MCU Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitochondrial calcium uniporter|This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] (NCBI Entrez Gene Database, 90550)
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Genes

336 genes differentially expressed following the MCU gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TREM2 triggering receptor expressed on myeloid cells 2 2.73707
EPB42 erythrocyte membrane protein band 4.2 2.73707
NME8 NME/NM23 family member 8 2.73707
TMEM191B transmembrane protein 191B 2.73707
WT1 Wilms tumor 1 2.73707
PDE7B phosphodiesterase 7B 2.73707
PTH2 parathyroid hormone 2 2.73707
SLC15A5 solute carrier family 15, member 5 2.73707
APOA2 apolipoprotein A-II 2.73707
ASB10 ankyrin repeat and SOCS box containing 10 2.73707
KMT2C lysine (K)-specific methyltransferase 2C 2.73707
GSTM5 glutathione S-transferase mu 5 2.73707
CLEC19A C-type lectin domain family 19, member A 2.73707
COLEC10 collectin sub-family member 10 (C-type lectin) 2.73707
GPR55 G protein-coupled receptor 55 2.73707
GPR52 G protein-coupled receptor 52 2.73707
CABP4 calcium binding protein 4 2.73707
SLC35G6 solute carrier family 35, member G6 2.73707
MBLAC1 metallo-beta-lactamase domain containing 1 2.73707
GLYAT glycine-N-acyltransferase 2.73707
UPB1 ureidopropionase, beta 2.73707
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.73707
RRAD Ras-related associated with diabetes 2.73707
NEU4 sialidase 4 2.73707
MYCT1 myc target 1 2.73707
GIMAP2 GTPase, IMAP family member 2 2.73707
VSX1 visual system homeobox 1 2.73707
CAPS calcyphosine 2.73707
WRAP53 WD repeat containing, antisense to TP53 2.73707
MYO1G myosin IG 2.73707
SP5 Sp5 transcription factor 2.73707
C2ORF78 chromosome 2 open reading frame 78 2.73707
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.73707
PRDM1 PR domain containing 1, with ZNF domain 2.73707
STEAP4 STEAP family member 4 2.73707
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.73707
IL2RA interleukin 2 receptor, alpha 2.73707
TREML2 triggering receptor expressed on myeloid cells-like 2 2.73707
SUSD2 sushi domain containing 2 2.73707
SFTPB surfactant protein B 2.73707
TPSD1 tryptase delta 1 2.73707
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.73707
BHLHE40 basic helix-loop-helix family, member e40 2.73707
DEFB124 defensin, beta 124 2.73707
LRRC10B leucine rich repeat containing 10B 2.73707
MOGAT3 monoacylglycerol O-acyltransferase 3 2.73707
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.73707
KIF2B kinesin family member 2B 2.73707
FAM9B family with sequence similarity 9, member B 2.73707
FGF20 fibroblast growth factor 20 2.73707
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.73707
STMN4 stathmin-like 4 2.73707
FMO2 flavin containing monooxygenase 2 (non-functional) 2.73707
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.73707
ACSL5 acyl-CoA synthetase long-chain family member 5 2.73707
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.73707
NHLH1 nescient helix loop helix 1 2.73707
ASB9 ankyrin repeat and SOCS box containing 9 2.73707
SRPK2 SRSF protein kinase 2 2.73707
DYNLRB2 dynein, light chain, roadblock-type 2 2.73707
F5 coagulation factor V (proaccelerin, labile factor) 2.73707
MGAT4D MGAT4 family, member D 2.73707
ALX4 ALX homeobox 4 2.73707
TEKTL1 tektin like 1 2.73707
LITAFD LITAF domain containing 2.73707
IQCN IQ motif containing N 2.73707
GSTT4 glutathione S-transferase theta 4 2.73707
CCDC187 coiled-coil domain containing 187 2.73707
H1-6 H1.6 linker histone, cluster member 2.73707
SELENOT selenoprotein T 2.73707
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.73707
ALDOB aldolase B, fructose-bisphosphate 2.73707
OTOF otoferlin 2.73707
CSAG3 CSAG family, member 3 2.73707
DYNAP dynactin associated protein 2.73707
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.73707
MAG myelin associated glycoprotein 2.73707
ITK IL2-inducible T-cell kinase 2.73707
SPMAP1 sperm microtubule associated protein 1 2.73707
OASL 2'-5'-oligoadenylate synthetase-like 2.73707
IZUMO4 IZUMO family member 4 2.73707
GRXCR1 glutaredoxin, cysteine rich 1 2.73707
HBA2 hemoglobin, alpha 2 2.73707
OVGP1 oviductal glycoprotein 1, 120kDa 2.73707
HRH1 histamine receptor H1 2.73707
AGTR1 angiotensin II receptor, type 1 2.73707
LIX1 Lix1 homolog (chicken) 2.73707
TMEM235 transmembrane protein 235 2.73707
LRRC71 leucine rich repeat containing 71 2.73707
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.73707
OOSP1 oocyte secreted protein 1, pseudogene 2.73707
S100P S100 calcium binding protein P 2.73707
TCF23 transcription factor 23 2.73707
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.73707
MIA melanoma inhibitory activity 2.73707
DMBX1 diencephalon/mesencephalon homeobox 1 2.73707
SIM2 single-minded family bHLH transcription factor 2 2.73707
TMCO2 transmembrane and coiled-coil domains 2 2.73707
CLEC12A C-type lectin domain family 12, member A 2.73707
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.73707
GPR150 G protein-coupled receptor 150 2.73707
RAD51AP2 RAD51 associated protein 2 2.73707
EFCAB3 EF-hand calcium binding domain 3 2.73707
KLHL1 kelch-like family member 1 2.73707
THTPA thiamine triphosphatase 2.73707
CXCR5 chemokine (C-X-C motif) receptor 5 2.73707
DGCR6 DiGeorge syndrome critical region gene 6 2.73707
PCP2 Purkinje cell protein 2 2.73707
C16ORF78 chromosome 16 open reading frame 78 2.73707
KLHDC1 kelch domain containing 1 2.73707
CASQ2 calsequestrin 2 (cardiac muscle) 2.73707
CASS4 Cas scaffolding protein family member 4 2.73707
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.73707
GOLGA8Q golgin A8 family, member Q 2.73707
PLA2G5 phospholipase A2, group V 2.73707
LRRC46 leucine rich repeat containing 46 2.73707
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.73707
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.73707
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.73707
LCT lactase 2.73707
NMBR neuromedin B receptor 2.73707
MAMLD1 mastermind-like domain containing 1 2.73707
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.73707
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.73707
COL9A2 collagen, type IX, alpha 2 2.73707
ANKRD53 ankyrin repeat domain 53 2.73707
TPPP3 tubulin polymerization-promoting protein family member 3 2.73707
CLEC9A C-type lectin domain family 9, member A 2.73707
DMRT3 doublesex and mab-3 related transcription factor 3 2.73707
DAW1 dynein assembly factor with WDR repeat domains 1 2.73707
DLX3 distal-less homeobox 3 2.73707
DMRTA2 DMRT-like family A2 2.73707
MUC7 mucin 7, secreted 2.73707
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.73707
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.73707
SHISA8 shisa family member 8 2.73707
MUC13 mucin 13, cell surface associated 2.73707
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.73707
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.73707
HOPX HOP homeobox 2.73707
KLK15 kallikrein-related peptidase 15 2.73707
KLK5 kallikrein-related peptidase 5 2.73707
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.73707
CCDC87 coiled-coil domain containing 87 2.73707
PADI1 peptidyl arginine deiminase, type I 2.73707
FRMPD1 FERM and PDZ domain containing 1 2.73707
TEX36 testis expressed 36 2.73707
CCDC169 coiled-coil domain containing 169 2.73707
CLCNKB chloride channel, voltage-sensitive Kb 2.73707
SYTL4 synaptotagmin-like 4 2.73707
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.73707
CETP cholesteryl ester transfer protein, plasma 2.73707
LAMP5 lysosomal-associated membrane protein family, member 5 2.73707
MMP12 matrix metallopeptidase 12 2.73707
CHRDL2 chordin-like 2 2.73707
CCDC83 coiled-coil domain containing 83 2.73707
NRSN1 neurensin 1 2.73707
NFE2 nuclear factor, erythroid 2 2.73707
WNK4 WNK lysine deficient protein kinase 4 2.73707
VPREB3 pre-B lymphocyte 3 2.73707
IRX3 iroquois homeobox 3 2.73707
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.73707
LRRC74A leucine rich repeat containing 74A 2.73707
ASCL2 achaete-scute family bHLH transcription factor 2 2.73707
APOL1 apolipoprotein L, 1 2.73707
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.73707
SLITRK1 SLIT and NTRK-like family, member 1 2.73707
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.73707
PATE1 prostate and testis expressed 1 2.73707
ROM1 retinal outer segment membrane protein 1 2.73707
PRR15L proline rich 15-like 2.73707
MZB1 marginal zone B and B1 cell-specific protein 2.73707
WDFY4 WDFY family member 4 2.73707
TCF21 transcription factor 21 2.73707
ANKRD62 ankyrin repeat domain 62 2.73707
NLRP14 NLR family, pyrin domain containing 14 2.73707
INPPL1 inositol polyphosphate phosphatase-like 1 2.72579
CDKN3 cyclin-dependent kinase inhibitor 3 2.72579
C1ORF53 chromosome 1 open reading frame 53 2.68117
DDA1 DET1 and DDB1 associated 1 2.66847
STXBP5L syntaxin binding protein 5-like 2.55873
OTOA otoancorin 2.55628
CD86 CD86 molecule 2.55628
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.55628
CYB5D1 cytochrome b5 domain containing 1 2.54044
DERA deoxyribose-phosphate aldolase (putative) 2.51279
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.50346
SPEN spen family transcriptional repressor 2.49418
PRRC1 proline-rich coiled-coil 1 2.4563
APOLD1 apolipoprotein L domain containing 1 2.45347
IDS iduronate 2-sulfatase 2.40319
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 2.38819
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.38589
SRR serine racemase 2.36946
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.36884
TLCD5 TLC domain containing 5 2.34018
CYC1 cytochrome c-1 2.33175
EWSR1 EWS RNA-binding protein 1 2.30607
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.29159
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.28534
RPL29 ribosomal protein L29 2.28534
NHSL1 NHS-like 1 2.27152
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.26126
NEU3 sialidase 3 (membrane sialidase) 2.26126
NLRC3 NLR family, CARD domain containing 3 2.25794
TRIT1 tRNA isopentenyltransferase 1 2.24366
EIF4A3 eukaryotic translation initiation factor 4A3 2.22625
COL6A1 collagen, type VI, alpha 1 2.21454
MUTYH mutY homolog 2.18953
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.1833
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.18011
TBL2 transducin (beta)-like 2 2.14445
LAMP2 lysosomal-associated membrane protein 2 2.14376
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.11845
CRYZ crystallin, zeta (quinone reductase) 2.11363
SRSF6 serine/arginine-rich splicing factor 6 2.1127
ERBIN erbb2 interacting protein 2.11046
SBK2 SH3 domain binding kinase family, member 2 2.1072
KANSL1 KAT8 regulatory NSL complex subunit 1 2.10015
H3C6 H3 clustered histone 6 2.09404
ICE2 interactor of little elongation complex ELL subunit 2 2.09404
ONECUT2 one cut homeobox 2 2.09385
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.07996
INTS15 integrator complex subunit 15 2.0741
WTIP Wilms tumor 1 interacting protein 2.0621
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.04508
FOXP1 forkhead box P1 2.03228
PRR7 proline rich 7 (synaptic) 2.03184
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.02586
RNF208 ring finger protein 208 2.01942
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 2.01289
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 2.00751

decreased expression

Symbol Name Standardized Value
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -2.73707
GJA5 gap junction protein, alpha 5, 40kDa -2.73707
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone -2.73707
PLIN4 perilipin 4 -2.73707
ZNF469 zinc finger protein 469 -2.73707
TIGD6 tigger transposable element derived 6 -2.73707
SLC35G2 solute carrier family 35, member G2 -2.73707
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.73707
MANSC4 MANSC domain containing 4 -2.73707
CNBD2 cyclic nucleotide binding domain containing 2 -2.73707
MCU mitochondrial calcium uniporter -2.73707
WNT5B wingless-type MMTV integration site family, member 5B -2.73707
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.73707
PTBP2 polypyrimidine tract binding protein 2 -2.73707
SOD1 superoxide dismutase 1, soluble -2.73707
TMEM92 transmembrane protein 92 -2.73707
PWWP3B PWWP domain containing 3B -2.73707
AGER advanced glycosylation end product-specific receptor -2.73707
ASIC1 acid sensing (proton gated) ion channel 1 -2.73707
ANAPC2 anaphase promoting complex subunit 2 -2.73707
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.73707
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.72579
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.72579
CFAP157 cilia and flagella associated protein 157 -2.72579
IFT70B intraflagellar transport 70B -2.72579
BIN2 bridging integrator 2 -2.72579
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.72579
LOC124903233 uncharacterized LOC124903233 -2.72579
LDHC lactate dehydrogenase C -2.72579
TMEM79 transmembrane protein 79 -2.72579
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -2.72579
CNTFR ciliary neurotrophic factor receptor -2.72579
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 -2.72579
ZEB2 zinc finger E-box binding homeobox 2 -2.72579
TMPRSS5 transmembrane protease, serine 5 -2.72579
PCDHB6 protocadherin beta 6 -2.72579
CFAP65 cilia and flagella associated protein 65 -2.72579
TNNI1 troponin I type 1 (skeletal, slow) -2.72579
DRICH1 aspartate-rich 1 -2.72579
DNASE1L2 deoxyribonuclease I-like 2 -2.72579
BTNL2 butyrophilin-like 2 -2.72579
ITGA11 integrin, alpha 11 -2.72579
PRSS50 protease, serine, 50 -2.72579
SPI1 Spi-1 proto-oncogene -2.72579
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.72579
HLA-DOB major histocompatibility complex, class II, DO beta -2.72579
SPTBN5 spectrin, beta, non-erythrocytic 5 -2.72579
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.72579
PENK proenkephalin -2.72579
CSDC2 cold shock domain containing C2, RNA binding -2.72579
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 -2.69648
ZFYVE27 zinc finger, FYVE domain containing 27 -2.68909
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.65817
PDGFC platelet derived growth factor C -2.63264
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.61151
CDK3 cyclin-dependent kinase 3 -2.57937
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.52394
DLEU7 deleted in lymphocytic leukemia, 7 -2.51279
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.44797
CAPN3 calpain 3, (p94) -2.38395
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.38395
FOXP2 forkhead box P2 -2.38395
SDF4 stromal cell derived factor 4 -2.38329
MTMR2 myotubularin related protein 2 -2.38329
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.37094
TADA1 transcriptional adaptor 1 -2.36884
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.36058
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.35376
SIKE1 suppressor of IKBKE 1 -2.3477
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.33175
TEAD2 TEA domain family member 2 -2.31042
LAT2 linker for activation of T cells family, member 2 -2.29035
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -2.26126
CYRIB CYFIP related Rac1 interactor B -2.25308
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.24358
HOOK3 hook microtubule-tethering protein 3 -2.23112
WWC2 WW and C2 domain containing 2 -2.20535
ARL9 ADP-ribosylation factor-like 9 -2.19597
LATS1 large tumor suppressor kinase 1 -2.18953
ZFP82 ZFP82 zinc finger protein -2.18011
LMNB1 lamin B1 -2.17863
ZNF592 zinc finger protein 592 -2.17276
TSSK3 testis-specific serine kinase 3 -2.17017
ZNF442 zinc finger protein 442 -2.17017
NCKIPSD NCK interacting protein with SH3 domain -2.14445
ADORA2B adenosine A2b receptor -2.12904
TTLL12 tubulin tyrosine ligase-like family member 12 -2.12815
PUDP pseudouridine 5'-phosphatase -2.11658
BRD2 bromodomain containing 2 -2.10399
YARS1 tyrosyl-tRNA synthetase 1 -2.10399
PDGFRB platelet-derived growth factor receptor, beta polypeptide -2.09385
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.09385
HRC histidine rich calcium binding protein -2.08876
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.0848
PTPRT protein tyrosine phosphatase, receptor type, T -2.0848
AKAP11 A kinase (PRKA) anchor protein 11 -2.05096
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.05057
FAM184B family with sequence similarity 184, member B -2.04315
C2ORF76 chromosome 2 open reading frame 76 -2.03228
MON1B MON1 secretory trafficking family member B -2.03184
ZNF614 zinc finger protein 614 -2.01942
NT5DC1 5'-nucleotidase domain containing 1 -2.01577
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -2.01091
IER3IP1 immediate early response 3 interacting protein 1 -2.00126