MDA-MB-231 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

222 genes with high or low expression in MDA-MB-231 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
CRTAM cytotoxic and regulatory T cell molecule 3.18373
ADGRF5 adhesion G protein-coupled receptor F5 2.34375
CSF1 colony stimulating factor 1 (macrophage) 2.23679
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.20307
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.16655
ATP10D ATPase, class V, type 10D 2.05304
SRPK1 SRSF protein kinase 1 2.03995
CPD carboxypeptidase D 2.03875
BTD biotinidase 1.99486
OGFRL1 opioid growth factor receptor-like 1 1.99169
MORC4 MORC family CW-type zinc finger 4 1.98461
INSL6 insulin-like 6 1.93495
COL8A1 collagen, type VIII, alpha 1 1.89701
CLDND1 claudin domain containing 1 1.89543
NME7 NME/NM23 family member 7 1.89465
CST4 cystatin S 1.89309
CTBS chitobiase, di-N-acetyl- 1.86388
UBR2 ubiquitin protein ligase E3 component n-recognin 2 1.85081
CST2 cystatin SA 1.79743
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.77571
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 1.76229
CD58 CD58 molecule 1.72572
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.71922
CST1 cystatin SN 1.70699
KIF1BP KIF1 binding protein 1.69593
DNMBP dynamin binding protein 1.69167
TGFB2 transforming growth factor, beta 2 1.67498
ACO1 aconitase 1, soluble 1.67418
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 1.66817
DOCK9 dedicator of cytokinesis 9 1.65065
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 1.63684
SPINK4 serine peptidase inhibitor, Kazal type 4 1.63417
MAPK14 mitogen-activated protein kinase 14 1.63246
PTPRM protein tyrosine phosphatase, receptor type, M 1.62856
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 1.58215
C2 complement component 2 1.57993
RRAGB Ras-related GTP binding B 1.5604
TBC1D12 TBC1 domain family, member 12 1.55861
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1.55694
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 1.55617
MEGF9 multiple EGF-like-domains 9 1.54545
KLF15 Kruppel-like factor 15 1.54111
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 1.54106
TCEAL1 transcription elongation factor A (SII)-like 1 1.54006
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.529
WDR1 WD repeat domain 1 1.52597
SLC31A2 solute carrier family 31 (copper transporter), member 2 1.51508
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 1.50017
ZNF202 zinc finger protein 202 1.49705
CFP complement factor properdin 1.49574
CDC27 cell division cycle 27 1.49106
TTC12 tetratricopeptide repeat domain 12 1.48857
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 1.48785
EVI5 ecotropic viral integration site 5 1.47913
DOT1L DOT1-like histone H3K79 methyltransferase 1.46735
NABP1 nucleic acid binding protein 1 1.4633
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 1.46114
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 1.46037
PVRL3 poliovirus receptor-related 3 1.4561
ADAM8 ADAM metallopeptidase domain 8 1.45114
NPAS2 neuronal PAS domain protein 2 1.44856
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 1.44061
GSC2 goosecoid homeobox 2 1.43824
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 1.4343
FLNB filamin B, beta 1.4316
COL13A1 collagen, type XIII, alpha 1 1.43073
HYI hydroxypyruvate isomerase (putative) 1.4304
LDLR low density lipoprotein receptor 1.4298
STK16 serine/threonine kinase 16 1.42226

low expression

Symbol Name Standardized Value
SLC19A1 solute carrier family 19 (folate transporter), member 1 -3.53348
MYO19 myosin XIX -3.38361
RNF126P1 ring finger protein 126 pseudogene 1 -3.29091
ALPPL2 alkaline phosphatase, placental-like 2 -2.89044
CPT2 carnitine palmitoyltransferase 2 -2.61467
MPPE1 metallophosphoesterase 1 -2.53923
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -2.50366
GAS2 growth arrest-specific 2 -2.50281
GREM2 gremlin 2, DAN family BMP antagonist -2.40444
LIMK2 LIM domain kinase 2 -2.38278
HOXC8 homeobox C8 -2.35304
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.34924
IFT122 intraflagellar transport 122 -2.23976
ASRGL1 asparaginase like 1 -2.22484
TCHH trichohyalin -2.16652
DGCR14 DiGeorge syndrome critical region gene 14 -2.15483
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -2.14724
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.14629
HOXA6 homeobox A6 -2.14102
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.11353
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -2.10554
RCL1 RNA terminal phosphate cyclase-like 1 -2.10479
NF2 neurofibromin 2 (merlin) -2.09094
RAP1GAP RAP1 GTPase activating protein -2.08157
CORT cortistatin -2.06181
ING4 inhibitor of growth family, member 4 -2.05454
FABP3 fatty acid binding protein 3, muscle and heart -2.03941
KRT17 keratin 17, type I -2.01258
SLC35F5 solute carrier family 35, member F5 -2.00807
IL22 interleukin 22 -2.00682
TP53TG1 TP53 target 1 (non-protein coding) -2.00545
TSNAXIP1 translin-associated factor X interacting protein 1 -1.99488
PHEX phosphate regulating endopeptidase homolog, X-linked -1.99112
HIST1H3D histone cluster 1, H3d -1.99044
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -1.95432
ARID3A AT rich interactive domain 3A (BRIGHT-like) -1.95317
ONECUT1 one cut homeobox 1 -1.9491
IL2 interleukin 2 -1.9476
HIST1H2AE histone cluster 1, H2ae -1.92565
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -1.92104
CRELD2 cysteine-rich with EGF-like domains 2 -1.89893
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -1.88964
ESR1 estrogen receptor 1 -1.88339
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -1.87933
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -1.87925
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -1.86089
REN renin -1.85134
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -1.84394
RNF121 ring finger protein 121 -1.83659
TXNL4B thioredoxin-like 4B -1.83515
ARSA arylsulfatase A -1.82255
POLH polymerase (DNA directed), eta -1.8145
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -1.7779
SBSPON somatomedin B and thrombospondin, type 1 domain containing -1.77375
TMSB15A thymosin beta 15a -1.77054
CHD4 chromodomain helicase DNA binding protein 4 -1.76856
PRUNE prune exopolyphosphatase -1.76524
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -1.75301
TMEM47 transmembrane protein 47 -1.75069
PREPL prolyl endopeptidase-like -1.74735
DMXL1 Dmx-like 1 -1.74537
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -1.74388
DEPTOR DEP domain containing MTOR-interacting protein -1.74345
C3AR1 complement component 3a receptor 1 -1.743
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -1.74213
MBL1P mannose-binding lectin (protein A) 1, pseudogene -1.73358
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -1.73142
TAGLN3 transgelin 3 -1.72347
APOL2 apolipoprotein L, 2 -1.70778
FGFR3 fibroblast growth factor receptor 3 -1.70553
KIF22 kinesin family member 22 -1.68379
RIPPLY3 ripply transcriptional repressor 3 -1.68339
KRT20 keratin 20, type I -1.67867
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 -1.66813
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -1.66718
MRPS11 mitochondrial ribosomal protein S11 -1.66613
DEFA6 defensin, alpha 6, Paneth cell-specific -1.66415
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) -1.65423
NAG18 NAG18 mRNA -1.65203
HIST1H2AK histone cluster 1, H2ak -1.6515
IGHD immunoglobulin heavy constant delta -1.64963
HOXD11 homeobox D11 -1.64943
RPL37A ribosomal protein L37a -1.64358
CD226 CD226 molecule -1.63801
PLCB4 phospholipase C, beta 4 -1.63698
GPR65 G protein-coupled receptor 65 -1.63577
TKFC triokinase/FMN cyclase -1.6294
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -1.62666
DCSTAMP dendrocyte expressed seven transmembrane protein -1.62579
L2HGDH L-2-hydroxyglutarate dehydrogenase -1.62175
ITFG2 integrin alpha FG-GAP repeat containing 2 -1.6149
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -1.60474
MBD4 methyl-CpG binding domain protein 4 -1.59847
BTBD7 BTB (POZ) domain containing 7 -1.5982
TASP1 taspase, threonine aspartase, 1 -1.59324
SP4 Sp4 transcription factor -1.59283
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -1.59011
SIRPG signal-regulatory protein gamma -1.58612
RNPS1 RNA binding protein S1, serine-rich domain -1.57072
ADAM20 ADAM metallopeptidase domain 20 -1.56717
CNOT2 CCR4-NOT transcription complex, subunit 2 -1.56394
KLHL9 kelch-like family member 9 -1.56255
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.56145
PAPOLB poly(A) polymerase beta (testis specific) -1.55628
CIAPIN1 cytokine induced apoptosis inhibitor 1 -1.5543
ZNF442 zinc finger protein 442 -1.54978
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -1.54775
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.54575
ZMYM2 zinc finger, MYM-type 2 -1.53692
SLC7A4 solute carrier family 7, member 4 -1.5355
MAP1A microtubule-associated protein 1A -1.53225
ZNF750 zinc finger protein 750 -1.5269
SLC25A30 solute carrier family 25, member 30 -1.52641
ZNF207 zinc finger protein 207 -1.52269
KLHL11 kelch-like family member 11 -1.52251
THOC5 THO complex 5 -1.5217
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -1.51888
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -1.51666
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -1.51556
LOC81691 exonuclease NEF-sp -1.51139
NR5A2 nuclear receptor subfamily 5, group A, member 2 -1.5108
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -1.50108
SLC17A4 solute carrier family 17, member 4 -1.49347
HHLA3 HERV-H LTR-associating 3 -1.49109
RSC1A1 regulatory solute carrier protein, family 1, member 1 -1.48839
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -1.48825
GJA10 gap junction protein, alpha 10, 62kDa -1.48538
MSX1 msh homeobox 1 -1.47807
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene -1.47735
ITGA8 integrin, alpha 8 -1.475
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -1.47422
FLT4 fms-related tyrosine kinase 4 -1.47153
MAPK7 mitogen-activated protein kinase 7 -1.47068
HR hair growth associated -1.46932
GON4L gon-4-like (C. elegans) -1.46924
GPR19 G protein-coupled receptor 19 -1.4641
RUNX3 runt-related transcription factor 3 -1.46373
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -1.46285
RNF17 ring finger protein 17 -1.46249
RNF20 ring finger protein 20, E3 ubiquitin protein ligase -1.45862
GLS2 glutaminase 2 (liver, mitochondrial) -1.4562
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -1.456
USP18 ubiquitin specific peptidase 18 -1.44897
SYNC syncoilin, intermediate filament protein -1.4446
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -1.44093
PKLR pyruvate kinase, liver and RBC -1.43924
SLIT3 slit homolog 3 (Drosophila) -1.43885
HIRIP3 HIRA interacting protein 3 -1.42926
CES1 carboxylesterase 1 -1.42134
CALML3 calmodulin-like 3 -1.41759
CD27 CD27 molecule -1.41733
ZNF286A zinc finger protein 286A -1.41724
FOCAD focadhesin -1.41577
Funding