MDC1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mediator of DNA-damage checkpoint 1|The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9656)
External Link http://www.ncbi.nlm.nih.gov/gene/9656
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Genes

259 interacting proteins for MDC1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATR ATR serine/threonine kinase
ATXN2 ataxin 2
AUP1 ancient ubiquitous protein 1
BABAM1 BRISC and BRCA1 A complex member 1
BANF1 barrier to autointegration factor 1
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRD7 bromodomain containing 7
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC27 cell division cycle 27
CDC5L cell division cycle 5-like
CDK2 cyclin-dependent kinase 2
CDKN2AIP CDKN2A interacting protein
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CLOCK clock circadian regulator
CLU clusterin
COPE coatomer protein complex, subunit epsilon
COPS5 COP9 signalosome subunit 5
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSRP2 cysteine and glycine-rich protein 2
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CXORF57 chromosome X open reading frame 57
DCLRE1C DNA cross-link repair 1C
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DEPDC1B DEP domain containing 1B
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
DTX2 deltex 2, E3 ubiquitin ligase
EED embryonic ectoderm development
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EMD emerin
ENO1 enolase 1, (alpha)
EP300 E1A binding protein p300
EPS8 epidermal growth factor receptor pathway substrate 8
ESRRA estrogen-related receptor alpha
EXOSC2 exosome component 2
EXOSC8 exosome component 8
FAM175A family with sequence similarity 175, member A
FANCD2 Fanconi anemia, complementation group D2
FLNA filamin A, alpha
FLNB filamin B, beta
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATA4 GATA binding protein 4
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HDAC1 histone deacetylase 1
HDAC10 histone deacetylase 10
HDAC2 histone deacetylase 2
HDAC8 histone deacetylase 8
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HINFP histone H4 transcription factor
HMBOX1 homeobox containing 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSPA1B heat shock 70kDa protein 1B
IMMT inner membrane protein, mitochondrial
INO80E INO80 complex subunit E
JMJD1C jumonji domain containing 1C
KPNB1 karyopherin (importin) beta 1
LAS1L LAS1-like (S. cerevisiae)
LMNA lamin A/C
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM12 LSM12 homolog (S. cerevisiae)
LYAR Ly1 antibody reactive
MBD2 methyl-CpG binding domain protein 2
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL17 methyltransferase like 17
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKI67 marker of proliferation Ki-67
MPG N-methylpurine-DNA glycosylase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTA3 metastasis associated 1 family, member 3
MYH14 myosin, heavy chain 14, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO1D myosin ID
NAV3 neuron navigator 3
NBN nibrin
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
OSBPL8 oxysterol binding protein-like 8
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PDHB pyruvate dehydrogenase (lipoamide) beta
PDZD11 PDZ domain containing 11
PELO pelota homolog (Drosophila)
PGAM5 phosphoglycerate mutase family member 5
PHB2 prohibitin 2
PHGDH phosphoglycerate dehydrogenase
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PKNOX1 PBX/knotted 1 homeobox 1
PLRG1 pleiotropic regulator 1
POGZ pogo transposable element with ZNF domain
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP4C protein phosphatase 4, catalytic subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDM16 PR domain containing 16
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PYCR1 pyrroline-5-carboxylate reductase 1
PYCR2 pyrroline-5-carboxylate reductase family, member 2
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAG1 recombination activating gene 1
RAI14 retinoic acid induced 14
RAN RAN, member RAS oncogene family
RBM17 RNA binding motif protein 17
RBM39 RNA binding motif protein 39
RECQL5 RecQ protein-like 5
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMDN3 regulator of microtubule dynamics 3
RNF4 ring finger protein 4
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPL29 ribosomal protein L29
RPS27A ribosomal protein S27a
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERBP1 SERPINE1 mRNA binding protein 1
SF3A1 splicing factor 3a, subunit 1, 120kDa
SIN3B SIN3 transcription regulator family member B
SIRT7 sirtuin 7
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMN2 survival of motor neuron 2, centromeric
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOGA3 SOGA family member 3
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRSF1 serine/arginine-rich splicing factor 1
SRSF9 serine/arginine-rich splicing factor 9
SSR1 signal sequence receptor, alpha
STAT1 signal transducer and activator of transcription 1, 91kDa
STAU1 staufen double-stranded RNA binding protein 1
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAGLN2 transgelin 2
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THRAP3 thyroid hormone receptor associated protein 3
THYN1 thymocyte nuclear protein 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPM1 tropomyosin 1 (alpha)
TPM3 tropomyosin 3
TRIM28 tripartite motif containing 28
TRIP13 thyroid hormone receptor interactor 13
TSLIG2 tRNA splicing ligase complex subunit 2
TTF2 transcription termination factor, RNA polymerase II
U2SURP U2 snRNP-associated SURP domain containing
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBP1 upstream binding protein 1 (LBP-1a)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UIMC1 ubiquitin interaction motif containing 1
USF2 upstream transcription factor 2, c-fos interacting
USP28 ubiquitin specific peptidase 28
VAMP5 vesicle-associated membrane protein 5
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VRK1 vaccinia related kinase 1
WDR18 WD repeat domain 18
WDR33 WD repeat domain 33
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIZ widely interspaced zinc finger motifs
WRN Werner syndrome, RecQ helicase-like
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YEATS2 YEATS domain containing 2
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF251 zinc finger protein 251
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZNF768 zinc finger protein 768
ZZZ3 zinc finger, ZZ-type containing 3