MCM3AP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description minichromosome maintenance complex component 3 associated protein|The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 8888)
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27 interacting proteins for MCM3AP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APC adenomatous polyposis coli
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC73 cell division cycle 73
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLSTN1 calsyntenin 1
CRMP1 collapsin response mediator protein 1
ENY2 enhancer of yellow 2 homolog (Drosophila)
EP300 E1A binding protein p300
FAM118B family with sequence similarity 118, member B
LMNA lamin A/C
MCM3 minichromosome maintenance complex component 3
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
PCID2 PCI domain containing 2
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIRT7 sirtuin 7
SMAD3 SMAD family member 3
SMAD9 SMAD family member 9
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TERF2 telomeric repeat binding factor 2
TMEM216 transmembrane protein 216
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
UBC ubiquitin C