MCF7_SNS-314 Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 10nM perturbation in MCF7 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the MCF7_SNS-314 Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.256734
SYTL2 synaptotagmin-like 2 0.2134
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.140952
DSPP dentin sialophosphoprotein 0.120303
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.110818
GREB1 growth regulation by estrogen in breast cancer 1 0.105886
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.090279
PTPRK protein tyrosine phosphatase, receptor type, K 0.0885241
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0817036
IFI6 interferon, alpha-inducible protein 6 0.0798754
TFF1 trefoil factor 1 0.0719575
IGF1R insulin-like growth factor 1 receptor 0.0688763
SEPTIN9 septin 9 0.0666181
ZMYND8 zinc finger, MYND-type containing 8 0.0654144
RPL12 ribosomal protein L12 0.0649276
NEBL nebulette 0.0616898
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0584139
ASCC3 activating signal cointegrator 1 complex subunit 3 0.056488
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.054509
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0530587
TRPS1 trichorhinophalangeal syndrome I 0.0521607
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0514406
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0512961
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0507588
EXOC4 exocyst complex component 4 0.0502815
PRICKLE2 prickle homolog 2 (Drosophila) 0.0490751
ADNP activity-dependent neuroprotector homeobox 0.0483251
CALCR calcitonin receptor 0.047216
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0471922
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0456728
SMAD3 SMAD family member 3 0.0449364
PTPRG protein tyrosine phosphatase, receptor type, G 0.044281
RPS6 ribosomal protein S6 0.0434791
UBE2H ubiquitin-conjugating enzyme E2H 0.0434044
SMIM14 small integral membrane protein 14 0.0421494
TMEM164 transmembrane protein 164 0.04162
NSD1 nuclear receptor binding SET domain protein 1 0.0412622
H3-3B H3.3 histone B 0.0396786
RPS8 ribosomal protein S8 0.0396407
MED13 mediator complex subunit 13 0.0386844
TSC22D2 TSC22 domain family, member 2 0.0386391
KIAA1217 KIAA1217 0.0378593
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0377422
ABAT 4-aminobutyrate aminotransferase 0.0375789
NRIP1 nuclear receptor interacting protein 1 0.0374316
MALRD1 MAM and LDL receptor class A domain containing 1 0.0372317
TTC3 tetratricopeptide repeat domain 3 0.0364546
SYT1 synaptotagmin I 0.0364492
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0361554
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0359051
ARL15 ADP-ribosylation factor-like 15 0.0356903
MED13L mediator complex subunit 13-like 0.0355199
DNMBP dynamin binding protein 0.0352244
NCOA3 nuclear receptor coactivator 3 0.0339632
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0339482
FGF13 fibroblast growth factor 13 0.0338113
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0337113
CSDE1 cold shock domain containing E1, RNA-binding 0.0334533
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0330768
LMBR1 limb development membrane protein 1 0.0330305
SLTM SAFB-like, transcription modulator 0.0327676
IGSF1 immunoglobulin superfamily, member 1 0.0326609
PKN2 protein kinase N2 0.032237
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0320085
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0313242
NFIB nuclear factor I/B 0.031283
RPS2 ribosomal protein S2 0.0311271
AMBRA1 autophagy/beclin-1 regulator 1 0.0310967
EVL Enah/Vasp-like 0.0309732
TOM1L2 target of myb1-like 2 (chicken) 0.0309192
MRPL13 mitochondrial ribosomal protein L13 0.0308439
GSE1 Gse1 coiled-coil protein 0.0304256
MACC1 metastasis associated in colon cancer 1 0.0304014
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0301785
PDLIM5 PDZ and LIM domain 5 0.0301682
DDB2 damage-specific DNA binding protein 2, 48kDa 0.030006
TBC1D5 TBC1 domain family, member 5 0.0297217
CTSD cathepsin D 0.0296929
GSK3B glycogen synthase kinase 3 beta 0.0295344
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0293736
NBEAL1 neurobeachin-like 1 0.0293355
BRWD1 bromodomain and WD repeat domain containing 1 0.0292972
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0292898
SLX4IP SLX4 interacting protein 0.0289214
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0289097
DENND1A DENN/MADD domain containing 1A 0.0287545
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0285002
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0284857
ABI2 abl-interactor 2 0.0284194
PSD3 pleckstrin and Sec7 domain containing 3 0.0281811
ADIPOR2 adiponectin receptor 2 0.0281256
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.027685
PRKX protein kinase, X-linked 0.0275893
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0275773
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0275325
TXNIP thioredoxin interacting protein 0.0275014
BCL2 B-cell CLL/lymphoma 2 0.0274426
BCAS1 breast carcinoma amplified sequence 1 0.0273815
N4BP2L2 NEDD4 binding protein 2-like 2 0.0271228
ACBD6 acyl-CoA binding domain containing 6 0.0271184
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0271132
SPNS1 spinster homolog 1 (Drosophila) 0.0269397
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0269299
RUNX1 runt-related transcription factor 1 0.0267529
S100A11 S100 calcium binding protein A11 0.0266036
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0264914
TPD52 tumor protein D52 0.0262175
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0261528
PHF21A PHD finger protein 21A 0.0261319
ITPRID2 ITPR interacting domain containing 2 0.0259278
ARSD arylsulfatase D 0.0256834
MCC mutated in colorectal cancers 0.0255237
ZNF217 zinc finger protein 217 0.0253691
ABLIM1 actin binding LIM protein 1 0.0252966
RPL30 ribosomal protein L30 0.0250712
AREG amphiregulin 0.0246076
TRAPPC9 trafficking protein particle complex 9 0.0245029
RGS6 regulator of G-protein signaling 6 0.0243866
FOXA1 forkhead box A1 0.0243503
MTSS1 metastasis suppressor 1 0.0241474
GOLGB1 golgin B1 0.0240915
RPS20 ribosomal protein S20 0.0239966
BMP7 bone morphogenetic protein 7 0.0239809
DST dystonin 0.0237507
TOP2B topoisomerase (DNA) II beta 180kDa 0.0237139
CLTC clathrin, heavy chain (Hc) 0.0235206
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0233858
HELZ helicase with zinc finger 0.0232381
MBNL3 muscleblind-like splicing regulator 3 0.0230224
RPL5 ribosomal protein L5 0.0229824
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0228438
RPS14 ribosomal protein S14 0.022772
KTN1 kinectin 1 (kinesin receptor) 0.0227152
ARHGAP12 Rho GTPase activating protein 12 0.0227082
CST3 cystatin C 0.0225536
EEF2 eukaryotic translation elongation factor 2 0.022552
SYT12 synaptotagmin XII 0.0225064
ZNF106 zinc finger protein 106 0.0224463
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0223822
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0222286
DICER1 dicer 1, ribonuclease type III 0.022105
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0220297
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.021875
MREG melanoregulin 0.0218423
SFXN1 sideroflexin 1 0.0218378
HIP1 huntingtin interacting protein 1 0.0218226
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0217546
RAB7A RAB7A, member RAS oncogene family 0.0217305
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0216429
ADGRG6 adhesion G protein-coupled receptor G6 0.0216172
S100A10 S100 calcium binding protein A10 0.0214904
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0214695
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0213824
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0213435
RFX7 regulatory factor X, 7 0.0213201
CUX1 cut-like homeobox 1 0.021166
RSF1 remodeling and spacing factor 1 0.0211653
SP3 Sp3 transcription factor 0.0211471
DPH6 diphthamine biosynthesis 6 0.0211151
SECISBP2L SECIS binding protein 2-like 0.0210934
FAM193A family with sequence similarity 193, member A 0.0210748
MAST4 microtubule associated serine/threonine kinase family member 4 0.0210687
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0210548
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0210308
AFF4 AF4/FMR2 family, member 4 0.02102
WDR43 WD repeat domain 43 0.0208826
RPL37A ribosomal protein L37a 0.0208679
SPRED2 sprouty-related, EVH1 domain containing 2 0.0208174
POLH polymerase (DNA directed), eta 0.020738
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0206562
PCNX1 pecanex 1 0.0206543
CERS6 ceramide synthase 6 0.0206509
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0206404
SOS2 son of sevenless homolog 2 (Drosophila) 0.0205844
HIPK1 homeodomain interacting protein kinase 1 0.0205557
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.020505
TMEM144 transmembrane protein 144 0.0204659
ANKRD11 ankyrin repeat domain 11 0.0203221
CPT1A carnitine palmitoyltransferase 1A (liver) 0.0202801
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0201551
NAV2 neuron navigator 2 0.0200911
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0200491
NIPBL Nipped-B homolog (Drosophila) 0.0199809
COP1 COP1 E3 ubiquitin ligase 0.019905
TAPBP TAP binding protein (tapasin) 0.0198292
DSCAM Down syndrome cell adhesion molecule 0.0198164
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0197377
IVD isovaleryl-CoA dehydrogenase 0.0197202
MED12L mediator complex subunit 12-like 0.0196123
PHACTR2 phosphatase and actin regulator 2 0.0195622
FOXP1 forkhead box P1 0.0195253
CAPN8 calpain 8 0.0194555
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0194434
PALLD palladin, cytoskeletal associated protein 0.0193576
HIPK2 homeodomain interacting protein kinase 2 0.0193506
NCKAP5 NCK-associated protein 5 0.0192875
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0192609
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0192259
CATSPERB catsper channel auxiliary subunit beta 0.0192149
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0190661
DENND4C DENN/MADD domain containing 4C 0.0190023
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0189992
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0189529
NXNL2 nucleoredoxin-like 2 0.0189118
XBP1 X-box binding protein 1 0.0188186
GPHN gephyrin 0.0187728
ARID1A AT rich interactive domain 1A (SWI-like) 0.0187623
IST1 increased sodium tolerance 1 homolog (yeast) 0.0187409
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0187271
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0187204
RREB1 ras responsive element binding protein 1 0.0186736
RAB21 RAB21, member RAS oncogene family 0.018655
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0185253
GDF15 growth differentiation factor 15 0.0184709
ARTN artemin 0.0184316
FOXO1 forkhead box O1 0.0184185
PKP4 plakophilin 4 0.0184033
IKBIP IKBKB interacting protein 0.0183946
RPS29 ribosomal protein S29 0.018336
LRP10 low density lipoprotein receptor-related protein 10 0.0182814
RAB1A RAB1A, member RAS oncogene family 0.0181969
MYB v-myb avian myeloblastosis viral oncogene homolog 0.0181784
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0181419
NCEH1 neutral cholesterol ester hydrolase 1 0.0181384
MAML3 mastermind-like 3 (Drosophila) 0.0181005
RNF130 ring finger protein 130 0.0180846
REST RE1-silencing transcription factor 0.0180822
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.0180263
FRAS1 Fraser extracellular matrix complex subunit 1 0.017902
RPL14 ribosomal protein L14 0.0178718
BBX bobby sox homolog (Drosophila) 0.017815
SUCO SUN domain containing ossification factor 0.0177348
NELFA negative elongation factor complex member A 0.0177205
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0177135
CADM1 cell adhesion molecule 1 0.0176735
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0176694
TMEM64 transmembrane protein 64 0.017664
KAZN kazrin, periplakin interacting protein 0.0176458
SMAD5 SMAD family member 5 0.0176407
CBR4 carbonyl reductase 4 0.017639
HIPK3 homeodomain interacting protein kinase 3 0.0175928
RPS3A ribosomal protein S3A 0.0175919
ACTN4 actinin, alpha 4 0.0175673
CELF1 CUGBP, Elav-like family member 1 0.0175363
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0175359
PRDM4 PR domain containing 4 0.0175336
STK38 serine/threonine kinase 38 0.0174982
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0174778
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0174128
IQANK1 IQ motif and ankyrin repeat containing 1 0.0174114
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0173639
ATXN3 ataxin 3 0.0173344
DENND5A DENN/MADD domain containing 5A 0.0173021
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0172774
CXXC5 CXXC finger protein 5 0.0172625
GFUS GDP-L-fucose synthase 0.0171981
SQLE squalene epoxidase 0.0171383
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0171206
RMDN1 regulator of microtubule dynamics 1 0.0171155
FOXO3 forkhead box O3 0.0170866
STX8 syntaxin 8 0.017079
MAP2K5 mitogen-activated protein kinase kinase 5 0.0170762
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0170117
TM7SF3 transmembrane 7 superfamily member 3 0.0169888
DEK DEK proto-oncogene 0.0169822
CLTB clathrin, light chain B 0.0169475
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0169128
TRIM56 tripartite motif containing 56 0.0168865
FTL ferritin, light polypeptide 0.016868
RPL13A ribosomal protein L13a 0.0168361
KMT2C lysine (K)-specific methyltransferase 2C 0.0168259
WWC3 WWC family member 3 0.0167852
MGLL monoglyceride lipase 0.0167498
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0167443
RPL18 ribosomal protein L18 0.0167398
EPS8L2 EPS8-like 2 0.0167332
WASHC4 WASH complex subunit 4 0.0166836
TBC1D4 TBC1 domain family, member 4 0.0166803
MAVS mitochondrial antiviral signaling protein 0.0166229
ATXN1 ataxin 1 0.0165532
RPS27 ribosomal protein S27 0.0165383
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0165212
CCSER1 coiled-coil serine-rich protein 1 0.0165209
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0164726
PCLO piccolo presynaptic cytomatrix protein 0.0164711
YBX3 Y box binding protein 3 0.0164659
CLASP2 cytoplasmic linker associated protein 2 0.0164658
ITGB5 integrin, beta 5 0.0164497
AKAP9 A kinase (PRKA) anchor protein 9 0.0164353
SCFD1 sec1 family domain containing 1 0.0164191
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0163471
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0163396
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0162767
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0162597
PARK7 parkinson protein 7 0.016231
NBAS neuroblastoma amplified sequence 0.0162123
RAB31 RAB31, member RAS oncogene family 0.0162083
THADA thyroid adenoma associated 0.016196
APOD apolipoprotein D 0.0160829
CCDC6 coiled-coil domain containing 6 0.0160123
BCL9L B-cell CLL/lymphoma 9-like 0.0159957
RPS23 ribosomal protein S23 0.0159948
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.0159866
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0159705
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.0159443
OSBPL9 oxysterol binding protein-like 9 0.0159121
TPT1 tumor protein, translationally-controlled 1 0.015788
UBE3A ubiquitin protein ligase E3A 0.0157842
AFF1 AF4/FMR2 family, member 1 0.0157591
PFDN4 prefoldin subunit 4 0.0157535
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0157044
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0156803
IER3 immediate early response 3 0.0155787
PHF12 PHD finger protein 12 0.015575
COPA coatomer protein complex, subunit alpha 0.015512
ATP11C ATPase, class VI, type 11C 0.0155114
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0155012
RARA retinoic acid receptor, alpha 0.0154771
PTBP3 polypyrimidine tract binding protein 3 0.0154766
NCKAP1 NCK-associated protein 1 0.0154375
AURKAIP1 aurora kinase A interacting protein 1 0.0154035
USP15 ubiquitin specific peptidase 15 0.0153985
TLK2 tousled-like kinase 2 0.0153873
NRF1 nuclear respiratory factor 1 0.0153767
NFE2L2 nuclear factor, erythroid 2-like 2 0.0153764
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.015376
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0153564
TNRC6B trinucleotide repeat containing 6B 0.015356
USP48 ubiquitin specific peptidase 48 0.0153435
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0153097
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0152981
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0152454
ARHGAP32 Rho GTPase activating protein 32 0.0152121
ACER2 alkaline ceramidase 2 0.0151559
APTX aprataxin 0.0151392
EIF4B eukaryotic translation initiation factor 4B 0.0151238
TET2 tet methylcytosine dioxygenase 2 0.0151196
IFI27 interferon, alpha-inducible protein 27 0.0150971
TRIM33 tripartite motif containing 33 0.0150836
EP300 E1A binding protein p300 0.0150449
MAGED1 melanoma antigen family D1 0.0150423
GLCCI1 glucocorticoid induced 1 0.0150337
BMERB1 bMERB domain containing 1 0.0150118
BMP2K BMP2 inducible kinase 0.0149961
ULK2 unc-51 like autophagy activating kinase 2 0.0149872
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0149756
LCOR ligand dependent nuclear receptor corepressor 0.0149621
RC3H1 ring finger and CCCH-type domains 1 0.0149521
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0149437
SRPK2 SRSF protein kinase 2 0.0149426
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0148809
MYL12B myosin, light chain 12B, regulatory 0.0148767
WDPCP WD repeat containing planar cell polarity effector 0.0148681
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0148587
FBXO22 F-box protein 22 0.0148587
RHOD ras homolog family member D 0.0148316
KLHDC10 kelch domain containing 10 0.0147896
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0147347
MON2 MON2 homolog (S. cerevisiae) 0.0147225
RNF115 ring finger protein 115 0.0147192
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0147166
KYNU kynureninase 0.0147029
SAMD12 sterile alpha motif domain containing 12 0.0147016
PHPT1 phosphohistidine phosphatase 1 0.0146907
IDS iduronate 2-sulfatase 0.0146885
TCF12 transcription factor 12 0.0146773
CROT carnitine O-octanoyltransferase 0.0146663
MYO10 myosin X 0.0146306
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0146281
FHIT fragile histidine triad 0.0146063
YY1 YY1 transcription factor 0.0145893
DTNB dystrobrevin, beta 0.0145709
SET SET nuclear proto-oncogene 0.0145662
METAP2 methionyl aminopeptidase 2 0.0145575
SETX senataxin 0.0145262
INTS14 integrator complex subunit 14 0.0145174
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.0144736
AOPEP aminopeptidase O (putative) 0.0144725
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 0.0144586
INTS2 integrator complex subunit 2 0.0144234
ARHGAP24 Rho GTPase activating protein 24 0.0144221
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0143875
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0142984
SH3KBP1 SH3-domain kinase binding protein 1 0.0142656
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0142326
ACYP2 acylphosphatase 2, muscle type 0.0142005
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.014179
UBE4B ubiquitination factor E4B 0.0141662
TASOR2 transcription activation suppressor family member 2 0.0141626
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0141254
SERF2 small EDRK-rich factor 2 0.0141245
WASF2 WAS protein family, member 2 0.0140967
LURAP1L leucine rich adaptor protein 1-like 0.0140863
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0140098
FGF12 fibroblast growth factor 12 0.0139554
ENSA endosulfine alpha 0.0139328
PGR progesterone receptor 0.0138614
EML4 echinoderm microtubule associated protein like 4 0.0138286
RPL32 ribosomal protein L32 0.0138132
CLOCK clock circadian regulator 0.0138014
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0137635
WASL Wiskott-Aldrich syndrome-like 0.0137595
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0137318
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0137108
KIAA1328 KIAA1328 0.0137066
SLC39A9 solute carrier family 39, member 9 0.0136972
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.0136722
GLRA3 glycine receptor, alpha 3 0.013637
TSC22D1 TSC22 domain family, member 1 0.0136275
TJP1 tight junction protein 1 0.0136216
ANKRD50 ankyrin repeat domain 50 0.0136152
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.0135659
MYOF myoferlin 0.0135424
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.0135209
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0135144
PDCD6IP programmed cell death 6 interacting protein 0.0134812
SEC62 SEC62 homolog (S. cerevisiae) 0.0134758
SPATS2 spermatogenesis associated, serine-rich 2 0.0134345
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0134253
LRRC58 leucine rich repeat containing 58 0.0134104
PCYOX1 prenylcysteine oxidase 1 0.0133372
RPL35 ribosomal protein L35 0.0133202
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0133038
GFOD2 glucose-fructose oxidoreductase domain containing 2 0.0132782
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.013266
TMEM120B transmembrane protein 120B 0.0132624
NLN neurolysin (metallopeptidase M3 family) 0.0132294
RETREG3 reticulophagy regulator family member 3 0.0132142
ZNF138 zinc finger protein 138 0.013214
ATRN attractin 0.0132105
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.0131862
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0131782
RPSA ribosomal protein SA 0.0131746
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0131732
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0131632
FEM1B fem-1 homolog b (C. elegans) 0.0131551
KMT2A lysine (K)-specific methyltransferase 2A 0.0131295
CMYA5 cardiomyopathy associated 5 0.0131186
PAIP2 poly(A) binding protein interacting protein 2 0.0131024
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0130901
TEX14 testis expressed 14 0.0130862
GTF2I general transcription factor IIi 0.0130711
MAN2A1 mannosidase, alpha, class 2A, member 1 0.013066
CRYL1 crystallin, lambda 1 0.0130312
C6ORF62 chromosome 6 open reading frame 62 0.0130154
HMGN1 high mobility group nucleosome binding domain 1 0.0129938
RPLP1 ribosomal protein, large, P1 0.0129826
THBS1 thrombospondin 1 0.0129548
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.012923
HSDL2 hydroxysteroid dehydrogenase like 2 0.0129139
DOCK6 dedicator of cytokinesis 6 0.012878
NCOA4 nuclear receptor coactivator 4 0.0128751
MYO1E myosin IE 0.0128533
SYTL5 synaptotagmin-like 5 0.012844
IARS1 isoleucyl-tRNA synthetase 1 0.0128383
CHD8 chromodomain helicase DNA binding protein 8 0.0128314
ATXN7 ataxin 7 0.0128175
BCLAF3 BCLAF1 and THRAP3 family member 3 0.0128135
ITM2B integral membrane protein 2B 0.0128105
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0128098
POMT2 protein-O-mannosyltransferase 2 0.0127906
ASTN2 astrotactin 2 0.012787
MICU2 mitochondrial calcium uptake 2 0.012776
IQSEC2 IQ motif and Sec7 domain 2 0.0127099
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.0127083
COMMD10 COMM domain containing 10 0.0126995
ZCCHC10 zinc finger, CCHC domain containing 10 0.0126812
NEK7 NIMA-related kinase 7 0.0126356
RPL19 ribosomal protein L19 0.0126257
DPY19L4 dpy-19-like 4 (C. elegans) 0.0126126
GLB1 galactosidase, beta 1 0.0126097
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0126061
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0126005
PERP PERP, TP53 apoptosis effector 0.0125997
FBXL17 F-box and leucine-rich repeat protein 17 0.0125803
RPL37 ribosomal protein L37 0.0125758
ZCCHC7 zinc finger, CCHC domain containing 7 0.0125744
JADE3 jade family PHD finger 3 0.0125652
SESN2 sestrin 2 0.0125534
ECE1 endothelin converting enzyme 1 0.0125276
RABGAP1L RAB GTPase activating protein 1-like 0.0124964
SESN1 sestrin 1 0.0124683
XRRA1 X-ray radiation resistance associated 1 0.0124659
MACROH2A1 macroH2A.1 histone 0.0124647
THEM4 thioesterase superfamily member 4 0.012451
IFT88 intraflagellar transport 88 0.01245
CLSTN2 calsyntenin 2 0.0124392
PBX1 pre-B-cell leukemia homeobox 1 0.0124304
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0124115
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0123621
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.0123043
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0122963
PAPOLA poly(A) polymerase alpha 0.0122957
ANKRD13D ankyrin repeat domain 13 family, member D 0.0122728
PDE4D phosphodiesterase 4D, cAMP-specific 0.0122626
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0122306
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0122249
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 0.0122237
COL12A1 collagen, type XII, alpha 1 0.0122198
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.0122181

decreased expression

Symbol Name Standardized Value
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.188302
BCAS3 breast carcinoma amplified sequence 3 -0.12803
WWOX WW domain containing oxidoreductase -0.117191
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.107584
KRT18 keratin 18, type I -0.103593
IGFBP5 insulin-like growth factor binding protein 5 -0.0836213
GATA3 GATA binding protein 3 -0.0827802
HSPB1 heat shock 27kDa protein 1 -0.0773796
GFRA1 GDNF family receptor alpha 1 -0.0736207
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0733632
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0705261
MKI67 marker of proliferation Ki-67 -0.0679838
PKM pyruvate kinase, muscle -0.0670734
ATAD2 ATPase family, AAA domain containing 2 -0.0601957
TPM4 tropomyosin 4 -0.0591937
GRHL2 grainyhead-like 2 (Drosophila) -0.0590538
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0578154
PARD6B par-6 family cell polarity regulator beta -0.0543341
VMP1 vacuole membrane protein 1 -0.0527446
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0479663
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.047684
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0471583
TNRC18 trinucleotide repeat containing 18 -0.0462944
RTN3 reticulon 3 -0.0452895
KRT8 keratin 8, type II -0.0452716
PRR11 proline rich 11 -0.0419483
NRCAM neuronal cell adhesion molecule -0.041942
CNKSR3 CNKSR family member 3 -0.0415472
ESR1 estrogen receptor 1 -0.0415038
BSG basigin (Ok blood group) -0.0402221
EMP2 epithelial membrane protein 2 -0.0395596
CLIC4 chloride intracellular channel 4 -0.0381441
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0378544
FLNA filamin A, alpha -0.0373171
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0367332
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.036719
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0363155
CYRIB CYFIP related Rac1 interactor B -0.0362694
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0359989
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0358816
ATXN2 ataxin 2 -0.0354493
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0353611
DHDDS dehydrodolichyl diphosphate synthase -0.0347454
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0343202
SMC4 structural maintenance of chromosomes 4 -0.0342387
RNF216 ring finger protein 216 -0.0342047
LDLR low density lipoprotein receptor -0.0337918
SACK1B scaffolding CK1 anchoring protein B -0.0336308
SKA2 spindle and kinetochore associated complex subunit 2 -0.0329877
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0328993
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0328832
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0328822
RFWD3 ring finger and WD repeat domain 3 -0.0328762
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0323948
ADCY1 adenylate cyclase 1 (brain) -0.0323546
DOCK1 dedicator of cytokinesis 1 -0.032253
PARD3 par-3 family cell polarity regulator -0.0321372
MACROD2 MACRO domain containing 2 -0.0320632
PLEC plectin -0.0320421
PRRC2B proline-rich coiled-coil 2B -0.0316539
POTEF POTE ankyrin domain family, member F -0.0312684
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0307767
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0307658
COX6C cytochrome c oxidase subunit VIc -0.030566
ENO1 enolase 1, (alpha) -0.0303898
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0299996
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0297374
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -0.0293013
LUC7L LUC7-like (S. cerevisiae) -0.0286685
NRG3 neuregulin 3 -0.0285265
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0278089
ADCY9 adenylate cyclase 9 -0.0278003
TUBD1 tubulin, delta 1 -0.0275828
RAD9A RAD9 homolog A (S. pombe) -0.0275766
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0272772
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0270994
FAF1 Fas (TNFRSF6) associated factor 1 -0.027044
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0269824
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0269562
LMNA lamin A/C -0.0269122
TENM3 teneurin transmembrane protein 3 -0.0268049
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0267407
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0265012
CLDN3 claudin 3 -0.0264899
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0261302
DNM2 dynamin 2 -0.0260512
CD9 CD9 molecule -0.0259819
SIN3A SIN3 transcription regulator family member A -0.0256085
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0254235
HM13 histocompatibility (minor) 13 -0.0254046
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0254013
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0253587
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.025264
TUBA1B tubulin, alpha 1b -0.0251175
TPX2 TPX2, microtubule-associated -0.0249039
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0246546
DHCR7 7-dehydrocholesterol reductase -0.0245532
LOC112694756 uncharaterized LOC112694756 -0.0241544
TPD52L1 tumor protein D52-like 1 -0.0238311
FLNB filamin B, beta -0.023816
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0236731
CAPNS1 calpain, small subunit 1 -0.0235979
NHSL1 NHS-like 1 -0.0235393
THEM6 thioesterase superfamily member 6 -0.0235199
SVIL supervillin -0.0235105
NCOR2 nuclear receptor corepressor 2 -0.0234152
LRP1B low density lipoprotein receptor-related protein 1B -0.0233945
PCBP2 poly(rC) binding protein 2 -0.023354
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0233166
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0233044
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -0.0232454
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0231326
SYNGR2 synaptogyrin 2 -0.0229955
TCERG1 transcription elongation regulator 1 -0.0229875
ZFAND3 zinc finger, AN1-type domain 3 -0.0228689
SOGA1 suppressor of glucose, autophagy associated 1 -0.022754
RBM39 RNA binding motif protein 39 -0.022734
KIAA1958 KIAA1958 -0.0225523
PCDH7 protocadherin 7 -0.0225211
DCDC2 doublecortin domain containing 2 -0.0225006
UGDH UDP-glucose 6-dehydrogenase -0.0223853
VDAC2 voltage-dependent anion channel 2 -0.0222623
RPL8 ribosomal protein L8 -0.0220496
TRIM37 tripartite motif containing 37 -0.0218719
PBX3 pre-B-cell leukemia homeobox 3 -0.0218526
RHOBTB3 Rho-related BTB domain containing 3 -0.0217468
GLG1 golgi glycoprotein 1 -0.0217284
ARHGAP35 Rho GTPase activating protein 35 -0.0216722
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0216517
ACACA acetyl-CoA carboxylase alpha -0.0214622
TMSB10 thymosin beta 10 -0.0214474
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0213083
CBX1 chromobox homolog 1 -0.0211782
MIS18BP1 MIS18 binding protein 1 -0.0210029
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0209935
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -0.0209836
RPS28 ribosomal protein S28 -0.0209662
C1ORF21 chromosome 1 open reading frame 21 -0.020958
FAM168B family with sequence similarity 168, member B -0.0208471
SFTPA2 surfactant protein A2 -0.0208186
TPD52L2 tumor protein D52-like 2 -0.0207936
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.0207417
CUEDC1 CUE domain containing 1 -0.0207256
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0207151
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.0206316
ITPKC inositol-trisphosphate 3-kinase C -0.0205074
SFXN2 sideroflexin 2 -0.0204915
MYADM myeloid-associated differentiation marker -0.0203565
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -0.0203495
CCT7 chaperonin containing TCP1, subunit 7 (eta) -0.0202652
CLIC1 chloride intracellular channel 1 -0.0202423
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0202243
UBB ubiquitin B -0.0202
KIAA1671 KIAA1671 -0.0201081
SETD5 SET domain containing 5 -0.020008
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.019947
NUP160 nucleoporin 160kDa -0.0199077
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.0198838
MTOR mechanistic target of rapamycin (serine/threonine kinase) -0.0198662
TPR translocated promoter region, nuclear basket protein -0.0198273
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0197441
SAPCD2 suppressor APC domain containing 2 -0.0196845
DNASE1 deoxyribonuclease I -0.0196769
MBNL1 muscleblind-like splicing regulator 1 -0.0196425
MTDH metadherin -0.0196044
FANCI Fanconi anemia, complementation group I -0.0194754
ODF2 outer dense fiber of sperm tails 2 -0.0194487
ARRB1 arrestin, beta 1 -0.0194358
RGS3 regulator of G-protein signaling 3 -0.0194232
ACLY ATP citrate lyase -0.0193374
FCHSD2 FCH and double SH3 domains 2 -0.0193112
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0192747
UBE2M ubiquitin-conjugating enzyme E2M -0.0192401
PUS7 pseudouridylate synthase 7 (putative) -0.019145
PNISR PNN-interacting serine/arginine-rich protein -0.0190441
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0190006
SYNJ2BP synaptojanin 2 binding protein -0.0189714
SUMF2 sulfatase modifying factor 2 -0.0189713
TTF2 transcription termination factor, RNA polymerase II -0.0189411
MIDEAS mitotic deacetylase associated SANT domain protein -0.0188755
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0188736
USP34 ubiquitin specific peptidase 34 -0.0188416
FDPS farnesyl diphosphate synthase -0.0188336
ATRAID all-trans retinoic acid-induced differentiation factor -0.0187629
KDM3B lysine (K)-specific demethylase 3B -0.0187469
MASTL microtubule associated serine/threonine kinase-like -0.0187133
ERBIN erbb2 interacting protein -0.0186299
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0186228
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -0.0183931
PLXDC2 plexin domain containing 2 -0.0183842
MECOM MDS1 and EVI1 complex locus -0.0183507
BRCA2 breast cancer 2, early onset -0.0183261
PPCDC phosphopantothenoylcysteine decarboxylase -0.0183098
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0183093
EZR ezrin -0.0182512
TPM3 tropomyosin 3 -0.0182473
EEF2K eukaryotic elongation factor 2 kinase -0.0182191
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0182173
NCOA2 nuclear receptor coactivator 2 -0.0182062
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.018205
AVL9 AVL9 homolog (S. cerevisiase) -0.0181531
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -0.0181438
GTF2IRD1 GTF2I repeat domain containing 1 -0.0180977
NCOA6 nuclear receptor coactivator 6 -0.0180513
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0180378
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0180254
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0180147
CIP2A cellular inhibitor of PP2A -0.0180044
SNX8 sorting nexin 8 -0.0179744
CBX5 chromobox homolog 5 -0.0179522
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.017923
FAM13B family with sequence similarity 13, member B -0.0178645
TRIM28 tripartite motif containing 28 -0.0178199
NUP153 nucleoporin 153kDa -0.0178127
FTO fat mass and obesity associated -0.0177935
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.0177543
ANLN anillin, actin binding protein -0.0177091
CLDN7 claudin 7 -0.0176815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0175453
STRBP spermatid perinuclear RNA binding protein -0.0174864
FKBP4 FK506 binding protein 4, 59kDa -0.0173804
PDE7A phosphodiesterase 7A -0.0173758
KDM2B lysine (K)-specific demethylase 2B -0.0173655
RPS25 ribosomal protein S25 -0.0173388
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -0.017294
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0172638
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0172513
PRPF3 pre-mRNA processing factor 3 -0.0172468
SRRM2 serine/arginine repetitive matrix 2 -0.0172395
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0172083
RBL1 retinoblastoma-like 1 -0.0170698
TUBB tubulin, beta class I -0.017024
BRCA1 breast cancer 1, early onset -0.0170089
PRKCI protein kinase C, iota -0.0169795
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0169561
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0169426
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.0169235
TGFB2 transforming growth factor, beta 2 -0.0168228
AZIN1 antizyme inhibitor 1 -0.0167806
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.016626
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0166013
GCN1 GCN1 activator of EIF2AK4 -0.0165928
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0165831
SETD1B SET domain containing 1B -0.0165743
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -0.0165703
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0165357
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0165125
CMIP c-Maf inducing protein -0.016512
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0164031
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0163679
AKAP13 A kinase (PRKA) anchor protein 13 -0.0163421
CCDC57 coiled-coil domain containing 57 -0.0162559
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0162396
ZFHX3 zinc finger homeobox 3 -0.0162291
SAP30BP SAP30 binding protein -0.0161842
CC2D1A coiled-coil and C2 domain containing 1A -0.0161724
BICDL2 BICD family like cargo adaptor 2 -0.0161706
QKI QKI, KH domain containing, RNA binding -0.016126
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0161065
SPDEF SAM pointed domain containing ETS transcription factor -0.0160852
USP25 ubiquitin specific peptidase 25 -0.0160703
HEATR5B HEAT repeat containing 5B -0.0160623
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.0160559
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0160535
INSIG1 insulin induced gene 1 -0.0160222
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.0159651
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0159152
BCAS2 breast carcinoma amplified sequence 2 -0.0159097
AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.0158749
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0158189
GINM1 glycoprotein integral membrane 1 -0.0158026
ZZZ3 zinc finger, ZZ-type containing 3 -0.0157147
ITGAV integrin, alpha V -0.0156811
TBL1X transducin (beta)-like 1X-linked -0.0156741
RPL36A ribosomal protein L36a -0.0156613
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.015661
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0156407
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0156177
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.0156172
LNPEP leucyl/cystinyl aminopeptidase -0.0156157
MPG N-methylpurine-DNA glycosylase -0.0156093
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0155913
ECPAS Ecm29 proteasome adaptor and scaffold -0.0155838
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0155815
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -0.015564
KIF20B kinesin family member 20B -0.0155513
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.015503
FANCA Fanconi anemia, complementation group A -0.015468
POGZ pogo transposable element with ZNF domain -0.0154372
SINHCAF SIN3-HDAC complex associated factor -0.0153797
TPBG trophoblast glycoprotein -0.0153195
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0153127
PER2 period circadian clock 2 -0.0153018
ZNF367 zinc finger protein 367 -0.0152918
LNX2 ligand of numb-protein X 2 -0.0152895
SIK3 SIK family kinase 3 -0.0152197
MZT2B mitotic spindle organizing protein 2B -0.0151505
RPL3 ribosomal protein L3 -0.0151281
NCOR1 nuclear receptor corepressor 1 -0.0151158
BICDL1 BICD family like cargo adaptor 1 -0.0150798
CCDC88C coiled-coil domain containing 88C -0.0150567
NUDC nudC nuclear distribution protein -0.0150531
CAB39 calcium binding protein 39 -0.0149877
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -0.0149659
GATAD2A GATA zinc finger domain containing 2A -0.0149533
ETF1 eukaryotic translation termination factor 1 -0.0149428
DGKH diacylglycerol kinase, eta -0.0149191
PARP1 poly (ADP-ribose) polymerase 1 -0.014812
CPAP centrosome assembly and centriole elongation protein -0.0147937
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0147621
KIF4A kinesin family member 4A -0.0147427
RBBP7 retinoblastoma binding protein 7 -0.0146923
MYO9B myosin IXB -0.014686
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -0.0146658
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0146415
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0146246
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0145939
KIF23 kinesin family member 23 -0.0145835
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -0.0145811
LIN54 lin-54 DREAM MuvB core complex component -0.0145665
TTC19 tetratricopeptide repeat domain 19 -0.0145493
ZNF292 zinc finger protein 292 -0.0144834
OCIAD1 OCIA domain containing 1 -0.0144728
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -0.0144181
SLC35B1 solute carrier family 35, member B1 -0.0144055
CHD1L chromodomain helicase DNA binding protein 1-like -0.0143667
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.014362
ZFR zinc finger RNA binding protein -0.0143441
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0143434
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0143336
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0142655
PLXND1 plexin D1 -0.0142512
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.0142326
QPCTL glutaminyl-peptide cyclotransferase-like -0.0142316
FAF2 Fas associated factor family member 2 -0.0142129
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0141979
MROH1 maestro heat-like repeat family member 1 -0.0141941
AHI1 Abelson helper integration site 1 -0.0141862
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -0.0141789
MYO5B myosin VB -0.0141654
IGSF3 immunoglobulin superfamily, member 3 -0.0141624
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.0141375
SRPK1 SRSF protein kinase 1 -0.0141337
CYBA cytochrome b-245, alpha polypeptide -0.0141296
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0140832
FIGN fidgetin -0.0140719
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0140654
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0140586
MBTD1 mbt domain containing 1 -0.0140452
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0140162
STX5 syntaxin 5 -0.0140014
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0139842
BLTP2 bridge-like lipid transfer protein family member 2 -0.0139836
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0139741
LYPD6B LY6/PLAUR domain containing 6B -0.0139565
CCDC124 coiled-coil domain containing 124 -0.0139531
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.0139329
NINL ninein-like -0.0139079
RPL7A ribosomal protein L7a -0.0139004
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0138554
CLIP1 CAP-GLY domain containing linker protein 1 -0.0138365
TFRC transferrin receptor -0.0137908
TUBB4B tubulin, beta 4B class IVb -0.0137541
ZNF652 zinc finger protein 652 -0.013691
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0136704
CENPF centromere protein F, 350/400kDa -0.0136269
SF3B5 splicing factor 3b, subunit 5, 10kDa -0.0136244
MPHOSPH9 M-phase phosphoprotein 9 -0.0136236
GPC6 glypican 6 -0.0136159
DIAPH3 diaphanous-related formin 3 -0.0136015
MFSD11 major facilitator superfamily domain containing 11 -0.0135972
MCU mitochondrial calcium uniporter -0.0135733
AACS acetoacetyl-CoA synthetase -0.013548
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.0135378
PUM1 pumilio RNA-binding family member 1 -0.0135349
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0135338
HPCAL1 hippocalcin-like 1 -0.0135106
M6PR mannose-6-phosphate receptor (cation dependent) -0.0134961
TMPO thymopoietin -0.013479
ZNRF3 zinc and ring finger 3 -0.0134517
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0134408
GMDS GDP-mannose 4,6-dehydratase -0.0134383
H4C3 H4 clustered histone 3 -0.0134337
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -0.013407
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.01336
MCM3AP minichromosome maintenance complex component 3 associated protein -0.0133494
RAI1 retinoic acid induced 1 -0.0133477
PDLIM7 PDZ and LIM domain 7 (enigma) -0.0133432
STK4 serine/threonine kinase 4 -0.0132907
ZNF331 zinc finger protein 331 -0.0132761
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.0132571
TMEM260 transmembrane protein 260 -0.0132522
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0132199
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.0132117
TBCA tubulin folding cofactor A -0.013199
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.0131814
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0131715
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0131533
ISOC1 isochorismatase domain containing 1 -0.0131433
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0131367
CD63 CD63 molecule -0.0131176
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.0131173
RC3H2 ring finger and CCCH-type domains 2 -0.0131083
TOGARAM1 TOG array regulator of axonemal microtubules 1 -0.0131041
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0130949
FOXK1 forkhead box K1 -0.0130922
ARCN1 archain 1 -0.0130719
DYNC2I2 dynein 2 intermediate chain 2 -0.0130368
MCM6 minichromosome maintenance complex component 6 -0.0130307
SPIDR scaffolding protein involved in DNA repair -0.0130066
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -0.0129828
CLDN4 claudin 4 -0.0129653
MICU1 mitochondrial calcium uptake 1 -0.012955
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0129423
HOOK2 hook microtubule-tethering protein 2 -0.0129373
PDS5A PDS5 cohesin associated factor A -0.0128702
SYCP2 synaptonemal complex protein 2 -0.0128364
USP3 ubiquitin specific peptidase 3 -0.0128056
RCC1 regulator of chromosome condensation 1 -0.0127963
FERMT2 fermitin family member 2 -0.012769
ITPK1 inositol-tetrakisphosphate 1-kinase -0.0127258
CHEK2 checkpoint kinase 2 -0.0127156
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0126795
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0126679
POLK polymerase (DNA directed) kappa -0.0126445
HID1 HID1 domain containing -0.0126215
SYTL4 synaptotagmin-like 4 -0.0126164
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0126138
PRDX5 peroxiredoxin 5 -0.0126085
GPATCH8 G patch domain containing 8 -0.0125905
RASA2 RAS p21 protein activator 2 -0.0125815
NAP1L4 nucleosome assembly protein 1-like 4 -0.0125802
STARD10 StAR-related lipid transfer (START) domain containing 10 -0.0125743
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.0125603
SMC1A structural maintenance of chromosomes 1A -0.0125525
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0125491
ASCC2 activating signal cointegrator 1 complex subunit 2 -0.0125296
PTBP2 polypyrimidine tract binding protein 2 -0.0125122
MAN2C1 mannosidase, alpha, class 2C, member 1 -0.0125072
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -0.0124523
FUS FUS RNA binding protein -0.0124464
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0124392
CGGBP1 CGG triplet repeat binding protein 1 -0.0124266
ALCAM activated leukocyte cell adhesion molecule -0.0124061
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0123932
MTMR3 myotubularin related protein 3 -0.0123728
PRRT3 proline-rich transmembrane protein 3 -0.012372
SLF2 SMC5-SMC6 complex localization factor 2 -0.0123679
SH3GL1 SH3-domain GRB2-like 1 -0.0123632
EGFL7 EGF-like-domain, multiple 7 -0.0123607
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -0.0123591
MXD1 MAX dimerization protein 1 -0.0123544
PCGF6 polycomb group ring finger 6 -0.0123279
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.0123105
LCORL ligand dependent nuclear receptor corepressor-like -0.0122818
PRPF6 pre-mRNA processing factor 6 -0.0122491
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0122177
FASN fatty acid synthase -0.0122115
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0121954
FAM168A family with sequence similarity 168, member A -0.012169
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -0.012163
POLE polymerase (DNA directed), epsilon, catalytic subunit -0.0121524
TCF20 transcription factor 20 (AR1) -0.0121453
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -0.0121418
SENP5 SUMO1/sentrin specific peptidase 5 -0.0121411
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0121378
UQCRC1 ubiquinol-cytochrome c reductase core protein I -0.0121322
LMX1B LIM homeobox transcription factor 1, beta -0.0121077
RBM6 RNA binding motif protein 6 -0.0121059
USP22 ubiquitin specific peptidase 22 -0.0121009
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.0120965
PLPPR2 phospholipid phosphatase related 2 -0.0120858
JPT1 Jupiter microtubule associated homolog 1 -0.0120844
DPEP2 dipeptidase 2 -0.0120811
SREBF2 sterol regulatory element binding transcription factor 2 -0.0120528
PRKCSH protein kinase C substrate 80K-H -0.0120412
PPP1R7 protein phosphatase 1, regulatory subunit 7 -0.0120407
BCAS4 breast carcinoma amplified sequence 4 -0.0120388
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0120101
GPSM2 G-protein signaling modulator 2 -0.0119714
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0119684
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0119598
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -0.0119534
CMC2 C-x(9)-C motif containing 2 -0.0119411
MLXIP MLX interacting protein -0.0119118
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -0.0119113
KIF18B kinesin family member 18B -0.0118871
KIF13A kinesin family member 13A -0.0118831
TTC1 tetratricopeptide repeat domain 1 -0.0118555
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0118543
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -0.0118455
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.0118066
NSD2 nuclear receptor binding SET domain protein 2 -0.0117859
DCP1A decapping mRNA 1A -0.0117827
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.011777
NTN1 netrin 1 -0.011772
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 -0.011768
NPTN neuroplastin -0.0117492
ADPGK ADP-dependent glucokinase -0.0117412
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.01174