3D RAB3D, member RAS oncogene family 0.0241336
DSPP dentin sialophosphoprotein 0.0240231
TRAF3 TNF receptor-associated factor 3 0.0240155
ZNF680 zinc finger protein 680 0.0239588
LARP4 La ribonucleoprotein domain family, member 4 0.0239524
SQSTM1 sequestosome 1 0.0239174
MED13L mediator complex subunit 13-like 0.0239113
PHPT1 phosphohistidine phosphatase 1 0.0238069
TMEM131L transmembrane 131 like 0.0236604
ACTG1 actin gamma 1 0.0236278
TRIM33 tripartite motif containing 33 0.0236018
UBE2H ubiquitin-conjugating enzyme E2H 0.0235624
TET3 tet methylcytosine dioxygenase 3 0.023521
LMNA lamin A/C 0.023515
MCC mutated in colorectal cancers 0.0233255
ACBD6 acyl-CoA binding domain containing 6 0.0233072
SCD5 stearoyl-CoA desaturase 5 0.0232774
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0231094
PKM pyruvate kinase, muscle 0.023094
TMEM164 transmembrane protein 164 0.0228703
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0227515
TSPAN15 tetraspanin 15 0.0227487
ATXN7 ataxin 7 0.022736
RPSA ribosomal protein SA 0.0227189
JMJD1C jumonji domain containing 1C 0.0226759
CCDC83 coiled-coil domain containing 83 0.0226527
FNDC3B fibronectin type III domain containing 3B 0.0226278
SEC13 SEC13 homolog (S. cerevisiae) 0.0225794
CLEC16A C-type lectin domain family 16, member A 0.0224974
TOP2B topoisomerase (DNA) II beta 180kDa 0.0224687
PTPRE protein tyrosine phosphatase, receptor type, E 0.0224289
PKP4 plakophilin 4 0.0223351
PGR progesterone receptor 0.0222964
WAC WW domain containing adaptor with coiled-coil 0.0221697
RBM6 RNA binding motif protein 6 0.02215
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.022059
RPL37A ribosomal protein L37a 0.0220423
NPAS3 neuronal PAS domain protein 3 0.0219898
PCLO piccolo presynaptic cytomatrix protein 0.0218601
CAPN2 calpain 2, (m/II) large subunit 0.0218421
CA12 carbonic anhydrase XII 0.0218126
RPN2 ribophorin II 0.0216935
ANKRD28 ankyrin repeat domain 28 0.0216569
ADNP activity-dependent neuroprotector homeobox 0.021554
FOXA1 forkhead box A1 0.0215282
PFN1 profilin 1 0.0213863
PTEN phosphatase and tensin homolog 0.0213671
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0213507
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0212603
TMEM144 transmembrane protein 144 0.0212523
PXDN peroxidasin 0.0212166
ADAM17 ADAM metallopeptidase domain 17 0.0211421
MTA3 metastasis associated 1 family, member 3 0.0210789
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0210344
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0209826
NAP1L1 nucleosome assembly protein 1-like 1 0.0209356
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207613
MAPK6 mitogen-activated protein kinase 6 0.0207244
RPS8 ribosomal protein S8 0.0207181
GTF2I general transcription factor IIi 0.0206565
RFX7 regulatory factor X, 7 0.0205043
NRF1 nuclear respiratory factor 1 0.0204993
KDM2A lysine (K)-specific demethylase 2A 0.0203496
BICD1 bicaudal D homolog 1 (Drosophila) 0.0202985
CDYL2 chromodomain protein, Y-like 2 0.0202225
NHSL1 NHS-like 1 0.0201412
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0201395
OSBPL9 oxysterol binding protein-like 9 0.0201341
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0200869
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0200249
SOX4 SRY (sex determining region Y)-box 4 0.0199056
STK10 serine/threonine kinase 10 0.0199049
ARHGAP12 Rho GTPase activating protein 12 0.0198552
RAB1A RAB1A, member RAS oncogene family 0.0198452
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0197868
TKT transketolase 0.0197649
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0196457
DCLK1 doublecortin-like kinase 1 0.0195227
RPS23 ribosomal protein S23 0.0195088
KDM6A lysine (K)-specific demethylase 6A 0.0193584
PRKX protein kinase, X-linked 0.0193338
CC2D1A coiled-coil and C2 domain containing 1A 0.0193201
KMT2A lysine (K)-specific methyltransferase 2A 0.019228
TMEM117 transmembrane protein 117 0.0192134
RPS15 ribosomal protein S15 0.019207
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0191706
PTPRG protein tyrosine phosphatase, receptor type, G 0.0191246
S100A11 S100 calcium binding protein A11 0.0190754
NAV2 neuron navigator 2 0.018957
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0189338
MON2 MON2 homolog (S. cerevisiae) 0.018929
ZMAT3 zinc finger, matrin-type 3 0.0188326
TJP1 tight junction protein 1 0.0187462
ACBD3 acyl-CoA binding domain containing 3 0.0187376
TLE3 transducin-like enhancer of split 3 0.0186488
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0186132
SPATS2 spermatogenesis associated, serine-rich 2 0.0185909
ACTN1 actinin, alpha 1 0.0184421
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0184368
MICU1 mitochondrial calcium uptake 1 0.0184191
TMSB4X thymosin beta 4, X-linked 0.0183902
SCRN1 secernin 1 0.0182377
CAPN8 calpain 8 0.0181424
FAR1 fatty acyl CoA reductase 1 0.0180646
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0180307
MYH14 myosin, heavy chain 14, non-muscle 0.01797
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.017961
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.017945
REST RE1-silencing transcription factor 0.0179431
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0178548
PALLD palladin, cytoskeletal associated protein 0.0178357
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0178137
TMEM150C transmembrane protein 150C 0.0177971
ENO1 enolase 1, (alpha) 0.0177827
CDC14A cell division cycle 14A 0.0177597
TOR1AIP2 torsin A interacting protein 2 0.0176966
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.017687
RTN4 reticulon 4 0.017659
MANBA mannosidase, beta A, lysosomal 0.0176508
PDLIM5 PDZ and LIM domain 5 0.0176438
ERRFI1 ERBB receptor feedback inhibitor 1 0.0176382
RPS19 ribosomal protein S19 0.0176026
MYO5A myosin VA (heavy chain 12, myoxin) 0.0175539
TRIP11 thyroid hormone receptor interactor 11 0.0175478
WDR43 WD repeat domain 43 0.0174335
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0173846
RBM14-RBM4 RBM14-RBM4 readthrough 0.0173789
KIAA1191 KIAA1191 0.0173701
MAX MYC associated factor X 0.0173582
LARP4B La ribonucleoprotein domain family, member 4B 0.0173508
HSDL2 hydroxysteroid dehydrogenase like 2 0.0173454
RPL27 ribosomal protein L27 0.0173105
IFT43 intraflagellar transport 43 0.017292
RPL35A ribosomal protein L35a 0.0172703
KTN1 kinectin 1 (kinesin receptor) 0.0172486
PDS5A PDS5 cohesin associated factor A 0.0172254
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0171979
RPS3 ribosomal protein S3 0.0171963
STOX2 storkhead box 2 0.0171696
RPS4X ribosomal protein S4, X-linked 0.017151
LYPD6B LY6/PLAUR domain containing 6B 0.0171417
DCP2 decapping mRNA 2 0.0171339
PACS2 phosphofurin acidic cluster sorting protein 2 0.0170882
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0170834
EGR1 early growth response 1 0.0170789
RBM47 RNA binding motif protein 47 0.0170565
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0.0170094
ABI2 abl-interactor 2 0.016949
IARS1 isoleucyl-tRNA synthetase 1 0.016948
RPLP2 ribosomal protein, large, P2 0.0169246
TTC17 tetratricopeptide repeat domain 17 0.0169009
CHURC1 churchill domain containing 1 0.0168979
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0168944
LOC112694756 uncharaterized LOC112694756 0.0168866
KYNU kynureninase 0.0168399
RPL7 ribosomal protein L7 0.0168037
SNX14 sorting nexin 14 0.0166784
CCDC186 coiled-coil domain containing 186 0.0166759
STX16 syntaxin 16 0.0165933
TTPAL tocopherol (alpha) transfer protein-like 0.0165918
ITGAV integrin, alpha V 0.0165737
HDAC8 histone deacetylase 8 0.0165645
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0165118
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0164666
LRP10 low density lipoprotein receptor-related protein 10 0.0164327
SSH2 slingshot protein phosphatase 2 0.0163802
RSL24D1 ribosomal L24 domain containing 1 0.0163769
MARCHF6 membrane associated ring-CH-type finger 6 0.0163617
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0163577
TDG thymine-DNA glycosylase 0.0163256
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0163114
CSRP1 cysteine and glycine-rich protein 1 0.0162929
PRKCE protein kinase C, epsilon 0.0162909
TTLL10 tubulin tyrosine ligase-like family member 10 0.0162848
SETD7 SET domain containing (lysine methyltransferase) 7 0.0162771
FOXO1 forkhead box O1 0.016265
NLK nemo-like kinase 0.0162491
HSPB1 heat shock 27kDa protein 1 0.0162039
MPRIP myosin phosphatase Rho interacting protein 0.0161985
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0161562
SIDT1 SID1 transmembrane family, member 1 0.0161443
ETNK1 ethanolamine kinase 1 0.0160985
CCDC137 coiled-coil domain containing 137 0.0160696
PGCKA1 PDCD10 and GCKIII kinases associated 1 0.0160259
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.0159606
ASB8 ankyrin repeat and SOCS box containing 8 0.0159202
ULK1 unc-51 like autophagy activating kinase 1 0.0159135
LRP5 low density lipoprotein receptor-related protein 5 0.0158991
LPIN1 lipin 1 0.0158801
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.0158403
NEK7 NIMA-related kinase 7 0.0158104
LMTK2 lemur tyrosine kinase 2 0.0158063
ITPRID2 ITPR interacting domain containing 2 0.0157827
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0157726
MAML3 mastermind-like 3 (Drosophila) 0.0157332
RAD23B RAD23 homolog B (S. cerevisiae) 0.0157231
SUSD6 sushi domain containing 6 0.015721
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0156943
ANO6 anoctamin 6 0.0156786
FOSL2 FOS-like antigen 2 0.0156552
FASN fatty acid synthase 0.0156072
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0155857
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.015547
SCAPER S-phase cyclin A-associated protein in the ER 0.0154991
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0154789
SH3RF1 SH3 domain containing ring finger 1 0.0154538
SAMD4A sterile alpha motif domain containing 4A 0.0154049
DYM dymeclin 0.0154041
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0153945
FBXL17 F-box and leucine-rich repeat protein 17 0.0153726
RB1 retinoblastoma 1 0.0153551
RPL23 ribosomal protein L23 0.0153453
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0152717
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0152364
ANAPC11 anaphase promoting complex subunit 11 0.0152111
DSTN destrin (actin depolymerizing factor) 0.0152081
N4BP2L2 NEDD4 binding protein 2-like 2 0.0151895
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0151709
MRC2 mannose receptor, C type 2 0.0151689
VEZF1 vascular endothelial zinc finger 1 0.0151517
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0151499
REEP3 receptor accessory protein 3 0.0151179
MAPK10 mitogen-activated protein kinase 10 0.0150963
DOCK1 dedicator of cytokinesis 1 0.015089
PKN1 protein kinase N1 0.0150825
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0150694
FOSL1 FOS-like antigen 1 0.0150421
MPG N-methylpurine-DNA glycosylase 0.0150296
ZMIZ1 zinc finger, MIZ-type containing 1 0.0150285
KMT5B lysine methyltransferase 5B 0.0149627
ANKRD11 ankyrin repeat domain 11 0.014956
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.0149491
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0149487
KMT2E lysine (K)-specific methyltransferase 2E 0.0149437
SMIM44 small integral membrane protein 44 0.0149402
NEMF nuclear export mediator factor 0.0149217
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0149039
ZNF251 zinc finger protein 251 0.0148196
SCAF8 SR-related CTD-associated factor 8 0.0148095
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.014803
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0147592
VWA8 von Willebrand factor A domain containing 8 0.0147088
NUBPL nucleotide binding protein-like 0.0146691
NOTCH3 notch 3 0.0146321
COL4A5 collagen, type IV, alpha 5 0.014626
ANXA2 annexin A2 0.0146232
UGDH UDP-glucose 6-dehydrogenase 0.014605
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0145851
TMPRSS4 transmembrane protease, serine 4 0.0145783
NECAB1 N-terminal EF-hand calcium binding protein 1 0.0145201
BABAM2 BRISC and BRCA1 A complex member 2 0.0145115
CREBBP CREB binding protein 0.0144927
PDCD6 programmed cell death 6 0.0144902
TRAK1 trafficking protein, kinesin binding 1 0.0144803
ZNF407 zinc finger protein 407 0.0144657
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.014462
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.014441
ZFP36L2 ZFP36 ring finger protein-like 2 0.0144324
UBE2I ubiquitin-conjugating enzyme E2I 0.0144241
TLE5 TLE family member 5, transcriptional modulator 0.0144011
PUM1 pumilio RNA-binding family member 1 0.0143799
GDNF glial cell derived neurotrophic factor 0.0143551
TASOR2 transcription activation suppressor family member 2 0.0143518
TXNRD1 thioredoxin reductase 1 0.0143489
YIPF5 Yip1 domain family, member 5 0.0143476
SERF2 small EDRK-rich factor 2 0.0143311
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0142933
TSC22D1 TSC22 domain family, member 1 0.0142823
STAU1 staufen double-stranded RNA binding protein 1 0.0142721
GPX4 glutathione peroxidase 4 0.0142696
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0142652
DCAF7 DDB1 and CUL4 associated factor 7 0.0142254
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0141473
COG8 component of oligomeric golgi complex 8 0.0141381
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0141306
KAZN kazrin, periplakin interacting protein 0.0141277
UBE4A ubiquitination factor E4A 0.0141082
TM7SF3 transmembrane 7 superfamily member 3 0.0140786
BRD1 bromodomain containing 1 0.0140632
MEIS1 Meis homeobox 1 0.0140431
PLCB4 phospholipase C, beta 4 0.0140305
HSPA4 heat shock 70kDa protein 4 0.0140228
CCNL1 cyclin L1 0.0140196
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0139926
RPS12 ribosomal protein S12 0.0139851
FNBP1 formin binding protein 1 0.0139802
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0139791
KIF5B kinesin family member 5B 0.0139787
MXD4 MAX dimerization protein 4 0.013966
KIAA0513 KIAA0513 0.0139594
AAK1 AP2 associated kinase 1 0.0139474
SLX9 SLX9 ribosome biogenesis factor 0.0139403
KCTD10 potassium channel tetramerization domain containing 10 0.0139319
MTPN myotrophin 0.0138827
ECPAS Ecm29 proteasome adaptor and scaffold 0.0138826
PRSS8 protease, serine, 8 0.0138753
ULK2 unc-51 like autophagy activating kinase 2 0.0138744
RGS22 regulator of G-protein signaling 22 0.0138683
RNF114 ring finger protein 114 0.0137982
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0137846
WWC2 WW and C2 domain containing 2 0.0137696
CUEDC1 CUE domain containing 1 0.0137616
MGLL monoglyceride lipase 0.0137278
RPL21 ribosomal protein L21 0.0137205
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0137114
LEKR1 leucine, glutamate and lysine rich 1 0.0136675
PIAS1 protein inhibitor of activated STAT, 1 0.0136509
SH3KBP1 SH3-domain kinase binding protein 1 0.0136223
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.0136159
FRS2 fibroblast growth factor receptor substrate 2 0.0136014
RABGAP1 RAB GTPase activating protein 1 0.0135873
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0135755
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0135745
CTTNBP2NL CTTNBP2 N-terminal like 0.0135724
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0135547
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0135491
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.013539
ACER2 alkaline ceramidase 2 0.0135365
OLA1 Obg-like ATPase 1 0.0135276
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.0135239
RAD23A RAD23 homolog A (S. cerevisiae) 0.0134881
ZNFX1 zinc finger, NFX1-type containing 1 0.0134817
ATP11C ATPase, class VI, type 11C 0.0134793
MAVS mitochondrial antiviral signaling protein 0.0134722
SEPTIN9 septin 9 0.0134687
TOR1B torsin family 1, member B (torsin B) 0.0134606
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0134253
NPEPPS aminopeptidase puromycin sensitive 0.0134229
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0134041
CHD4 chromodomain helicase DNA binding protein 4 0.0133901
PCNX2 pecanex 2 0.0133686
DNM1L dynamin 1-like 0.0133446
SESN2 sestrin 2 0.0133432
IDS iduronate 2-sulfatase 0.0132881
IP6K1 inositol hexakisphosphate kinase 1 0.0132833
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0132826
AXIN1 axin 1 0.0132679
BTBD10 BTB (POZ) domain containing 10 0.0132489
SDC4 syndecan 4 0.0132467
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0132292
HM13 histocompatibility (minor) 13 0.0132197

decreased expression

Symbol Name Standardized Value
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.162145
EVL Enah/Vasp-like -0.146494
GFRA1 GDNF family receptor alpha 1 -0.13616
TFF1 trefoil factor 1 -0.117318
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.107091
IFI6 interferon, alpha-inducible protein 6 -0.0943943
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0886567
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0873084
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0821968
ESR1 estrogen receptor 1 -0.0794261
EMP2 epithelial membrane protein 2 -0.0782004
MKI67 marker of proliferation Ki-67 -0.0781366
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0759292
LRP1B low density lipoprotein receptor-related protein 1B -0.069953
LDLR low density lipoprotein receptor -0.0621069
ATAD2 ATPase family, AAA domain containing 2 -0.0574723
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0571169
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0558304
GPC6 glypican 6 -0.0535621
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.0529803
PLXDC2 plexin domain containing 2 -0.0527165
DSCAM Down syndrome cell adhesion molecule -0.0521528
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.051966
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0507493
TRIM37 tripartite motif containing 37 -0.0503807
NCOA3 nuclear receptor coactivator 3 -0.0486845
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0486037
TUBD1 tubulin, delta 1 -0.0452376
LY6E lymphocyte antigen 6 complex, locus E -0.0446902
BIRC6 baculoviral IAP repeat containing 6 -0.0422692
SKA2 spindle and kinetochore associated complex subunit 2 -0.0414962
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0412528
CLDN3 claudin 3 -0.0409533
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0401964
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0397382
BRCA1 breast cancer 1, early onset -0.0389154
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0388485
PARD6B par-6 family cell polarity regulator beta -0.0370706
IGF1R insulin-like growth factor 1 receptor -0.0367864
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0352035
NRIP1 nuclear receptor interacting protein 1 -0.0349392
JARID2 jumonji, AT rich interactive domain 2 -0.0346857
TMCC1 transmembrane and coiled-coil domain family 1 -0.0345877
BCAS3 breast carcinoma amplified sequence 3 -0.0337996
DCDC2 doublecortin domain containing 2 -0.0328536
BCL2 B-cell CLL/lymphoma 2 -0.0326086
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0317447
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0310289
TPX2 TPX2, microtubule-associated -0.0308461
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0305615
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0304146
PARD3 par-3 family cell polarity regulator -0.0302927
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0300779
SRPK2 SRSF protein kinase 2 -0.0299098
SYNGR2 synaptogyrin 2 -0.0297214
THSD4 thrombospondin, type I, domain containing 4 -0.0294609
SRSF4 serine/arginine-rich splicing factor 4 -0.0293839
CENPF centromere protein F, 350/400kDa -0.029355
ALCAM activated leukocyte cell adhesion molecule -0.0292894
ANKRD17 ankyrin repeat domain 17 -0.0292796
CLIC4 chloride intracellular channel 4 -0.0291221
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0291221
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0291115
NSD2 nuclear receptor binding SET domain protein 2 -0.0287176
RNF213 ring finger protein 213 -0.0285146
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0278254
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0277122
ADCY1 adenylate cyclase 1 (brain) -0.0274893
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0273999
UBC ubiquitin C -0.0272406
ARFGEF3 ARFGEF family member 3 -0.0271785
AURKA aurora kinase A -0.0270738
ADCY9 adenylate cyclase 9 -0.0270685
TPR translocated promoter region, nuclear basket protein -0.0270017
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0267771
TPM4 tropomyosin 4 -0.0267138
TBC1D5 TBC1 domain family, member 5 -0.0265197
SACK1B scaffolding CK1 anchoring protein B -0.0265075
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0259364
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0257649
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0257253
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0256602
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -0.0256446
GPATCH8 G patch domain containing 8 -0.0256287
LAMP2 lysosomal-associated membrane protein 2 -0.0255052
CCSER1 coiled-coil serine-rich protein 1 -0.0254687
SDK1 sidekick cell adhesion molecule 1 -0.0254479
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0254051
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0253736
KNTC1 kinetochore associated 1 -0.0253375
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.0251502
SLF2 SMC5-SMC6 complex localization factor 2 -0.0251246
ELP2 elongator acetyltransferase complex subunit 2 -0.0251178
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.0249328
FANCA Fanconi anemia, complementation group A -0.0247957
PDE8A phosphodiesterase 8A -0.0247681
SEC11A SEC11 homolog A (S. cerevisiae) -0.0247314
ZNRF3 zinc and ring finger 3 -0.024651
TFF3 trefoil factor 3 (intestinal) -0.0246484
LMBR1 limb development membrane protein 1 -0.024601
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.0245992
KAT6B K(lysine) acetyltransferase 6B -0.0245115
DHCR7 7-dehydrocholesterol reductase -0.024244
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.0242294
C21ORF58 chromosome 21 open reading frame 58 -0.0241461
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0239822
RPL4 ribosomal protein L4 -0.0239754
HEATR5B HEAT repeat containing 5B -0.0239272
NCKAP5 NCK-associated protein 5 -0.0238726
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0236429
PBX3 pre-B-cell leukemia homeobox 3 -0.0235959
TMPO thymopoietin -0.0235827
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0235117
HMCN1 hemicentin 1 -0.0234743
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.023405
EEF2 eukaryotic translation elongation factor 2 -0.0233686
NPDC1 neural proliferation, differentiation and control, 1 -0.0233478
KDM3B lysine (K)-specific demethylase 3B -0.0232877
DENR density-regulated protein -0.0232279
FAM222B family with sequence similarity 222, member B -0.0232116
LMAN2 lectin, mannose-binding 2 -0.0232015
NCAM2 neural cell adhesion molecule 2 -0.0230274
RPL30 ribosomal protein L30 -0.0230021
MREG melanoregulin -0.0229789
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0226853
TTC39A tetratricopeptide repeat domain 39A -0.0226291
VMP1 vacuole membrane protein 1 -0.0225565
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0225503
COX6C cytochrome c oxidase subunit VIc -0.0224877
CHD9 chromodomain helicase DNA binding protein 9 -0.0224312
NECTIN2 nectin cell adhesion molecule 2 -0.0224291
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0222279
KIF4A kinesin family member 4A -0.0222276
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0222038
PRC1 protein regulator of cytokinesis 1 -0.0221047
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.0220601
PLEC plectin -0.0219434
IGFBP5 insulin-like growth factor binding protein 5 -0.0219285
BSG basigin (Ok blood group) -0.0218458
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0216725
NFIB nuclear factor I/B -0.0216445
KIF20B kinesin family member 20B -0.0213975
SVIL supervillin -0.021395
KPNB1 karyopherin (importin) beta 1 -0.0213881
ATRNL1 attractin-like 1 -0.0213577
MIS18BP1 MIS18 binding protein 1 -0.0213364
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.0213212
FNBP4 formin binding protein 4 -0.0212417
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.02114
PRR11 proline rich 11 -0.0211057
CSAD cysteine sulfinic acid decarboxylase -0.0210637
UBN2 ubinuclein 2 -0.0210494
DERL1 derlin 1 -0.0210095
MACROD2 MACRO domain containing 2 -0.0209991
SYCP2 synaptonemal complex protein 2 -0.0208801
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0208171
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0205991
GLG1 golgi glycoprotein 1 -0.0204614
BPTF bromodomain PHD finger transcription factor -0.0203635
SPOPL speckle-type POZ protein-like -0.0202893
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0201107
ITGB4 integrin, beta 4 -0.0201075
TXNIP thioredoxin interacting protein -0.0199904
BRWD1 bromodomain and WD repeat domain containing 1 -0.0199662
WWOX WW domain containing oxidoreductase -0.0198957
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0198077
FANCI Fanconi anemia, complementation group I -0.0196512
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0195654
SREBF2 sterol regulatory element binding transcription factor 2 -0.0195304
SOS1 son of sevenless homolog 1 (Drosophila) -0.0194771
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.019447
SDCCAG8 serologically defined colon cancer antigen 8 -0.0193875
FDPS farnesyl diphosphate synthase -0.0193453
ICA1 islet cell autoantigen 1, 69kDa -0.0193442
FAM174B family with sequence similarity 174, member B -0.0193426
RABGAP1L RAB GTPase activating protein 1-like -0.0193126
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0192383
GATA3 GATA binding protein 3 -0.0192115
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0190975
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0190759
FAF1 Fas (TNFRSF6) associated factor 1 -0.0189449
SFXN2 sideroflexin 2 -0.0189415
BAG6 BCL2-associated athanogene 6 -0.0189336
SHROOM3 shroom family member 3 -0.0187798
SETD1B SET domain containing 1B -0.0187238
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0187228
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.0186441
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0185644
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0185428
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0184295
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0183302
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0183169
CAPZB capping protein (actin filament) muscle Z-line, beta -0.018307
ARL3 ADP-ribosylation factor-like 3 -0.0182437
PDZRN3 PDZ domain containing ring finger 3 -0.0181968
PHGDH phosphoglycerate dehydrogenase -0.0181398
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0180846
SAPCD2 suppressor APC domain containing 2 -0.0180435
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0180271
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -0.0179685
XBP1 X-box binding protein 1 -0.01795
IQANK1 IQ motif and ankyrin repeat containing 1 -0.0179315
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0179048
ENOSF1 enolase superfamily member 1 -0.0178958
LMNB2 lamin B2 -0.0178914
NRDC nardilysin convertase -0.0177494
MTG2 mitochondrial ribosome-associated GTPase 2 -0.0176843
SLC38A1 solute carrier family 38, member 1 -0.0176606
RGS3 regulator of G-protein signaling 3 -0.0176139
SEC16A SEC16 homolog A (S. cerevisiae) -0.0176115
ZZZ3 zinc finger, ZZ-type containing 3 -0.0175698
PITPNA phosphatidylinositol transfer protein, alpha -0.0174888
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0174824
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0174787
RCOR1 REST corepressor 1 -0.0174157
TUBB4B tubulin, beta 4B class IVb -0.0173769
AKAP9 A kinase (PRKA) anchor protein 9 -0.0173543
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0173307
TTC28 tetratricopeptide repeat domain 28 -0.0173091
SYT10 synaptotagmin X -0.0171472
MYO9A myosin IXA -0.0171449
DHRS7B dehydrogenase/reductase (SDR family) member 7B -0.0171391
ASXL1 additional sex combs like transcriptional regulator 1 -0.0171179
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0170584
KRT18 keratin 18, type I -0.0170103
ANLN anillin, actin binding protein -0.0170023
H1-10 H1.10 linker histone -0.0168746
IFITM3 interferon induced transmembrane protein 3 -0.0168678
IGFBP4 insulin-like growth factor binding protein 4 -0.0168652
SSR1 signal sequence receptor, alpha -0.0168563
HID1 HID1 domain containing -0.0167946
RFWD3 ring finger and WD repeat domain 3 -0.0167732
CALR calreticulin -0.0167691
ARHGAP35 Rho GTPase activating protein 35 -0.0167558
STK11 serine/threonine kinase 11 -0.0167087
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0167023
TMEM59 transmembrane protein 59 -0.0166521
CHD3 chromodomain helicase DNA binding protein 3 -0.0166212
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.0166045
SGMS1 sphingomyelin synthase 1 -0.0165886
ZNF106 zinc finger protein 106 -0.0165805
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -0.016547
PTPRF protein tyrosine phosphatase, receptor type, F -0.0165304
CBX5 chromobox homolog 5 -0.0164977
VASP vasodilator-stimulated phosphoprotein -0.0164508
BRCA2 breast cancer 2, early onset -0.0164022
REV1 REV1, polymerase (DNA directed) -0.0163867
CLDN4 claudin 4 -0.0163831
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0163029
ERP29 endoplasmic reticulum protein 29 -0.0162983
HDLBP high density lipoprotein binding protein -0.0162959
CTBP2 C-terminal binding protein 2 -0.0162451
RBL2 retinoblastoma-like 2 -0.0162208
ATG7 autophagy related 7 -0.016198
MAGT1 magnesium transporter 1 -0.0161898
SPPL2A signal peptide peptidase like 2A -0.016124
DIS3L DIS3 like exosome 3'-5' exoribonuclease -0.0161028
UTRN utrophin -0.01607
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0160671
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0160408
ZC3H7A zinc finger CCCH-type containing 7A -0.0160405
NUP98 nucleoporin 98kDa -0.0160292
ZNF644 zinc finger protein 644 -0.0159433
ARSG arylsulfatase G -0.0159149
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0158921
SMAD2 SMAD family member 2 -0.0158266
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -0.0157264
NCOR1 nuclear receptor corepressor 1 -0.0156941
NTN1 netrin 1 -0.0156811
UBXN7 UBX domain protein 7 -0.015676
DEK DEK proto-oncogene -0.015647
CDV3 CDV3 homolog (mouse) -0.0156078
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.0155668
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0155299
TMEM132A transmembrane protein 132A -0.0155211
ZNF398 zinc finger protein 398 -0.0154616
CDT1 chromatin licensing and DNA replication factor 1 -0.0154494
PRUNE1 prune exopolyphosphatase 1 -0.0154028
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.015353
WDR62 WD repeat domain 62 -0.0153296
LITAF lipopolysaccharide-induced TNF factor -0.0153293
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0152975
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0152945
CPEB3 cytoplasmic polyadenylation element binding protein 3 -0.0152838
GSE1 Gse1 coiled-coil protein -0.0152462
TPM3 tropomyosin 3 -0.0152251
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0152174
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0152151
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.0151827
CYBA cytochrome b-245, alpha polypeptide -0.0150575
LIN52 lin-52 DREAM MuvB core complex component -0.0150169
C1ORF21 chromosome 1 open reading frame 21 -0.015016
GRHL2 grainyhead-like 2 (Drosophila) -0.0149883
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.0149825
SUB1 SUB1 homolog (S. cerevisiae) -0.0149811
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0149595
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0149536
CCDC7 coiled-coil domain containing 7 -0.0149394
THRB thyroid hormone receptor, beta -0.014937
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0149345
TPBG trophoblast glycoprotein -0.0149045
HPCAL1 hippocalcin-like 1 -0.0149014
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -0.0149009
MCM4 minichromosome maintenance complex component 4 -0.014892
CYBC1 cytochrome b-245 chaperone 1 -0.0148543
SGO2 shugoshin 2 -0.0148467
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0148443
PPP6C protein phosphatase 6, catalytic subunit -0.0148214
BCLAF1 BCL2-associated transcription factor 1 -0.0148123
AHNAK AHNAK nucleoprotein -0.0148111
G6PC3 glucose 6 phosphatase, catalytic, 3 -0.0147796
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.01477
COL5A1 collagen, type V, alpha 1 -0.0147608
SHLD2 shieldin complex subunit 2 -0.0147294
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0147012
FCHSD2 FCH and double SH3 domains 2 -0.0146817
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -0.0146629
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0146379
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -0.0145881
CAMKMT calmodulin-lysine N-methyltransferase -0.0145802
XYLT1 xylosyltransferase I -0.0145741
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0144714
KIAA1958 KIAA1958 -0.0144639
TUBB tubulin, beta class I -0.0144482
UBE3C ubiquitin protein ligase E3C -0.0144302
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0143778
F11R F11 receptor -0.0143447
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0143443
METTL16 methyltransferase like 16 -0.0143369
TIAM1 T-cell lymphoma invasion and metastasis 1 -0.0143266
ITSN2 intersectin 2 -0.0143082
ASF1B anti-silencing function 1B histone chaperone -0.0142734
AARS1 alanyl-tRNA synthetase 1 -0.0142668
ENTREP1 endosomal transmembrane epsin interactor 1 -0.0142461
HLA-E major histocompatibility complex, class I, E -0.0142164
UBE3A ubiquitin protein ligase E3A -0.0142154
FAM234A family with sequence similarity 234 member A -0.0142134
MPHOSPH8 M-phase phosphoprotein 8 -0.0141978
ARRDC4 arrestin domain containing 4 -0.0141829
JUP junction plakoglobin -0.0141343
ZNF236 zinc finger protein 236 -0.0141196
SUMF2 sulfatase modifying factor 2 -0.0141193
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0141166
TMEM245 transmembrane protein 245 -0.0140943
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.014062
TFRC transferrin receptor -0.0140609
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0140541
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0140302
TNPO3 transportin 3 -0.0140266
CFAP44 cilia and flagella associated protein 44 -0.0140109
SLC75A1 solute carrier family 75 member 1 -0.0140085
ELOVL1 ELOVL fatty acid elongase 1 -0.0139346
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0139344
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0139016
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0138944
RPAP3 RNA polymerase II associated protein 3 -0.0138663
CHLSN cholesin -0.0138242
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -0.0137843
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0137735
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0137637
AK1 adenylate kinase 1 -0.0137582
CANT1 calcium activated nucleotidase 1 -0.0137557
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0137217
SRRM1 serine/arginine repetitive matrix 1 -0.013714
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0136879
FMN1 formin 1 -0.0136811
STX8 syntaxin 8 -0.0136489
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.0136469
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0136434
PCBP3 poly(rC) binding protein 3 -0.013609
TTF2 transcription termination factor, RNA polymerase II -0.0135929
CENPE centromere protein E, 312kDa -0.0135701
PRKCI protein kinase C, iota -0.0135287
NPC2 Niemann-Pick disease, type C2 -0.0134888
CARNMT1 carnosine N-methyltransferase 1 -0.0134753
ATXN2 ataxin 2 -0.0134605
ACACA acetyl-CoA carboxylase alpha -0.0134593
NEMP1 nuclear envelope integral membrane protein 1 -0.0134031
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0133897
CD47 CD47 molecule -0.0133733
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0133676
IRS1 insulin receptor substrate 1 -0.0133487
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0133402
ZDHHC12 zinc finger, DHHC-type containing 12 -0.0133362
RAD21 RAD21 homolog (S. pombe) -0.0133194
AGFG1 ArfGAP with FG repeats 1 -0.0132957
APMAP adipocyte plasma membrane associated protein -0.0132831
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0132641
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -0.0132373
ABR active BCR-related -0.0132199
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -0.0132055
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -0.0132039
IPO9 importin 9 -0.0131993
DOCK6 dedicator of cytokinesis 6 -0.0131946
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0131912
NUDC nudC nuclear distribution protein -0.0131907
GOPC golgi-associated PDZ and coiled-coil motif containing -0.0131815
ANAPC5 anaphase promoting complex subunit 5 -0.013167
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0131235
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0131125
FBXW4 F-box and WD repeat domain containing 4 -0.0131113
ATM ATM serine/threonine kinase -0.013091
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0130787
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -0.0130624
SLMAP sarcolemma associated protein -0.0130605
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.0130295
DEPDC1B DEP domain containing 1B -0.013007
ARL5B ADP-ribosylation factor-like 5B -0.0129992
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0129824
EXD3 exonuclease 3'-5' domain containing 3 -0.0129615
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0129543
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0129494
CYTH1 cytohesin 1 -0.0129486
STK24 serine/threonine kinase 24 -0.0129453
SKP1 S-phase kinase-associated protein 1 -0.012939
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0129333
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.012929
PLXND1 plexin D1 -0.0129032
ISG15 ISG15 ubiquitin-like modifier -0.0128982
GPATCH2 G patch domain containing 2 -0.0128646
DNA2 DNA replication helicase/nuclease 2 -0.0128594
RAB21 RAB21, member RAS oncogene family -0.0127828
DGKE diacylglycerol kinase, epsilon 64kDa -0.0127548
RBBP8 retinoblastoma binding protein 8 -0.0127445
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -0.0127433
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -0.0126847
EP300 E1A binding protein p300 -0.0126771
RHOA ras homolog family member A -0.0126508
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0126447
BCAP31 B-cell receptor-associated protein 31 -0.0126406
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0125905
SACK1H scaffolding CK1 anchoring protein H -0.0125898
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0125832
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0125763
RTN4RL1 reticulon 4 receptor-like 1 -0.0125753
DMXL2 Dmx-like 2 -0.0125718
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0125641
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0125492
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -0.0125311
RMDN3 regulator of microtubule dynamics 3 -0.0125256
ORC5 origin recognition complex, subunit 5 -0.0125185
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -0.012516
ADI1 acireductone dioxygenase 1 -0.0125134
UQCRC1 ubiquinol-cytochrome c reductase core protein I -0.012502
ATE1 arginyltransferase 1 -0.0124896
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -0.0124587
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0124376
MASTL microtubule associated serine/threonine kinase-like -0.0124033
ZNF804B zinc finger protein 804B -0.0123925
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0123865
FOXN3 forkhead box N3 -0.0123749
SORT1 sortilin 1 -0.0123369
SMC3 structural maintenance of chromosomes 3 -0.0123307
CEP170 centrosomal protein 170kDa -0.0122744
TRAP1 TNF receptor-associated protein 1 -0.0122576
TSC2 tuberous sclerosis 2 -0.0122408
VCL vinculin -0.0122297
RAD18 RAD18 E3 ubiquitin protein ligase -0.0122274
NUP88 nucleoporin 88kDa -0.0122176
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0122147
DYNC2I2 dynein 2 intermediate chain 2 -0.0122007
CLIC1 chloride intracellular channel 1 -0.012153
CDC27 cell division cycle 27 -0.0121505
WDR33 WD repeat domain 33 -0.0120857
NBEAL1 neurobeachin-like 1 -0.0120519
LSR lipolysis stimulated lipoprotein receptor -0.0120474
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.0120252
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -0.0120184
EEIG2 EEIG family member 2 -0.0120149
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -0.0120123
BRAT1 BRCA1-associated ATM activator 1 -0.0120093
FAF2 Fas associated factor family member 2 -0.0120002
EP400 E1A binding protein p400 -0.0119736
PTDSS1 phosphatidylserine synthase 1 -0.0119736
FLII flightless I homolog (Drosophila) -0.0119728
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.01196
SETD5 SET domain containing 5 -0.0119303
DNAAF9 dynein axonemal assembly factor 9 -0.011907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0119067
TLK2 tousled-like kinase 2 -0.0119063
CHEK2 checkpoint kinase 2 -0.011903
ZYG11A zyg-11 family member A, cell cycle regulator -0.0119021
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0118989
WDPCP WD repeat containing planar cell polarity effector -0.0118527
ZNF627 zinc finger protein 627 -0.0118496
HDAC4 histone deacetylase 4 -0.011842
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0118407
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0118336
ZC3H8 zinc finger CCCH-type containing 8 -0.0118241
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0118197
HCFC1 host cell factor C1 -0.0118184
ITGB5 integrin, beta 5 -0.0118039
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -0.0117973
EDF1 endothelial differentiation-related factor 1 -0.011788
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.0117695
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -0.0117658
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0117592
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0117544
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0117445
GMPS guanine monphosphate synthase -0.0117261