MDAMB231 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000768
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Genes

184 gene knockdowns changing fitness of MDAMB231 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
ARMC12 armadillo repeat containing 12 7.78714
OR5AC2 olfactory receptor, family 5, subfamily AC, member 2 6.09794
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 6.093
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 5.88527
OR7A5 olfactory receptor, family 7, subfamily A, member 5 5.85747
AP2B1 adaptor-related protein complex 2, beta 1 subunit 5.5169
CHAT choline O-acetyltransferase 5.47923
RAP1A RAP1A, member of RAS oncogene family 4.83361
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 4.70023
EVA1A eva-1 homolog A (C. elegans) 4.46817
OR7C1 olfactory receptor, family 7, subfamily C, member 1 4.40375
OR6Q1 olfactory receptor, family 6, subfamily Q, member 1 (gene/pseudogene) 4.40075
TDRD12 tudor domain containing 12 4.16385
VTCN1 V-set domain containing T cell activation inhibitor 1 4.10109
NPR2 natriuretic peptide receptor 2 4.08426
FITM2 fat storage-inducing transmembrane protein 2 4.02814
TMEM98 transmembrane protein 98 3.93327
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 3.93045
OR10H3 olfactory receptor, family 10, subfamily H, member 3 3.92028
ZNF226 zinc finger protein 226 3.85732
TPM2 tropomyosin 2 (beta) 3.77235
CCL27 chemokine (C-C motif) ligand 27 3.72399
VWA3B von Willebrand factor A domain containing 3B 3.68132
CNGA3 cyclic nucleotide gated channel alpha 3 3.66526
LCT lactase 3.56383
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 3.4855
MKRN3 makorin ring finger protein 3 3.46998
ZEB1 zinc finger E-box binding homeobox 1 3.45649
HIPK4 homeodomain interacting protein kinase 4 3.43076
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.39909
HAO2 hydroxyacid oxidase 2 (long chain) 3.38075
LCE3D late cornified envelope 3D 3.3786
OR1M1 olfactory receptor, family 1, subfamily M, member 1 3.37586
ARL15 ADP-ribosylation factor-like 15 3.32817
OR5K3 olfactory receptor, family 5, subfamily K, member 3 3.32229
LCE2D late cornified envelope 2D 3.30757
LNP1 leukemia NUP98 fusion partner 1 3.29049
REG4 regenerating islet-derived family, member 4 3.28779
GRB10 growth factor receptor-bound protein 10 3.28154
RFLNA refilin A 3.24556
IGFL2 IGF-like family member 2 3.24395
ARHGAP15 Rho GTPase activating protein 15 3.22962
NID2 nidogen 2 (osteonidogen) 3.22197
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.21551
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 3.21183
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.21143
HEPACAM2 HEPACAM family member 2 3.1635
ZNF443 zinc finger protein 443 3.14952
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 3.14029
STMN2 stathmin 2 3.13239
NANS N-acetylneuraminic acid synthase 3.12206
OR52B2 olfactory receptor, family 52, subfamily B, member 2 3.10121
NMU neuromedin U 3.07734
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 3.05438
PLVAP plasmalemma vesicle associated protein 3.02116
RAB18 RAB18, member RAS oncogene family 2.99582
RBBP7 retinoblastoma binding protein 7 2.9189
TP53BP1 tumor protein p53 binding protein 1 2.91719
RAB42 RAB42, member RAS oncogene family 2.90268
SPARCL1 SPARC-like 1 (hevin) 2.87108
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 2.868
TMEM26 transmembrane protein 26 2.83181
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.82801
MARCO macrophage receptor with collagenous structure 2.80689
UBL4B ubiquitin-like 4B 2.80466
CALN1 calneuron 1 2.8033
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.80195
TREML1 triggering receptor expressed on myeloid cells-like 1 2.78242
BCAP31 B-cell receptor-associated protein 31 2.76116
LPPR4 lipid phosphate phosphatase-related protein type 4 2.75015
FCHO2 FCH domain only 2 2.73095
COMP cartilage oligomeric matrix protein 2.70995
OR13C4 olfactory receptor, family 13, subfamily C, member 4 2.68923
PROS1 protein S (alpha) 2.68073
LRRC18 leucine rich repeat containing 18 2.6792
KIAA2022 KIAA2022 2.67902
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2.67887
PRSS3 protease, serine, 3 2.66679
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.64704
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.64161
C9ORF152 chromosome 9 open reading frame 152 2.60531
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 2.59977
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.58784
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.5869
SYNE2 spectrin repeat containing, nuclear envelope 2 2.54111
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 2.53429
TBC1D20 TBC1 domain family, member 20 2.53014
SFRP1 secreted frizzled-related protein 1 2.5106
FTMT ferritin mitochondrial 2.50956
MYO3B myosin IIIB 2.49844
RHOC ras homolog family member C 2.49441
PPAP2A phosphatidic acid phosphatase type 2A 2.49224
ITGA11 integrin, alpha 11 2.49175
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.48648
DSTN destrin (actin depolymerizing factor) 2.47487
HVCN1 hydrogen voltage gated channel 1 2.47146
C20ORF196 chromosome 20 open reading frame 196 2.45224
IL12RB1 interleukin 12 receptor, beta 1 2.4475
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.44743
TMEM174 transmembrane protein 174 2.44386
DLEU7 deleted in lymphocytic leukemia, 7 2.43822
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.4332
ACTBL2 actin, beta-like 2 2.4279
C1QTNF6 C1q and tumor necrosis factor related protein 6 2.42479
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.41754
OR7G3 olfactory receptor, family 7, subfamily G, member 3 2.41631
PLP1 proteolipid protein 1 2.40391
BCAR3 breast cancer anti-estrogen resistance 3 2.39878
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 2.39717
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.39604
COL15A1 collagen, type XV, alpha 1 2.39557
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.38449
AMER2 APC membrane recruitment protein 2 2.38363
MBD5 methyl-CpG binding domain protein 5 2.38237
FAM159B family with sequence similarity 159, member B 2.37557
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 2.36049
PRSS50 protease, serine, 50 2.35957
HBS1L HBS1-like translational GTPase 2.35793
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.35155
PEA15 phosphoprotein enriched in astrocytes 15 2.34796
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.3415
POLN polymerase (DNA directed) nu 2.33822
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.33377
GPR17 G protein-coupled receptor 17 2.31923
IL31RA interleukin 31 receptor A 2.31375
ELMO2 engulfment and cell motility 2 2.30753
RNF183 ring finger protein 183 2.29449
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 2.29447
PRADC1 protease-associated domain containing 1 2.28197
TSHB thyroid stimulating hormone, beta 2.28188
ZNF285 zinc finger protein 285 2.27843
C19ORF57 chromosome 19 open reading frame 57 2.27004
NHLH2 nescient helix loop helix 2 2.26286
ITGAD integrin, alpha D 2.25791
OR13F1 olfactory receptor, family 13, subfamily F, member 1 2.25235
PRSS36 protease, serine, 36 2.25171
PHC1 polyhomeotic homolog 1 (Drosophila) 2.24699
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.24575
ZNF225 zinc finger protein 225 2.24194
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.23493
UBB ubiquitin B 2.22699
HAPLN1 hyaluronan and proteoglycan link protein 1 2.21861
TMEM252 transmembrane protein 252 2.21336
NTS neurotensin 2.21158
PCDH15 protocadherin-related 15 2.20856
NOS2 nitric oxide synthase 2, inducible 2.19793
SEPTIN10 septin 10 2.19237
ZNF273 zinc finger protein 273 2.1902
CCIN calicin 2.18787
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.18145
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2.16474
CD2 CD2 molecule 2.16157
TCHHL1 trichohyalin-like 1 2.15157
CCNO cyclin O 2.13846
CCL26 chemokine (C-C motif) ligand 26 2.12599
RYR1 ryanodine receptor 1 (skeletal) 2.12447
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.12412
ALCAM activated leukocyte cell adhesion molecule 2.10786
PRSS53 protease, serine, 53 2.10199
FXYD4 FXYD domain containing ion transport regulator 4 2.10068
FCRLA Fc receptor-like A 2.09739
RORB RAR-related orphan receptor B 2.08329
SLC22A25 solute carrier family 22, member 25 2.08262
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.07835
CRIP3 cysteine-rich protein 3 2.06708
C1ORF162 chromosome 1 open reading frame 162 2.05702
CCDC132 coiled-coil domain containing 132 2.04938
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.04782
MTMR3 myotubularin related protein 3 2.04262
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.04027
KRTDAP keratinocyte differentiation-associated protein 2.0354
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.03246
CYB5RL cytochrome b5 reductase-like 2.0317
OR7G2 olfactory receptor, family 7, subfamily G, member 2 2.01921
USP1 ubiquitin specific peptidase 1 2.01827
CARTPT CART prepropeptide 2.01821
SMS spermine synthase 2.01693
SIAH1 siah E3 ubiquitin protein ligase 1 2.01423
STX7 syntaxin 7 2.01415
ZNF536 zinc finger protein 536 2.0101
TMEM233 transmembrane protein 233 2.00851
FAM212B family with sequence similarity 212, member B 2.00608
FMNL1 formin-like 1 2.00588
MRPS36 mitochondrial ribosomal protein S36 2.00269