MCM8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description minichromosome maintenance complex component 8|The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 84515)
External Link http://www.ncbi.nlm.nih.gov/gene/84515
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29 interacting proteins for MCM8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
CCNA1 cyclin A1
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
FKBP5 FK506 binding protein 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HNF4A hepatocyte nuclear factor 4, alpha
KEAP1 kelch-like ECH-associated protein 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM9 minichromosome maintenance complex component 9
MCMBP minichromosome maintenance complex binding protein
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
RB1 retinoblastoma 1