MCF7_SNS-314 Mesylate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 100nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_SNS-314 Mesylate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.273108
SYTL2 synaptotagmin-like 2 0.144254
PTPRK protein tyrosine phosphatase, receptor type, K 0.140784
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.116554
THSD4 thrombospondin, type I, domain containing 4 0.102199
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0918749
CCND1 cyclin D1 0.0911246
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0816529
FLNA filamin A, alpha 0.0733256
GPC6 glypican 6 0.0728969
MAST4 microtubule associated serine/threonine kinase family member 4 0.071128
RPS8 ribosomal protein S8 0.0708824
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0679648
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0662358
MSI2 musashi RNA-binding protein 2 0.0631292
TET2 tet methylcytosine dioxygenase 2 0.0629448
VMP1 vacuole membrane protein 1 0.0612289
USP32 ubiquitin specific peptidase 32 0.0581852
RPS2 ribosomal protein S2 0.0568896
MED13 mediator complex subunit 13 0.0564653
DTNA dystrobrevin, alpha 0.0561233
BPTF bromodomain PHD finger transcription factor 0.0559676
RPS17 ribosomal protein S17 0.0509467
RDX radixin 0.0506718
SMAD3 SMAD family member 3 0.0506507
POGZ pogo transposable element with ZNF domain 0.049395
SEPTIN9 septin 9 0.0490257
KIAA1217 KIAA1217 0.0488532
COL4A5 collagen, type IV, alpha 5 0.0487045
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0482457
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0465526
ACTG1 actin gamma 1 0.0455102
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0429617
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0418539
DSPP dentin sialophosphoprotein 0.041836
SMIM14 small integral membrane protein 14 0.0400959
AK1 adenylate kinase 1 0.0396983
BCL2 B-cell CLL/lymphoma 2 0.0396731
PAWR PRKC, apoptosis, WT1, regulator 0.0393313
S100A10 S100 calcium binding protein A10 0.0392665
KRT19 keratin 19, type I 0.0390084
IGSF1 immunoglobulin superfamily, member 1 0.0386225
GSK3B glycogen synthase kinase 3 beta 0.0382021
ADGRG6 adhesion G protein-coupled receptor G6 0.0379851
PBX1 pre-B-cell leukemia homeobox 1 0.0376975
ITGAV integrin, alpha V 0.0375325
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.036623
CYRIB CYFIP related Rac1 interactor B 0.0363702
BRD4 bromodomain containing 4 0.0357587
MALRD1 MAM and LDL receptor class A domain containing 1 0.0354255
CALCR calcitonin receptor 0.0348649
NF1 neurofibromin 1 0.0342816
RUNX1 runt-related transcription factor 1 0.0340614
SYT1 synaptotagmin I 0.0335081
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0334953
HM13 histocompatibility (minor) 13 0.0334114
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0333753
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0332734
NEBL nebulette 0.0329588
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0327693
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0326956
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0324323
CSNK1A1 casein kinase 1, alpha 1 0.0321325
POTEF POTE ankyrin domain family, member F 0.0318933
CLTC clathrin, heavy chain (Hc) 0.031563
TLK2 tousled-like kinase 2 0.0315252
KRT8 keratin 8, type II 0.0312525
USP48 ubiquitin specific peptidase 48 0.0309953
FRMD5 FERM domain containing 5 0.0309104
KIF13A kinesin family member 13A 0.0307317
TSC22D2 TSC22 domain family, member 2 0.03065
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0304284
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0302285
MYO1E myosin IE 0.0301888
NRP1 neuropilin 1 0.0301746
ATXN7L1 ataxin 7-like 1 0.0300226
MYO1B myosin IB 0.0295909
DAAM1 dishevelled associated activator of morphogenesis 1 0.0295657
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0294966
EIF4B eukaryotic translation initiation factor 4B 0.0293125
PTPRG protein tyrosine phosphatase, receptor type, G 0.0293013
RPSA ribosomal protein SA 0.0291363
RPS19 ribosomal protein S19 0.0290041
MED13L mediator complex subunit 13-like 0.0289492
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0289431
THADA thyroid adenoma associated 0.0289401
JAK1 Janus kinase 1 0.0288793
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.0286028
CTSD cathepsin D 0.0285233
FTH1 ferritin, heavy polypeptide 1 0.0283933
CXXC5 CXXC finger protein 5 0.0275904
NSD1 nuclear receptor binding SET domain protein 1 0.0275237
TOB1 transducer of ERBB2, 1 0.0274605
PXDN peroxidasin 0.0274247
RAB7A RAB7A, member RAS oncogene family 0.0272799
PRKCA protein kinase C, alpha 0.0272671
ATP9A ATPase, class II, type 9A 0.0272071
RPLP1 ribosomal protein, large, P1 0.0270894
MYO9A myosin IXA 0.0270257
YY1 YY1 transcription factor 0.0268802
BCL2L1 BCL2-like 1 0.0268533
RPL6 ribosomal protein L6 0.0267114
THBS1 thrombospondin 1 0.0264365
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0263756
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0263056
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0262458
SKIL SKI-like proto-oncogene 0.0262322
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0262315
NCAM2 neural cell adhesion molecule 2 0.0260696
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0260408
MYOF myoferlin 0.0259186
NBEAL1 neurobeachin-like 1 0.0258812
PTK2 protein tyrosine kinase 2 0.0258675
MBD5 methyl-CpG binding domain protein 5 0.0258462
NCOA3 nuclear receptor coactivator 3 0.0257866
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0256957
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0256369
DARS1 aspartyl-tRNA synthetase 1 0.0254738
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0251989
LARP4 La ribonucleoprotein domain family, member 4 0.0251969
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0250089
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0249971
OSBPL10 oxysterol binding protein-like 10 0.0249294
RPL31 ribosomal protein L31 0.0248273
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0246171
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0244109
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0242206
ZFAND3 zinc finger, AN1-type domain 3 0.0241424
ATXN1 ataxin 1 0.0239933
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0238392
MYH9 myosin, heavy chain 9, non-muscle 0.0237882
JMJD1C jumonji domain containing 1C 0.0237694
GTF2I general transcription factor IIi 0.0237253
STK24 serine/threonine kinase 24 0.0236576
USP15 ubiquitin specific peptidase 15 0.0235899
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.0234575
PFN1 profilin 1 0.0234051
RPL12 ribosomal protein L12 0.0233485
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.023308
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0232907
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0232081
NAV1 neuron navigator 1 0.0231886
MIDN midnolin 0.023188
CHD7 chromodomain helicase DNA binding protein 7 0.0231689
ATOSA atos homolog A 0.0231207
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0230138
ARFGEF3 ARFGEF family member 3 0.0229273
ABAT 4-aminobutyrate aminotransferase 0.0229271
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.0228028
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0227507
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.022749
SETD5 SET domain containing 5 0.0226891
TBC1D5 TBC1 domain family, member 5 0.022682
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0226333
CADM1 cell adhesion molecule 1 0.0225614
GPHN gephyrin 0.0225387
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0225337
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0225303
TRIM56 tripartite motif containing 56 0.0223718
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.022293
H3-3B H3.3 histone B 0.0222534
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0222192
RTN3 reticulon 3 0.0222078
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0222066
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0220464
RPL7L1 ribosomal protein L7-like 1 0.0219446
ELP4 elongator acetyltransferase complex subunit 4 0.0218234
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0216147
CCDC170 coiled-coil domain containing 170 0.0214441
AFF1 AF4/FMR2 family, member 1 0.021428
IER3 immediate early response 3 0.0214053
PTPRE protein tyrosine phosphatase, receptor type, E 0.0213938
RSRC1 arginine/serine-rich coiled-coil 1 0.0213937
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0212372
AAK1 AP2 associated kinase 1 0.0211444
ENSA endosulfine alpha 0.0210935
COG5 component of oligomeric golgi complex 5 0.0210681
KRT80 keratin 80, type II 0.0210364
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0210031
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0209648
NSD3 nuclear receptor binding SET domain protein 3 0.0209555
ZHX2 zinc fingers and homeoboxes 2 0.0209429
UGDH UDP-glucose 6-dehydrogenase 0.0208823
CCAR1 cell division cycle and apoptosis regulator 1 0.0207997
NEK1 NIMA-related kinase 1 0.0207321
PLXNB2 plexin B2 0.0207285
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0207211
EIF5 eukaryotic translation initiation factor 5 0.0206699
PLK2 polo-like kinase 2 0.0205847
ZFP36L2 ZFP36 ring finger protein-like 2 0.0205805
MTSS1 metastasis suppressor 1 0.0204928
SLC35D4 solute carrier family 35 member D4 0.020464
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0204574
MAP2K5 mitogen-activated protein kinase kinase 5 0.0203661
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0203118
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0202863
PCLO piccolo presynaptic cytomatrix protein 0.0202827
SSR1 signal sequence receptor, alpha 0.0201686
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.0201455
SCCPDH saccharopine dehydrogenase (putative) 0.020038
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0200317
ZBTB10 zinc finger and BTB domain containing 10 0.0200043
MB21D2 Mab-21 domain containing 2 0.0198808
DOCK4 dedicator of cytokinesis 4 0.0197824
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0197742
BTBD2 BTB (POZ) domain containing 2 0.0196643
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0195952
TRIP12 thyroid hormone receptor interactor 12 0.0195614
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0195317
LOC112694756 uncharaterized LOC112694756 0.0195031
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0194708
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0194265
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0192903
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0192265
MBNL1 muscleblind-like splicing regulator 1 0.0192211
STK4 serine/threonine kinase 4 0.0192197
SPRED2 sprouty-related, EVH1 domain containing 2 0.0191919
MLXIP MLX interacting protein 0.0191749
UBE2H ubiquitin-conjugating enzyme E2H 0.0191365
GIGYF2 GRB10 interacting GYF protein 2 0.0191295
AGFG1 ArfGAP with FG repeats 1 0.0191128
MZT2A mitotic spindle organizing protein 2A 0.0190875
MCL1 myeloid cell leukemia 1 0.0190558
TRIM44 tripartite motif containing 44 0.0190357
SAMD4A sterile alpha motif domain containing 4A 0.0190203
DENND4C DENN/MADD domain containing 4C 0.0189499
TPD52 tumor protein D52 0.0189389
RSF1 remodeling and spacing factor 1 0.0189226
GOLGB1 golgin B1 0.0189099
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0188402
RAD23B RAD23 homolog B (S. cerevisiae) 0.0187556
GLS2 glutaminase 2 (liver, mitochondrial) 0.018729
DCP1A decapping mRNA 1A 0.0187058
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0186832
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0186725
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.0186267
MGLL monoglyceride lipase 0.0185552
COPB1 coatomer protein complex, subunit beta 1 0.0185216
INF2 inverted formin, FH2 and WH2 domain containing 0.0185193
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0184602
KIF2A kinesin heavy chain member 2A 0.018326
SENP5 SUMO1/sentrin specific peptidase 5 0.0183055
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0182668
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0182565
TGFB2 transforming growth factor, beta 2 0.0182345
FGF12 fibroblast growth factor 12 0.0180697
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0180507
SNX29 sorting nexin 29 0.0180403
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0180236
LARP4B La ribonucleoprotein domain family, member 4B 0.0179939
RPS12 ribosomal protein S12 0.0179624
RPL35A ribosomal protein L35a 0.0179039
PCNX1 pecanex 1 0.0178914
RPS11 ribosomal protein S11 0.0178913
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0178603
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.0177886
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0177432
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0177101
ACER2 alkaline ceramidase 2 0.0177022
ANAPC11 anaphase promoting complex subunit 11 0.0176762
BBS9 Bardet-Biedl syndrome 9 0.0176502
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.0176336
KRIT1 KRIT1, ankyrin repeat containing 0.0175964
MORF4L2 mortality factor 4 like 2 0.0175907
CAPN8 calpain 8 0.0175621
CCDC83 coiled-coil domain containing 83 0.0175394
WIPF1 WAS/WASL interacting protein family, member 1 0.0175228
RBBP8 retinoblastoma binding protein 8 0.0174277
FOXO3 forkhead box O3 0.0174137
MED12 mediator complex subunit 12 0.0173678
COPE coatomer protein complex, subunit epsilon 0.0173474
RAB1A RAB1A, member RAS oncogene family 0.0172884
SCAMP2 secretory carrier membrane protein 2 0.0172848
EEA1 early endosome antigen 1 0.0172718
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0172501
TNRC6B trinucleotide repeat containing 6B 0.0172211
COL12A1 collagen, type XII, alpha 1 0.0172034
GLRX3 glutaredoxin 3 0.017167
SH3RF1 SH3 domain containing ring finger 1 0.0171515
GIPC1 GIPC PDZ domain containing family, member 1 0.0171256
PLXDC2 plexin domain containing 2 0.0170963
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0170756
MIDEAS mitotic deacetylase associated SANT domain protein 0.0170675
SYNPO2 synaptopodin 2 0.0170504
MAX MYC associated factor X 0.016971
OAZ1 ornithine decarboxylase antizyme 1 0.016965
PRDX2 peroxiredoxin 2 0.0169556
PCDH9 protocadherin 9 0.0169525
ACBD3 acyl-CoA binding domain containing 3 0.016949
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0169341
PDE8A phosphodiesterase 8A 0.0168713
KDM1A lysine (K)-specific demethylase 1A 0.0168612
TASOR2 transcription activation suppressor family member 2 0.0168567
ANKRD28 ankyrin repeat domain 28 0.0168403
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.0167984
AHCYL2 adenosylhomocysteinase-like 2 0.0167118
MGMT O-6-methylguanine-DNA methyltransferase 0.0167032
SESN2 sestrin 2 0.016661
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0166449
MPZ myelin protein zero 0.0166249
SMAP1 small ArfGAP 1 0.0166165
PFDN5 prefoldin subunit 5 0.0165576
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0164844
BMP7 bone morphogenetic protein 7 0.0164834
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0164321
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0164291
PSEN1 presenilin 1 0.016353
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0163498
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.016329
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.0163005
UBTD2 ubiquitin domain containing 2 0.016289
TPD52L1 tumor protein D52-like 1 0.0162835
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0162558
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0162545
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.016245
ANO6 anoctamin 6 0.0162422
PALLD palladin, cytoskeletal associated protein 0.0162249
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.0161868
UBXN2A UBX domain protein 2A 0.0161508
WDR44 WD repeat domain 44 0.0161443
DRAM1 DNA-damage regulated autophagy modulator 1 0.0160313
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0160233
STX6 syntaxin 6 0.01602
PDIA6 protein disulfide isomerase family A, member 6 0.016014
NCKAP1 NCK-associated protein 1 0.0160108
EFNA5 ephrin-A5 0.015991
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.01597
ADAM17 ADAM metallopeptidase domain 17 0.0159629
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.0159548
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0158982
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0158892
TRIM27 tripartite motif containing 27 0.0158254
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0157758
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0157639
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0157542
RPS15A ribosomal protein S15a 0.0157008
TMEM144 transmembrane protein 144 0.0156957
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0156951
NFIB nuclear factor I/B 0.0156061
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0155956
MARCHF7 membrane associated ring-CH-type finger 7 0.0155935
PICALM phosphatidylinositol binding clathrin assembly protein 0.0155893
RPS27L ribosomal protein S27-like 0.015589
WWC1 WW and C2 domain containing 1 0.0155052
FBXO28 F-box protein 28 0.0154885
OSBPL8 oxysterol binding protein-like 8 0.0154647
VWA8 von Willebrand factor A domain containing 8 0.0154199
WDFY3 WD repeat and FYVE domain containing 3 0.0154194
MAPK6 mitogen-activated protein kinase 6 0.0153934
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.0153879
ABHD12 abhydrolase domain containing 12 0.015356
MTMR3 myotubularin related protein 3 0.0153485
CEP192 centrosomal protein 192kDa 0.015338
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0153165
N4BP2L2 NEDD4 binding protein 2-like 2 0.0152887
TRAPPC9 trafficking protein particle complex 9 0.0152868
RIC1 RAB6A GEF complex partner 1 0.0152619
STK10 serine/threonine kinase 10 0.0152491
TPI1 triosephosphate isomerase 1 0.0152387
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.0152354
REPS1 RALBP1 associated Eps domain containing 1 0.0152348
ANKRD50 ankyrin repeat domain 50 0.015229
TLK1 tousled-like kinase 1 0.0152207
MYO1D myosin ID 0.0152197
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.0152089
UTRN utrophin 0.0151718
COP1 COP1 E3 ubiquitin ligase 0.0151486
WWC2 WW and C2 domain containing 2 0.0150861
ADISSP adipose secreted signaling protein 0.0150464
GTF3A general transcription factor IIIA 0.0150277
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0150237
H2AC6 H2A clustered histone 6 0.0149758
TOM1L2 target of myb1-like 2 (chicken) 0.0149465
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0149459
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0149249
MCC mutated in colorectal cancers 0.014892
ZNF43 zinc finger protein 43 0.0148795
TRAF3 TNF receptor-associated factor 3 0.0148669
PCNX2 pecanex 2 0.0148563
ADGRA3 adhesion G protein-coupled receptor A3 0.0148513
RPL35 ribosomal protein L35 0.0148491
CCDC137 coiled-coil domain containing 137 0.0148481
BLTP1 bridge-like lipid transfer protein family member 1 0.0148136
THRAP3 thyroid hormone receptor associated protein 3 0.0148135
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0148112
ZBTB37 zinc finger and BTB domain containing 37 0.0147748
RFX7 regulatory factor X, 7 0.0147576
DOCK8 dedicator of cytokinesis 8 0.014747
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.0147369
LRRC58 leucine rich repeat containing 58 0.0146498
RPL38 ribosomal protein L38 0.014617
OPHN1 oligophrenin 1 0.0146084
CDK12 cyclin-dependent kinase 12 0.0146073
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.0145972
KRTAP11-1 keratin associated protein 11-1 0.0145932
KIFBP kinesin family binding protein 0.0145789
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0145455
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.0145261
RAB40C RAB40C, member RAS oncogene family 0.014522
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0145065
ITGB4 integrin, beta 4 0.0144753
AXIN1 axin 1 0.0144648
CTNND2 catenin (cadherin-associated protein), delta 2 0.0144631
TBX2 T-box 2 0.0144298
ZNF148 zinc finger protein 148 0.0144228
STK40 serine/threonine kinase 40 0.014407
MACROH2A1 macroH2A.1 histone 0.0143973
CATSPERB catsper channel auxiliary subunit beta 0.0143787
PHAX phosphorylated adaptor for RNA export 0.0142544
SRP72 signal recognition particle 72kDa 0.0142217
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0141952
VGLL4 vestigial-like family member 4 0.0141742
STX16 syntaxin 16 0.0141598
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0141311
FBXO22 F-box protein 22 0.0140596
RAD51C RAD51 paralog C 0.0140523
CD47 CD47 molecule 0.0140468
STK26 serine/threonine protein kinase 26 0.0140375
FMNL2 formin-like 2 0.0140352
CBR4 carbonyl reductase 4 0.0139914
RAD54L2 RAD54-like 2 (S. cerevisiae) 0.0139803
SRFBP1 serum response factor binding protein 1 0.013949
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0139244
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0139153
PARD3 par-3 family cell polarity regulator 0.013905
IRS1 insulin receptor substrate 1 0.013894
RPL4 ribosomal protein L4 0.0138734
CDK8 cyclin-dependent kinase 8 0.0138511
DNM3 dynamin 3 0.0138298
SFPQ splicing factor proline/glutamine-rich 0.0138252
FERMT2 fermitin family member 2 0.0137923
HMGN1 high mobility group nucleosome binding domain 1 0.0137693
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.0137666
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0137534
MCM3AP minichromosome maintenance complex component 3 associated protein 0.0137524
USP42 ubiquitin specific peptidase 42 0.0137511
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.0137503
ADIPOR2 adiponectin receptor 2 0.0137477
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0137468
DGKD diacylglycerol kinase, delta 130kDa 0.0137374
AHI1 Abelson helper integration site 1 0.0137199
LTBP1 latent transforming growth factor beta binding protein 1 0.0136884
PRR14L proline rich 14-like 0.0136659
ALCAM activated leukocyte cell adhesion molecule 0.0136626
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.013659
RPLP2 ribosomal protein, large, P2 0.0136417
IST1 increased sodium tolerance 1 homolog (yeast) 0.013632
ARHGAP12 Rho GTPase activating protein 12 0.0136264
GRAMD1A GRAM domain containing 1A 0.0136257
SHISA9 shisa family member 9 0.0136042
RBM47 RNA binding motif protein 47 0.0135766
SBF2 SET binding factor 2 0.0135573
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0135547
MRPS16 mitochondrial ribosomal protein S16 0.0135509
TMSB4X thymosin beta 4, X-linked 0.0135318
SLIT2 slit homolog 2 (Drosophila) 0.013528
ZFP36L1 ZFP36 ring finger protein-like 1 0.0134956
RYBP RING1 and YY1 binding protein 0.0134896
ADNP activity-dependent neuroprotector homeobox 0.0134752
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.01347
FBXW11 F-box and WD repeat domain containing 11 0.0134525
EEIG1 estrogen-induced osteoclastogenesis regulator 1 0.01343
SRPK2 SRSF protein kinase 2 0.0134213
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.0134205
ATMIN ATM interactor 0.0134187
WAC WW domain containing adaptor with coiled-coil 0.0133721
RMDN1 regulator of microtubule dynamics 1 0.0133686
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0133673
CA2 carbonic anhydrase II 0.0133369
CRACDL CRACD like 0.0133306
GMDS GDP-mannose 4,6-dehydratase 0.0133032
DMTF1 cyclin D binding myb-like transcription factor 1 0.0132691
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0132643
NPAS2 neuronal PAS domain protein 2 0.0131763
PEAK1 pseudopodium-enriched atypical kinase 1 0.0131758
WSB1 WD repeat and SOCS box containing 1 0.0131426
RSL24D1 ribosomal L24 domain containing 1 0.0131142
STYX serine/threonine/tyrosine interacting protein 0.0131104
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.0130606
NIBAN2 niban apoptosis regulator 2 0.0130012
GSN gelsolin 0.012972
ATP5F1E ATP synthase F1 subunit epsilon 0.0128939
NUBPL nucleotide binding protein-like 0.0128917
PCBP2 poly(rC) binding protein 2 0.0128835
PCNP PEST proteolytic signal containing nuclear protein 0.0128804
UBL4A ubiquitin-like 4A 0.0128736
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0128564
TENM3 teneurin transmembrane protein 3 0.0128561
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0128516
ZNF33A zinc finger protein 33A 0.0128378
RPL34 ribosomal protein L34 0.0128342
NOP56 NOP56 ribonucleoprotein 0.0128126
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 0.0128064
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0127294
RNF130 ring finger protein 130 0.0127048
ARMH4 armadillo like helical domain containing 4 0.0126995
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.0126973
ZNF124 zinc finger protein 124 0.012682
LIMK2 LIM domain kinase 2 0.0126471
LRRC41 leucine rich repeat containing 41 0.0126399

decreased expression

Symbol Name Standardized Value
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.211898
WWOX WW domain containing oxidoreductase -0.161587
GFRA1 GDNF family receptor alpha 1 -0.131984
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -0.122227
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0810316
IGFBP5 insulin-like growth factor binding protein 5 -0.0793891
TRIM37 tripartite motif containing 37 -0.0782565
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0768546
ESR1 estrogen receptor 1 -0.0700009
EMP2 epithelial membrane protein 2 -0.0628132
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.059177
MACROD2 MACRO domain containing 2 -0.0584817
NRIP1 nuclear receptor interacting protein 1 -0.0547468
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.053354
EVL Enah/Vasp-like -0.0492477
C1ORF21 chromosome 1 open reading frame 21 -0.0450256
ZFHX3 zinc finger homeobox 3 -0.0442262
PBX3 pre-B-cell leukemia homeobox 3 -0.0435773
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.0435483
ATAD2 ATPase family, AAA domain containing 2 -0.043516
IFI6 interferon, alpha-inducible protein 6 -0.0430821
BCAS1 breast carcinoma amplified sequence 1 -0.0427292
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0425613
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0420859
RAD51B RAD51 paralog B -0.0420028
SULF2 sulfatase 2 -0.0415778
TFF1 trefoil factor 1 -0.0406899
PLEC plectin -0.0404076
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0398402
CNKSR3 CNKSR family member 3 -0.0396706
ADCY1 adenylate cyclase 1 (brain) -0.0396649
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0395913
FAF1 Fas (TNFRSF6) associated factor 1 -0.0392232
IGF1R insulin-like growth factor 1 receptor -0.0391578
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0389891
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0381092
DSCAM Down syndrome cell adhesion molecule -0.037611
STRBP spermatid perinuclear RNA binding protein -0.0375867
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0364178
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0362347
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0360027
SKA2 spindle and kinetochore associated complex subunit 2 -0.0353556
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.034818
SVIL supervillin -0.0348078
GATA3 GATA binding protein 3 -0.0330991
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.0322524
NRCAM neuronal cell adhesion molecule -0.032234
FANCC Fanconi anemia, complementation group C -0.0317572
NRG3 neuregulin 3 -0.0316724
AGR2 anterior gradient 2 -0.0315552
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0309349
FANCA Fanconi anemia, complementation group A -0.0302827
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.029631
CLDN3 claudin 3 -0.0294903
CALR calreticulin -0.0288167
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0287723
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0287549
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.028672
HSPB1 heat shock 27kDa protein 1 -0.0286086
HMCN1 hemicentin 1 -0.0283701
ANLN anillin, actin binding protein -0.0281786
CENPP centromere protein P -0.0281563
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.028054
SYTL4 synaptotagmin-like 4 -0.0280289
FBP1 fructose-1,6-bisphosphatase 1 -0.0279013
RGS3 regulator of G-protein signaling 3 -0.0275019
DCDC2 doublecortin domain containing 2 -0.0274158
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.027191
FLNB filamin B, beta -0.0270334
JARID2 jumonji, AT rich interactive domain 2 -0.026912
NUP155 nucleoporin 155kDa -0.0268769
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.0268719
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0268532
DLC1 DLC1 Rho GTPase activating protein -0.0267396
ELP2 elongator acetyltransferase complex subunit 2 -0.0265615
LMBR1 limb development membrane protein 1 -0.0265392
ADAR adenosine deaminase, RNA-specific -0.0265165
TMEM64 transmembrane protein 64 -0.0264932
STC2 stanniocalcin 2 -0.0263013
MACF1 microtubule-actin crosslinking factor 1 -0.0262355
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.026096
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0260174
HIP1 huntingtin interacting protein 1 -0.0259655
LMNB1 lamin B1 -0.0258898
CLIC4 chloride intracellular channel 4 -0.0258842
TRERF1 transcriptional regulating factor 1 -0.0257321
ACACA acetyl-CoA carboxylase alpha -0.0255059
ZMYND8 zinc finger, MYND-type containing 8 -0.0254487
UGCG UDP-glucose ceramide glucosyltransferase -0.0254077
TMEM150C transmembrane protein 150C -0.0254016
SFXN2 sideroflexin 2 -0.0252352
DHCR7 7-dehydrocholesterol reductase -0.0252113
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0251614
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0250183
CHD6 chromodomain helicase DNA binding protein 6 -0.0248736
TMCC1 transmembrane and coiled-coil domain family 1 -0.0248667
CDK19 cyclin-dependent kinase 19 -0.02475
LAMP2 lysosomal-associated membrane protein 2 -0.024401
STAU1 staufen double-stranded RNA binding protein 1 -0.0243693
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.02431
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0241799
CST3 cystatin C -0.0241503
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0239437
ZNF638 zinc finger protein 638 -0.0238428
MKI67 marker of proliferation Ki-67 -0.0236959
VDAC2 voltage-dependent anion channel 2 -0.0234634
TET3 tet methylcytosine dioxygenase 3 -0.023451
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0231486
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.0229914
ENO1 enolase 1, (alpha) -0.0229364
HLTF helicase-like transcription factor -0.0228895
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0228851
NHSL1 NHS-like 1 -0.0227829
PTPRF protein tyrosine phosphatase, receptor type, F -0.0227325
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0227229
KAZN kazrin, periplakin interacting protein -0.0226627
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0225896
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0225854
NBAS neuroblastoma amplified sequence -0.0225479
HAT1 histone acetyltransferase 1 -0.0225059
MASTL microtubule associated serine/threonine kinase-like -0.0224298
PUM2 pumilio RNA-binding family member 2 -0.0223129
GPATCH8 G patch domain containing 8 -0.0222614
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0221361
TAC4 tachykinin 4 (hemokinin) -0.0220408
BCLAF1 BCL2-associated transcription factor 1 -0.022024
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -0.0219391
RPLP0 ribosomal protein, large, P0 -0.0219314
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0218046
RNF115 ring finger protein 115 -0.0217657
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0217605
ZC3H13 zinc finger CCCH-type containing 13 -0.0217549
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0217125
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0216785
TPM4 tropomyosin 4 -0.0215814
TRPS1 trichorhinophalangeal syndrome I -0.0214822
ERBIN erbb2 interacting protein -0.0214183
CENPF centromere protein F, 350/400kDa -0.0213202
RC3H1 ring finger and CCCH-type domains 1 -0.0212517
CDC27 cell division cycle 27 -0.0209952
ECHDC2 enoyl CoA hydratase domain containing 2 -0.0209847
LTAP1 lipid transport auxiliary protein 1 -0.0207907
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0207423
XBP1 X-box binding protein 1 -0.0206554
PDIA4 protein disulfide isomerase family A, member 4 -0.0206343
RPS29 ribosomal protein S29 -0.0205843
ICA1 islet cell autoantigen 1, 69kDa -0.0205649
RFWD3 ring finger and WD repeat domain 3 -0.0205554
DIAPH1 diaphanous-related formin 1 -0.0205359
PRRC2B proline-rich coiled-coil 2B -0.0204791
STIL SCL/TAL1 interrupting locus -0.0204785
FAM222B family with sequence similarity 222, member B -0.0203798
CD81 CD81 molecule -0.0203719
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0203305
ASCC1 activating signal cointegrator 1 complex subunit 1 -0.0202892
IFI27 interferon, alpha-inducible protein 27 -0.0202776
DST dystonin -0.02021
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0200719
TMPO thymopoietin -0.0200049
RNASEK ribonuclease, RNase K -0.0199654
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0198839
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0198149
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0196789
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0195732
RTF2 replication termination factor 2 -0.0195718
NUP58 nucleoporin 58 -0.0195578
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0195146
TAPBP TAP binding protein (tapasin) -0.0194984
FOXK2 forkhead box K2 -0.0194479
RPS5 ribosomal protein S5 -0.0194331
PCYOX1 prenylcysteine oxidase 1 -0.0193958
GOLGA2 golgin A2 -0.0193803
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0193586
RC3H2 ring finger and CCCH-type domains 2 -0.0193423
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0193369
BAG3 BCL2-associated athanogene 3 -0.0192867
FDPS farnesyl diphosphate synthase -0.0192572
APRT adenine phosphoribosyltransferase -0.0192537
RPL30 ribosomal protein L30 -0.019239
AGO2 argonaute RISC catalytic component 2 -0.0191758
SPINT1 serine peptidase inhibitor, Kunitz type 1 -0.0191706
CSDE1 cold shock domain containing E1, RNA-binding -0.0191403
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0191253
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.019124
KIDINS220 kinase D-interacting substrate, 220kDa -0.0190658
CMIP c-Maf inducing protein -0.0190106
CYBA cytochrome b-245, alpha polypeptide -0.0189735
PARD6B par-6 family cell polarity regulator beta -0.0189573
RB1CC1 RB1-inducible coiled-coil 1 -0.018879
RPL29 ribosomal protein L29 -0.0188293
PRC1 protein regulator of cytokinesis 1 -0.0187821
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0187805
MYB v-myb avian myeloblastosis viral oncogene homolog -0.0186173
GINM1 glycoprotein integral membrane 1 -0.0185912
PRRT3 proline-rich transmembrane protein 3 -0.0185632
TTC28 tetratricopeptide repeat domain 28 -0.0185554
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0185122
NCKAP5 NCK-associated protein 5 -0.0184449
PRKCSH protein kinase C substrate 80K-H -0.0183865
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0183688
SPPL2A signal peptide peptidase like 2A -0.0183677
TMEM165 transmembrane protein 165 -0.0182984
KDM6A lysine (K)-specific demethylase 6A -0.0182961
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0182568
ZBTB4 zinc finger and BTB domain containing 4 -0.0182404
MROH1 maestro heat-like repeat family member 1 -0.0182093
CD151 CD151 molecule (Raph blood group) -0.0181929
HLA-E major histocompatibility complex, class I, E -0.0181674
SPOPL speckle-type POZ protein-like -0.0181415
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0181408
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.018103
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0180868
SPNS1 spinster homolog 1 (Drosophila) -0.0180509
TPM1 tropomyosin 1 (alpha) -0.0180427
TPX2 TPX2, microtubule-associated -0.0179643
FBXO11 F-box protein 11 -0.0179147
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0179068
GRN granulin -0.0178183
LUC7L LUC7-like (S. cerevisiae) -0.0177121
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.0176209
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0174428
TTF2 transcription termination factor, RNA polymerase II -0.01744
PCBP3 poly(rC) binding protein 3 -0.0173683
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0173644
FAM13B family with sequence similarity 13, member B -0.0173609
BMPR1A bone morphogenetic protein receptor, type IA -0.0173426
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0172778
GON4L gon-4-like (C. elegans) -0.0172448
SEC23A Sec23 homolog A (S. cerevisiae) -0.0172222
GLG1 golgi glycoprotein 1 -0.0171658
APOLD1 apolipoprotein L domain containing 1 -0.0171294
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0171287
NCOR1 nuclear receptor corepressor 1 -0.017114
PDLIM7 PDZ and LIM domain 7 (enigma) -0.0171005
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.017065
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.017019
BCAS3 breast carcinoma amplified sequence 3 -0.0169971
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0169954
CCDC47 coiled-coil domain containing 47 -0.0169795
CFDP1 craniofacial development protein 1 -0.016947
NCOA2 nuclear receptor coactivator 2 -0.01693
KIAA0319L KIAA0319-like -0.0169012
NSD2 nuclear receptor binding SET domain protein 2 -0.0168981
MTOR mechanistic target of rapamycin (serine/threonine kinase) -0.0168637
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0168111
LDLR low density lipoprotein receptor -0.0168069
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0167485
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0167449
KCMF1 potassium channel modulatory factor 1 -0.0167239
BCL2L11 BCL2-like 11 (apoptosis facilitator) -0.0167108
POU2F1 POU class 2 homeobox 1 -0.0167022
WASL Wiskott-Aldrich syndrome-like -0.0166896
SUN1 Sad1 and UNC84 domain containing 1 -0.0166726
APOD apolipoprotein D -0.0166432
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0165994
DCPH1 damage control phosphatase 1 -0.016585
RPS28 ribosomal protein S28 -0.016569
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -0.0164695
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0164382
CERS2 ceramide synthase 2 -0.016421
ATRAID all-trans retinoic acid-induced differentiation factor -0.0163853
ESYT1 extended synaptotagmin-like protein 1 -0.0163189
TPR translocated promoter region, nuclear basket protein -0.016255
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0161066
MAPK14 mitogen-activated protein kinase 14 -0.0160447
DNA2 DNA replication helicase/nuclease 2 -0.0160135
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.0159928
BRCA1 breast cancer 1, early onset -0.0159686
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0159563
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0159453
BIRC6 baculoviral IAP repeat containing 6 -0.0159428
SDK1 sidekick cell adhesion molecule 1 -0.0159354
EMCN endomucin -0.0159178
FIGN fidgetin -0.0159024
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0158805
EMC3 ER membrane protein complex subunit 3 -0.0158293
TOP2B topoisomerase (DNA) II beta 180kDa -0.0158291
CKAP5 cytoskeleton associated protein 5 -0.0157371
PRKCE protein kinase C, epsilon -0.0157314
TM9SF3 transmembrane 9 superfamily member 3 -0.0157277
COBL cordon-bleu WH2 repeat protein -0.0157021
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0156623
SECISBP2 SECIS binding protein 2 -0.0156167
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0155879
CNTRL centriolin -0.0154983
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0154165
LRP1B low density lipoprotein receptor-related protein 1B -0.0153461
PRR11 proline rich 11 -0.0152991
FBXL20 F-box and leucine-rich repeat protein 20 -0.0152674
NUP210L nucleoporin 210kDa-like -0.0152059
ICMT isoprenylcysteine carboxyl methyltransferase -0.0151964
POLK polymerase (DNA directed) kappa -0.0151865
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.015149
AOPEP aminopeptidase O (putative) -0.0151473
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0151272
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 -0.0151168
QPCTL glutaminyl-peptide cyclotransferase-like -0.0151055
SOGA1 suppressor of glucose, autophagy associated 1 -0.0151027
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.0150875
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0150622
MCM3 minichromosome maintenance complex component 3 -0.0150568
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0150252
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0150243
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0149312
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -0.0149248
DNASE1 deoxyribonuclease I -0.0149143
TOM1L1 target of myb1 (chicken)-like 1 -0.0148902
NECAB1 N-terminal EF-hand calcium binding protein 1 -0.0148769
HDGF hepatoma-derived growth factor -0.0148612
SEC31A SEC31 homolog A (S. cerevisiae) -0.0148472
KSR2 kinase suppressor of ras 2 -0.0148359
TICRR TOPBP1-interacting checkpoint and replication regulator -0.0148117
CLDN4 claudin 4 -0.014704
JUP junction plakoglobin -0.0146941
PRPF6 pre-mRNA processing factor 6 -0.0146898
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -0.0146782
AFDN afadin, adherens junction formation factor -0.0146641
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.014653
COG7 component of oligomeric golgi complex 7 -0.0146439
SCAPER S-phase cyclin A-associated protein in the ER -0.0145707
PER2 period circadian clock 2 -0.0145571
STXBP4 syntaxin binding protein 4 -0.0145389
RGS6 regulator of G-protein signaling 6 -0.0145205
AKAP1 A kinase (PRKA) anchor protein 1 -0.0145186
SKA3 spindle and kinetochore associated complex subunit 3 -0.0144897
VSIG10 V-set and immunoglobulin domain containing 10 -0.0144152
ARHGAP44 Rho GTPase activating protein 44 -0.0143626
MGME1 mitochondrial genome maintenance exonuclease 1 -0.0143427
MMS22L MMS22-like, DNA repair protein -0.0143285
CLOCK clock circadian regulator -0.0143151
MYH10 myosin, heavy chain 10, non-muscle -0.0142809
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0142275
NUCB1 nucleobindin 1 -0.0142271
TRIR telomerase RNA component interacting RNase -0.0142198
XPO1 exportin 1 -0.0142095
KLHL20 kelch-like family member 20 -0.0141776
GOLPH3L golgi phosphoprotein 3-like -0.0141659
MPDU1 mannose-P-dolichol utilization defect 1 -0.0141347
MRTFB myocardin related transcription factor B -0.0140896
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.0140769
ARHGAP24 Rho GTPase activating protein 24 -0.014023
TUBB tubulin, beta class I -0.0140144
BCAR3 breast cancer anti-estrogen resistance 3 -0.0139934
ATXN7 ataxin 7 -0.0139906
TTC3 tetratricopeptide repeat domain 3 -0.0139783
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.0139475
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0139454
RLF rearranged L-myc fusion -0.0139222
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0139075
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0138937
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0138777
PRKCI protein kinase C, iota -0.0138753
FKBP4 FK506 binding protein 4, 59kDa -0.0138008
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0137895
PERP PERP, TP53 apoptosis effector -0.0137486
RPL18 ribosomal protein L18 -0.0137319
SEC16A SEC16 homolog A (S. cerevisiae) -0.0137206
THOC7 THO complex 7 -0.0137017
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0136926
CLDN7 claudin 7 -0.013691
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.013683
ZDHHC12 zinc finger, DHHC-type containing 12 -0.0136735
FBXL17 F-box and leucine-rich repeat protein 17 -0.0136692
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.01366
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -0.0136544
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0136331
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -0.0135887
RPL37A ribosomal protein L37a -0.0135637
TRA2B transformer 2 beta homolog (Drosophila) -0.0135507
ULK4 unc-51 like kinase 4 -0.0135298
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -0.0135229
SGPP1 sphingosine-1-phosphate phosphatase 1 -0.013507
TM2D1 TM2 domain containing 1 -0.0134838
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0134772
SETX senataxin -0.0134527
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0134522
DEGS2 delta(4)-desaturase, sphingolipid 2 -0.0134489
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0134402
JTB jumping translocation breakpoint -0.0133965
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0133819
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0133733
PNPLA8 patatin-like phospholipase domain containing 8 -0.0133653
BICRAL BICRA like chromatin remodeling complex associated protein -0.0133559
ATE1 arginyltransferase 1 -0.013349
METTL16 methyltransferase like 16 -0.0133262
NRBP1 nuclear receptor binding protein 1 -0.0132714
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -0.0132465
STMN1 stathmin 1 -0.0132022
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0131848
TRIM24 tripartite motif containing 24 -0.013159
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0131573
NUP188 nucleoporin 188kDa -0.0131451
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0131219
TNRC18 trinucleotide repeat containing 18 -0.0131104
CREBBP CREB binding protein -0.0130924
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0130786
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0130642
TCF20 transcription factor 20 (AR1) -0.0130634
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0130614
SPATA13 spermatogenesis associated 13 -0.0130597
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0130433
KIF11 kinesin family member 11 -0.0130293
SCAMP3 secretory carrier membrane protein 3 -0.0130185
TMEM63A transmembrane protein 63A -0.0130082
CPA6 carboxypeptidase A6 -0.0129727
SORT1 sortilin 1 -0.012967
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0129131
TBC1D31 TBC1 domain family, member 31 -0.012898
ACBD6 acyl-CoA binding domain containing 6 -0.0128564
COMMD10 COMM domain containing 10 -0.012839
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -0.0128356
TRAPPC10 trafficking protein particle complex 10 -0.0128282
TRIQK triple QxxK/R motif containing -0.0128235
ERCC3 excision repair cross-complementation group 3 -0.0127967
RAI1 retinoic acid induced 1 -0.0127937
TNRC6A trinucleotide repeat containing 6A -0.0127871
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0127849
IFT122 intraflagellar transport 122 -0.0127786
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.0127664
APP amyloid beta (A4) precursor protein -0.0127543
DOCK7 dedicator of cytokinesis 7 -0.0127306
AKAP11 A kinase (PRKA) anchor protein 11 -0.0127298
ILF2 interleukin enhancer binding factor 2 -0.0127225
PPA2 pyrophosphatase (inorganic) 2 -0.012708
MTBP MDM2 binding protein -0.0127044
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -0.0127005
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.0126778
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.012632
SACK1B scaffolding CK1 anchoring protein B -0.0126279
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0126192
TUBA1C tubulin, alpha 1c -0.012613
ECT2 epithelial cell transforming 2 -0.0125876
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.0125503
XPO6 exportin 6 -0.012544
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0125416
TTC13 tetratricopeptide repeat domain 13 -0.0125303
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -0.012528
LPP LIM domain containing preferred translocation partner in lipoma -0.012494
GLI3 GLI family zinc finger 3 -0.0124812
SQLE squalene epoxidase -0.0124576
SMG5 SMG5 nonsense mediated mRNA decay factor -0.0124275
RPS14 ribosomal protein S14 -0.0123845
TNK2 tyrosine kinase, non-receptor, 2 -0.0123754
PLCG1 phospholipase C, gamma 1 -0.0123636
CBX3 chromobox homolog 3 -0.0123144
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0123051
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -0.0122784
PBX4 pre-B-cell leukemia homeobox 4 -0.0122363
LCMT1 leucine carboxyl methyltransferase 1 -0.0122207
WDR20 WD repeat domain 20 -0.012216
ADRM1 adhesion regulating molecule 1 -0.0121956
PANK2 pantothenate kinase 2 -0.0121791
ENAH enabled homolog (Drosophila) -0.0121525
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -0.0121429
SYT12 synaptotagmin XII -0.0121398
SRSF4 serine/arginine-rich splicing factor 4 -0.0121225
CKAP4 cytoskeleton-associated protein 4 -0.012109
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -0.0120994
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0120903
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0120877
TM7SF2 transmembrane 7 superfamily member 2 -0.0120779
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 -0.0120673
KANSL2 KAT8 regulatory NSL complex subunit 2 -0.0120671
S100A6 S100 calcium binding protein A6 -0.0120483
AARS1 alanyl-tRNA synthetase 1 -0.0120329
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0120263
DCAKD dephospho-CoA kinase domain containing -0.0119953
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0119943
RPL23A ribosomal protein L23a -0.0119819
DYNC2I2 dynein 2 intermediate chain 2 -0.0119693
TMUB1 transmembrane and ubiquitin-like domain containing 1 -0.0119547
AMBRA1 autophagy/beclin-1 regulator 1 -0.0119533
SLK STE20-like kinase -0.011951
ALMS1 Alstrom syndrome protein 1 -0.0119346
USP49 ubiquitin specific peptidase 49 -0.0119267
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0119145
P4HB prolyl 4-hydroxylase, beta polypeptide -0.011911
BLTP3B bridge-like lipid transfer protein family member 3B -0.0118998
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0118755
ENTREP1 endosomal transmembrane epsin interactor 1 -0.0118702
NME3 NME/NM23 nucleoside diphosphate kinase 3 -0.0118507
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0118224
BCL7A B-cell CLL/lymphoma 7A -0.0118169
EPB41 erythrocyte membrane protein band 4.1 -0.0118118
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -0.0118116
DESI2 desumoylating isopeptidase 2 -0.0118078
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0118071
AKAP13 A kinase (PRKA) anchor protein 13 -0.0118012
SHARPIN SHANK-associated RH domain interactor -0.0117978
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.011793
SON SON DNA binding protein -0.0117822
EDC3 enhancer of mRNA decapping 3 -0.0117661
TATDN1 TatD DNase domain containing 1 -0.0117639
DEPDC1B DEP domain containing 1B -0.0117529
COPS9 COP9 signalosome subunit 9 -0.0117514
SAMD1 sterile alpha motif domain containing 1 -0.0117348
ARL3 ADP-ribosylation factor-like 3 -0.011727
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 -0.0117219
UBN1 ubinuclein 1 -0.011706
TRA2A transformer 2 alpha homolog (Drosophila) -0.0117059