MDAMB453 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
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Genes

927 gene knockdowns changing fitness of MDAMB453 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
F11R F11 receptor 3.19303
ZNF195 zinc finger protein 195 3.19303
STK35 serine/threonine kinase 35 3.18989
SLC26A2 solute carrier family 26 (anion exchanger), member 2 3.14224
OR2B2 olfactory receptor, family 2, subfamily B, member 2 3.09368
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 3.0831
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 3.05141
ARF1 ADP-ribosylation factor 1 3.04731
SLC26A11 solute carrier family 26 (anion exchanger), member 11 3.02636
FXYD2 FXYD domain containing ion transport regulator 2 2.98042
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.97363
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.86864
ZBTB17 zinc finger and BTB domain containing 17 2.86394
EXO1 exonuclease 1 2.79824
H2BFM H2B histone family, member M 2.73612
ZNF135 zinc finger protein 135 2.71023
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.68114
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.67887
ZNF91 zinc finger protein 91 2.66962
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.63613
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 2.61833
RBM19 RNA binding motif protein 19 2.61378
GMIP GEM interacting protein 2.55453
PKN1 protein kinase N1 2.51776
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 2.49134
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 2.48996
CIR1 corepressor interacting with RBPJ, 1 2.48299
GUSBP4 glucuronidase, beta pseudogene 4 2.46559
PCDHGA11 protocadherin gamma subfamily A, 11 2.46444
LSM1 LSM1, U6 small nuclear RNA associated 2.45897
MATN3 matrilin 3 2.45854
EMX1 empty spiracles homeobox 1 2.43129
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 2.37297
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.36209
USP30 ubiquitin specific peptidase 30 2.34236
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2.33718
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.3269
RASD2 RASD family, member 2 2.32519
SLA2 Src-like-adaptor 2 2.28766
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.28587
ARF5 ADP-ribosylation factor 5 2.28322
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.27726
OR7E5P olfactory receptor, family 7, subfamily E, member 5 pseudogene 2.2651
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.26044
GVINP1 GTPase, very large interferon inducible pseudogene 1 2.24509
ST13P4 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 4 2.245
COG2 component of oligomeric golgi complex 2 2.24373
RCN2 reticulocalbin 2, EF-hand calcium binding domain 2.23252
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.23047
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.16493
CDC42 cell division cycle 42 2.16058
ARSA arylsulfatase A 2.15978
CALU calumenin 2.14815
LTB lymphotoxin beta (TNF superfamily, member 3) 2.14154
OLFM1 olfactomedin 1 2.10563
ZNF432 zinc finger protein 432 2.10522
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.09296
MPL MPL proto-oncogene, thrombopoietin receptor 2.09046
HYLS1 hydrolethalus syndrome 1 2.07856
SLC6A10P solute carrier family 6 (neurotransmitter transporter), member 10, pseudogene 2.07336
NANP N-acetylneuraminic acid phosphatase 2.07123
HAL histidine ammonia-lyase 2.06334
MECP2 methyl CpG binding protein 2 2.03994
PEBP1 phosphatidylethanolamine binding protein 1 2.03201
JMJD1C jumonji domain containing 1C 2.02903
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.02713
COG3 component of oligomeric golgi complex 3 1.98872
CD300C CD300c molecule 1.98828
VN1R5 vomeronasal 1 receptor 5 (gene/pseudogene) 1.97832
RNF17 ring finger protein 17 1.97724
CXCL16 chemokine (C-X-C motif) ligand 16 1.97245
KIF16B kinesin family member 16B 1.97045
TRPM5 transient receptor potential cation channel, subfamily M, member 5 1.97024
SPPL2A signal peptide peptidase like 2A 1.96962
HYAL1 hyaluronoglucosaminidase 1 1.965
TSHZ2 teashirt zinc finger homeobox 2 1.96273
VHLL von Hippel-Lindau tumor suppressor-like 1.94854
MDH1B malate dehydrogenase 1B, NAD (soluble) 1.9476
BAZ2B bromodomain adjacent to zinc finger domain, 2B 1.9407
HIST4H4 histone cluster 4, H4 1.93011
KISS1R KISS1 receptor 1.92921
API5 apoptosis inhibitor 5 1.92748
TAS2R31 taste receptor, type 2, member 31 1.92564
MSH2 mutS homolog 2 1.91162
S1PR2 sphingosine-1-phosphate receptor 2 1.91103
WIF1 WNT inhibitory factor 1 1.90896
RAB28 RAB28, member RAS oncogene family 1.90798
TGFB1 transforming growth factor, beta 1 1.90595
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.8967
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.88421
IL22 interleukin 22 1.88145
RGS11 regulator of G-protein signaling 11 1.87456
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 1.8677
EFCAB1 EF-hand calcium binding domain 1 1.84745
MAN1A2 mannosidase, alpha, class 1A, member 2 1.84517
SEC24C SEC24 family member C 1.84432
MMP19 matrix metallopeptidase 19 1.8308
EPS15 epidermal growth factor receptor pathway substrate 15 1.8235
OR1S2 olfactory receptor, family 1, subfamily S, member 2 1.81708
CCL8 chemokine (C-C motif) ligand 8 1.81626
ALAS1 5'-aminolevulinate synthase 1 1.80568
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 1.80419
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 1.80408
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 1.79887
MYL4 myosin, light chain 4, alkali; atrial, embryonic 1.79885
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 1.79235
ZNF362 zinc finger protein 362 1.78743
GOPC golgi-associated PDZ and coiled-coil motif containing 1.77692
RC3H2 ring finger and CCCH-type domains 2 1.77672
ZNF584 zinc finger protein 584 1.77528
ZNF780B zinc finger protein 780B 1.7484
CSF1 colony stimulating factor 1 (macrophage) 1.74652
AKIP1 A kinase (PRKA) interacting protein 1 1.74257
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.72987
POLL polymerase (DNA directed), lambda 1.72854
AANAT aralkylamine N-acetyltransferase 1.71393
PLCZ1 phospholipase C, zeta 1 1.71262
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 1.71107
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 1.70885
CDKL3 cyclin-dependent kinase-like 3 1.70112
STS steroid sulfatase (microsomal), isozyme S 1.70074
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 1.69174
IQGAP2 IQ motif containing GTPase activating protein 2 1.68697
ANXA7 annexin A7 1.68642
CD59 CD59 molecule, complement regulatory protein 1.68524
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.68329
LIPH lipase, member H 1.68258
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.66916
SGPL1 sphingosine-1-phosphate lyase 1 1.66072
COBL cordon-bleu WH2 repeat protein 1.65855
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.65436
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 1.65239
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.64977
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 1.64223
RGS9 regulator of G-protein signaling 9 1.63872
IMPACT impact RWD domain protein 1.6373
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.63719
TRIM60 tripartite motif containing 60 1.63141
BRWD1 bromodomain and WD repeat domain containing 1 1.62797
COX7B2 cytochrome c oxidase subunit VIIb2 1.62491
DSCAML1 Down syndrome cell adhesion molecule like 1 1.62095
FZD3 frizzled class receptor 3 1.61619
L3MBTL4 l(3)mbt-like 4 (Drosophila) 1.60885
SCARF1 scavenger receptor class F, member 1 1.60483
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.60416
OAZ1 ornithine decarboxylase antizyme 1 1.60244
EED embryonic ectoderm development 1.59853
MAB21L2 mab-21-like 2 (C. elegans) 1.5963
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 1.58931
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 1.58478
HIST1H2BM histone cluster 1, H2bm 1.58439
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 1.58373
GNA13 guanine nucleotide binding protein (G protein), alpha 13 1.57905
PNPLA6 patatin-like phospholipase domain containing 6 1.57745
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein 1.56726
GALK2 galactokinase 2 1.56354
MAPT microtubule-associated protein tau 1.56322
CPT1B carnitine palmitoyltransferase 1B (muscle) 1.55696
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 1.55313
OR51T1 olfactory receptor, family 51, subfamily T, member 1 1.54235
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.54153
KIAA0430 KIAA0430 1.53131
TSC1 tuberous sclerosis 1 1.52331
F3 coagulation factor III (thromboplastin, tissue factor) 1.5204
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.51534
FGG fibrinogen gamma chain 1.5146
ADAM29 ADAM metallopeptidase domain 29 1.50938
OR3A3 olfactory receptor, family 3, subfamily A, member 3 1.50306
OR10A2 olfactory receptor, family 10, subfamily A, member 2 1.49939
RHOV ras homolog family member V 1.49576
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 1.49573
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 1.49157
IRS2 insulin receptor substrate 2 1.49085
TRIM62 tripartite motif containing 62 1.48972
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 1.48655
RARS2 arginyl-tRNA synthetase 2, mitochondrial 1.48647
CTSB cathepsin B 1.4786
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 1.47727
CHGA chromogranin A 1.47671
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 1.47404
OR2T5 olfactory receptor, family 2, subfamily T, member 5 1.47361
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 1.47277
CHRD chordin 1.46192
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 1.46096
AGBL2 ATP/GTP binding protein-like 2 1.45869
ARSF arylsulfatase F 1.45211
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.45123
ZNF35 zinc finger protein 35 1.44779
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 1.44761
DPCR1 diffuse panbronchiolitis critical region 1 1.44651
MBOAT7 membrane bound O-acyltransferase domain containing 7 1.44621
TULP3 tubby like protein 3 1.4458
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.44127
FRMPD2 FERM and PDZ domain containing 2 1.4395
DPP8 dipeptidyl-peptidase 8 1.43414
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.43347
AHCYL2 adenosylhomocysteinase-like 2 1.43323
GREB1 growth regulation by estrogen in breast cancer 1 1.43044
S100A13 S100 calcium binding protein A13 1.42778
ARHGAP29 Rho GTPase activating protein 29 1.42606
ANAPC2 anaphase promoting complex subunit 2 1.42056
STAT5A signal transducer and activator of transcription 5A 1.41742
UBE2D2 ubiquitin-conjugating enzyme E2D 2 1.41586
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 1.40733
RSAD1 radical S-adenosyl methionine domain containing 1 1.4061
PYCR2 pyrroline-5-carboxylate reductase family, member 2 1.40283
PCDHA8 protocadherin alpha 8 1.40161
CCKBR cholecystokinin B receptor 1.39862
EPAS1 endothelial PAS domain protein 1 1.39529
GYS2 glycogen synthase 2 (liver) 1.39462
IFNA7 interferon, alpha 7 1.39199
SLC16A4 solute carrier family 16, member 4 1.38647
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.38145
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 1.38124
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 1.37985
RHOA ras homolog family member A 1.37933
PZP pregnancy-zone protein 1.37897
OR10A5 olfactory receptor, family 10, subfamily A, member 5 1.37892
H2AFB2 H2A histone family, member B2 1.37645
ACVR1 activin A receptor, type I 1.37628
IGF1R insulin-like growth factor 1 receptor 1.37252
SENP5 SUMO1/sentrin specific peptidase 5 1.37104
IRF2BP2 interferon regulatory factor 2 binding protein 2 1.3679
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 1.36459
PCDHGB1 protocadherin gamma subfamily B, 1 1.36437
MARCO macrophage receptor with collagenous structure 1.36323
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.36171
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.36089
RIOK1 RIO kinase 1 1.35767
GUSBP1 glucuronidase, beta pseudogene 1 1.35029
TAAR6 trace amine associated receptor 6 1.35002
OR8G5 olfactory receptor, family 8, subfamily G, member 5 1.34928
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.34333
SFXN2 sideroflexin 2 1.33945
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 1.33939
ZNF555 zinc finger protein 555 1.33877
MYNN myoneurin 1.33872
SCUBE3 signal peptide, CUB domain, EGF-like 3 1.33822
TMEM241 transmembrane protein 241 1.33389
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 1.33038
JMJD6 jumonji domain containing 6 1.32931
EVX1 even-skipped homeobox 1 1.32658
DOCK2 dedicator of cytokinesis 2 1.32574
SPRED2 sprouty-related, EVH1 domain containing 2 1.32199
EGFL6 EGF-like-domain, multiple 6 1.30469
SAFB scaffold attachment factor B 1.30083
PPP1R8 protein phosphatase 1, regulatory subunit 8 1.30071
SIX4 SIX homeobox 4 1.29998
SIM2 single-minded family bHLH transcription factor 2 1.2934
TPR translocated promoter region, nuclear basket protein 1.28866
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.28715
AMY2A amylase, alpha 2A (pancreatic) 1.27937
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.27787
INSM2 insulinoma-associated 2 1.2777
SCYL3 SCY1-like 3 (S. cerevisiae) 1.27381
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 1.27255
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.26918
ZNF222 zinc finger protein 222 1.26394
ARL9 ADP-ribosylation factor-like 9 1.26299
ADAM22 ADAM metallopeptidase domain 22 1.26137
NPC2 Niemann-Pick disease, type C2 1.25934
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 1.25529
TAS2R14 taste receptor, type 2, member 14 1.25382
PCDHGA5 protocadherin gamma subfamily A, 5 1.25287
HIST1H4E histone cluster 1, H4e 1.25256
PRMT6 protein arginine methyltransferase 6 1.24657
KLK15 kallikrein-related peptidase 15 1.24278
PLA2G4B phospholipase A2, group IVB (cytosolic) 1.24177
KIF20A kinesin family member 20A 1.24167
XYLT2 xylosyltransferase II 1.24105
BBX bobby sox homolog (Drosophila) 1.24077
CHST10 carbohydrate sulfotransferase 10 1.24065
ADGRE1 adhesion G protein-coupled receptor E1 1.23639
KLK12 kallikrein-related peptidase 12 1.23498
HEMK1 HemK methyltransferase family member 1 1.23077
CHN2 chimerin 2 1.22807
SCN5A sodium channel, voltage gated, type V alpha subunit 1.22358
NIT1 nitrilase 1 1.22275
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 1.22014
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.21793
BLOC1S1-RDH5 BLOC1S1-RDH5 readthrough 1.21081
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.21021
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.20766
LSAMP limbic system-associated membrane protein 1.20352
IL26 interleukin 26 1.20328
CBX6 chromobox homolog 6 1.20201
KCNIP4 Kv channel interacting protein 4 1.19996
PHOX2A paired-like homeobox 2a 1.19588
ZNF154 zinc finger protein 154 1.19517
TATDN2 TatD DNase domain containing 2 1.18972
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 1.18836
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.18024
GOLGA4 golgin A4 1.17931
FLT3 fms-related tyrosine kinase 3 1.17832
GFOD2 glucose-fructose oxidoreductase domain containing 2 1.17815
ADAM17 ADAM metallopeptidase domain 17 1.17772
USP10 ubiquitin specific peptidase 10 1.1747
MRRF mitochondrial ribosome recycling factor 1.17325
ZFP36L2 ZFP36 ring finger protein-like 2 1.1719
ANTXR1 anthrax toxin receptor 1 1.16597
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 1.16506
ELAVL2 ELAV like neuron-specific RNA binding protein 2 1.16483
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 1.1634
RHO rhodopsin 1.16279
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.16214
TNS3 tensin 3 1.162
PRDM2 PR domain containing 2, with ZNF domain 1.16027
ILF2 interleukin enhancer binding factor 2 1.15923
ITPKA inositol-trisphosphate 3-kinase A 1.15726
TEX30 testis expressed 30 1.15479
NFRKB nuclear factor related to kappaB binding protein 1.15217
RNF112 ring finger protein 112 1.15165
EPHA4 EPH receptor A4 1.14799
KCTD3 potassium channel tetramerization domain containing 3 1.14675
PCDHGB3 protocadherin gamma subfamily B, 3 1.14349
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 1.13307
ZNF79 zinc finger protein 79 1.13001
IGLL1 immunoglobulin lambda-like polypeptide 1 1.1298
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.12863
RXFP4 relaxin/insulin-like family peptide receptor 4 1.12824
NR6A1 nuclear receptor subfamily 6, group A, member 1 1.1271
CETN3 centrin, EF-hand protein, 3 1.12513
SCN1B sodium channel, voltage gated, type I beta subunit 1.12509
ACOX3 acyl-CoA oxidase 3, pristanoyl 1.12407
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.12365
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1.12244
C18ORF8 chromosome 18 open reading frame 8 1.12124
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1.11986
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.11838
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 1.11752
MGP matrix Gla protein 1.11662
TSSK3 testis-specific serine kinase 3 1.11593
ANPEP alanyl (membrane) aminopeptidase 1.1157
CTSC cathepsin C 1.11496
OR2G2 olfactory receptor, family 2, subfamily G, member 2 1.11349
OR51F2 olfactory receptor, family 51, subfamily F, member 2 1.10889
IL17RC interleukin 17 receptor C 1.10492
TRAF1 TNF receptor-associated factor 1 1.1038
KRT18 keratin 18, type I 1.10362
LDLRAP1 low density lipoprotein receptor adaptor protein 1 1.10346
HIST3H3 histone cluster 3, H3 1.09568
RCOR3 REST corepressor 3 1.08858
ATP11A ATPase, class VI, type 11A 1.08707
NRIP1 nuclear receptor interacting protein 1 1.08661
TNNC2 troponin C type 2 (fast) 1.08514
NINJ2 ninjurin 2 1.08071
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.07745
ZNF333 zinc finger protein 333 1.06965
ZNF514 zinc finger protein 514 1.06651
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 1.06558
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 1.06027
ZNF22 zinc finger protein 22 1.05961
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.05647
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.05546
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 1.05427
SNX2 sorting nexin 2 1.05406
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 1.05001
EMX2 empty spiracles homeobox 2 1.04822
PHF5A PHD finger protein 5A 1.04721
VTA1 vesicle (multivesicular body) trafficking 1 1.0434
SOX10 SRY (sex determining region Y)-box 10 1.04309
DDIT4 DNA-damage-inducible transcript 4 1.04258
GRK4 G protein-coupled receptor kinase 4 1.03956
CCR10 chemokine (C-C motif) receptor 10 1.03902
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 1.03734
SORCS3 sortilin-related VPS10 domain containing receptor 3 1.0371
METAP1 methionyl aminopeptidase 1 1.0369
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 1.03681
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.03652
AIF1L allograft inflammatory factor 1-like 1.03632
USP6 ubiquitin specific peptidase 6 1.03091
FFAR2 free fatty acid receptor 2 1.03083
ZNF569 zinc finger protein 569 1.02184
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.02174
HCAR1 hydroxycarboxylic acid receptor 1 1.02099
HIST1H2BB histone cluster 1, H2bb 1.01977
AP3M2 adaptor-related protein complex 3, mu 2 subunit 1.01698
TEC tec protein tyrosine kinase 1.01688
AKAP3 A kinase (PRKA) anchor protein 3 1.01274
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 1.01266
ARHGAP1 Rho GTPase activating protein 1 1.01026
SHBG sex hormone-binding globulin 1.00951
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.00906
SLC14A2 solute carrier family 14 (urea transporter), member 2 1.00725
HAND2 heart and neural crest derivatives expressed 2 1.00672
BCAR3 breast cancer anti-estrogen resistance 3 1.00486
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 1.00466
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 1.00285
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 1.00229
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough 1.0007

decreased fitness

Symbol Name Standardized Value
HIST1H2AK histone cluster 1, H2ak -3.57733
ZNF688 zinc finger protein 688 -3.56435
HIST1H2AM histone cluster 1, H2am -3.52301
IREB2 iron-responsive element binding protein 2 -3.42274
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -3.18464
NEB nebulin -3.08714
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -3.04166
FOXA3 forkhead box A3 -2.83095
EME1 essential meiotic structure-specific endonuclease 1 -2.81083
FOXA1 forkhead box A1 -2.78089
C11ORF45 chromosome 11 open reading frame 45 -2.74614
SP3 Sp3 transcription factor -2.7458
CDK4 cyclin-dependent kinase 4 -2.73592
PCDHGA10 protocadherin gamma subfamily A, 10 -2.70257
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.67563
ZC3H18 zinc finger CCCH-type containing 18 -2.65869
CKAP5 cytoskeleton associated protein 5 -2.64661
EP300 E1A binding protein p300 -2.64189
SPDEF SAM pointed domain containing ETS transcription factor -2.61921
ELAC2 elaC ribonuclease Z 2 -2.61318
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.61001
CDK10 cyclin-dependent kinase 10 -2.5973
EIF3F eukaryotic translation initiation factor 3, subunit F -2.59488
MYLK3 myosin light chain kinase 3 -2.57531
DUSP22 dual specificity phosphatase 22 -2.55382
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.54488
SOX6 SRY (sex determining region Y)-box 6 -2.53618
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -2.50792
FOXK2 forkhead box K2 -2.47782
UBA2 ubiquitin-like modifier activating enzyme 2 -2.46967
PREB prolactin regulatory element binding -2.46043
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.44848
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.44447
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.42183
DNM2 dynamin 2 -2.41671
CENPA centromere protein A -2.4098
COX7C cytochrome c oxidase subunit VIIc -2.40902
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.38025
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.35422
NUCLEOLIN nucleolin multifunctional protein -2.34932
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.34584
NLGN1 neuroligin 1 -2.34377
RPS17 ribosomal protein S17 -2.32461
ZNF57 zinc finger protein 57 -2.31192
SHFM1 split hand/foot malformation (ectrodactyly) type 1 -2.30801
DLAT dihydrolipoamide S-acetyltransferase -2.30407
SIN3A SIN3 transcription regulator family member A -2.30024
GPR83 G protein-coupled receptor 83 -2.29408
PLXNA3 plexin A3 -2.28154
PMPCB peptidase (mitochondrial processing) beta -2.28104
SENP3-EIF4A1 SENP3-EIF4A1 readthrough (NMD candidate) -2.27837
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -2.26236
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.24323
DNASE1L2 deoxyribonuclease I-like 2 -2.24217
HIST1H2AE histone cluster 1, H2ae -2.22653
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.22597
KRT13 keratin 13, type I -2.21955
TP73 tumor protein p73 -2.21521
CARD9 caspase recruitment domain family, member 9 -2.21051
TRRAP transformation/transcription domain-associated protein -2.21036
RREB1 ras responsive element binding protein 1 -2.19907
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.19749
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.18603
PHF11 PHD finger protein 11 -2.18159
ERBB2IP erbb2 interacting protein -2.17568
CD207 CD207 molecule, langerin -2.16509
CAMK1 calcium/calmodulin-dependent protein kinase I -2.16355
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.15078
AAK1 AP2 associated kinase 1 -2.15016
MET MET proto-oncogene, receptor tyrosine kinase -2.12191
RSPO3 R-spondin 3 -2.11771
AK1 adenylate kinase 1 -2.1125
FNTA farnesyltransferase, CAAX box, alpha -2.10332
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -2.0964
SRRT serrate, RNA effector molecule -2.08545
SMC2 structural maintenance of chromosomes 2 -2.08021
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -2.07392
FOXD4L4 forkhead box D4-like 4 -2.07149
FOXD4L5 forkhead box D4-like 5 -2.06574
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.06534
KARS lysyl-tRNA synthetase -2.06372
ZNF217 zinc finger protein 217 -2.06244
SP8 Sp8 transcription factor -2.0579
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.04808
RAB43 RAB43, member RAS oncogene family -2.04518
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.03423
LRP3 low density lipoprotein receptor-related protein 3 -2.03002
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.01983
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.01545
FZD9 frizzled class receptor 9 -2.01393
ABAT 4-aminobutyrate aminotransferase -2.01321
MPPE1 metallophosphoesterase 1 -2.01089
BIRC5 baculoviral IAP repeat containing 5 -2.00976
RPS14 ribosomal protein S14 -2.00476
H2AFZ H2A histone family, member Z -2.0001
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -1.99807
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -1.99142
IARS isoleucyl-tRNA synthetase -1.98867
ZNF571 zinc finger protein 571 -1.98142
PEX5 peroxisomal biogenesis factor 5 -1.97609
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -1.97099
RXRG retinoid X receptor, gamma -1.95662
RPL37 ribosomal protein L37 -1.954
GRK1 G protein-coupled receptor kinase 1 -1.95046
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -1.9498
ARHGAP15 Rho GTPase activating protein 15 -1.94927
LOC390705 protein phosphatase 2, regulatory subunit B'', beta pseudogene -1.94676
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit -1.94433
CLIC2 chloride intracellular channel 2 -1.9371
ZNF48 zinc finger protein 48 -1.93466
TOP2A topoisomerase (DNA) II alpha 170kDa -1.92556
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -1.92484
ZNF140 zinc finger protein 140 -1.92119
CDC5L cell division cycle 5-like -1.90614
POLR1C polymerase (RNA) I polypeptide C, 30kDa -1.90264
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -1.89913
HOXA10 homeobox A10 -1.89169
ANK2 ankyrin 2, neuronal -1.88526
NDOR1 NADPH dependent diflavin oxidoreductase 1 -1.88262
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -1.87232
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -1.87064
ZNF595 zinc finger protein 595 -1.86568
PRPF31 pre-mRNA processing factor 31 -1.85976
ADGRD2 adhesion G protein-coupled receptor D2 -1.84288
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa -1.84279
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -1.8382
ZNF490 zinc finger protein 490 -1.838
BCHE butyrylcholinesterase -1.83577
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -1.83483
ERBB3 erb-b2 receptor tyrosine kinase 3 -1.83465
MYBPH myosin binding protein H -1.83268
CAPN7 calpain 7 -1.83256
GATA4 GATA binding protein 4 -1.82762
TRIM41 tripartite motif containing 41 -1.81202
PHPT1 phosphohistidine phosphatase 1 -1.8107
TRIM50 tripartite motif containing 50 -1.81023
FOSL2 FOS-like antigen 2 -1.80703
RARB retinoic acid receptor, beta -1.80582
SEPHS1 selenophosphate synthetase 1 -1.8055
RUVBL2 RuvB-like AAA ATPase 2 -1.80446
CELA2B chymotrypsin-like elastase family, member 2B -1.80416
CDK13 cyclin-dependent kinase 13 -1.8037
AURKB aurora kinase B -1.80354
CAND1 cullin-associated and neddylation-dissociated 1 -1.80155
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -1.80014
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -1.79552
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -1.79313
GALNS galactosamine (N-acetyl)-6-sulfatase -1.79209
CUL1 cullin 1 -1.79036
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -1.79029
RPS4X ribosomal protein S4, X-linked -1.78588
GTPBP4 GTP binding protein 4 -1.78256
HIST1H3A histone cluster 1, H3a -1.78044
MYF6 myogenic factor 6 (herculin) -1.77766
LOC100508408 -1.77317
ATM ATM serine/threonine kinase -1.77105
BRCA1 breast cancer 1, early onset -1.77034
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -1.7692
PRPF8 pre-mRNA processing factor 8 -1.75375
PLCD3 phospholipase C, delta 3 -1.7522
TSPAN17 tetraspanin 17 -1.74914
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -1.74275
NUMA1 nuclear mitotic apparatus protein 1 -1.73346
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -1.73167
RPS13 ribosomal protein S13 -1.72993
IL1B interleukin 1, beta -1.7292
ITGB4 integrin, beta 4 -1.72856
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.72828
MRPL38 mitochondrial ribosomal protein L38 -1.72392
RNASET2 ribonuclease T2 -1.71699
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -1.70966
RAB22A RAB22A, member RAS oncogene family -1.70864
BRD4 bromodomain containing 4 -1.70042
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 -1.69875
CDK9 cyclin-dependent kinase 9 -1.69773
U2AF2 U2 small nuclear RNA auxiliary factor 2 -1.69465
UNKL unkempt family zinc finger-like -1.69355
HIST1H4L histone cluster 1, H4l -1.69264
KRT73 keratin 73, type II -1.68949
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -1.6868
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -1.68456
KISS1 KiSS-1 metastasis-suppressor -1.68343
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -1.68338
GPR31 G protein-coupled receptor 31 -1.67869
ZNF546 zinc finger protein 546 -1.67863
GSC goosecoid homeobox -1.6774
MYH9 myosin, heavy chain 9, non-muscle -1.67489
ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough -1.67303
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -1.67235
VPREB1 pre-B lymphocyte 1 -1.67093
SRM spermidine synthase -1.6709
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -1.67054
EIF3H eukaryotic translation initiation factor 3, subunit H -1.66999
MXD3 MAX dimerization protein 3 -1.66239
MBD6 methyl-CpG binding domain protein 6 -1.66186
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -1.66137
RPGR retinitis pigmentosa GTPase regulator -1.65877
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 -1.65853
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -1.65484
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -1.65259
PHACTR4 phosphatase and actin regulator 4 -1.65142
SRSF1 serine/arginine-rich splicing factor 1 -1.64762
ZNF250 zinc finger protein 250 -1.63997
PMVK phosphomevalonate kinase -1.63884
HOXD11 homeobox D11 -1.63794
TUBG1 tubulin, gamma 1 -1.63523
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -1.63316
CANX calnexin -1.63155
CYC1 cytochrome c-1 -1.63143
OVOL1 ovo-like zinc finger 1 -1.62949
COX11 COX11 cytochrome c oxidase copper chaperone -1.62914
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -1.62661
RPS6 ribosomal protein S6 -1.62404
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -1.6189
CP ceruloplasmin (ferroxidase) -1.61544
ABHD16A abhydrolase domain containing 16A -1.61484
ZNF436 zinc finger protein 436 -1.61314
MRPL37 mitochondrial ribosomal protein L37 -1.60709
ADORA1 adenosine A1 receptor -1.60451
ZNF45 zinc finger protein 45 -1.6041
CNGB3 cyclic nucleotide gated channel beta 3 -1.6022
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -1.60064
USP40 ubiquitin specific peptidase 40 -1.5985
GRSF1 G-rich RNA sequence binding factor 1 -1.59536
MORC3 MORC family CW-type zinc finger 3 -1.59455
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -1.58839
CCR7 chemokine (C-C motif) receptor 7 -1.5864
EGR3 early growth response 3 -1.58359
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -1.58165
TCOF1 Treacher Collins-Franceschetti syndrome 1 -1.58053
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -1.57725
PNPT1 polyribonucleotide nucleotidyltransferase 1 -1.57652
TRPS1 trichorhinophalangeal syndrome I -1.56681
GPBAR1 G protein-coupled bile acid receptor 1 -1.56612
TRIP13 thyroid hormone receptor interactor 13 -1.55855
PFAS phosphoribosylformylglycinamidine synthase -1.55711
ELF1 E74-like factor 1 (ets domain transcription factor) -1.55204
COL5A2 collagen, type V, alpha 2 -1.5401
PPIA peptidylprolyl isomerase A (cyclophilin A) -1.53742
EIF4A1 eukaryotic translation initiation factor 4A1 -1.53503
NIN ninein (GSK3B interacting protein) -1.52282
ZNF500 zinc finger protein 500 -1.51961
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -1.51767
GUK1 guanylate kinase 1 -1.51757
DPRX divergent-paired related homeobox -1.51333
GTPBP1 GTP binding protein 1 -1.51181
HNRNPM heterogeneous nuclear ribonucleoprotein M -1.51162
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -1.50679
ISY1-RAB43 ISY1-RAB43 readthrough -1.5062
FBXO17 F-box protein 17 -1.50573
IL3RA interleukin 3 receptor, alpha (low affinity) -1.50252
ARHGAP17 Rho GTPase activating protein 17 -1.50146
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -1.4983
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -1.49764
L3MBTL2 l(3)mbt-like 2 (Drosophila) -1.49539
SKA2 spindle and kinetochore associated complex subunit 2 -1.49474
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.49017
CLASP2 cytoplasmic linker associated protein 2 -1.48774
NAMPT nicotinamide phosphoribosyltransferase -1.48479
GPX1 glutathione peroxidase 1 -1.47863
HCCS holocytochrome c synthase -1.47835
SLC45A2 solute carrier family 45, member 2 -1.4782
LRPPRC leucine-rich pentatricopeptide repeat containing -1.47743
SEC13 SEC13 homolog (S. cerevisiae) -1.47559
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -1.47397
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -1.46604
UQCRC1 ubiquinol-cytochrome c reductase core protein I -1.45686
PRKCZ protein kinase C, zeta -1.45213
LOC647208 protein phosphatase 2, regulatory subunit B'', beta pseudogene -1.45161
T T, brachyury homolog (mouse) -1.4477
NINJ1 ninjurin 1 -1.44763
CDC34 cell division cycle 34 -1.44448
KDM1A lysine (K)-specific demethylase 1A -1.44271
BMP2 bone morphogenetic protein 2 -1.43769
LDHB lactate dehydrogenase B -1.43529
ETFDH electron-transferring-flavoprotein dehydrogenase -1.43359
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -1.42752
LTK leukocyte receptor tyrosine kinase -1.42515
AFG3L2 AFG3-like AAA ATPase 2 -1.42489
UGCG UDP-glucose ceramide glucosyltransferase -1.42318
KRT19 keratin 19, type I -1.42132
SDS serine dehydratase -1.41995
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -1.41685
D2HGDH D-2-hydroxyglutarate dehydrogenase -1.416
IL1R1 interleukin 1 receptor, type I -1.41548
CENPF centromere protein F, 350/400kDa -1.41472
GATAD2A GATA zinc finger domain containing 2A -1.41426
TRIM36 tripartite motif containing 36 -1.41393
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -1.41254
E2F1 E2F transcription factor 1 -1.41246
FLNB filamin B, beta -1.4041
ZBTB45 zinc finger and BTB domain containing 45 -1.40323
RBBP4 retinoblastoma binding protein 4 -1.39453
PHF23 PHD finger protein 23 -1.38902
NFIB nuclear factor I/B -1.38592
MYL12B myosin, light chain 12B, regulatory -1.38104
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -1.37915
IL36A interleukin 36, alpha -1.37808
ADGRE3 adhesion G protein-coupled receptor E3 -1.37077
ATP5EP2 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 -1.36358
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -1.36182
BCOR BCL6 corepressor -1.3617
INSM1 insulinoma-associated 1 -1.3603
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -1.36025
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -1.35623
HSPA9 heat shock 70kDa protein 9 (mortalin) -1.35517
NMBR neuromedin B receptor -1.3529
IMPAD1 inositol monophosphatase domain containing 1 -1.35192
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -1.35127
YBX1 Y box binding protein 1 -1.34848
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -1.34715
EIF5B eukaryotic translation initiation factor 5B -1.34366
RPS11 ribosomal protein S11 -1.34323
HRK harakiri, BCL2 interacting protein -1.34102
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -1.34069
GTPBP3 GTP binding protein 3 (mitochondrial) -1.34068
LHX5 LIM homeobox 5 -1.33977
MRC2 mannose receptor, C type 2 -1.33737
LIG4 ligase IV, DNA, ATP-dependent -1.33385
TSHZ3 teashirt zinc finger homeobox 3 -1.33281
TANK TRAF family member-associated NFKB activator -1.33015
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -1.32755
ZFYVE16 zinc finger, FYVE domain containing 16 -1.32648
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -1.32471
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -1.3218
HNRNPK heterogeneous nuclear ribonucleoprotein K -1.32089
PLAU plasminogen activator, urokinase -1.31999
MADD MAP-kinase activating death domain -1.31894
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -1.3186
HIST3H2A histone cluster 3, H2a -1.3178
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -1.31688
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -1.31555
OR2T1 olfactory receptor, family 2, subfamily T, member 1 -1.3137
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -1.31207
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -1.31115
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -1.31061
CDKL4 cyclin-dependent kinase-like 4 -1.30793
PDE9A phosphodiesterase 9A -1.30724
MED12 mediator complex subunit 12 -1.30542
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -1.29819
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -1.29569
CLIP1 CAP-GLY domain containing linker protein 1 -1.29414
RUFY1 RUN and FYVE domain containing 1 -1.28951
ZNF81 zinc finger protein 81 -1.288
RPL31 ribosomal protein L31 -1.28593
RPS9 ribosomal protein S9 -1.28543
CCDC71 coiled-coil domain containing 71 -1.28438
UBE2F-SCLY UBE2F-SCLY readthrough (NMD candidate) -1.28381
SF3B3 splicing factor 3b, subunit 3, 130kDa -1.28115
RXRB retinoid X receptor, beta -1.27781
MYLIP myosin regulatory light chain interacting protein -1.27265
BRD8 bromodomain containing 8 -1.27219
SYT9 synaptotagmin IX -1.27115
TAS2R4 taste receptor, type 2, member 4 -1.27063
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -1.27039
NPC1 Niemann-Pick disease, type C1 -1.27012
DLX6 distal-less homeobox 6 -1.26986
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -1.26513
MSRA methionine sulfoxide reductase A -1.26331
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -1.26243
MTA1 metastasis associated 1 -1.2615
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -1.25965
TAS2R38 taste receptor, type 2, member 38 -1.25842
ZRANB2 zinc finger, RAN-binding domain containing 2 -1.25736
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -1.25282
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -1.25204
IVNS1ABP influenza virus NS1A binding protein -1.25094
MCTP2 multiple C2 domains, transmembrane 2 -1.25008
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -1.24738
ZMYM1 zinc finger, MYM-type 1 -1.24641
SON SON DNA binding protein -1.24492
ATXN7 ataxin 7 -1.24223
IL13 interleukin 13 -1.24196
UBQLN4 ubiquilin 4 -1.24084
FETUB fetuin B -1.23805
AQR aquarius intron-binding spliceosomal factor -1.23467
MED28 mediator complex subunit 28 -1.23426
SAE1 SUMO1 activating enzyme subunit 1 -1.23404
FGFR1 fibroblast growth factor receptor 1 -1.23314
SIRT2 sirtuin 2 -1.23043
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -1.22963
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -1.22889
ZNF461 zinc finger protein 461 -1.22628
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -1.22587
CDC37 cell division cycle 37 -1.22327
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -1.22037
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -1.21995
RNF167 ring finger protein 167 -1.21647
ZNF117 zinc finger protein 117 -1.2053
ZNF568 zinc finger protein 568 -1.203
PCDHA2 protocadherin alpha 2 -1.20196
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -1.20059
GPR78 G protein-coupled receptor 78 -1.20002
MRPS28 mitochondrial ribosomal protein S28 -1.19993
ECD ecdysoneless homolog (Drosophila) -1.19785
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -1.19544
PFN1 profilin 1 -1.19484
CALML3 calmodulin-like 3 -1.19262
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -1.18638
CYBRD1 cytochrome b reductase 1 -1.18388
SECISBP2L SECIS binding protein 2-like -1.18352
RBM47 RNA binding motif protein 47 -1.18257
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -1.18171
PCDHB9 protocadherin beta 9 -1.1813
RPS19 ribosomal protein S19 -1.18129
ACAA1 acetyl-CoA acyltransferase 1 -1.18044
SP1 Sp1 transcription factor -1.18043
PSAT1 phosphoserine aminotransferase 1 -1.17916
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -1.17825
H3F3C H3 histone, family 3C -1.17725
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -1.17595
A2ML1 alpha-2-macroglobulin-like 1 -1.17568
APOM apolipoprotein M -1.17464
GRK7 G protein-coupled receptor kinase 7 -1.17402
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -1.1734
RASA1 RAS p21 protein activator (GTPase activating protein) 1 -1.16883
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -1.16799
RAB1B RAB1B, member RAS oncogene family -1.16646
GAK cyclin G associated kinase -1.1634
PCSK6 proprotein convertase subtilisin/kexin type 6 -1.1611
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -1.15979
SORD sorbitol dehydrogenase -1.1597
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -1.15856
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -1.15817
LRRK2 leucine-rich repeat kinase 2 -1.14742
GTF2A1 general transcription factor IIA, 1, 19/37kDa -1.14417
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -1.14407
DUX3 double homeobox 3 -1.14173
PKD2L2 polycystic kidney disease 2-like 2 -1.1416
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -1.14098
TRIM45 tripartite motif containing 45 -1.14075
HIST1H3H histone cluster 1, H3h -1.14006
ARHGAP20 Rho GTPase activating protein 20 -1.13854
HIST1H3D histone cluster 1, H3d -1.13794
MDK midkine (neurite growth-promoting factor 2) -1.13653
ADCK1 aarF domain containing kinase 1 -1.13634
HIST2H2AC histone cluster 2, H2ac -1.1345
NPHP4 nephronophthisis 4 -1.13299
RAB11FIP5 RAB11 family interacting protein 5 (class I) -1.12959
BAG6 BCL2-associated athanogene 6 -1.12679
ZNF655 zinc finger protein 655 -1.12624
IGF2R insulin-like growth factor 2 receptor -1.12615
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -1.1222
EIF4E eukaryotic translation initiation factor 4E -1.1217
PRDM10 PR domain containing 10 -1.12138
MED9 mediator complex subunit 9 -1.11834
THOP1 thimet oligopeptidase 1 -1.11819
ACTC1 actin, alpha, cardiac muscle 1 -1.11816
PTPRM protein tyrosine phosphatase, receptor type, M -1.11259
PARP12 poly (ADP-ribose) polymerase family, member 12 -1.11211
HIST1H2AC histone cluster 1, H2ac -1.11179
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -1.10914
KCTD6 potassium channel tetramerization domain containing 6 -1.10574
SSB Sjogren syndrome antigen B (autoantigen La) -1.10133
COX4I1 cytochrome c oxidase subunit IV isoform 1 -1.09867
CELF3 CUGBP, Elav-like family member 3 -1.09493
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -1.09469
DSCAM Down syndrome cell adhesion molecule -1.09466
URI1 URI1, prefoldin-like chaperone -1.09089
CHRM4 cholinergic receptor, muscarinic 4 -1.09074
FGD5 FYVE, RhoGEF and PH domain containing 5 -1.09021
ANKRD17 ankyrin repeat domain 17 -1.08952
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -1.08813
NACA nascent polypeptide-associated complex alpha subunit -1.08809
ERCC1 excision repair cross-complementation group 1 -1.08801
PEX12 peroxisomal biogenesis factor 12 -1.08466
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 -1.08265
RNF149 ring finger protein 149 -1.0813
OC90 otoconin 90 -1.08047
SLC25A40 solute carrier family 25, member 40 -1.08044
PHACTR3 phosphatase and actin regulator 3 -1.08036
GRB2 growth factor receptor-bound protein 2 -1.08004
E2F3 E2F transcription factor 3 -1.08001
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.078
RPTOR regulatory associated protein of MTOR, complex 1 -1.07776
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -1.07567
TACC3 transforming, acidic coiled-coil containing protein 3 -1.07406
FIP1L1 factor interacting with PAPOLA and CPSF1 -1.07369
C8G complement component 8, gamma polypeptide -1.07359
TASP1 taspase, threonine aspartase, 1 -1.07313
LONP1 lon peptidase 1, mitochondrial -1.07253
TUSC1 tumor suppressor candidate 1 -1.07247
CD72 CD72 molecule -1.06994
BCL2L10 BCL2-like 10 (apoptosis facilitator) -1.06945
LAMA3 laminin, alpha 3 -1.06763
TUBGCP3 tubulin, gamma complex associated protein 3 -1.06714
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -1.06498
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -1.061
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -1.05431
SNRPC small nuclear ribonucleoprotein polypeptide C -1.05386
MMP14 matrix metallopeptidase 14 (membrane-inserted) -1.05378
EIF5A eukaryotic translation initiation factor 5A -1.05237
CSE1L CSE1 chromosome segregation 1-like (yeast) -1.04889
CXCL6 chemokine (C-X-C motif) ligand 6 -1.04869
NCBP1 nuclear cap binding protein subunit 1, 80kDa -1.04747
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -1.04611
ABLIM3 actin binding LIM protein family, member 3 -1.04484
RPSAP9 ribosomal protein SA pseudogene 9 -1.04466
TCF4 transcription factor 4 -1.04459
EPX eosinophil peroxidase -1.04369
ADGRL2 adhesion G protein-coupled receptor L2 -1.04264
LAMP2 lysosomal-associated membrane protein 2 -1.04262
SOX18 SRY (sex determining region Y)-box 18 -1.04042
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -1.04
SIN3B SIN3 transcription regulator family member B -1.03916
PECR peroxisomal trans-2-enoyl-CoA reductase -1.0391
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -1.03904
HPCA hippocalcin -1.03684
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -1.03592
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -1.03465
SIAH3 siah E3 ubiquitin protein ligase family member 3 -1.03363
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -1.03279
HSPD1 heat shock 60kDa protein 1 (chaperonin) -1.03113
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -1.02876
C17ORF75 chromosome 17 open reading frame 75 -1.02694
DCHS2 dachsous cadherin-related 2 -1.02572
IDE insulin-degrading enzyme -1.02403
APOA2 apolipoprotein A-II -1.02239
CHAF1A chromatin assembly factor 1, subunit A (p150) -1.01789
RNASEH2A ribonuclease H2, subunit A -1.0177
TAS2R60 taste receptor, type 2, member 60 -1.01713
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.01696
CX3CL1 chemokine (C-X3-C motif) ligand 1 -1.01674
STAMBPL1 STAM binding protein-like 1 -1.01632
COPS8 COP9 signalosome subunit 8 -1.01579
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -1.01241
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -1.01195
ATF4 activating transcription factor 4 -1.01156
ZNF788 zinc finger family member 788 -1.00958
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -1.00889
CABP4 calcium binding protein 4 -1.00586
MKRN3 makorin ring finger protein 3 -1.00542
GAP43 growth associated protein 43 -1.00527
NFX1 nuclear transcription factor, X-box binding 1 -1.00496
MYBBP1A MYB binding protein (P160) 1a -1.00276
PRICKLE4 prickle homolog 4 (Drosophila) -1.00078
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -1.00044